Article
Chemistry, Medicinal
Naoyuki Toriumi, Atsuya Muranaka, Masanobu Uchiyama
Summary: Deuteration of phthalocyanines, a representative class of organic NIR dyes, is found to enhance both the fluorescence quantum yield and the fluorescence lifetime compared with nondeuterated phthalocyanines.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Shuichi Suzuki, Daiki Yamaguchi, Yoshiaki Uchida, Takeshi Naota
Summary: The liquescent dihydrophenazine radical cation showed drastic changes in near-infrared transparency and opaqueness through hysteretic phase transitions without measurable degradation, with changes in electronic and magnetic properties between solid and liquid states. These variations were attributed to the dynamic dissociation and association of a pi-dimer structure, even under neat conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Lei G. Wang, Antonio R. Montano, Anas M. Masillati, Jocelyn A. Jones, Connor W. Barth, Jason R. Combs, Sashini Udeshika Kumarapeli, Nourhan A. Shams, Nynke S. van den Berg, Alexander L. Antaris, S. N. Galvis, Ian Mcdowall, Syed Zaki Husain Rizvi, Adam W. G. Alani, Jonathan M. Sorger, Summer L. Gibbs
Summary: A library of near-infrared (NIR) fluorophores has been developed for nerve-specific imaging during surgery by combining drug-like molecular design and fluorophore chemistry. These fluorophores are compatible with the clinically available da Vinci Surgical System and can accurately visualize prostatic nerves, paving the way for reducing nerve injury in prostate cancer patients.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Z. Liu, X. Zhang
Summary: A theoretical investigation of vanadium naphthalocyanine (VONc) was performed, including the molecular, electronic structures, and vibrational spectrum. The study compared VONc with other metal naphthalocyanines and found differences in symmetry and bond lengths. VONc exhibited the smallest HOMO-LUMO gap among the studied compounds. Accurate vibrational mode assignments were obtained using calculated potential energy distribution and animated pictures. A new symbol system was adopted to improve the clarity of the assignments, and corrections were made based on experimental comparisons.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Nicoleta Sandu, Claudia G. Chilom, Melinda David, Monica Florescu
Summary: This study investigated the interaction between the hydrophilic drug levothyroxine (LT4) and bovine serum albumin (BSA). Various techniques including UV-vis measurements, Fourier-transform infrared spectroscopy (FT-IR), fluorescence, fluorescence resonance energy transfer (FRET), Surface Plasmon Resonance (SPR), and molecular docking analysis were used. The results showed that LT4 binds to BSA through ground-state complex formation, driven mainly by hydrogen bonds and van der Waals forces. The immobilization of BSA was found to be crucial for the binding of LT4. These findings have important implications for understanding the pharmacological significance of LT4-protein binding.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Hirofumi Ueda, Soichiro Sato, Kenta Noda, Hiroyuki Hakamata, Eunsang Kwon, Nagao Kobayashi, Hidetoshi Tokuyama
Summary: A biomimetic oxidative dimerization method for tryptophan derivatives was developed using oxygen as a bulk oxidant in aqueous media catalyzed by an iron octacarboxy phthalocyanine complex. The highly active iron catalyst enables aerobic enzyme-mimetic oxidation in a flask. This method provides a facile access to a broad range of dimerized peptides with unique scaffold, which can be used as a powerful tool for creating new small- and medium-sized molecules as drug candidates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Getulio P. Oliveira-Jr, Raquel H. Barbosa, Lauren Thompson, Brandy Pinckney, Moriah Murphy-Thornley, Shulin Lu, Jennifer Jones, Clinton H. Hansen, John Tigges, Wesley P. Wong, Ionita C. Ghiran
Summary: The method based on delayed electrophoretic mobility offers sensitive detection of miRNAs-MB hybridization, with single nucleotide specificity, making it a rapid and affordable approach for quantification.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Connor W. W. Barth, Syed Zaki Husain Rizvi, Anas M. M. Masillati, Samrat Chakraborty, Lei G. G. Wang, Antonio R. R. Montano, Dani A. A. Szafran, William S. S. Greer, Nynke S. S. van den Berg, Jonathan Sorger, Deepa A. A. Rao, Adam W. G. Alani, Summer L. L. Gibbs
Summary: Patients undergoing gynecological procedures often suffer from long-term side effects caused by nerve damage. A near-infrared fluorescent contrast agent, LGW08-35, has been developed for real-time visualization of important nerves during nerve-sparing gynecologic surgeries, which can help eliminate incontinence and sexual dysfunction in patients.
Article
Chemistry, Applied
Arpita Panda, Dmytro Kobzev, Olesia Kulyk, Andrii Bazylevich, Gary Gellerman, Leonid Patsenker
Summary: Mitochondria play a crucial role in maintaining cell viability, and dysfunction can lead to serious diseases. In order to achieve selective imaging and targeted therapy, a series of novel mitochondria-specific dyes with better visualization and higher fluorescence intensity have been developed.
Article
Pathology
Ryan J. Dikdan, Salvatore A. E. Marras, Amanda P. Field, Alicia Brownlee, Alexander Cironi, D. Ashley Hill, Sanjay Tyagi
Summary: Developed a multiplex quantitative RT-PCR assay that can identify different variants of SARS-CoV-2 and other important mutations with high sensitivity and specificity. The assay can be easily implemented on widely available devices and aids in tracking the spread of variants.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2022)
Article
Chemistry, Analytical
Yamin Fu, Ke Xiao, Qingqing Zhang, Xiaohua Zhang, Cuicui Du, Jinhua Chen
Summary: Water pollution is a significant environmental concern. In this study, a switchable photocurrent-polarity platform based on iron phthalocyanine was developed for highly selective assay of arsenate. The platform showed a low detection limit and a wide linear response range, meeting the detection requirement for arsenic concentration in drinking water. Additionally, the platform effectively avoided false-positive or false-negative results and could simultaneously separate arsenate from the detection system.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yu-Ting Kao, Silvia Calabrese, Nadine Borst, Michael Lehnert, Yu-Kai Lai, Franziska Schlenker, Peter Juelg, Roland Zengerle, Piotr Garstecki, Felix von Stetten
Summary: A novel microfluidic one-pot wash-free fluorescence in situ hybridization (FISH) assay was developed for detection and quantification of bacterial load, offering simplicity, speed, and accuracy in analysis. This method is significant for quantitative analysis of bacterial load.
Review
Chemistry, Applied
Songjiao Li, Peipei Wang, Ke Yang, Ying Liu, Dan Cheng, Longwei He
Summary: A near-infrared methylene blue-based fluorogenic probe with on/off activation ability is crucial for detecting and monitoring biological analytes within cells and organisms. By using biomarker-activated probes, precise results can be obtained with minimal photodamage and biological interferences. This review highlights the recent advancements in activatable methylene blue-based fluorogenic probes, focusing on strategies for detecting and imaging disease-related biomarkers and the potential challenges and opportunities in developing new methods to detect and image biomarkers.
Article
Chemistry, Analytical
Veeresh A. Sajjan, Shambhulinga Aralekallu, Manjunatha Nemakal, Manjunatha Palanna, C. P. Keshavananda Prabhu, Lokesh Koodlur Sannegowda
Summary: In this study, a Schiff-base embedded cobalt (II) complex was successfully prepared and characterised, followed by modification of glassy carbon electrode for the electroanalytical detection of 4-nitrophenol. The GCE/CoTTIMPPc exhibited excellent performance in terms of stability, sensitivity, reproducibility and reliability, demonstrating its potential for environmental monitoring applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Hongyu Guo, Jiaqiao Yang, Jian Zeng, Xiaoqi Yu, Shanshan Yu, Lin Pu
Summary: The first near IR fluorescent probe for chemoselective and enantioselective recognition of arginine in aqueous solution is reported. This probe, consisting of a 1,1'-binaphthyl-based chiral aldehyde unit and a rhodamine-based near IR chromophore, in combination with La3+, shows highly selective fluorescent enhancement with arginine at lambda=764 nm upon excitation at lambda=690 nm. Little or no fluorescence response is observed towards the chirality miss-matched arginine enantiomer or other common amino acids and their enantiomers. This probe also allows visual discrimination of the arginine enantiomers due to its rapid and distinct color change upon interaction with the substrate.