期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 35, 页码 12560-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja906183g
关键词
-
资金
- NSF CAREER Award [CHE-0645447]
- NIH [R01-GM084022]
- NSF [CHE-9629688]
We describe a new oxaziridine-mediated approach to the amination of sp(3)-hybridized C-H bonds. In the presence of a copper(II) catalyst, N-sulfonyl oxaziridines participate in efficient intramolecular cyclization reactions to afford a variety of piperidine and tetrahydroisoquinoline structures. The aminal intermediates provide a convenient functional handle for further elaboration of these structures, demonstrating the utility of this new methodology for the rapid construction of structurally complex nitrogen-containing heterocycles.
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