期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 7, 页码 2484-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja8086938
关键词
-
资金
- NIH [DP2-OD2441, R01-DE013023-08]
We introduce a family of protein nanoparticles capable of sensing analytes in conjunction with magnetic resonance imaging (MRI). The new sensors are derived from the iron storage protein ferritin (Ft); they are designed and optimized using facile protein engineering methods, and self-assembled in cells harboring specific combinations of DNA coding sequences. As illustration, we show that suitably constructed Ft-based sensors can report activity of the important neural signaling enzyme protein kinase A (PKA). Phosphorylation of the engineered Ft-based nanoparticles by PKA promotes clustering and changes in T-2-weighted MRI signal.
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