期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 35, 页码 12556-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja905930s
关键词
-
资金
- ACS Petroleum Research Fund
- GlaxoSmithKline
A new method for the asymmetric synthesis of a-alkyl-a,B-dihydroxy esters that involves tandem Wittig rearrangement/aldol reactions of O-benzyl- or O-allylglycolate esters derived from 2-phenylcyclohexanol is described. This sequence constructs two C-C bonds and two stereocenters, one of which is quaternary, to afford syn diol products with excellent stereocontrol. Cleavage of the chiral auxiliary affords enantiomerically enriched products with up to 95% ee. The application of this method to the preparation of a key intermediate in the synthesis of the antifungal agent alternaric acid is also described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据