期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 131, 期 30, 页码 10775-10782出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja903899c
关键词
-
资金
- NIGMS [GM80442]
A regioselective, rhodium-catalyzed cycloaddition between a variety of internal, unsymmetrical alkynes is described. We document the impact of both steric and electronic properties of the alkyne on reaction course, efficiency, and enantioselectivity. The substituent that better stabilizes a positive charge or the larger group, all else being equal, inserts distal to the carbonyl moiety in a predictable and controllable fashion. The reaction scope is broad and the enantioselectivities are high, providing an instruction manual for substrate choice when utilizing this reaction as a synthetic tool.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据