Article
Chemistry, Multidisciplinary
Hongjuan Wang, Dezhi Yang, Wen Zhang, Junke Song, Ningbo Gong, Mingchao Yu, Shiying Yang, Baoxi Zhang, Qiwen Liu, Guanhua Du, Yang Lu
Summary: This study aimed to improve the solubility and oral bioavailability of Rhein through cocrystal formation. The results showed a 50-fold increase in in vitro dissolution of Rhe-Mat cocrystal in pure water. In vivo studies revealed a faster absorption rate and higher peak blood concentration for Rhe-Mat cocrystal compared to pure Rhein.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
David Specklin, Anais Coffinet, Laure Vendier, Iker del Rosal, Chiara Dinoi, Antoine Simonneau
Summary: A series of unprecedented group 6-group 11, N-2-bridged, heterobimetallic complexes have been synthesized and characterized, which are very labile and exhibit structural similarities to Lewis pairs. Computational analysis reveals important electrostatic components in the mu-N-2-[Au(NHC)](+) bond in the gold complexes.
INORGANIC CHEMISTRY
(2021)
Article
Thermodynamics
Carolina Torquetti, Patricia Osorio Ferreira, Amanda Cosmo de Almeida, Richard Perosa Fernandes, Flavio Junior Caires
Summary: This article describes the mechanochemical synthesis, characterization, and thermoanalytical study of new cocrystals of ciprofloxacin with picolinic acid in a 1:1 molar ratio. The study confirmed the formation of new cocrystals and showed an increase in solubility compared to the pure drug.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Chemistry, Physical
Tait A. Francis, Helen E. Maynard-Casely, Morgan L. Cable, Robert Hodyss, Courtney Ennis
Summary: Recently, it has been proposed that the formation of molecular cocrystals in condensed aerosol particles is an efficient pathway for the generation of complex organics in Titan's atmosphere. This process may facilitate the transport of biologically important precursors to the surface where they can be sequestered in organic karstic and sand environments. However, current laboratory techniques for synthesizing these cocrystals may not accurately represent the microphysics of aerosol nucleation and growth in planetary atmospheres.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Physical
Alberto Cedillo-Cruz, Diego Martinez-Otero, Joaquin Barroso-Flores, Erick Cuevas-Yanez
Summary: The crystal structures of the cocrystals of PPTE/DNPH were determined by X-ray diffraction analyses, which revealed important hydrogen bond interactions and crystal packing. Theoretical studies also showed that the cocrystal PPTE/DNPH exhibited different reactivity modulation compared to the coformer compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Alex N. Manin, Denis E. Boycov, Olga R. Simonova, Tatyana V. Volkova, Andrei Churakov, German L. Perlovich
Summary: Thermodynamic parameters for the formation of cocrystals of carbamazepine with structurally related coformers were determined using experimental and computational techniques. The relationship between solubility products and solubility values of the coformers was found, and the relationship between the entropy term and molecular volume of cocrystal formation was revealed. A new method for assessing cocrystal stability based on hydrogen bond propensity analysis was proposed. The experimental and theoretical results on the thermodynamic parameters were in good agreement.
Article
Chemistry, Multidisciplinary
Juan Saulo Gonzalez-Gonzalez, Raquel Jimenez-Lopez, David Ortegon-Reyna, Gabino Gonzalez-Carrillo, Francisco Javier Martinez-Martinez
Summary: Featured Application ATR-IR spectroscopy was used to investigate the modification of the solid form of theophylline, and pharmaceutical cocrystallization was found to alter the properties of active pharmaceutical ingredients. The mechanochemical synthesis and spectroscopic characterization of the catechol-theophylline cocrystal revealed the formation of a new solid phase. Experimental and theoretical results showed a good correlation between the chemical shifts in the C-13 NMR spectra of the cocrystal, providing valuable insights into the structure and properties of the cocrystal.
APPLIED SCIENCES-BASEL
(2021)
Article
Thermodynamics
Patricia Osorio Ferreira, Aniele de Moura, Amanda Cosmo de Almeida, Everton Carvalho dos Santos, Ana Carolina Kogawa, Flavio Junior Caires
Summary: Cocrystallization is an efficient strategy to enhance the physicochemical properties of bioactive agents. In this study, a new norfloxacin-saccharin cocrystal and a cocrystal-solvate were synthesized using mechanochemical methods, with solubility experiments showing significant improvements in aqueous solubility compared to the pristine state.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Pharmacology & Pharmacy
Si Nga Wong, Kam-Hung Low, Yi Lam Poon, Xinyue Zhang, Ho Wan Chan, Shing Fung Chow
Summary: This study successfully synthesized a cocrystal of remdesivir (RDV) with salicylic acid (SA) through liquid-assisted grinding and thermal annealing. The molecular structure of RDV-SA was resolved through powder X-ray analysis. RDV-SA was further developed as inhaled dry powders for potential COVID-19 therapy, displaying improved release in simulated lung fluid compared to raw RDV.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hanan Fael, Rafael Barbas, Rafel Prohens, Clara Rafols, Elisabet Fuguet
Summary: A new cocrystal of Norfloxacin with enhanced solubility was successfully synthesized using a solvent-mediated transformation experiment. The dissolution rate of the cocrystal was found to be approximately 10 times higher than that of Norfloxacin alone. The dissolution behavior of Norfloxacin was influenced by the dissolution at pH 2.0.
Article
Chemistry, Physical
Yun-xia Yang, Hong-juan Wang, Shi-hui Fu, Xiao-na Ma
Summary: By utilizing solution crystallization technology, a cocrystal of testosterone and 4, 4-dihydroxyl biphenyl was successfully synthesized and showed significantly improved solubility and dissolution rate, indicating its potential as a strategy for enhancing poorly soluble active pharmaceutical ingredients.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Multidisciplinary
Michael Bowker, Serena DeBeer, Nicholas F. Dummer, Graham J. Hutchings, Matthias Scheffler, Ferdi Schueth, Stuart H. Taylor, Harun Tueysuez
Summary: Catalysis plays a significant role in the manufacturing industry and contributes greatly to the global domestic product. However, the understanding of heterogeneous catalysis lags behind other fields. FUNCAT aims to address the challenges of heterogeneous catalysis in green industry and the circular economy, with a focus on critical processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Morgan L. Cable, Tomce Runcevski, Helen E. Maynard-Casely, Tuan H. Vu, Robert Hodyss
Summary: This article focuses on the binary co-crystals of small organic molecules in the mineralogy of Saturn's moon Titan. The study of these cryominerals is crucial for understanding various processes occurring on this alien world. By examining the formation and properties of these co-crystals, researchers can connect them to the formation of large-scale surface features observed on Titan.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Indumathi Sathisaran, Sameer Vishvanath Dalvi
Summary: The study describes the synthesis of new eutectic and cocrystal of Nevirapine with enhanced dissolution, demonstrating potential applications in biopharmaceuticals.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Kapil S. Ingle, Keshab M. Bairagi, Jyoti Swarup Thakur, Ranganathan Sathishkumar, Ramanaiah Chennuru, Bikash Baishya, Susanta K. Nayak
Summary: A series of 4-cyano-4'-alkoxybiphenyl compounds with varying spacer chain lengths were synthesized for the study of a halogen-bonded complex. The XB liquid crystalline complexes were characterized and the C N center dot center dot center dot I XB interaction was established. The analysis showed that even carbon chain lengths exhibited higher alterations in isotropic temperature compared to odd carbon chain lengths.
CRYSTAL GROWTH & DESIGN
(2023)