Article
Engineering, Electrical & Electronic
Zilin Wang, Yunfan Shi, Zheyao Wang
Summary: This paper introduces a new method for Cu-Cu bonding without CMP and annealing, using a sacrificial Sn layer. The method involves three steps: reflowing a Cu-Sn bump at 250°C with redox gases to change the Sn layer from solid to porous, performing pre-bonding at 200°C to transform the porous Sn to porous Cu-Sn intermetallic compounds (IMCs), and performing final bonding at 250°C with formic acid gas sweeping to convert Cu-Sn bonding to Cu-Cu bonding. This method has successfully achieved high bonding strength and high yield in bonding Cu bumps with a diameter of 5 μm and a pitch of 25 μm.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Nikoleta Kircheva, Silvia Angelova, Stefan Dobrev, Vladislava Petkova, Valya Nikolova, Todor Dudev
Summary: Silver biochemistry is linked to copper in biological systems, but copper is essential in many organisms while no known biological process requires silver. This study aims to evaluate the factors controlling the competition between silver and copper in T1Cu proteins. The results show the susceptibility of T1Cu proteins to silver attack, which provides important insights into the metabolism and biotransformation of silver in organisms.
Article
Materials Science, Multidisciplinary
Yuyu Wei, Ping Lu, Chenxi Zhu, Kunpeng Zhao, Xiaoyue Lu, Hong Su, Xun Shi, Lidong Chen, Fangfang Xu
Summary: The binary compounds Cu2X (X = S, Se) and their solid solutions exhibit excellent thermoelectric performance but suffer from poor stability due to copper precipitation issues. High density lamellar defects consisting of close-packed S/Se double layers were observed, with atomic copper showing unique characteristics near these defects. These findings provide new insights into the investigation of copper precipitation problems and suggest a potentially important role of these defects in thermoelectric properties.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Physical
Kefu Zhu, Shiqiang Wei, Quan Zhou, Shuangming Chen, Yunxiang Lin, Pengjun Zhang, Yuyang Cao, Changda Wang, Yixiu Wang, Yujian Xia, Dengfeng Cao, Zeinab Mohamed, Xin Guo, Xiya Yang, Xiaojun Wu, Li Song
Summary: Transition metal selenides have received great attention due to their high theoretical capacity, but the fluctuation in volume during charge/discharge process leads to significant reduction in electrochemical performance. In this study, carbon-regulated copper(I) selenide (Cu2Se@C) is designed to enhance the stability and ion diffusion in selenide electrodes, resulting in improved storage kinetics. The experimental results show that the capacitance process plays a crucial role in the Cu2Se@C material.
Article
Biochemistry & Molecular Biology
Yujia Jiang, Binbin Su, Honghui Chen, Tongtong Zhang, Haiping Liu, Yang Yu
Summary: By inserting the lanthanide binding tag (LBT) into the copper binding loop of Azurin protein, a new protein called Az-LBT with two metal bonding centers was created, showing strong luminescence upon coordination with Tb3+ and luminescence quenching upon Cu2+ binding, with high metal specificity and a detection limit of 0.65 μM for Cu2+.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Zhongyuan Guan, Haihang Ye, Peiwen Lv, Lijin Wang, Jing Zhang, Bin Zou, Aiwei Tang
Summary: The growth of multinary Cu-based chalcogenide nanocrystals involves the presence of copper vacancies affecting exciton recombination, the high reaction activity of selenium leading to red-shift in photoluminescence maximum, and the competitive relationship between growth and diffusion of zinc resulting in red- or blue-shift in photoluminescence maximum.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Physical
Huihui Yan, Zhengwei Yang, Chiwei Xu, Jing Li, Yiwen Liu, Runtian Zheng, Haoxiang Yu, Liyuan Zhang, Jie Shu
Summary: Aqueous Cu-S battery with four-electron sulfur reaction has been developed, achieving high capacity discharge and recyclability by protecting the copper metal anode from dendrite formation.
ENERGY STORAGE MATERIALS
(2022)
Article
Chemistry, Physical
Xuyan Cao, Biao Wan, Hanyu Liu, Lailei Wu, Yansun Yao, Huiyang Gou
Summary: Under moderate pressure, four K-Cu compounds have been predicted to form, with one compound showing a simulated X-ray diffraction pattern matching a compound synthesized in 2004. These compounds exhibit diverse structural features, including Cu dimers, linear and zigzag Cu chains, and Cu-centered polyhedrons. Analysis of the electronic structure reveals Cu atoms behaving as anions accepting electrons from K atoms, with covalent Cu-Cu interaction associated with sp hybridizations.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Energy & Fuels
Jiayong Zhang, Bin Yao, Zhanhui Ding, Yongfeng Li, Ding Ma, Mengge Li, Yuting Sun, Chunkai Wang, Yue Liu, Xiaofei Sun
Summary: By tuning the ratio of copper ions in the precursor solution, the poor short-circuit current density caused by silver substitution in Cu2ZnSn(S,Se)4 solar cells is effectively mitigated, leading to improved performance of the Ag-substituted CZTSSe solar cells.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2023)
Article
Chemistry, Inorganic & Nuclear
Balaji Mohan, Kyung Hee Oh, Kyeongmun Park, Mohammad Yusuf, Ji Chan Park, Kang Hyun Park, Buhyun Youn
Summary: In this study, hollow cubic Cu(x)O nanoparticles (approx. 23 nm) incorporated with CNF (HC-Cu(x)O/CNF) were fabricated by the controlled thermal oxidation of solid cubic Cu2O nanoparticles (approx. 21 nm) supported on carbon nanofibers (SC-Cu2O/CNF) under airflow. These hollow Cu(x)O nanocubes with increased surface areas exhibited excellent catalytic activity for unsymmetrical chalcogenide synthesis under ligand-free conditions. The synthesis process involved the transformation of solid Cu(2)O cubes/CNF to hollow Cu(x)O cubes/CNF through thermal oxidation, utilizing the Kirkendall effect.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Po-Fan Lin, Dinh-Phuc Tran, Hung-Che Liu, Yi-Yi Li, Chih Chen
Summary: This study explores a new low-temperature method for copper-to-copper direct bonding and quantitatively evaluates the bonding quality through microstructural analysis. It is found that the bonding quality of chemically mechanically planarized (CMP) copper films is superior to electropolished copper films. This new method allows for shorter bonding time and has the potential to reduce the thermal budget and manufacturing cost of current 3D ICs packaging technology.
Article
Chemistry, Multidisciplinary
Guoning Liu, Shaopeng Qi, Jinxi Chen, Yongbing Lou, Yixin Zhao, Clemens Burda
Summary: This research presents a colloidal synthesis strategy for highly dispersed, platelet-shaped, antimony-doped copper sulfide semiconductor nanocrystals with a tunable dominant localized surface plasmon resonance band. The study quantifies the resulting plasmonic features and elucidates the carrier concentration requirements for a continuum of LSPR spectra. Building on previous work on binary plasmonics, this method introduces a much wider and finer tunability with ternary semiconductor plasmonics.
Article
Chemistry, Multidisciplinary
Fei Wang, Ying Chen, Weidong Rao, Shu-Su Shen, Shun-Yi Wang
Summary: A Cu-catalyzed cascade reaction has been developed for the construction of S (Se)-containing organosilicon compounds using four-membered silacyclobutanes (SCBs) and thiosulfonates. The protocol exhibits a wide substrate scope, high functional group compatibility, and mild reaction conditions, enabling the formation of new C-S (Se) and Si-O bonds in a single step.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Minghui Zhang, Li-Yin Gao, Jun-Jie Li, Rong Sun, Zhi-Quan Liu
Summary: The study achieved Cu-Cu direct bonding at room temperature by using highly (111) oriented copper with a nanotwin structure. The Cu-Cu joints were analyzed using SEM, EBSD, and TEM, and perfect bonding was confirmed by HRTEM and EELS. The (111) nt-Cu demonstrated excellent resistance to oxidation and fast Cu(111) surface diffusivity, enabling high-performance bonding at room temperature.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Andrew J. Peloquin, Colin D. McMillen, Scott T. Iacono, William T. Pennington
Summary: This study investigates the roles of chalcogen and halogen bonding in the formation of cocrystals of Ph3P=E (E=O, S, Se) with organoiodines. Different structures and interactions were observed among the chalcogenides and organoiodines, with some selenium...organoiodine ChB formations being rare examples. The strength of the interactions was analyzed using natural bond orbital (NBO) theory, with calculated energies falling between 3.14 kcal/mol and 12.81 kcal/mol.
Article
Biochemistry & Molecular Biology
Aaron P. Ledray, Sudharsan Dwaraknath, Khetpakorn Chakarawet, Madeline R. Sponholtz, Claire Merchen, Casey Van Stappen, Guodong Rao, R. David Britt, Yi Lu
Summary: A biosynthetic model of oxidases was constructed by replacing tyrosine with tryptophan, and it was demonstrated that tryptophan can also promote the oxygen reduction reaction, although with lower activity. Structural analysis and experimental results indicate that the difference in activity is due to the higher reduction potential of tryptophan. This study provides the first evidence that tryptophan can promote the oxygen reduction reaction and offers a structural basis for the observation of varying activities.
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Skye Shepherd, Nantao Li, Congnyu Che, Tingjie Song, Yanyu Xiong, Isabella Rose Palm, Bin Zhao, Manish Kohli, Utkan Demirci, Yi Lu, Brian T. T. Cunningham
Summary: In this study, an efficient target recycling amplification process (TRAP) using photonic resonator absorption microscopy was developed for the digital detection of exosomal microRNAs (miRNAs). The TRAP approach demonstrated high sensitivity, robust selectivity, and a broad dynamic range, making it ideal for quantifying miRNA biomarkers in low concentrations or sample volume. Compared to traditional qRT-PCR, TRAP showed similar accuracy in profiling exosomal miRNAs derived from cancer cells, but with significantly enhanced detection limits for miRNA-375 and miRNA-21.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biophysics
Shanni Hong, Zhenglin Yang, Quanbing Mou, Yunxia Luan, Bingbo Zhang, Renjun Pei, Yi Lu
Summary: This study presents a fluorescence aptamer sensor that can monitor the rapid leaching kinetics of quantum dots and the concentration of ions in living cells in real time. The sensor shows high specificity and can be used to study the biosafety and cytotoxicity mechanisms of various cadmium-based quantum dots.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Physical
Dieter Plessers, Alexander J. Heyer, Hannah M. Rhoda, Max L. Bols, Edward I. Solomon, Robert A. Schoonheydt, Bert F. Sels
Summary: The industrial implementation of a direct methane-to-methanol process would bring about environmental and economic benefits. Copper zeolites can effectively catalyze this reaction at lower temperatures, especially mordenite zeolites which enable high methanol production. By changing the co-cation, a new method for simplifying the material is introduced, allowing for better analysis, which has implications for the study and tuning of heterogeneous catalysts in general.
Article
Chemistry, Multidisciplinary
Yunling Deng, Sudharsan Dwaraknath, Wenhao O. Ouyang, Cory J. Matsumoto, Stephanie Ouchida, Yi Lu
Summary: Researchers have synthesized cobalt porphyrin substituted myoglobin (CoMb) as a homogeneous catalyst for photo-driven CO2 to CO conversion in water. By optimizing the activity and product selectivity through varying pH and concentrations of the enzyme and the photosensitizer, they achieved high efficiency of CO generation. They further enhanced the CO2-reducing performance by introducing positively charged residues near the active site of CoMb.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Bohee Kim, Magdalene T. T. Brueggemeyer, Wesley J. J. Transue, Younwoo Park, Jaeheung Cho, Maxime A. A. Siegler, Edward I. I. Solomon, Kenneth D. D. Karlin
Summary: Lytic polysaccharide monooxygenases are important in converting biomass to biofuel, and recent studies show that their peroxygenase activity using H2O2 as an oxidant is more important than their monooxygenase functionality. New insights into this activity have been described, including ligand-substrate hydroxylation and Fenton-type chemistry reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Zhimei Huang, Xianbo Ma, Fengze Jiang, Rong Wang, Zhenkun Wu, Yi Lu
Summary: DNAwalkers have been widely used in biosynthesis, biocomputing, and biosensing due to their programmability, biocompatibility, and signal amplification capacity. A dual spatially localized DNA walker was designed to drive high-speed stochastic movement along three-dimensional tracks using bipedal catalysts. The colocalization of autocatalytic circuits and the use of bipedal catalysts significantly increased the reaction kinetics. An RNA-responsive PCHA walker was constructed for mRNA imaging in live cells, providing a novel and efficient tool for biomolecule detection and biological functions regulation.
Article
Biotechnology & Applied Microbiology
Yuan Ma, Weijie Guo, Quanbing Mou, Xiangli Shao, Mingkuan Lyu, Valeria Garcia, Linggen Kong, Whitney Lewis, Carson Ward, Zhenglin Yang, Xingxin Pan, S. Stephen Yi, Yi Lu
Summary: GlycoRNA imaging in cells is achieved through a proximity ligation assay called ARPLA. This assay allows visualization of glycoRNAs, a recently discovered class of glycosylated molecules, in single cells with high sensitivity and selectivity. ARPLA enables the detection of spatial distributions of glycoRNAs on the cell surface, their colocalization with lipid rafts, and the intracellular trafficking of glycoRNAs.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuting Wu, Seyed-Fakhreddin Torabi, Ryan J. Lake, Shanni Hong, Zhengxin Yu, Peiwen Wu, Zhenglin Yang, Kevin Nelson, Weijie Guo, Gregory T. Pawel, Jacqueline Van Stappen, Xiangli Shao, Liviu M. Mirica, Yi Lu
Summary: By developing DNAzyme-based fluorescent turn-on sensors, we can selectively visualize either Fe2+ or Fe3+, revealing a decreased Fe3+/Fe2+ ratio during ferroptosis and an increased Fe3+/Fe2+ ratio in Alzheimer's disease mouse brain. The elevated Fe3+/Fe2+ ratio was mainly observed in amyloid plaque regions, suggesting a correlation between amyloid plaques and the accumulation of Fe3+ and/or conversion of Fe2+ to Fe3+. Our sensors can provide deep insights into the biological roles of labile iron redox cycling.
Article
Chemistry, Multidisciplinary
Huanhuan Fan, Claire E. E. McGhee, Ryan J. J. Lake, Zhenglin Yang, Zijian Guo, Xiao-Bing Zhang, Yi Lu
Summary: Manganese is an essential element in the human body and its detection in living cells is important. However, specific fluorescent sensors for Mn2+ are rare due to its paramagnetism and poor selectivity against other metal ions. This study reports the development of an RNA-cleaving DNAzyme with high selectivity for Mn2+ and its conversion into a fluorescent sensor. The sensor has been successfully used to detect Mn2+ in immune cells and tumor cells, as well as monitor the degradation of manganese-based nanomaterials in tumor cells.
Article
Chemistry, Multidisciplinary
Jeffrey T. T. Babicz Jr, Melanie S. Rogers, Dory E. DeWeese, Kyle D. Sutherlin, Rahul Banerjee, Lars H. Bottger, Yoshitaka Yoda, Nobumoto Nagasawa, Makina Saito, Shinji Kitao, Masayuki Kurokuzu, Yasuhiro Kobayashi, Kenji Tamasaku, Makoto Seto, John D. Lipscomb, Edward I. Solomon
Summary: The extradiol dioxygenases and intradiol dioxygenases play a crucial role in the carbon cycle by catalyzing oxidative aromatic ring cleavage. This study investigates the mechanisms behind their regiospecificity in cleavage, using EDO and IDO enzymes as models. The results reveal the structural and electronic properties of key intermediates and propose a viable mechanism for intradiol cleavage.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Augustin Braun, Leland B. Gee, Michael W. Mara, Ethan A. Hill, Thomas Kroll, Dennis Nordlund, Dimosthenis Sokaras, Pieter Glatzel, Britt Hedman, Keith O. Hodgson, A. S. Borovik, Michael L. Baker, Edward I. Solomon
Summary: Fe K-edge XAS is widely used for studying high-valent iron intermediates in catalysts. The 4p-mixing into the 3d orbitals complicates the analysis, but understanding it correctly enables deeper insights into the structure and reactivity. This study reveals that the loss of inversion in the equatorial plane leads to 4p mixing into the 3dx2-y2,xy orbitals, providing structural insights for distinguishing 6- vs 5-coordinate active sites. Furthermore, the study investigates the electronic structure of Fe(IV)=O active sites and their reactivity selectivity through O K-edge XAS.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Casey Van Stappen, Huiguang Dai, Anex Jose, Shiliang Tian, Edward I. Solomon, Yi Lu
Summary: This research investigates the influence of the primary and secondary coordination sphere on CuII-catalyzed S-nitrosylation. The study reveals that kinetic competency is correlated with Cu-S bond strength, Cu spin localization, and relative S(p(s)) vs S(p(p)) contributions to the ground state.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hyeongtaek Lim, Magdalene T. Brueggemeyer, Wesley J. Transue, Katlyn K. Meier, Stephen M. Jones, Thomas Kroll, Dimosthenis Sokaras, Bradley Kelemen, Britt Hedman, Keith O. Hodgson, Edward I. Solomon
Summary: This study investigates the electronic structure of the d(10) Cu(I) active site in LPMO using Kβ X-ray emission spectroscopy (XES). The lack of inversion symmetry in the His-brace site enables the required 3d/p mixing for intensity in the Kβ valence-to-core (VtC) XES spectrum of Cu(I)-LPMO. These Kβ XES data are correlated to density functional theory (DFT) calculations to define the bonding, particularly the frontier molecular orbital (FMO) of the Cu(I) site. These experimentally validated DFT calculations are used to evaluate the reaction coordinate for homolytic cleavage of the H2O2 O-O bond and understand the activation of the geometric and electronic structure of the Cu(I)-LPMO site for rapid reactivity with H2O2.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Asmita Singha, Alina Sekretareva, Lizhi Tao, Hyeongtaek Lim, Yang Ha, Augustin Braun, Stephen M. Jones, Britt Hedman, Keith O. Hodgson, R. David Britt, Daniel J. Kosman, Edward I. Solomon
Summary: In multicopper oxidases (MCOs), the T1 Cu accepts electrons from the substrate and transfers them to the TNC, reducing O-2 to H2O. The literature fails to explain the wide range of T1 potentials in MCOs, ranging from 340 to 780 mV. This study focuses on the difference in potential of the T1 center in Fet3p and Trametes versicolor laccase (TvL) that have the same ligand set, and reveals that second-sphere H-bonding interactions and carboxylate residues significantly lower the T1 potential.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)