Article
Biochemistry & Molecular Biology
Xinyu Jin, Li Cheng, Yan Hong, Zhaofeng Li, Caiming Li, Xiaofeng Ban, Zhengbiao Gu
Summary: The surface adhesion of starch gel is influenced by its molecular structure. This study investigated the heat-moisture treatment (HMT) to reduce the surface adhesiveness of vermicelli after cooking and explored the mechanism behind the increased thermal stability. The results showed that the surface adhesiveness decreased by 72.12% at 26% moisture content. HMT increased the crystallinity and thickness of the crystalline layer, resulting in an increased proportion of long double helixes and improved thermal stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Paul J. Arcoria, Rachel Ware, Sunny Makwana, Diego Troya, Felicia A. Etzkorn
Summary: Fluoro- and chloro-alkene mimics of Gly-Pro and Pro-Pro can participate in n ->pi* donation to stabilize PPII conformations, but are poor n.p* acceptors. Proteo-alkene mimics lack significant n ->pi* interactions, leading to unstable PPII-like geometries.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Applied
Nairu Ji, Chenchen Yu, Xinyu Han, Xinrong He, Shuai Kang, Tianliang Bai, Hong Liu, Guixia Chen, Minjie Cao, Guangming Liu
Summary: This study investigated methods to reduce the immunoreactivity of alpha-TM. It was found that glycation of alpha-TM with xylose significantly reduced its IgG/IgE-binding capacity. Additionally, five epitope peptides were found to bind with the site-specific IgE prepared by the glycated alpha-TM. Two glycation sites (M68 and N202/N203) were identified to affect the immunoreactivity of alpha-TM, suggesting that glycation could be used to develop hypo-allergenic abalone products.
Article
Polymer Science
Xuemin Li, Kun Li, Zhaobin Chen, Xiaoniu Yang
Summary: This study investigates the effect of hydrogen bonds on the structure and properties of polyurethanes by incorporating UPy groups. It is found that the increase in hydrogen bond content leads to changes in the crystallization behavior and phase structure of polyurethanes, resulting in tunable mechanical properties and great potentials in smart materials.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Irena Roterman, Katarzyna Stapor, Dawid Dulak, Leszek Konieczny
Summary: The experimentally determined structures of amyloid forms are primarily characterized by the two-dimensional forms of a single polypeptide chain, which is made possible by the beta structure and the numerous hydrogen bonds. This study proposes a possible mechanism for obtaining such a structure based on the geometric characterization of the polypeptide chain and molecular dynamics results. The potential mechanism of amyloid transformation is presented using transthyretin and amyloid A beta as examples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zhi Wang, Mengkai Hu, Ming Fang, Qiang Wang, Ruiqi Lu, Hengwei Zhang, Meijuan Xu, Xian Zhang, Zhiming Rao
Summary: The thermal stability of alpha-glucosidase was significantly improved by constructing cyclized proteins, allowing for continuous production of isomaltooligosaccharides at higher temperatures.
FERMENTATION-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Eloise Masquelier, Sheng-Ping Liang, Lior Sepunaru, Daniel E. Morse, Michael J. Gordon
Summary: The reversible electrochemical triggering of polylysine conformational transition was achieved at a Pt electrode, allowing for easy distinction of different reduction processes. In situ UV absorbance and circular dichroism spectroscopies were used to track the evolution of alpha-helix formation, while isotope experiments confirmed direct electroreduction as the cause of subsequent alpha-helix formation. The site-selective electrochemistry and optical methodologies present potential for studying and controlling dynamic structural evolution in biomolecular systems.
BIOELECTROCHEMISTRY
(2022)
Article
Thermodynamics
Mehrdad Seifali Abbas-Abadi
Summary: Numerous studies have been conducted on the stability, thermo-mechanical degradation, and pyrolysis of polymers with hydrocarbon skeleton. Different responses of polymers to thermo-mechanical and thermal degradations are observed based on their main structure, side groups, and presence of double bonds. Structural and process parameters play a significant role in determining the resulting pyrolysis products, with suitable processes identified as a means to reduce non-recyclable polymers. Literature review in this field highlights the impact of chemical bonds and degradation mechanisms on the quality and quantity of pyrolytic products. Efforts to reduce polymeric waste sent to landfills focus on understanding the degradation mechanisms, related products, and required activation energy for various studied polymers.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Biochemistry & Molecular Biology
Cevdet Nacar
Summary: This study investigates the variations in propensity of amino acid pairings to alpha-helices in globular proteins depending on helix length. The findings show that the propensity of certain amino acid pairings to alpha-helix increases with helix length, while others decrease.
Article
Chemistry, Physical
Vinicius C. Port, Rodrigo A. Cormanich
Summary: This study reexamined the conformational preferences of 1,2-difluoroethane (DFE) and its chlorine and bromine derivatives through a comparative approach, finding that hyperconjugation is the main driving force behind their conformational preferences. Electrostatics was found to be negligible, while steric effects played a minor role in general.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Xuhui Lin, Weiqin Tian, Wei Wu, Yirong Mo
Summary: This study proposes a partial triple metal-carbon bonding model to explain the agostic interaction in transition metal carbene compounds. It suggests that besides the traditional sigma and pi bonds, there is a third force called pi(CHR) -> d(M) bonding. The model is validated by computational methods and demonstrates its impact on the geometry, energy, and spectra of carbene compounds. Additionally, it highlights the role of ancillary ligands in modulating the bonding through electronic and steric effects.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Applied
Yuan Wang, Shuqiao Yang, Liang Zhang, Fang Yuan, Like Mao, Jinfang Liu, Yanxiang Gao
Summary: This study aimed to investigate the effects of different processes on insoluble undenatured type II collagen (IUC-II). The results showed that wet media milling (WMM) process had the best performance in terms of particle size, wetting rate, and suspension stability. However, all mechanical processes caused disruption of the triple helix structure of IUC-II. Low-acyl gellan gum (LAGG) could protect the triple helix structure and enhance the powdery properties of IUC-II treated by WMM process.
Article
Biochemistry & Molecular Biology
Seong-Cheol Park, Jong-Kook Lee, Young-Min Kim, Jung Ro Lee
Summary: Due to the emergence of drug-resistant pathogens, scientists have discovered antimicrobial peptides (AMPs) with high antibacterial activity and cell selectivity. By modifying the amino acids in the peptide chain, they have enhanced the antimicrobial effects and salt tolerance, while reducing cytotoxicity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Zhang Zhengchu, Xiong Wei, Lu Hua
Summary: Polypeptides have a similar main chain structure to proteins and can form various secondary structures, providing a new dimension for regulating material properties. In this study, hydrogels crosslinked with polypeptides of different secondary structures were prepared, and their properties were investigated. The results showed that hydrogels crosslinked with α-helical polypeptides exhibited greater rigidity, higher toughness, and faster recovery compared to those crosslinked with random coil polypeptides.
ACTA CHIMICA SINICA
(2023)
Article
Chemistry, Multidisciplinary
Zhuang Wang, Yuxiu Liu, Hongjian Song, Qingmin Wang
Summary: In this study, we developed an electrochemical protocol for the synthesis of hemiaminal ethers containing tetrahydrofuran rings. The protocol involves alpha-C(sp(3))-H/N-H cross-coupling reactions between tetrahydrofuran and sulfonamides or amides, and does not require a chemical oxidant. The reaction can be conducted at room temperature, and provides moderate to high yields of the desired products.
Article
Pharmacology & Pharmacy
Andreas Reiner, Joshua Levitz, Ehud Y. Isacoff
CURRENT OPINION IN PHARMACOLOGY
(2015)
Article
Biology
Shai Berlin, Stephanie Szobota, Andreas Reiner, Elizabeth C. Carroll, Michael A. Kienzler, Alice Guyon, Tong Xiao, Dirk Tauner, Ehud Y. Isacoff
Article
Neurosciences
Joshua Levitz, Andrei T. Popescu, Andreas Reiner, Ehud Y. Isacoff
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2016)
Review
Neurosciences
Andreas Reiner, Joshua Levitz
Review
Neurosciences
Christine R. Rose, Lisa Felix, Andre Zeug, Dirk Dietrich, Andreas Reiner, Christian Henneberger
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Chemistry, Multidisciplinary
A. Rullo, A. Reiner, A. Reiter, D. Trauner, E. Y. Isacoff, G. A. Woolley
CHEMICAL COMMUNICATIONS
(2014)
Article
Chemistry, Multidisciplinary
Michael A. Kienzler, Andreas Reiner, Eric Trautman, Stan Yoo, Dirk Trauner, Ehud Y. Isacoff
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Biochemistry & Molecular Biology
Andreas Reiner, Ehud Y. Isacoff
NATURE CHEMICAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Benjamin M. Gaub, Michael H. Berry, Amy E. Holt, Andreas Reiner, Michael A. Kienzler, Natalia Dolgova, Sergei Nikonov, Gustavo D. Aguirre, William A. Beltran, John G. Flannery, Ehud Y. Isacoff
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Adela Dudic, Andreas Reiner
BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Stefan Pollok, Andreas Reiner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Robin Herbrechter, Nadine Hube, Raoul Buchholz, Andreas Reiner
Summary: This study provides a comprehensive overview of alternative splicing and editing in human brain iGluRs, identifying new splice events and assessing the abundance of alternative events.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Purushotham Selvakumar, Joon Lee, Nandish Khanra, Changhao He, Hermany Munguba, Lisa Kiese, Johannes Broichhagen, Andreas Reiner, Joshua Levitz, Joel R. Meyerson
Summary: KARs are ionotropic glutamate receptors that assemble into tetramers from five subunit types; they show extreme diversity in subunit combination forms; can form different receptor complexes, including di-heteromers, tri-heteromers, and tetra-heteromers.
Editorial Material
Biochemistry & Molecular Biology
Andreas Reiner, Inge Kuhl
BIOLOGICAL CHEMISTRY
(2022)
Article
Anatomy & Morphology
Steffen Gonda, Jan Giesen, Alexander Sieberath, Fabian West, Raoul Buchholz, Oliver Klatt, Tim Ziebarth, Andrea Raek, Sabine Kleinhubbert, Christian Riedel, Michael Hollmann, Mohammad I. K. Hamad, Andreas Reiner, Petra Wahle
FRONTIERS IN NEUROANATOMY
(2020)