Article
Biochemistry & Molecular Biology
Hidenori Okamura, Giang Hoang Trinh, Zhuoxin Dong, Yoshiaki Masaki, Kohji Seio, Fumi Nagatsugi
Summary: Unnatural base pairs (UBPs) with selective pairing properties have been widely used in nucleic acid-based technologies. In this study, we demonstrate a new design concept for achieving exclusive base pairing through the spatial separation of recognition units. By introducing alkynylated purines and pyridazines with pseudo-nucleobases, we successfully achieved stable and exclusive pairing properties in the DNA major groove. This study highlights the potential of separating the recognition interface as a strategy for developing new types of UBPs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Organic
Dan-Yang Zhang, Xiao-Xia Wang, Ya-Nan Wang, Min Wang, Peng-Yu Zhuang, Yang Jin, Hang Liu
Summary: Nine sesquiterpenoid dimers were isolated from Chloranthus henryi var. hupehensis, showing significant cytotoxicities against various cancer cells, with compound 7 exhibiting the most potent effects. The unique structures of these compounds suggest potential anti-tumor properties, with one specific compound demonstrating outstanding induction of apoptosis in cancer cells.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Juri Eyberg, Daniela Goehringer, Amila Salihovic, Clemens Richert
Summary: Oligonucleotides are important tools in various fields including diagnostics and therapeutics. However, the use of ethynylpyridone C-nucleosides as analogs of thymidine is hindered by low yields of solid-phase syntheses. This study presents the synthesis of an improved building block that enables the high yield and purity synthesis of oligonucleotides containing ethynylmethylpyridone C-nucleoside.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Mohamed N. Abd Al Moaty, Yeldez El Kilany, Laila Fathy Awad, Nihal Ahmed Ibrahim, Marwa M. Abu-Serie, Amira El-Yazbi, Mohamed Teleb
Summary: Breast cancer, the most frequent cancer worldwide, can be effectively treated by targeting DNA. This study developed a new approach using DNA-targeting agents with carbohydrate appendages to induce cytotoxicity against breast cancer cells. The results showed that the new benzimidazole acyclic C-nucleosides had a more potent DNA-damaging effect than doxorubicin.
ARCHIV DER PHARMAZIE
(2023)
Article
Polymer Science
Mohammad Dahmardeh Ghalehno, Hossein Yousefi
Summary: This study produced four types of cellulose nanomaterials from wheat straw and added them separately to carboxymethyl cellulose to create nanocomposites. The different nanomaterials had varying effects on the properties of the composites, with TCNFs leading to the highest transparency and tensile strength.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Shuvankar Naskar, Jens Mueller
Summary: Metal-mediated base pairs allow for the site-specific incorporation of transition metal ions into nucleic acid structures, creating nucleic acid-metal complexes with metal-based functionality. The design of nucleic acids with externally triggered metal-binding affinity, such as copper(II) ions upon light irradiation, can lead to the regulation of functionality in nucleic acids.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Qusai Hassan, Zhixin Meng, Meissam Noroozifar, Kagan Kerman
Summary: Sugarcane biochar and methylene blue were used to develop a graphite paste electrode (GPE-SC-MB) for the simultaneous detection of four DNA bases. The linear ranges and detection limits were as follows: G: 0.67-38.67 μM and 0.037 μM, A: 0.67-126.67 μM and 0.042 μM, and T/C: 6.67-1600 μM and 4.25 μM, 5.33 μM. The GPE-SC-MB showed recovery values between 99.0 and 103.0% when tested in human saliva, indicating the effectiveness of sugarcane biochar as an electrode modifier for sensitive electrochemical sensors.
Article
Green & Sustainable Science & Technology
Hector Jesus Pegoretti Leite de Souza, Fernando Munoz, Regis Teixeira Mendonca, Katia Saez, Rodrigo Olave, Cristina Segura, Daniel P. L. de Souza, Thiago de Paula Protasio, Roque Rodriguez-Soalleiro
Summary: This study compared wood pellets made from different biomass feedstocks and found that pellets made from Pinus radiata were more suitable for bioenergy production. The anatomical structure of the pellets played a crucial role in determining their quality.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming-yue Wu, Yong Li, Bin-jie Fu, Guo-shu Wang, Zhi-gang Chu, Dan Deng
Summary: This study evaluated the performance of four artificial intelligence-aided diagnostic systems in identifying and measuring four types of pulmonary nodules. Results showed that different systems had varying levels of accuracy and precision in identifying different types of nodules, with SGGNs being the most difficult to recognize.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Qusai Hassan, Chevon Riley, Meissam Noroozifar, Kagan Kerman
Summary: In this study, a novel hybrid nanomaterial-based electrochemical sensor was developed for the simultaneous detection of four DNA bases. Graphene oxide quantum dots (GOQDs) were synthesized and used to prepare a hybrid nanomaterial with multi-walled carbon nanotubes (GOQD-MWCNT). The modified sensor showed linear calibration plots up to a concentration of 50, 50, 500, and 500 μM for guanine, adenine, thymine, and cytosine, respectively. The sensor was also successfully applied for the determination of DNA bases in artificial saliva samples, with recovery values ranging from 95.9% to 106.8%.
Article
Computer Science, Interdisciplinary Applications
Candelaria Mosquera, Facundo Nahuel Diaz, Fernando Binder, Jose Martin Rabellino, Sonia Elizabeth Benitez, Alejandro Daniel Beresnak, Alberto Seehaus, Gabriel Ducrey, Jorge Alberto Ocantos, Daniel Roberto Luna
Summary: This study presents a new approach for exploiting heterogeneous labels from different chest x-ray datasets and achieved satisfactory results in local testing. By combining outputs from different architectures, a unified tool was formed to improve the accuracy of detecting abnormal chest x-rays.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Genetics & Heredity
Sunjay Jude Fernandes, Matilda Ericsson, Mohsen Khademi, Maja Jagodic, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum, Jesper Tegner
Summary: This study explores the primary role of CD4(+) and CD19(+) cells in multiple sclerosis (MS), identifying CCDC114 and SERTAD1 as two dysregulated genes through multilayer analysis. These findings offer new insights into understanding MS and its genetic, epigenetic, and transcriptional mechanisms.
Article
Multidisciplinary Sciences
Xiangzhe Li, Boram Kang, Youngsub Eom, Jingxiang Zhong, Hyung Keun Lee, Hyo Myung Kim, Jong Suk Song
Summary: This study investigated the toxicity effects of different chemical components of particulate matter on the ocular surface. It was found that the cytotoxic effects of SiO2, CB, and ZnO nanoparticles depend on particle properties, cell type, exposure concentration, and time. TiO2 showed no toxicity. The toxicity was more severe in corneal epithelial cells compared to conjunctival epithelial cells. The toxicity was mediated by reactive oxygen species (ROS)-induced oxidative stress, leading to apoptosis and mitochondrial damage. SIRT1 may play a potential protective role in this process.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Electrical & Electronic
Rinky Sha, Nandimalla Vishnu, Sushmee Badhulika
Summary: This work demonstrates the synthesis of marcasite FeS2 as a low-cost electrochemical platform for the separation-less sensing of four nucleobases of DNA. The marcasite FeS2 exhibits high surface area micro-flowers with vertically grown interwoven 2D nanosheets. Under optimized conditions, the marcasite FeS2 electrode can simultaneously determine multiple DNA bases with excellent reproducibility and stability. Moreover, the sensor is successfully utilized for the detection of nucleobases of denatured DNA, showing potential for bio-analytical and sensing applications.
IEEE TRANSACTIONS ON NANOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Thomas Stocker, Haoyan Li, Elias P. Bamidis, Uwe Baumert, Lea Hoffmann, Andrea Wichelhaus, Hisham Sabbagh
Summary: The aim of this study was to measure the effect of varying normal forces on frictional forces applied to different types of brackets and archwires made of NiTi and stainless steel. The results showed that the combination of normal force, bracket system, and wire dimension had a significant effect on friction. Passive self-ligating brackets and moderately tied ligatures generated lower friction forces. Stainless steel archwires delivered higher friction compared to NiTi wires. The choice of wire-type and ligation should be carefully considered for the intended treatment step.
DENTAL MATERIALS JOURNAL
(2022)
