Article
Oncology
Qianqian Xing, Youxin Feng, Haimei Sun, Shu Yang, Tingyi Sun, Xiaoxia Guo, Fengqing Ji, Bo Wu, Deshan Zhou
Summary: The study demonstrated that MARCO plays an important role in the phagocytosis of tumor cells by macrophages. MARCO expression was correlated with macrophages' ability to carry out phagocytosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Katsuhisa Kawai, Arata Nishigaki, Seiji Moriya, Youhei Egami, Nobukazu Araki
Summary: This study demonstrates that optogenetic photo-manipulation of PA-Rac1 can induce remarkable cell surface ruffling and macropinocytic cup formation. The formation of Rab10-positive tubules from premacropinosomes suggests a novel endocytic pathway separate from canonical macropinocytosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pia Lazki-Hagenbach, Elisabeth Kleeblatt, Hydar Ali, Ronit Sagi-Eisenberg
Summary: This study reveals the internalization and distribution patterns of MRGPRX2 following its binding with neuropeptide substance P, as well as its involvement in macropinosome resolution and receptor delivery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Developmental Biology
Robert R. Kay
Summary: Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma membrane, involving the engulfment of medium droplets into micron-sized vesicles for digestion and absorption. It is constitutive in certain immune cells and stimulated in others by growth factors, indicating a deep evolutionary history. The process is driven by the actin cytoskeleton and is increasingly studied for its medical implications in immune response, cancer development, and as a cellular entry point for viruses and drugs.
CELLS & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
WonMo Ahn, Bhupesh Singla, Brendan Marshall, Gabor Csanyi
Summary: Membrane ruffling is the formation of motile plasma membrane protrusions containing a meshwork of newly polymerized actin filaments. Ruffles may form spontaneously or in response to growth factors, inflammatory cytokines, and phorbol esters. Some protrusions may reorganize into circular membrane ruffles that fuse at their distal margins and form cups.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Microbiology
Aftab Nadeem, Athar Alam, Eric Toh, Si Lhyam Myint, Zia Ur Rehman, Tao Liu, Marta Bally, Anna Arnqvist, Hui Wang, Jun Zhu, Karina Persson, Bernt Eric Uhlin, Sun Nyunt Wai
Summary: Vibrio cholerae is the causative agent of cholera, with recent findings identifying MakA as a potent virulence factor. MakA interacts with mammalian cells through phosphatidic acid, promoting macropinocytosis and leading to autophagy activation. This discovery sheds light on the potential role of MakA as an anti-colonization factor during late stages of cholera infection.
Review
Cell Biology
Lauren V. Albrecht, Nydia Tejeda-Munoz, Edward M. De Robertis
Summary: Recent investigations have revealed that Wnt signaling can regulate various cell physiological effects, promoting cell growth by mechanisms such as Wnt receptor endocytosis, Wnt-induced protein stabilization, and metabolic changes. A key element is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular bodies and lysosomes, which affects the phosphorylation motifs of GSK3 and protein degradation. These effects are independent of new protein synthesis and contribute to cell growth.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 37
(2021)
Article
Neurosciences
Lu Wang, Han-Yu Yang, Cai-Xia Zang, Jun-Mei Shang, Hui Liu, Zi-Hong Zhang, Fang-Yu Yuan, Cheng Ju, Fang-Yuan Li, Xiu-Qi Bao, Dan Zhang
Summary: The study revealed the crucial role of macrophage receptor with collagenous structure (Marco) in regulating neuroinflammation, with Toll-like receptor 2 (TLR2) acting as an important co-receptor of Marco to potentiate the neuroinflammatory response through interaction with the SRCR domain of Marco. Knocking down TLR2 resulted in decreased Marco expression, indicating the direct binding of TLR2 to the SRCR domain of Marco in regulating neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Cao, Weili Mai, Rui Li, Shuwei Deng, Lan Li, Yanxi Zhou, Qiushi Qin, Yue Zhang, Xingang Zhou, Ming Han, Pu Liang, Yonghong Yan, Yu Hao, Wen Xie, Jie Yan, Liuluan Zhu
Summary: The study found that in the progression of nonalcoholic fatty liver disease, liver macrophages polarized towards M2 type and promoted HSC autophagy by secreting PGE2, worsening liver fibrosis. The PGE2/EP4 pathway may be a promising therapeutic target to prevent NASH progression into cirrhosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Jiao Liu, Siqi Ming, Weifeng Song, Xiaojun Meng, Qiang Xiao, Minhao Wu, Yongjian Wu, Hanbin Xie, Jie Zhou, Haibo Zhong, Xi Huang
Summary: BTLA promotes host defense against mycobacteria by enhancing autophagy, which may provide potential therapeutic interventions against tuberculosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Lina S. Silva-Bermudez, Tatyana N. Sevastyanova, Christina Schmuttermaier, Carolina De La Torre, Leonie Schumacher, Harald Klueter, Julia Kzhyshkowska
Summary: Titanium nanoparticles (TiNPs) have a dual effect on the GDF-15/stabilin-1 interaction in macrophage system, by increasing the production of GDF-15 and suppressing stabilin-1-mediated clearance function. This can lead to unbalanced pro-fibrotic reactions and implant complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Md. Arif Sakil, Kyosuke Mukae, Ryo Funada, Toshihisa Kotake, Shigeaki Ueno, Most Mohoshena Aktar, Md. Shyduzzaman Roni, Yuko Inoue-Aono, Yuji Moriyasu
Summary: The physiological implications of autophagy in plant cells have yet to be fully understood. In this study, the consequences of autophagy in the moss Physcomitrella were investigated. It was found that autophagy promotes starch synthesis in Physcomitrella by supplying the energy obtained by oxidizing autophagy-produced amino acids.
Article
Immunology
Yue Su, Wei Zhang, Ruoxi Zhang, Quan Yuan, Ruixia Wu, Xiaoxuan Liu, Jimusi Wuri, Ran Li, Tao Yan
Summary: This study found that activation of α7nAChR improves cerebral and cardiac dysfunction after ICH through autophagy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Baiwang Ding, Sifan Zhou, Zhoujian Wang, Wei Liu, Lei Gao, Yani Ding, Hua Huang, Qixing Zhu, Jiaxiang Zhang
Summary: Trichloroethylene (TCE) induces occupational medicamentosa-like dermatitis due to TCE (OMDT) with immune liver injury, and TNF-α plays an important role in macrophage polarization and liver injury. This study aimed to investigate the regulatory effects of TNF-α on macrophage polarization and autophagy in TCE-induced liver injury. The results showed that TNF-α/TNFR1 promoted M1 polarization of macrophages and suppressed macrophage autophagy via the mTOR pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Engineering, Environmental
Chan-Wei Yu, Yi-Chun Wu, Vivian Hsiu-Chuan Liao
Summary: Nanoplastics, a type of emerging pollutant, pose significant safety concerns as they are widely used and continuously released into the environment, which results in potential risks to humans and the environment. Recent studies have shown that exposure to polystyrene nanoparticles disrupts circadian rhythms and reduces stress resistance in Caenorhabditis elegans. This study further explores the relationship between circadian rhythm disruption, endocytosis, and autophagy under nanoparticle exposure, revealing that disrupted circadian rhythm impairs stress resistance through endocytosis and autophagy impairment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)