Article
Immunology
Uday C. Ghoshal, Kok-Ann Gwee, Gerald Holtmann, Yanmei Li, Soo Jung Park, Marcellus Simadibrata, Kentaro Sugano, Henry Cohen, Eamonn M. M. Quigley
Summary: The survey conducted among physicians from seven countries in the Asia-Pacific region revealed varying rates of antibiotic prescription, with lower rates in Australia, Japan, and South Korea (11% to 19% of visits resulted in an antibiotic prescription) compared to higher rates in Indonesia, India, China, and Singapore (41% to 61%). While the majority of physicians agreed that antibiotics disrupt intestinal microbiota, rates of probiotic co-prescription remain low in many countries.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Wanqian Liao, Chongxiang Chen, Tianmeng Wen, Qingyu Zhao
Summary: This meta-analysis showed that probiotics significantly reduce the incidence of antibiotic-associated diarrhea in adults without increasing adverse events. Early use of probiotics during antibiotic therapy is recommended to prevent antibiotic-associated diarrhea. Further research should focus on optimal dosage and duration of probiotics for specific recommendations.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Julie Zhu, Tyler Pitre, Carmen Ching, Dena Zeraatkar, Steven Gruchy
Summary: This study conducted a systematic review and meta-analysis to investigate the impact of probiotic supplementation on COVID-19 symptom trajectory and patient outcomes. The results showed that probiotic supplements can reduce the incidence of diarrhea, cough or dyspnea, and adverse events, and may improve the composite endpoint measured by clinical escalation or mortality.
Review
Geriatrics & Gerontology
Liying Zhang, Xiaofeng Zeng, Daxin Guo, Yupei Zou, Huatian Gan, Xiaoli Huang
Summary: The study found that giving probiotics within two days of antibiotic treatment can effectively reduce the incidence of AAD in elderly individuals. Therefore, it is recommended to routinely distribute probiotics to prevent the development of AAD in elderly individuals receiving antibiotic treatment.
Review
Environmental Sciences
Greater Kayode Oyejobi, Waidi Folorunso Sule, Sunday Babatunde Akinde, Fazal Mehmood Khan, Faith Ogolla
Summary: Enteric bacterial pathogens and the high prevalence of multidrug-resistant strains in Nigeria raise concerns. Bacteriophages offer a promising alternative for combating these pathogens.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Veterinary Sciences
Carolyn E. Arnold, Rachel Pilla, M. Keith Chaffin, Jessica L. Leatherwood, Tryon A. Wickersham, Todd R. Callaway, Sara D. Lawhon, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski
Summary: This study examined the influence of various factors on the fecal microbiota of healthy horses, revealing that the amount of grain in the diet and colitis had significant effects. Horses with AAD showed more severe dysbiosis compared to those with Salmonella infection.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Immunology
Alex O. Awuor, Billy Ogwel, Helen Powell, Jennifer R. Verani, Samba O. Sow, M. Jahangir Hossain, John B. Ochieng, Jane Juma, Leslie P. Jamka, Anna Roose, Sanogo Doh, Emily L. Deichsel, Uma Onwuchekwa, Adama Mamby Keita, Martin Antonio, Joquina Chiquita M. Jones, Syed M. A. Zaman, Henry Badji, Irene N. Kasumba, Dilruba Nasrin, James A. Platts-Mills, Eric R. Houpt, David M. Berendes, Ciara E. Sugerman, Marc-Alain Widdowson, Sharon M. Tennant, Eric D. Mintz, Richard Omore, Karen L. Kotloff
Summary: Inappropriate antibiotic prescribing is common for diarrheal diseases, leading to antimicrobial resistance. The VIDA study found that 77% of diarrhea cases and 41% of dysentery cases were prescribed unnecessary or incorrect antibiotics. Interventions are needed to improve adherence to international guidelines in low- and middle-income countries.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Srishti Saha, Kristin Mara, Darrell S. Pardi, Sahil Khanna
Summary: This study retrospectively investigated the durability of fecal microbiota transplantation (FMT) in patients with recurrent Clostridioides difficile infection (CDI). The results showed that the majority of patients had a durable response to FMT at 1 year post-treatment despite exposure to CDI risk factors, with antibiotic use being a predictor of decreased durability of FMT.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jennie Johnstone, Maureen Meade, Francois Lauzier, John Marshall, Erick Duan, Joanna Dionne, Yaseen M. Arabi, Diane Heels-Ansdell, Lehana Thabane, Daphnee Lamarche, Michael Surette, Nicole Zytaruk, Sangeeta Mehta, Peter Dodek, Lauralyn McIntyre, Shane English, Bram Rochwerg, Tim Karachi, William Henderson, Gordon Wood, Daniel Ovakim, Margaret Herridge, John Granton, M. Elizabeth Wilcox, Alberto Goffi, Henry T. Stelfox, Daniel Niven, John Muscedere, Francois Lamontagne, Frederick D'Aragon, Charles St-Arnaud, Ian Ball, Dave Nagpal, Martin Girard, Pierre Aslanian, Emmanuel Charbonney, David Williamson, Wendy Sligl, Jan Friedrich, Neill K. Adhikari, Francois Marquis, Patrick Archambault, Kosar Khwaja, Arnold Kristof, James Kutsogiannis, Ryan Zarychanski, Bojan Paunovic, Brenda Reeve, Francois Lellouche, Paul Hosek, Jennifer Tsang, Alexandra Binnie, Sebastien Trop, Osama Loubani, Richard Hall, Robert Cirone, Steve Reynolds, Paul Lysecki, Eyal Golan, Rodrigo Cartin-Ceba, Robert Taylor, Deborah Cook
Summary: This study found that there was no significant difference in the incidence of ventilator-associated pneumonia among critically ill patients treated with probiotic Lactobacillus rhamnosus GG compared to placebo, not supporting its use in this population.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Infectious Diseases
Caitlin M. M. McCracken, Kendall J. J. Tucker, Gregory B. B. Tallman, Haley K. K. Holmer, Brie N. N. Noble, Jessina C. C. McGregor
Summary: This study aimed to assess understanding of antibiotic resistance and evaluate antibiotic use themes among the general public in the United States. Nearly all respondents had taken an antibiotic previously, and their definitions of antibiotic resistance were categorized into six central themes. There were significant differences in the themes identified between those who reported having shared an antibiotic and those who had not.
Article
Medicine, General & Internal
Roman Maslennikov, Andrey Svistunov, Vladimir Ivashkin, Anna Ufimtseva, Elena Poluektova, Irina Efremova, Anatoly Ulyanin, Alexey Okhlobystin, Svetlana Kardasheva, Anastasia Kurbatova, Anna Levshina, Diana Grigoriadis, Shamil Magomedov, Natiya Dzhakhaya, Oleg Shifrin, Maria Zharkova, Elena Yuryeva, Nataliya Kokina, Manana Shirtladze, Olga Kiseleva
Summary: Diarrhea in COVID-19 can manifest differently, with late antibiotic-associated diarrhea lasting longer and being more severe, and associated with an increased risk of death.
Article
Immunology
Travis J. Carlson, Anne J. Gonzales-Luna, Melissa F. Wilcox, Sarah G. Theriault, Faris S. Alnezary, Pankaj Patel, Bumhee K. Ahn, Evan J. Zasowski, Kevin W. Garey
Summary: The study demonstrated a 46% relative reduction in the odds of developing CDI in patients who received corticosteroids within the past 90 days. The results provide the best clinical evidence to further support mechanistic studies underlying this phenomenon.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Kathryn E. Cherny, Emily B. Muscat, Aakash Balaji, Jayabrata Mukherjee, Egon A. Ozer, Michael P. Angarone, Alan R. Hauser, Joseph S. Sichel, Emmanuel Amponsah, Larry K. Kociolek
Summary: This study compared the prevalence and strains of Clostridium innocuum between individuals with antibiotic-associated diarrhea (AAD) and asymptomatic controls. The findings showed that C. innocuum was more frequently isolated from asymptomatic controls than AAD subjects, with similar strain types regardless of diarrheal symptoms. The study highlights the clinical microbiology challenges of differentiating C. innocuum-associated diarrhea from asymptomatic colonization and distinguishing diarrhea caused by C. difficile from C. innocuum.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Twisha S. Patel, Olivia L. McGovern, Garrett Mahon, Hanako Osuka, Icaro Boszczowski, Jose M. Munita, Maria Isabel Garzon, Matias C. Salomao, Giovanna Marssola, Bruno M. Tavares, Debora B. Francisco, Alessandra P. A. Gurgel, Tiago Arantes, Andrea Bori, Cassimiro Nogueira, Anne Peters, Maria Spencer, Cristian Orellana, Mario Barbe, Constanza Lopez, Stacie Stender, Fernanda C. Lessa
Summary: An ecological evaluation was conducted to assess antibiotic use among inpatients in Argentina, Brazil, and Chile during the COVID-19 pandemic. The study showed a substantial increase in antibiotic use compared to the pre-pandemic period. This highlights the importance of maintaining or strengthening antibiotic stewardship activities during pandemic or emergency healthcare facility responses.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Timothy J. Dallman, Saskia Neuert, Cristina Fernandez Turienzo, Michelle Berin, Emily Richardson, Pablo Fuentes-Utrilla, Nicholas Loman, Saheer Gharbia, Claire Jenkins, Ron H. Behrens, Gauri Godbole, Michael Brown
Summary: International travel is a risk factor for acquisition of resistant organisms, as shown by increased abundance and diversity of antibiotic resistance genes in fecal samples post-travel. Resistance genes for macrolides, third-generation cephalosporins, aminoglycosides, and sulfonamides were particularly increased. The study also found a significant association between diarrhea or antibiotic use and increased resistome abundance.
MICROBIOLOGY SPECTRUM
(2023)