Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel

(2014) Juan Du et al.   FASEB JOURNAL

Decreased Anxiety-Like Behavior and G q/11-Dependent Responses in the Amygdala of Mice Lacking TRPC4 Channels

(2014) A. Riccio et al.   JOURNAL OF NEUROSCIENCE

Prefrontal Cortical Circuit for Depression- and Anxiety-Related Behaviors Mediated by Cholecystokinin: Role of  FosB

(2014) V. Vialou et al.   JOURNAL OF NEUROSCIENCE

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase

(2013) Jinmei Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Imipramine-Induced c-Fos Expression in the Medial Prefrontal Cortex is Decreased in the ACTH-Treated Rats

(2013) Bingjin Li et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties

(2013) P A Zunszain et al.   MOLECULAR PSYCHIATRY

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

(2013) Alize J. Ferrari et al.   PLOS MEDICINE

Constitutively Active TRPC Channels of Adipocytes Confer a Mechanism for Sensing Dietary Fatty Acids and Regulating Adiponectin

(2012) Piruthivi Sukumar et al.   CIRCULATION RESEARCH

TRPC Channels and their Implications for Neurological Diseases

(2012) Senthil Selvaraj et al.   CNS & Neurological Disorders-Drug Targets

Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse

(2012) J. S. Kaczmarek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1

(2011) L. H. Jiang et al.   CURRENT DRUG TARGETS

A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain

(2011) S. V. Puram et al.   GENES & DEVELOPMENT

The Effects of Fluoxetine Treatment in a Chronic Mild Stress Rat Model on Depression-Related Behavior, Brain Neurotrophins and ERK Expression

(2011) Maya First et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels

(2011) Shouping Wang et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

Amygdala-Specific Reduction of  1-GABAA Receptors Disrupts the Anticonvulsant, Locomotor, and Sedative, But Not Anxiolytic, Effects of Benzodiazepines in Mice

(2010) S. A. Heldt et al.   JOURNAL OF NEUROSCIENCE

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression

(2010) N. Farah Idayu et al.   PHYTOMEDICINE

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

(2009) Antonio Riccio et al.   CELL

Transient Receptor Potential Canonical 5 Channels Activate Ca2+/Calmodulin Kinase I  to Promote Axon Formation in Hippocampal Neurons

(2009) M. A. Davare et al.   JOURNAL OF NEUROSCIENCE

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior

(2008) Xiaoli Qi et al.   BEHAVIOURAL BRAIN RESEARCH

Measurement of Immediate-Early Gene Activation-c-fosand Beyond

(2008) K. J. Kovács   JOURNAL OF NEUROENDOCRINOLOGY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE