Review
Immunology
Laura Canesi, Manon Auguste, Teresa Balbi, Petra Prochazkova
Summary: Annelids and mollusks, as important ecological groups, possess effective and diverse innate immune systems, similar to vertebrates. Despite the lack of acquired immunity, they are capable of producing a wide range of immune effector molecules, allowing them to recognize and eliminate pathogens and respond to environmental stressors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marina P. Sinner, Florentin Masurat, Jonathan J. Ewbank, Nathalie Pujol, Henrik Bringmann
Summary: In C. elegans, a protein called NAS-38 promotes sleep during the molting process by activating immune pathways that lead to the expression of antimicrobial peptide genes. This signaling mechanism may also exist in other animals, including humans, to regulate sleep in response to injury and infection.
Review
Medicine, General & Internal
Marius-Cosmin Colceriu, Paul Luchian Aldea, Andreea-Liana Rachisan, Simona Clichici, Alexandra Sevastre-Berghian, Teodora Mocan
Summary: Vesicoureteral reflux is a concerning topic in pediatric nephrology due to its frequency, potential to develop into chronic kidney disease, and socio-economic implications. Understanding the physiopathology of urinary tract infections in patients with vesicoureteral reflux and the role of the innate immune system is crucial for proper management and prevention of antibiotic resistance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Dilan Khalili, Christina Kalcher, Stefan Baumgartner, Ulrich Theopold
Summary: The study reveals that expressing a dominant-active form of the Ras oncogene in Drosophila salivary glands leads to fibrotic lesions, which can be alleviated by the antimicrobial peptide drosomycin. This fibrotic lesion is characterized by disturbed basement membrane attracting clot components and a loss of cell polarity.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Lucian G. Scurtu, Olga Simionescu
Summary: The soluble factors in skin innate immunity, including pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines, play a crucial role in sensing threats and inducing inflammation. Recent interest in modulating these factors has increased due to their involvement in various skin inflammatory, infectious, and neoplastic disorders. Cytokine inhibitors have revolutionized the treatment of moderate to severe psoriasis and atopic dermatitis.
Article
Biochemistry & Molecular Biology
Claire K. Holley, Edward Cedrone, Duncan Donohue, Barry W. Neun, Daniela Verthelyi, Eric S. Pang, Marina A. Dobrovolskaia
Summary: The study evaluates the applicability of several in vitro assays for the screening of innate immune responses induced by IIRMIs and a model biotherapeutic, identifying cytokine secretion as a sensitive method. Signature cytokines, broad and narrow multiplex cytokine panels, and assay logistics are discussed in the context of performance of this in vitro assay.
Review
Biochemistry & Molecular Biology
Nadia Lampiasi
Summary: Mast cells and macrophages are innate immune cells that play important roles in maintaining tissue homeostasis and responding to inflammatory conditions. Their crosstalk is essential for optimal coordination of their functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ga-Hyun Son, Jae-Jun Lee, Youngmi Kim, Keun-Young Lee
Summary: The article describes the role of antimicrobial peptides (AMPs) in preterm births (PTBs), focusing on the changes of AMPs in the development of the disease, and proposing new perspectives on the role of AMPs in PTB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Nannette Y. Yount, Michael R. Yeaman, Gerard C. L. Wong
Summary: This study confirms the antimicrobial role of PACAP and reveals its selective induction in the brain during infection. Through various mechanisms, including disruption of pathogen membrane integrity and activation of cell death pathways, PACAP exhibits antimicrobial activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Elsayed S. I. Mohammed, Rasha Radey
Summary: The study aimed to investigate the effects of probiotics-feeding on the expression and localization of avian beta defensins and proinflammatory cytokines in the gastrointestinal tract. The results suggest that probiotics-feeding may enhance the immune defense system mediated by AvBDs against infection by Gram-negative bacteria.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Infectious Diseases
Atul Tyagi, Sudeep Roy, Sanjay Singh, Manoj Semwal, Ajit K. Shasany, Ashok Sharma, Ivo Provaznik
Summary: The study team developed an SVM-based model for designing and predicting plant-derived antifungal peptides. The analysis showed preferences for C, G, K, R, S in amino acid sequences, with G, K, R, A dominating the N-terminal and N, S, C, G preferring the C-terminal. Motif analysis revealed the presence of motifs like NYVF, NYVFP, YVFP, NYVFPA, VFPA.
Article
Biochemistry & Molecular Biology
Joao D. Magalhaes, Ana Raquel Esteves, Emanuel Candeias, Diana F. F. Silva, Nuno Empadinhas, Sandra Morais Cardoso
Summary: Mitochondria, which evolved from an endosymbiotic association, play a crucial role in regulating host metabolism, immunity, and cellular homeostasis. They share certain features with bacteria, known as mitochondrial-derived damage-associated molecular patterns (DAMPs), and their activities can be modulated by extracellular bacteria. In this study, it was found that mesencephalic neurons exposed to an environmental alphaproteobacterium activate innate immunity and show increased expression and aggregation of alpha-synuclein, which interacts with mitochondria, leading to dysfunction. These findings provide insights into the interaction between bacteria and neuronal mitochondria in triggering neuronal damage and neuroinflammation, and the role of bacterial-derived pathogen-associated molecular patterns (PAMPs) in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Minnan Bao, Yue Liang, Lang Lang, Chien Min Chen, Zuobing Zhang, Lan Wang
Summary: This study reports a novel antimicrobial peptide, Shcrustin, from the freshwater crab Sinopotamon henanense, which exhibits inhibitory activity against gram-positive and gram-negative bacteria. Shcrustin is expressed in different tissues of the crab and its expression increases after bacterial challenge but is suppressed in the presence of cadmium. RNA interference experiments suggest that Shcrustin may be involved in hemolymph phagocytosis to clear invading pathogens. Therefore, Shcrustin plays an important role in innate immunity and its expression and immune function may be affected by cadmium.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Beixiang Liu, Xueying Cao, Jiaxue Li, Zuosheng Jiang, Wei Qin, Hongyu Wang, Chengxiang Zhou, Qian Ren, Xin Huang
Summary: Bursicon is a neuropeptide hormone in insects that regulates cuticle tanning and wing development, and also regulates the secretion of antimicrobial peptides. This study identified Mnburs alpha and Mnburs beta in Macrobrachium nipponense, showing their widespread expression in immune tissues and their upregulation in response to pathogen invasion. Knockdown and recombinant protein experiments suggest that Mnburs alpha and Mnburs beta play positive roles in AMP synthesis, with a mechanism involving the transcription factor Relish in innate immunity.
Article
Immunology
Michela Terri, Flavia Trionfetti, Claudia Montaldo, Marco Cordani, Marco Tripodi, Manuel Lopez-Cabrera, Raffaele Strippoli
Summary: Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins leading to progressive thickening of the peritoneal membrane, which may be caused by insults such as peritoneal dialysis and abdominal surgery. This process can cause acute/chronic inflammation and injury, resulting in fibrosis, angiogenesis, and vasculopathy in the peritoneum.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Zsuzsanna Helyes, Jozsef Kun, Nora Dobrosi, Katalin Sandor, Jozsef Nemeth, Aniko Perkecz, Erika Pinter, Krisztina Szabadfi, Balazs Gaszner, Valeria Tekus, Janos Szolcsanyi, Martin Steinhoff, Hitoshi Hashimoto, Dora Reglodi, Tamas Biro
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2015)
Article
Dermatology
Timo Buhl, Mathias Sulk, Pawel Nowak, Joerg Buddenkotte, Ian McDonald, Jerome Aubert, Isabelle Carlavan, Sophie Deret, Pascale Reiniche, Michel Rivier, Johannes J. Voegel, Martin Steinhoff
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2015)
Article
Neurosciences
T. Akiyama, M. Nagamine, A. Davoodi, M. Iodi Carstens, F. Cevikbas, M. Steinhoff, E. Carstens
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Review
Dermatology
Martin Steinhoff, Martin Schmelz, Juergen Schauber
ACTA DERMATO-VENEREOLOGICA
(2016)
Review
Medicine, Research & Experimental
James R. Docherty, Martin Steinhoff, Dianne Lorton, Michael Detmar, Gregor Schafer, Anna Holmes, Anna Di Nardo
ADVANCES IN THERAPY
(2016)
Review
Medicine, Research & Experimental
Martin Steinhoff, Marc Vocanson, Johannes J. Voegel, Feriel Hacini-Rachinel, Gregor Schaefer
ADVANCES IN THERAPY
(2016)
Article
Allergy
Micha Feld, Richard Garcia, Joerg Buddenkotte, Shintaro Katayama, Katherine Lewis, Gareth Muirhead, Peter Hevezi, Kristin Plesser, Holger Schrumpf, Kaarel Krjutskov, Olga Sergeeva, Hans Werner Mueller, Sophia Tsoka, Juha Kere, Stacey R. Dillon, Martin Steinhoff, Bernhard Homey
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Dermatology
Tasuku Akiyama, Margaret Ivanov, Masaki Nagamine, Auva Davoodi, Mirela I. Carstens, Akihiko Ikoma, Ferda Cevikbas, Cordula Kempkes, Joerg Buddenkotte, Martin Steinhoff, E. Carstens
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Article
Oncology
Nesrine I. Affara, Brian Ruffell, Terry R. Medler, Andrew J. Gunderson, Magnus Johansson, Sophia Bornstein, Emily Bergsland, Martin Steinhoff, Yijin Li, Qian Gong, Yan Ma, Jane F. Wiesen, Melissa H. Wong, Molly Kulesz-Martin, Bryan Irving, Lisa M. Coussens
Article
Gastroenterology & Hepatology
TinaMarie Lieu, Gihan Jayaweera, Peishen Zhao, Daniel P. Poole, Dane Jensen, Megan Grace, Peter McIntyre, Romke Bron, Yvette M. Wilson, Matteus Krappitz, Silke Haerteis, Christoph Korbmacher, Martin S. Steinhoff, Romina Nassini, Serena Materazzi, Pierangelo Geppetti, Carlos U. Corvera, Nigel W. Bunnett
Article
Allergy
Ferda Cevikbas, Xidao Wang, Tasuku Akiyama, Cordula Kempkes, Terhi Savinko, Attila Antal, Gabriela Kukova, Timo Buhl, Akihiko Ikoma, Joerg Buddenkotte, Vassili Soumelis, Micha Feld, Harri Alenius, Stacey R. Dillon, Earl Carstens, Bernhard Homey, Allan Basbaum, Martin Steinhoff
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2014)
Review
Physiology
Martin S. Steinhoff, Bengt von Mentzer, Pierangelo Geppetti, Charalabos Pothoulakis, Nigel W. Bunnett
PHYSIOLOGICAL REVIEWS
(2014)
Article
Multidisciplinary Sciences
Jianghui Meng, Jiafu Wang, Martin Steinhoff, James Oliver Dolly
SCIENTIFIC REPORTS
(2016)
Article
Dermatology
J. Mark Jackson, Joseph Fowler, Angela Moore, Michael Jarratt, Terry Jones, Kappa Meadows, Martin Steinhoff, Diane Rudisill, Matthew Leoni
JOURNAL OF DRUGS IN DERMATOLOGY
(2014)
Article
Dermatology
Linda Stein Gold, Leon Kircik, Joseph Fowler, Jerry Tan, Zoe Draelos, Alan Fleischer, Melanie Appell, Martin Steinhoff, Charles Lynde, Hong Liu, Jean Jacovella
JOURNAL OF DRUGS IN DERMATOLOGY
(2014)