期刊
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
卷 67, 期 1, 页码 107-112出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2011.07.021
关键词
endothelial dysfunction; endothelium-dependent flow-mediated vasodilation; livedoid vasculopathy
类别
资金
- Chang Gung Memorial Hospital [CMRPG390511, CMRPG370922, CMRPG391241]
Background: Livedoid vasculopathy (LV) is a disease characterized by multiple painful and recurrent ulcerations on the feet, accompanied by atrophic scars. Many researchers suggest that a hypercoagulable status is the pathogenetic factor for LV. However, the cause of LV remains elusive. Objective: We sought to determine if endothelial dysfunction is present in patients with LV. Methods: This prospective study included 16 patients with LV and active ulcers and 16 matched control subjects. We reviewed detailed clinical parameters, including antinuclear antibody, high-sensitivity C-reactive protein, protein C, protein S, homocysteine, anti-SSA, anti-SSB, anticardiolipin antibody, and serum lipid profiles. Flow-mediated vasodilation of the brachial artery was used as an indicator of vascular endothelial function using high-resolution 2-dimensional ultrasonic imaging. Results: Blood pressure, blood biochemistry, high-sensitivity C-reactive protein, and homocysteine were not significantly different in patients with LV and control subjects. Nitroglycerin-mediated vasodilation was not significantly different in patients with LV and control subjects. However, flow-mediated vasodilation was much less in patients with LV than in the control group (3.58 +/- 2.32% vs 7.51 +/- 2.40%, P < .001). Limitations: The study was performed at a single site with a limited sample size. Conclusion: Peripheral vascular endothelial dysfunction was demonstrated in patients with LV by reduction of brachial flow-mediated vasodilation. (J Am Acad Dermatol 2012;67:107-12.)
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