Article
Immunology
Hana Besic, Darja Paro-Panjan, Gregor Nosan
Summary: Neonatal toxic shock syndrome (TSS)-like exanthematous disease is a rare condition in neonates infected with TSS toxin-1 producing Staphylococcus aureus, characterized by rash, low platelet count, and fever. Neonatologists should be aware of this disease as it can be a possible diagnosis in neonates with rash and low platelet count. The two reported cases of Neonatal TSS-like exanthematous disease are rare in Europe.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Woo Young Park, Sang Yun Lee, Gi Beom Kim, Mi Kyoung Song, Hye Won Kwon, Eun Jung, Eun Hwa Choi, June Dong Park
Summary: This study retrospectively reviewed the clinical characteristics and laboratory indices of KDSS, septic shock, and TSS, demonstrating that KDSS patients had a higher incidence of coronary aneurysms and left ventricle dysfunction. The optimal ESR and creatinine cutoff values for distinguishing KDSS and TSS were identified.
Article
Microbiology
Patrick M. Schlievert, Adriana V. Gaitan, Samuel H. Kilgore, Amy L. Roe, Johanna Maukonen, Liisa Lehtoranta, Donald Y. M. Leung, Daniel S. Marsman
Summary: This study examined the ability of two probiotic lactobacilli to inhibit the growth and toxin production of Staphylococcus aureus, as well as reduce the production of pro-inflammatory chemokines. The results showed that lactobacilli can inhibit the growth and toxin production of S. aureus, and decrease the production of chemokines induced by the toxin. These findings suggest that lactobacilli could potentially reduce the incidence of toxic shock syndrome associated with menstruation and enterocolitis.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Marion Moreews, Kenz Le Gouge, Samira Khaldi-Plassart, Remi Pescarmona, Anne-Laure Mathieu, Christophe Malcus, Sophia Djebali, Alicia Bellomo, Olivier Dauwalder, Magali Perret, Marine Villard, Emilie Chopin, Isabelle Rouvet, Francois Vandenesh, Celine Dupieux, Robin Pouyau, Sonia Teyssedre, Margaux Guerder, Tiphaine Louazon, Anne Moulin-Zinsch, Marie Duperril, Hugues Patural, Lisa Giovannini-Chami, Aurelie Portefaix, Behrouz Kassai, Fabienne Venet, Guillaume Monneret, Christine Lombard, Hugues Flodrops, Jean-Marie De Guillebon, Fanny Bajolle, Valerie Launay, Paul Bastard, Shen-Ying Zhang, Valerie Dubois, Olivier Thaunat, Jean-Christophe Richard, Mehdi Mezidi, Omran Allatif, Kahina Saker, Marlene Dreux, Laurent Abel, Jean-Laurent Casanova, Jacqueline Marvel, Sophie Trouillet-Assant, David Klatzmann, Thierry Walzer, Encarnita Mariotti-Ferrandiz, Etienne Javouhey, Alexandre Belot
Summary: MIS-C is characterized by increased serum inflammatory cytokines and a specific expansion of activated T cells expressing the V.21.3 T cell receptor beta chain variable region, not directed against SARS-CoV-2 antigenic peptides, which differentiates it from KD, TSS, and acute COVID-19. The T cell repertoire returns to baseline soon after MIS-C resolution.
SCIENCE IMMUNOLOGY
(2021)
Article
Food Science & Technology
Lianci Peng, Jiali Jiang, Tingting Chen, Dongyi Xu, Fengqing Hou, Qingyuan Huang, Yuanyi Peng, Chao Ye, Dong-Liang Hu, Rendong Fang
Summary: Staphylococcus aureus induces the expression of inflammatory cytokines in macrophages via the activation of the TLR4 and NLRP3 signaling pathways using its virulence factor TSST-1.
Article
Immunology
Ryan A. Maddox, Marissa K. Person, Jordan L. Kennedy, Jessica Leung, Joseph Y. Abrams, Dana L. Haberling, Lawrence B. Schonberger, Ermias D. Belay
Summary: Analysis of large national databases showed consistent KD-related hospitalization rates with no noticeable increase over time, but the percentage of KD hospitalizations with potential KDSS increased. Continued national surveillance is crucial to detect potential changes in disease epidemiology.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Zhimin Zheng, Yanzhi Huang, Zhiyi Wang, Jia Tang, Xiaoqian Chen, Ying Li, Meng Li, Chengye Zang, Yibo Wang, Liwu Wang, Yingwei Ma, Liwei Sun
Summary: The study aimed to identify the clinical features of Kawasaki Disease Shock Syndrome (KDSS) in children. The results showed that children with KDSS had more severe indicators of inflammation and more cardiac abnormalities compared to non-shocked KD. These patients were resistant to immunoglobulin treatment and required extra anti-inflammatory treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Emergency Medicine
Sabrina Sokolovsky, Parita Soni, Taryn Hoffman, Philip Kahn, Joshua Scheers-Masters
Summary: This case report describes a 36-year-old woman with a complete phenotype of Kawasaki Disease, who also had a history of COVID-19 infection, resembling the Multisystem Inflammatory Syndrome in Children (MIS-C). The findings suggest that a virulent strain of SARS-CoV-2 may cause a post-infectious inflammatory syndrome similar to Kawasaki Disease in adults, as well as children.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Enrico Masiello, Danilo Buonsenso, Ilaria Lazzareschi, Antonio Gatto, Marco Piastra, Antonio Chiaretti, Piero Valentini
Summary: This study presents a case of KD shock syndrome in an infant with high fever and persistent rash, with brain involvement revealed on MRI, which is rarely reported in KD and typically associated with cerebral vasculitis. This unique inflammation in the brain not related to vasculitis highlights the complexity of inflammatory syndromes such as MIS-C and Kawasaki-like syndrome in the context of SARS-CoV-2 outbreak.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
G. Biesbroek, B. Kapitein, I. M. Kuipers, M. P. Gruppen, D. van Stijn, T. E. Peros, M. van Veenendaal, M. H. A. Jansen, C. W. van der Zee, M. van der Kuip, E. G. J. von Asmuth, M. G. Mooij, M. E. J. den Boer, G. W. Landman, M. A. van Houten, D. Schonenberg-Meinema, A. M. Tutu van Furth, M. Boele van Hensbroek, H. Scherpbier, K. E. van Meijgaarden, T. H. M. Ottenhoff, S. A. Joosten, N. Ketharanathan, M. Blink, C. L. H. Brackel, H. L. Zaaijer, P. Hombrink, J. M. van den Berg, E. P. Buddingh, T. W. Kuijpers
Summary: MIS-C and KD both display similar hyper-inflammatory responses with cytokines, including drug-targetable cytokines.
Review
Respiratory System
Jingwei Liu, Chunfeng Yang, Zhen Zhang, Yumei Li
Summary: Patients with KDSS may develop ARDS due to fluid resuscitation and the release of inflammatory mediators. Early aggressive management and comprehensive treatment play a crucial role in improving prognosis.
BMC PULMONARY MEDICINE
(2022)
Article
Pediatrics
Jin Lee, Beom Joon Kim, Kyoung-Soon Cho, Jung Woo Rhim, Soo-Young Lee, Dae Chul Jeong
Summary: This study investigated the characteristics of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome (KDSS), comparing the similarities and differences between the two diseases. The study found that patients in the KDSS group had longer hospital stays and more severe systemic inflammation and organ dysfunction compared to the MIS-C group. MIS-C and KDSS shared demographic, clinical, and laboratory characteristics, as well as treatment and outcomes. The main difference between the two diseases was the identification of SARS-CoV-2 as an infectious trigger in the MIS-C group.
Article
Pediatrics
Cong Yi, Xiang She, Jia Chen
Summary: Two cases of Kawasaki disease in males with rare complications, including acute abdomen, KD shock syndrome, and macrophage activation syndrome, are presented. Both patients were successfully treated with intravenous immunoglobulin, aspirin, corticosteroids, vasoactive drugs, and symptomatic treatment.
FRONTIERS IN PEDIATRICS
(2023)
Review
Pediatrics
Lung Chang, Horng-Woei Yang, Tang-Yu Lin, Kuender D. Yang
Summary: Kawasaki Disease is an acute inflammatory illness that occurs in children, sharing symptoms with conditions related to COVID-19. Genetic factors, HLA allele types, and TLR expression are associated with KD. The disease presents varying phenotypic manifestations in terms of age, gender, IVIG resistance, macrophage activation, and shock syndrome.
FRONTIERS IN PEDIATRICS
(2021)
Article
Dermatology
Kelly N. Messingham, Michael P. Cahill, Samuel H. Kilgore, Ananya Munjal, Patrick M. Schlievert, Janet A. Fairley
Summary: This study explored the potential role of Staphylococcus aureus in bullous pemphigoid and found a high colonization rate of the bacteria in the lesions. The presence of the toxic shock syndrome toxin-1 in the lesional isolates suggests a possible link between S. aureus colonization and the development of bullous pemphigoid. Antibiotic treatment can eliminate S. aureus and improve clinical outcomes. It highlights the importance of early implementation of antibiotics in these patients, especially those with high-dose immunosuppression.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
