Article
Biochemistry & Molecular Biology
Regina G. G. Dare, Elayaraja Kolanthai, Craig J. J. Neal, Yifei Fu, Sudipta Seal, Celso V. V. Nakamura, Sueli O. S. Lautenschlager
Summary: Exposure to ultraviolet radiation can cause photodamage to cellular macromolecules, leading to photoaging and photocarcinogenesis. Cerium oxide nanoparticles (CNPs) exhibit antioxidant activity due to their enzyme-like properties. This study aimed to synthesize CNPs associated with tannic acid (TA) and investigate their photoprotective effects in UVB-exposed L929 fibroblasts.
Article
Dermatology
Kamila Zdunska-Peciak, Anna Kolodziejczak, Helena Rotsztejn
Summary: The study on the effects of ascorbic acid and ferulic acid treatment on the signs of photoaging showed significant improvements in skin hydration, melanin level, elasticity, and erythema intensity. Both acids demonstrated statistically significant impact on these skin parameters.
DERMATOLOGIC THERAPY
(2022)
Article
Nutrition & Dietetics
Yongjae Kim, Sungjae Shin, Namki Hong, Yumie Rhee
Summary: This study found that lower serum vitamin E levels were associated with decreased hand grip strength in older men living in the community, but not in women. Individuals with the lowest vitamin E levels had higher odds of low hand grip strength, independent of various other factors. Further validation of these findings is needed.
Article
Food Science & Technology
Abdullah AlSaleh, Mohammed Shahid, Eman Farid, Khalid Bindayna
Summary: This study aims to investigate the effects of ascorbic acid and nicotinamide on Panton-Valentine Leukocidin (PVL) cytotoxicity and granulocyte viability. The results demonstrate that ascorbic acid and nicotinamide can reduce PVL cytotoxicity and maintain cell viability. Further research is needed to explore the potential of these antioxidants in attenuating PVL cytotoxicity in PVL-related diseases.
Article
Biochemistry & Molecular Biology
Zhongmin Zhang, Yunling Xu, Ruicheng Lai, Huiyuan Deng, Fengling Zhou, Peiyan Wang, Xiubing Pang, Guoxin Huang, Xin Chen, Haoge Lin, Yong Lin, Zhenxing Chen, Jiang Lin
Summary: This study evaluated the protective effect of pearl extract against UV-induced photoaging. The results showed that pearl extract inhibited skin aging signs caused by UV irradiation and demonstrated antioxidant and anti-inflammatory properties. High dose pearl extract showed superior therapeutic effects compared to the positive control.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Ik Jun Moon, Hanju Yoo, Seung Hwan Paik, Hak Tae Kim, Su Yeon Kim, Youngsup Song, Sung Eun Chang
Summary: The study found that UDCA inhibits cellular aging processes and reduces melanin synthesis in skin cells. It also reduces the effects of UV-induced inflammation and melanogenesis, suggesting it could be an effective treatment for hyperpigmentation disorders associated with environmental aging.
Review
Biochemistry & Molecular Biology
Yong Chool Boo
Summary: Nicotinamide, a form of vitamin B3, has various biological activities and cosmeceutical properties. It can restore cellular energy metabolism, reduce oxidative stress and inflammation, enhance skin barrier, and inhibit pigmentation, leading to attenuation of skin aging and hyperpigmentation in clinical trials. Additionally, nicotinamide is well tolerated by the skin and may be a useful cosmeceutical ingredient for maintaining skin homeostasis.
Article
Biochemistry & Molecular Biology
Camilla Morresi, Alessia Luccarini, Fabio Marcheggiani, Gianna Ferretti, Elisabetta Damiani, Tiziana Bacchetti
Summary: PON2, an intracellular protein, plays a protective role against cell oxidative stress and apoptosis. This study explored the modulation of PON2 in human dermal fibroblasts exposed to UVA radiation and found that PON2 is up-regulated immediately after UVA exposure and gradually decreases in the post-exposure phase. This upregulation may be related to the increase in intracellular reactive oxygen species (ROS) and could play an important role in mitigating UVA-induced damage and preventing the consequences of UV exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Cristina Wohlke Vendruscolo, Gislaine Ricci Leonardi
Summary: The topical application of vitamin C and its derivatives in skincare is essential, but there is still a lack of scientific data regarding their efficacy, especially in vivo. Studies on the stability, safety, adverse reactions, and efficacy with standardized parameters and a relevant number of subjects are necessary for better understanding their effects.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Ayami Sato, Yuka Takino, Tomohiro Yano, Koji Fukui, Akihito Ishigami
Summary: The study revealed that in SMP30-KO mice, vitamin C mainly spares vitamin E in the liver and heart, while vitamin E spares vitamin C in the kidneys. The interaction between vitamin C and vitamin E is likely to be tissue specific.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Manas Kotepui, Frederick Ramirez Masangkay, Aongart Mahittikorn, Kwuntida Uthaisar Kotepui
Summary: This study used systematic review and meta-analysis to investigate the association between vitamin E levels and malaria. The results showed that vitamin E levels were significantly reduced in malaria patients, particularly in cases of severe malaria. The study highlights the potential role of vitamin E in the pathogenesis of malaria and suggests that improving vitamin E status may benefit disease outcomes.
Article
Multidisciplinary Sciences
Wai Ting Chong, Chin Ping Tan, Yoke Kqueen Cheah, Oi Ming Lai
Summary: In this study, a tocotrienol-based nanoemulsified system was evaluated for its wound healing effect using keratinocytes migration and zebrafish tail regeneration experiments. The results showed that the system can enhance wound healing through accelerated wound closure.
Article
Public, Environmental & Occupational Health
Sung Keun Park, Yeongu Chung, Chang-Mo Oh, Jae-Hong Ryoo, Ju Young Jung
Summary: The study suggests that higher dietary intake of vitamin C and vitamin E is associated with a lower risk of gastric intestinal metaplasia (GIM), especially in men.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Antonius T. Otten, Arno R. Bourgonje, Vera Peters, Behrooz Z. Alizadeh, Gerard Dijkstra, Hermie J. M. Harmsen
Summary: High-dose vitamin C supplementation can modulate the composition of gut microbiota in healthy individuals, leading to beneficial shifts in bacterial populations.
Article
Chemistry, Medicinal
Jing Kong, Xiao-Meng Hu, Wei-Wei Cai, Yu-Mei Wang, Chang-Feng Chi, Bin Wang
Summary: The aim of this study was to investigate the protective function and mechanism of TCP3 (PKK), TCP6 (YEGGD) and TCP9 (GPGLM) from skipjack tuna cardiac arterial bulbs using UVB-irradiated HaCaT cell model. The results showed that TCP3 (PKK), TCP6 (YEGGD) and TCP9 (GPGLM) had significant cytoprotective effect on UVB-irradiated HaCaT cells by reducing apoptosis, restoring mitochondrial membrane potential, and down-regulating the expression of apoptosis-related proteins. These peptides could also up-regulate the expression of antioxidant enzymes and scavenged reactive oxygen species. Molecular docking analysis suggested the inhibition mechanisms of these peptides. In conclusion, TCP3 (PKK), TCP6 (YEGGD) and TCP9 (GPGLM) have potential applications in the development of healthy and cosmetic products for UV-induced diseases.