Review
Genetics & Heredity
Alberto Floris, Mattia Congia, Elisabetta Chessa, Maria Maddalena Angioni, Matteo Piga, Alberto Cauli
Summary: Specific and high-quality evidence on the efficacy of current targeted therapies for axial disease in psoriatic arthritis (axPsA) is lacking. More studies specifically designed for axPsA and based on validated definition and outcome measures are urgently needed to provide reliable evidence.
FRONTIERS IN GENETICS
(2021)
Article
Dermatology
Ana Maria Le, Tiago Torres
Summary: Psoriasis, a chronic immune-mediated skin disease, can be effectively treated with new molecules such as Tapinarof and Roflumilast. Targeting different pathways, drugs like brepocitinib in clinical trials show promising potential. Ongoing preclinical studies on interleukin-2 inhibition and other novel approaches may lead to new treatment options in the future.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sonia Sundanum, Carl Orr, Douglas Veale
Summary: Psoriatic arthritis (PsA) is a systemic inflammatory condition with multiple clinical manifestations. Despite progress in understanding its pathobiology and emergence of targeted therapies, some patients still do not respond well to current treatments. The heterogeneous nature of the disease and varying disease activity make it challenging to devise management strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hyung Jin Hahn, Sang Gyu Kwak, Dong-Kyu Kim, Jong-Yeup Kim
Summary: Research indicates that individuals with Behcet disease are more likely to develop psoriasis, with higher risk seen in male BD patients and older individuals. Additionally, Behcet disease patients are also more prone to developing psoriatic arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Weize Gao, Zhan Wang, Wenshuai Li, Yongxin Li, Mingjun Liu
Summary: This review systematically demonstrates the research progress of psoriasis-related biomarkers and elaborates their related mechanisms in the pathological development of psoriasis and psoriatic arthritis. In addition, we summarize the development of biologic therapies for psoriasis and psoriatic arthritis in order to drive the broader discussion of psoriasis as an autoimmune-mediated inflammatory skin disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dermatology
Craig A. Elmets, Neil J. Korman, Elizabeth Farley Prater, Emily B. Wong, Reena N. Rupani, Dario Kivelevitch, April W. Armstrong, Cody Connor, Kelly M. Cordoro, Dawn M. R. Davis, Boni E. Elewski, Joel M. Gelfand, Kenneth B. Gordon, Alice B. Gottlieb, Daniel H. Kaplan, Arthur Kavanaugh, Matthew Kiselica, Daniela Kroshinsky, Mark Lebwohl, Craig L. Leonardi, Jason Lichten, Henry W. Lim, Nehal N. Mehta, Amy S. Paller, Sylvia L. Parra, Arun L. Pathy, Michael Siegel, Benjamin Stoff, Bruce Strober, Jashin J. Wu, Vidhya Hariharan, Alan Menter
Summary: This guideline addresses important clinical questions in psoriasis management and care, providing treatment recommendations and emphasizing the role of dermatologists in monitoring and educating patients, focusing on benefits and risks.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Dermatology
Andreas Pinter, Peter van de Kerkhof
Summary: This article summarizes a presentation on the role of topical therapies in managing psoriasis, highlighting current unmet needs and data gaps. Psoriasis has a significant impact on patients' daily lives, both physically and psychologically. Topical treatments play a crucial role in managing psoriasis, especially for mild-to-moderate cases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Summary: Psoriatic disease is a spectrum of diseases affecting both skin and musculoskeletal features, with a considerable number of patients progressing from cutaneous psoriasis to psoriatic arthritis. The use of proteomics technologies provides a unique opportunity to explore potential biomarkers for psoriatic arthritis.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Arani Vivekanantham, Dylan McGagh, Laura C. Coates
Summary: The treatment goals for PsA are to control inflammation, normalize functions, prevent complications, and tailor medication choices to individual patients. A "treat to target" approach is recommended to achieve remission or low disease activity.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Ailing Zou, Yongjun Chen, Nian Shi, Yu Ye
Summary: Biological therapies may increase the risk of herpes zoster in patients with psoriasis and psoriatic arthritis, especially tumor necrosis factor-alpha inhibitors. Younger age and female gender may be risk factors for developing herpes zoster.
Review
Biochemistry & Molecular Biology
Ana Belen Azuaga, Julio Ramirez, Juan D. D. Canete
Summary: Psoriatic arthritis is a chronic inflammatory disease associated with psoriasis and other comorbidities. Its complex pathogenesis involves genetic predisposition, environmental factors, and immune system activation. Research has identified therapeutic targets based on immune-inflammatory pathways, but heterogeneous responses remain a challenge. Translational research and integration of omics technologies are needed to improve outcomes and identify new targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Judith Haschka, David Simon, Sara Bayat, Zora Messner, Eleni Kampylafka, Filippo Fagni, Susanna Skalicky, Matthias Hackl, Heinrich Resch, Jochen Zwerina, Arnd Kleyer, Alexander Cavallaro, Michael Sticherling, Goerg Schett, Roland Kocijan, Juergen Rech
Summary: This study aimed to identify circulating miRNA signatures associated with psoriasis (PsO) and psoriatic arthritis (PsA) patients. The results show significant differences in miRNA signatures between PsA and PsO patients compared to controls, with five miRNAs being involved in bone and cartilage metabolism, suggesting a link between psoriatic inflammation and bone/cartilage changes.
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Materials Science, Biomaterials
Anqi Chen, Yuting Luo, Jie Xu, Xueran Guan, Huacheng He, Xuan Xuan, Jiang Wu
Summary: Psoriasis, an autoimmune inflammatory disease, requires more precise and effective topical treatments. The development of biomaterial-based therapies, such as microneedles and nanoparticles, shows promising potential for localized psoriasis treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Pharmacology & Pharmacy
Patrick O. Perche, Madison K. Cook, Steven R. Feldman
Summary: This article reviews the efficacy and safety of abrocitinib as an oral medication for patients with moderate-to-severe atopic dermatitis. The study found that abrocitinib is effective in treating atopic dermatitis, with higher efficacy compared to other conventional medications, and has fewer side effects.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Alexandra Taylor, Rohan Singh, Steven R. Feldman
Summary: This review highlights the pharmacokinetics, efficacy, and safety of recently approved calcipotriene and betamethasone dipropionate (C-BD) cream in the treatment of psoriasis. The results showed that C-BD cream was effective and safe, with higher treatment success rates compared to C-BD topical suspension and vehicle. The use of C-BD cream provides a convenient and preferred option for patients with mild-to-moderate psoriasis.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Lindsey A. Mohney, Rohan Singh, Steven R. Feldman
Summary: This study reviews the pharmacokinetics, efficacy, and safety of a newly approved topical Janus kinase 1 (JAK) inhibitor, ruxolitinib (RUX), in patients with atopic dermatitis (AD). The results suggest that RUX is an effective and safe therapy for AD in adult patients.
ANNALS OF PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Rohan Singh, Alexandra Taylor, Milaan A. Shah, Lindsay C. Strowd, Steven R. Feldman
Summary: This study reviewed the pharmacokinetics, efficacy, and safety of tralokinumab in the treatment of atopic dermatitis (AD). Data analysis demonstrated that tralokinumab is effective and safe as a monotherapy, in combination with topical corticosteroids (TCS), and in patients with resistance or contraindication to oral cyclosporine. Tralokinumab, which is associated with overexpression of IL-13, is an efficacious systemic treatment for moderate-to-severe AD.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Infectious Diseases
Patrick O. Perche, Gabrielle M. Peck, Lillian Robinson, Ayman Grada, Alan B. Fleischer Jr, Steven R. Feldman
Summary: Acne vulgaris is a common reason for patients to seek care from dermatologists in the US, but referring providers may be hesitant to prescribe acne treatments or certain medications. A study analyzed prescription rates for acne therapies from 1993 to 2016 and found that younger patients and privately insured patients were more likely to receive prescription treatments. Dermatologists were more likely to recommend prescription medications compared to family medicine and pediatric providers. Oral minocycline and oral doxycycline were the most commonly prescribed antibiotics, while benzoyl peroxide was the most utilized and recommended over-the-counter drug for acne.
Letter
Dermatology
William B. Song, Gabrielle M. Peck, Aakriti Neopaney, Daniel B. Shin, Alan B. Fleischer Jr, Steven R. Feldman, Joel M. Gelfand, Hideki Mochizuki, James T. Elder, Yukinori Okada
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Dermatology
Brenda M. Chiang, Joel M. Gelfand, David J. Margolis, Katrina Abuabara
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Diem-Phuong D. Dao, Jessica N. Pixley, Zeynep M. Akkurt, Steven R. Feldman
Summary: This article evaluates the effectiveness, safety, pharmacology, and clinical applications of topical sirolimus 0.2% gel for treating tuberous sclerosis complex (TSC)-associated facial angiofibromas. The gel showed improvement in tumor size and redness without any serious adverse events. It is considered a safe and effective noninvasive alternative to surgical procedures for TSC-related angiofibromas.
ANNALS OF PHARMACOTHERAPY
(2023)
Letter
Dermatology
Jessica N. Pixley, Mallory L. Zaino, Christina L. Kontzias, Rachel E. Tao, Steven R. Feldman
Summary: This study aimed to determine if showing patients their facial characteristics using an AI application would increase their use of sunscreen. The findings showed a decrease in self-reported sunscreen usage after the study, while skincare product usage remained unchanged.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Rachel E. Tao, Jessica N. Pixley, Phillip G. Holovach, Alan B. Fleischer Jr, Steven R. Feldman
Summary: Off-label treatments are commonly used for pediatric psoriasis, with topical treatments, especially unapproved tacrolimus, being the most common approach. This may indicate a hesitance to use corticosteroids in children.
DERMATOLOGY AND THERAPY
(2023)
Review
Infectious Diseases
Rachel E. Tao, Stuti Prajapati, Jessica N. Pixley, Ayman Grada, Steven R. Feldman
Summary: Tetracycline-class drugs are commonly used in dermatology for treating skin diseases. This study reviewed the available evidence on whether taking these drugs with food affects their absorption and clinical efficacy. The study found that co-administration with food decreased systemic absorption of tetracycline, while the impact on doxycycline and minocycline varied. Oral sarecycline showed decreased absorption with food. Only sarecycline demonstrated limited or no impact of food intake on clinical efficacy. The study suggested considering patient adherence when choosing to take doxycycline, minocycline, and sarecycline with food.
Review
Pharmacology & Pharmacy
Rithi J. J. Chandy, Diem-Phuong D. Dao, Cristian C. C. Rivis, Divya M. M. Shan, Steven R. R. Feldman
Summary: The objective of this study was to compare the safety and efficacy of noncorticosteroid topical treatments for plaque psoriasis. A literature search was conducted, and relevant articles and clinical trial data were analyzed. Six classes of noncorticosteroid topicals were studied, and the results showed that they are effective and safe for treating plaque psoriasis.
JOURNAL OF PHARMACY TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Heli A. A. Patel, Rishab R. R. Revankar, Sofia T. T. Pedroza, Shaveonte Graham, Steven R. R. Feldman
Summary: Understanding the genetic factors in psoriasis can help improve targeted treatment strategies. This review discusses the genes associated with psoriasis pathogenesis and their connection to available treatment options. Searching various databases, relevant genetic markers and treatments were identified. Gene variants involved in inflammatory pathways, such as interleukins and interferons, are commonly implicated in psoriasis. Some treatments, like IL23 and TYK2 inhibitors, target genes associated with psoriasis. Multiple genes are involved in psoriasis pathogenesis, providing potential avenues for developing new treatment strategies and improving outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Rachel E. Tao, Jessica N. Pixley, Christina L. Kontzias, Steven R. Feldman
Summary: Drug efficacy is best evaluated through randomized, controlled, double-blind clinical trials, while safety assessment is more challenging. The Medical Dictionary for Regulatory Activities (MedDRA) is used to track and categorize adverse events (AE) during clinical trials. This study reviewed recent clinical trials on atopic dermatitis to demonstrate the importance of understanding MedDRA in evaluating adverse events related to herpes simplex virus (HSV) infection.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Dermatology
Gaurav N. Pathak, Rithi J. Chandy, Vidisha Naini, Steven R. Feldman, Babar K. Rao
Summary: This study analyzed clinical trials on vitiligo and found that less than half of the trials used quality of life (QoL) assessments, with DLQI and CDLQI being the commonly used tools. As the number of trials increases, vitiligo-specific questionnaires may be more suitable for evaluating unique vitiligo-related concerns.
DERMATOLOGIC THERAPY
(2023)