Article
Biochemistry & Molecular Biology
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Summary: This study revealed that CST1 promotes gastric cancer metastasis and progression by regulating GPX4 and inhibiting ferroptosis. High CST1 expression is associated with poor prognosis, and it inhibits ferroptosis by stabilizing GPX4 and reducing intracellular ROS levels, enhancing migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells. CST1 may serve as a new oncological marker and therapeutic target for gastric cancer metastasis.
Article
Oncology
Weiwei Xie, Jun Yu, Yujia Yin, Xiaoqian Zhang, Xiaocui Zheng, Xipeng Wang
Summary: This study reveals the important role of OCT4 in the progression of ovarian cancer. OCT4 promotes the proliferation, migration, and invasion of cancer cells by influencing the PI3K/AKT/mTOR signaling axis and epithelial-mesenchymal transition (EMT) related proteins. Therefore, OCT4 could serve as a potential therapeutic target for ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiaosheng Wu, Hao Wang, Danping Zhu, Yixia Chai, Jing Wang, Weiyu Dai, Yizhi Xiao, Weimei Tang, Jiaying Li, Linjie Hong, Miaomiao Pei, Jieming Zhang, Zhizhao Lin, Jide Wang, Aimin Li, Side Liu
Summary: This study reveals the mechanism of how deubiquitinating enzyme USP3 promotes tumor progression and metastasis in gastric cancer. The downstream targets of USP3, COL9A3 and COL6A5, are identified using isobaric tags technique. The results show that USP3 interacts with and stabilizes COL9A3 and COL6A5 through deubiquitination, playing a crucial role in the oncogenic activity of USP3 both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jiwei Wang, Xi Ouyang, Zhiyong Zhou, Shengxun Mao, Xiaoqiang Niu, Huizi Li, Wei Xu, Yi Song, Jiaqing Cao, Bin Lai
Summary: This study demonstrated the oncogenic role of Ring finger protein 2 (RNF2) in colon cancer by promoting tumor growth, proliferation, migration, and invasion of cancer cells. RNF2 interacted with and degraded interferon regulatory factor 4 (IRF4), leading to increased tumorigenicity. RNF2 may serve as a potential therapeutic target for colon cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Cell Biology
Junjie Chu, Li Tao, Teng Yao, Zizheng Chen, Xiaoxiao Lu, Li Gao, Liang Fang, Jian Chen, Gaofei He, Shuying Shen, Deguang Zhang
Summary: The circRNA circRUNX1 plays an oncogenic role in the progression of papillary thyroid cancer (PTC), modulating PTC development through the miR-296-3p/DDHD2 pathway. This provides a basis for a potential therapeutic strategy for PTC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Liao Chen, Huirong Tang, Guobin Liu, Shufeng Xiao, Daoming Liang, Jun Ma, Yanlong Yang, Haibo Luo, Yong Zhu, Fujia Xie, Xi Cheng, Junlin Chi, Xuesong Wu
Summary: The upregulation of miR-196b and downregulation of ECRG4 were observed in gastric cancer tissues and cells. Inhibition of miR-196b suppressed cell proliferation, migration, and invasion, while ECRG4 was identified as a target of miR-196b. In vivo, miR-196b inhibition also led to decreased tumor volume and weight, suggesting its potential as a therapeutic target for gastric cancer.
Article
Oncology
Chen Zhao, Yingwei Li, Chunping Qiu, Jingying Chen, Huan Wu, Qiuman Wang, Xinyue Ma, Kun Song, Beihua Kong
Summary: DEAD-box RNA helicase 23 (DDX23) plays a key role in ovarian cancer, with its high expression predicting poor prognosis and silencing significantly inhibiting tumor growth and invasion. DDX23 regulates the mRNA processing of FOXM1, impacting the malignant progression of ovarian cancer. Additionally, DDX23 is transcriptionally activated by E2F1 and may be a potential target for precision therapy of ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shili Ning, Yuzhuo Chen, Guangzhi Wang, Yongtai Liu, Yingchi Yang, Zhongtao Zhang
Summary: The study found that high expression of RNF128 in colorectal cancer tissues is associated with enhanced proliferation, migration, and invasion abilities of cancer cells, and it promotes malignant behaviors by inhibiting the Hippo signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Cai Longjun, Zhang Jianjun, Pang Kun, Hao Lin, Shi Zhenduo, Dong Yang, Li Bibo, Zhang Zhiguo, Li Rui, Han Conghui
Summary: This study identifies abnormally expressed lncRNAs in bladder cancer, with a specific focus on the role of CASC9 in promoting bladder cancer cell growth and metastasis through regulation of miR-195-5p. The findings suggest that targeting the CASC9/miR-195-5p/TK1 axis could be a promising therapeutic strategy for bladder cancer treatment.
JOURNAL OF ONCOLOGY
(2022)
Article
Environmental Sciences
Mo Yi, Samei Lv, Yu He, Youwei Wu, Jian Zhang, Qian Chen
Summary: This study investigated the role of circKDM1B in hepatocellular carcinoma (HCC) and found that its overexpression was associated with tumor stage and poor prognosis in HCC patients. Knockdown of circKDM1B suppressed cell proliferation, migration, invasion, and promoted apoptosis in HCC cells. It was discovered that circKDM1B acted as a ceRNA of miR-1322 to upregulate PRC1 expression. Overexpression of miR-1322 inhibited cell proliferation, migration, invasion, and promoted apoptosis, which was partly reversed by PRC1 overexpression. CircKDM1B knockdown inhibited tumor growth in vivo.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Anatomy & Morphology
Chen Bai, Deng-gang Chen
Summary: This study explores the expression and clinical significance of NRCAM in gastric cancer. It is found that NRCAM expression is lower in gastric cancer tissues compared to normal tissues, and patients with higher NRCAM expression have poorer prognosis. In vitro experiments show that overexpression of NRCAM promotes cell growth, migration, and infiltration while reducing cell apoptosis. Furthermore, upregulation of NRCAM decreases E-cadherin and increases vimentin and N-cadherin protein levels in gastric cancer cells.
Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.
