Review
Chemistry, Multidisciplinary
Divya Bhansali, Shavonne L. Teng, Caleb S. Lee, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong
Summary: Pain is a common medical condition that affects many Americans, and current treatments are not satisfactory. Nanomedicine may offer new therapeutic approaches to address the challenges of pain management, including nanoparticle-based drug delivery, gene therapy, and nanomaterials-based scavenging.
Review
Nutrition & Dietetics
Shaden A. M. Khalifa, Mohamed H. Elashal, Nermeen Yosri, Ming Du, Syed G. Musharraf, Lutfun Nahar, Satyajit D. Sarker, Zhiming Guo, Wei Cao, Xiaobo Zou, Aida A. Abd El-Wahed, Jianbo Xiao, Hany A. Omar, Mohamed-Elamir F. Hegazy, Hesham R. El-Seedi
Summary: Bee pollen is a nutritious and medicinal product used in public health, containing active components that enhance bodily functions and provide protection against diseases. It is marketed as a functional food with promising industrial potentials, and widely applied in the food industry.
Editorial Material
Cell & Tissue Engineering
Misao Fujita, Taichi Hatta, Kazuki Ide
Summary: This article presents an updated analysis of the status and challenges faced by the Japanese regulatory framework for cell-based interventions, focusing on the recent revisions to the Act on the Safety of Regenerative Medicine.
Review
Cardiac & Cardiovascular Systems
Alberto Alperi, Marcel Almendarez, Rut Alvarez, Cesar Moris, Victor Leon, Iria Silva, Daniel Hernandez-Vaquero, Isaac Pascual, Pablo Avanzas
Summary: Transcatheter therapies have revolutionized the treatment of valvular heart diseases. The development of less invasive catheter-based therapies for tricuspid regurgitation is of high clinical relevance.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Tsai-Mu Cheng, Hsiu-Yi Chu, Haw-Ming Huang, Zi-Lin Li, Chiang-Ying Chen, Ya-Jung Shih, Jacqueline Whang-Peng, R. Holland Cheng, Ju-Ku Mo, Hung-Yun Lin, Kuan Wang
Summary: Nanotechnology, as a scientific advance in technology, has different effects on cell physiological responses due to changes in the shape of nanoparticles. The toxicity of nanomaterials is influenced by characteristics such as composition, surface chemistry, surface charge, and shape. This review explores the impact of NPs on nanomedicine and the mechanisms of cytotoxicity induced by different types of nanomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Judite R. M. Coimbra, Paula I. Moreira, Armanda E. Santos, Jorge A. R. Salvador
Summary: This review explores the biological functions and structures of QPCT/L enzymes, highlights their therapeutic relevance, and summarizes recent developments in the discovery of small-molecule inhibitors targeting these enzymes.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Medicinal
Lovepreet Singh, Kamaljit Singh
Summary: This review highlights the efficacy of ivermectin in controlling malaria through vector control and effective chemoprevention to reduce parasite transmission and related fatalities.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Rajnish Kumar, Anju Sharma, Janmejai Kumar Srivastava, Mohammed Haris Siddiqui, Md. Sahab Uddin, Lotfi Aleya
Summary: The outbreak of COVID-19 has had a significant global impact, with no specific treatment currently available, focusing mainly on preventive and supportive care. Researching available therapeutic options has become particularly important, with hydroxychloroquine being one of the more discussed treatment drugs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Doris Ogresta, Anna Mrzljak, Maja Cigrovski Berkovic, Ines Bilic-Curcic, Sanja Stojsavljevic-Shapeski, Lucija Virovic-Jukic
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus, and obesity. It is considered a multisystem disease with a strong association with cardiovascular disease and arterial hypertension. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. NAFLD patients may have a procoagulant state, which may worsen liver injury.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yongsik Cho, Sumin Jeong, Hyeonkyeong Kim, Donghyun Kang, Jeeyeon Lee, Seung-Baik Kang, Jin-Hong Kim
Summary: OA is the most common form of arthritis characterized by cartilage destruction and chronic pain. Current treatments aim to relieve symptoms, but new approaches such as DMOADs and regenerative methods targeting inflammatory cytokines and stimulating cartilage regeneration offer promise in controlling or reversing the disease. Researchers are exploring these avenues based on molecular understanding and some approaches are nearing general clinical use.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Carlos M. Grilo, Adrienne Juarascio
Summary: The review summarizes current treatments for binge-eating disorder (BED) in adults, including psychological, pharmacological, and combined approaches. Specific psychological treatments like CBT and IPT have shown efficacy, while a generalist intervention called BWL has produced similar results to CBT but with the added benefit of modest weight loss. Only one pharmaceutical agent (LDX) has FDA approval, with limited success for off-label medications.
CURRENT OBESITY REPORTS
(2023)
Review
Pharmacology & Pharmacy
Bryan J. Neth, Mason J. Webb, Ian F. Parney, Ugur T. Sener
Summary: Glioblastoma (GBM) is a common and aggressive brain tumor, and the immunosuppressive microenvironment in GBMs has led to interest in immunotherapy. While therapeutic vaccines have shown limited efficacy in GBMs and other cancers, recent results from the DCVax-L trial suggest promise for vaccine therapy in GBMs. Combination therapies with vaccines and immunomodulating agents may enhance antitumor immune responses. Clinicians should consider novel therapeutic strategies like vaccinations and await the results of ongoing and future trials.
Review
Medicine, General & Internal
Nadege Bourvis, David Cohen, Xavier Benarous
Summary: This article reviews the treatment recommendations and recent empirical evidence for borderline personality disorder (BPD) in adolescents. It suggests that structured psychotherapy is more beneficial for self-harm behaviors in adolescents with BPD. It emphasizes the importance of careful assessment and planning for medication use, as well as information sharing and support for patients and their families.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Cheng Wang, Shu Dai, Xingtao Zhao, Yafang Zhang, Lihong Gong, Ke Fu, Cheng Ma, Cheng Peng, Yunxia Li
Summary: This review comprehensively summarizes the molecular mechanisms of the anticancer effects of celastrol, a pentacyclic triterpenoid extracted from Tripterygium wilfordii Hook F. It has been found to exhibit significant broad-spectrum anticancer activities by inhibiting tumor cell proliferation, migration and invasion, inducing cell apoptosis, suppressing autophagy, hindering angiogenesis, and inhibiting tumor metastasis. Various signaling pathways have been identified as important molecular targets for its anticancer effects. However, celastrol also has adverse effects, low oral bioavailability, and a narrow therapeutic window, which present challenges for its development as an anticancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Amy Hyein Kim, Jung Eun Jang, Jin Han
Summary: Heart failure is a major cause of disease and death from cardiovascular diseases, especially for those with type 2 diabetes mellitus. The medical field is continuously improving standards for clinical management and therapeutic approaches to cater to the increasing number of affected individuals.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
