Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
E. M. Bruxel, C. R. Moreira-Maia, G. C. Akutagava-Martins, T. P. Quinn, M. Klein, B. Franke, M. Ribases, P. Rovira, C. Sanchez-Mora, D. B. Kappel, N. R. Mota, E. H. Grevet, C. H. D. Bau, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
Summary: This study conducted a meta-analysis to investigate the association between ADGRL3 gene variants and ADHD susceptibility in children and adults, finding significant correlation in children but not in adults. The results suggest that ADGRL3 gene is predominantly associated with childhood ADHD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada
Summary: This study demonstrates that the selective alpha 2A adrenoceptor agonist guanfacine has dual actions on catecholaminergic transmission, with acute attenuation of noradrenergic transmission and chronic enhancement of noradrenergic transmission and thalamocortical glutamatergic transmission. These dual actions likely contribute to the clinical effects of guanfacine against ADHD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yang Yang, Mechelle M. Lewis, Lan Kong, Richard B. Mailman
Summary: This study compared the effects of methylphenidate and 2-methyldihydrexidine on spatial working memory (sWM) using a rodent model. The results showed that 2-methyldihydrexidine had a better improvement effect on sWM compared to methylphenidate, while methylphenidate had the potential to impair sWM. These findings suggest that a dopamine D1 receptor agonist may be more effective than methylphenidate in the treatment of ADHD by modulating neural activity in the prefrontal cortex.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Psychology, Multidisciplinary
Erica D. Musser, Stephanie S. J. Morris, Kathleen Feeney, Rosario Pintos Lobo, Edward F. Ester
Summary: Inattention is a key symptom of ADHD, but the mechanisms underlying it are unclear. More specific approaches are needed to link disruptions in cognitive performance with ADHD behaviors. A pilot study found that even typically developing children did not maximally extract and combine information to maximize rewards in a cognitive task targeting attention selection mechanisms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Haoran Tao, Shujin Fan, Tianxin Zhu, Lili You, Dinghao Zheng, Li Yan, Meng Ren
Summary: The study suggests that there is a causal effect of ADHD and MDD on increasing the risk of T2DM, and T2DM also has an impact on ADHD. Factors such as smoking and obesity may play a role in mediating these effects.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Review
Multidisciplinary Sciences
Jung Tae Kim, Kibong Kim, Lin Ang, Hye Won Lee, Jun-Yong Choi, Myeong Soo Lee
Summary: This article describes a systematic review that aims to evaluate the effectiveness of acupuncture as a treatment for ADHD. The study will conduct literature searches in multiple databases and analyze the selected studies using the Cochrane Risk of Bias Assessment Tool. The findings of this review will be used to support relevant health policies and practices.
Article
Medicine, General & Internal
Johannes Lieslehto, Jari Tiihonen, Markku Laehteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
Summary: This study investigated the impact of pharmacotherapy on suicide risk in patients with borderline personality disorder (BPD). The results indicated that ADHD medication may reduce the risk of suicide, while mood stabilizers and antidepressants may increase the risk. The findings suggest that benzodiazepines should be used with caution due to their association with increased suicide risk in patients with BPD.
Article
Psychology, Developmental
Deborah Winders Davis, Kahir Jawad, William David Lohr, Marie Trace, Jennifer Le, Yana Feygin, Veronnie Faye Jones
Summary: The study aimed to evaluate the adherence to the American Academy of Pediatrics' clinical guidelines in treating ADHD in preschoolers. Using Medicaid claims data, it was found that more than half of the sample did not receive the recommended behavioral therapy prior to medication initiation. Those who received behavioral therapy had a higher rate of ADHD diagnosis. Only three diagnoses were significant in multivariate analyses. Conclusion: More research is needed to identify intervention targets. Limitations are acknowledged.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Mia Moses, Jeggan Tiego, Ditte Demontis, G. Bragi Walters, Hreinn Stefansson, Kari Stefansson, Anders D. Borglum, Aurina Arnatkeviciute, Mark A. Bellgrove
Summary: This study examined three potential endophenotypes for attention-deficit hyperactivity disorder (ADHD): working memory function, response inhibition, and reaction time variability. The results showed that higher genetic risk for ADHD was associated with higher ADHD traits, as well as poorer working memory performance and increased reaction time variability. Lower working memory performance, poorer response inhibition, and increased reaction time variability were associated with more pronounced ADHD traits. Working memory and reaction time variability partially mediated the relationship between genetic risk for ADHD and ADHD traits, explaining 14% and 16% of the association, respectively.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Anyi Yang, Edmund T. Rolls, Guiying Dong, Jingnan Du, Yuzhu Li, Jianfeng Feng, Wei Cheng, Xing-Ming Zhao
Summary: This study investigates the neural links between ADHD symptoms and prolonged screen time utilization (STU) using a large-scale dataset. The findings suggest that higher polygenic risk scores for ADHD are associated with longer STU and more severe symptoms. White matter microstructure, particularly in visual-related functions, plays a crucial role in mediating the association between ADHD risk and STU.
Article
Neurosciences
Markus Koelle, Sarah Mackert, Katharina Heckel, Alexandra Philipsen, Martin Ulrich, Georg Groen
Summary: This study found an association between RTV and white matter structural properties of the corticothalamic tract in adults with ADHD, which was not observed in healthy controls.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)