Article
Acoustics
Qi Min, Jiapei Zhu, Wanquan He, Quanbiao Wang, Shuping Ge, Shengyu Wang
Summary: The study analyzed the properties of a two-step standing-wave tube with abrupt cross-section using the transfer matrix method, investigating harmonic development and sound pressure level variations under different resonance frequencies.
Article
Physics, Applied
Jin-Chen Hsu, Chih-Lei Chao
Summary: This study introduces a microscale acoustofluidic system that manipulates microparticles using multi-band acoustic forces in a piezoelectric crystal plate. Experimental results demonstrate the trapping and patterning of microparticles at multiple frequencies, enabling planar manipulation of microparticles and cells. The proposed design can inspire innovative applications of acoustofluidic devices for microparticle manipulation and microfluidic mixing with a wide range of actuating frequencies.
APPLIED PHYSICS LETTERS
(2021)
Article
Engineering, Civil
Enrique M. Padilla, Rui Cao, Adrian H. Callaghan
Summary: In experimental campaigns investigating space-time varying signals, it is common to have a lower spatial resolution than desired due to various constraints. To overcome this limitation, a procedure called S-interp is presented, which involves interpolating wave fields along points at the same phase. The success of S-interp is demonstrated in reconstructing missing areas of experimental nonbreaking wave conditions. The main source of error is found to be the spacing between probes, while nonlinear effects of the wave fields are secondary. The potential application of S-interp to random sea-states is discussed.
IEEE JOURNAL OF OCEANIC ENGINEERING
(2023)
Article
Biology
Ana Guerra, Jorge Belinha, Naside Mangir, Sheila MacNeil, Renato Natal Jorge
Summary: Angiogenesis, the formation of new blood vessels from pre-existing ones, is mainly influenced by vascular endothelial growth factor (VEGF) and can be mimicked by a meshless-based model proposed in this study. Both the experimental assay and simulation results showed that treatments with VEGF increased the total vessel number and length. The model accurately simulates capillary network patterns for lower VEGF concentrations, but may show some discrepancies for higher concentrations due to changes in blood vessel width.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Jiajing Sheng, Boxuan Jiang, Ruijun Shi, Linsheng Shi, Dong Liu
Summary: Endothelial cells and neurons have common signaling pathways and molecular mediators for guiding vascular and neural development. This study focused on the role of sema4C in zebrafish embryos and found that it is expressed in both the nervous system and intersegmental vessels. Knockdown of sema4C caused abnormalities in vascular and neural pathfinding, while overexpressing sema4C mRNA neutralized the defects. These findings provide insights into the molecular mechanisms underlying blood vessel and nerve development.
Article
Developmental Biology
Gabriela D'Amico, Isabelle Fernandez, Jesus Gomez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke
Summary: Precise vascular patterning is dependent on the regulation of ERG transcription factor and DLL4/Notch signaling pathway. This study reveals that endothelial cell-specific focal adhesion kinase (FAK) controls ERG protein degradation, which in turn affects vascular development.
Article
Physics, Applied
Tigran Abrahamyan, Hovhannes Haroyan, David Hambaryan, Henrik Parsamyan, Arsen Babajanyan, Kiejin Lee, Barry Friedman, Khachatur Nerkararyan
Summary: The resonant response of a thin conducting rod with a finite length under microwave irradiation has been observed, and it can serve as a resonator for axial surface waves. The resonant frequency of the rod can be controlled by changing its dimensions and the electromagnetic characteristics of the surrounding environment. This phenomenon has potential applications in wavefront shaping metasurfaces and the study of dielectric medium properties in the microwave region.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Deepa Sharma, Gregory J. Czarnota
Summary: Sphingolipids play critical roles in determining cell fate, with ceramides promoting cell death and sphingosine promoting cell survival and angiogenesis. Vascular-targeted therapies can increase ceramide levels in endothelial cells, leading to apoptosis and tumor cure. On the other hand, blocking ceramide generation can reverse this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jiajing Sheng, Jiehuan Xu, Kaixi Geng, Dong Liu
Summary: Vessels and nerves are closely associated in anatomy and functions. This study found that sema6D plays a role in regulating the patterning of both the vascular network and neural system in zebrafish embryos. Deficiency of sema6D led to path finding defects in both intersegmental vessels and primary motor neurons in zebrafish embryos.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Optics
Praveen Kumar, Naveen K. Nishchal
Summary: This paper presents a convenient method to obtain the phase characterization curve of SLM using polarimetry, demonstrating the feasibility of the proposed approach through experimental results. The spatially uniform and linear phase response of SLM achieved through corrections in CGHs enables the generation of singular light fields through on-axis phase modulation.
OPTICS AND LASERS IN ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Anika Schumacher, Nadia Roumans, Timo Rademakers, Virginie Joris, Maria Jose Eischen-Loges, Martijn van Griensven, Vanessa L. S. LaPointe
Summary: Studying the modulation of oxygen availability in culture, researchers found that culturing kidney organoids in hypoxia can lead to improved vascularization. The endothelial network in kidney organoids cultured in hypoxia showed enhanced sprouting and interconnectivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Kyo-in Koo, Andreas Lenshof, Le Thi Huong, Thomas Laurell
Summary: This paper introduces a direct hydrogel extrusion process exposed to an ultrasound standing wave to align fibroblast cells into network structures, offering new insights for engineered organ and drug development. The ultrasound-exposed fibroblast cells displayed over 95% viability in culture medium for up to 10 days, showing promising potential for long-term applications.
Article
Biotechnology & Applied Microbiology
Suihong Liu, Qingxi Hu, Zhipeng Shen, Sasirekha Krishnan, Haiguang Zhang, Murugan Ramalingam
Summary: The study demonstrated the suitability of a 3D printable formulation for self-standing and vascular supportive structures, which has great potential in organ engineering. The formulated hydrogel showed excellent biocompatibility and vascular supportive behavior, making it possible to manufacture organs with complex shapes and structures.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Engineering, Biomedical
Parisa Pedram, Claudia Mazio, Giorgia Imparato, Paolo A. Netti, Aurelio Salerno
Summary: This study presents a computer-aided modular approach for constructing fully vascularized hybrid constructs. By controlling blood vessel growth and orientation, it is possible to effectively control the shape and vasculature architecture of the constructs. The results also highlight the influence of scaffold architectural features and spatial patterning on cell colonization and biosynthesis.
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Biochemistry & Molecular Biology
Christopher S. Farrar, Denise C. Hocking
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Materials Science, Multidisciplinary
Emma G. Norris, Joseph Majeski, Sarah E. Wayson, Holly Coleman, Regine Choe, Diane Dalecki, Denise C. Hocking
MATERIALS RESEARCH EXPRESS
(2019)
Article
Cell Biology
Christopher S. Farrar, Geoffrey T. Rouin, Benjamin L. Miller, Carol H. Raeman, Nancie A. Mooney, Denise C. Hocking
Article
Clinical Neurology
V Adduru, S. A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C. J. Griessenauer, A. M. Michael
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Review
Acoustics
Douglas L. Miller, Alyssa Abo, Jacques S. Abramowicz, Timothy A. Bigelow, Diane Dalecki, Eitan Dickman, John Donlon, Gerald Harris, Jason Nomura
JOURNAL OF ULTRASOUND IN MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Emma G. Norris, Diane Dalecki, Denise C. Hocking
APPLIED SCIENCES-BASEL
(2020)
Article
Immunology
Ninoshka R. J. Fernandes, Nicholas S. Reilly, Dillon C. Schrock, Denise C. Hocking, Patrick W. Oakes, Deborah J. Fowell
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Acoustics
Melinda A. Vander Horst, Carol H. Raeman, Diane Dalecki, Denise C. Hocking
Summary: The study evaluated the effects of pulsed ultrasound on chronic diabetic wounds in a mouse model, showing that ultrasound can enhance wound healing but with varying responses among individuals. The db(+)/ db(+) mouse model may help identify biological variables that influence individual responses to pulsed ultrasound and accelerate clinical translation.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Giovanna Rossi-Marquez, Maria Helguera, Manuel Briones, Cristian Aaron Davalos-Saucedo, Prospero Di Pierro
Summary: Edible coatings using mTG crosslinked whey protein-pectin are a promising alternative to enhance the shelf life of roasted peanut kernels, reducing peroxide value and water content while providing a better barrier effect to protect the kernels.
Article
Engineering, Biomedical
E. G. Norris, D. Dalecki, D. C. Hocking
MATERIALS TODAY BIO
(2019)
Proceedings Paper
Optics
Fernando Zvietcovich, Jannick P. Rolland, Emma Grygotis, Sarah Wayson, Maria Helguera, Diane Dalecki, Kevin J. Parker
OPTICAL ELASTOGRAPHY AND TISSUE BIOMECHANICS V
(2018)