Article
Clinical Neurology
Madeline E. Wood, Lisa Y. Xiong, Yuen Yan Wong, Rachel F. Buckley, Walter Swardfager, Mario Masellis, Andrew S. P. Lim, Emma Nichols, Renaud La Joie, Kaitlin B. Casaletto, Raj G. Kumar, Kristen Dams-O'Connor, Priya Palta, Kristen M. George, Claudia L. Satizabal, Lisa L. Barnes, Julie A. Schneider, Alexa Pichette Binet, Sylvia Villeneuve, Judy Pa, Adam E. Brickman, Sandra S. Black, Jennifer S. Rabin
Summary: Sex modifies the association between APOE epsilon 2 and cognitive decline, with APOE epsilon 2 protecting against decline in men but not women. Among APOE epsilon 2 carriers, men have slower decline than women. There are no sex-specific effects of APOE epsilon 2 in non-Hispanic Black adults.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cell Biology
Moeen Riaz, Aamira Huq, Joanne Ryan, Suzanne G. Orchard, Jane Tiller, Jessica Lockery, Robyn L. Woods, Rory Wolfe, Alan E. Renton, Alison M. Goate, Robert Sebra, Eric Schadt, Amy Brodtmann, Raj C. Shah, Elsdon Storey, Anne M. Murray, John J. McNeil, Paul Lacaze
Summary: This study showed that the incidence of dementia is low among healthy older individuals, but APOE epsilon 4 genotype and high PRS increase the relative risk. APOE epsilon 4 is associated with cognitive decline while PRS is not.
Article
Clinical Neurology
May A. Beydoun, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Ana I. Maldonado, Botong Shen, Michele K. Evans, Alan B. Zonderman
Summary: The study found that APOE4 dosage was associated with faster decline in cognitive memory tests among Whites, while in African American women, APOE4 dosage showed a potential protective effect in attention tests. However, inconsistent results were observed in other cognitive domains and across racial groups, warranting further longitudinal studies.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Kacie D. Deters, Elizabeth C. Mormino, Lei Yu, Michael W. Lutz, David A. Bennett, Lisa L. Barnes
Summary: The study investigated the effects of APOE-TOMM40-'523 haplotypes on cognitive decline in non-demented non-Hispanic Blacks (NHB) and compared these effects to non-Hispanic Whites (NHW). Results showed that the '523-S/S haplotype had different effects on cognitive decline in NHB depending on APOE allele, and that differences in the effect of epsilon 4-'523-S in NHB may explain previous mixed findings on epsilon 4 and decline in this population.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Jing Qian, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano-Pozo
Summary: The study found that compared to the APOE epsilon 3/epsilon 3 reference genotype, the APOE epsilon 2 and epsilon 4 alleles have opposite effects on the rate of cognitive decline. These effects are clinically relevant and largely independent of the differential APOE allele effects on AD and comorbid pathologies, indicating that APOE genotype contributes to the heterogeneity in the rate of clinical progression in AD.
Article
Neurosciences
Benjamin Sweigart, Stacy L. Andersen, Anastasia Gurinovich, Stephanie Cosentino, Nicole Schupf, Thomas T. Perls, Paola Sebastiani
Summary: The study found that individuals carrying the APOE E2 allele had a slower rate of cognitive decline, indicating a protective effect against cognitive impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Nutrition & Dietetics
Yun Zhang, Xurui Jin, Michael W. Lutz, Sang-Yhun Ju, Keyang Liu, Guang Guo, Yi Zeng, Yao Yao
Summary: The study found that individuals carrying the APOE e4 allele experienced faster cognitive decline, while high DDPI and daily fish intake were associated with slower cognitive decline. Additionally, frequent fish intake was more beneficial in mitigating cognitive decline among APOE e4 allele carriers, especially for women.
CLINICAL NUTRITION
(2021)
Article
Neurosciences
Ioanna Katzourou, Ganna Leonenko, Dobril Ivanov, Alun Meggy, Rachel Marshall, Rebecca Sims, Julie Williams, Peter Holmans, Valentina Escott-Price
Summary: This study aimed to explore the genetic architecture of cognitive decline in AD patients, and found no significant association between APOE ε2 or ε4 alleles and the rate of cognitive decline. Further exploration is needed to uncover possible genetic variants that affect the rate of decline in patients with AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Yun Zhang, Shihui Fu, Ding Ding, Michael W. Lutz, Yi Zeng, Yao Yao
Summary: The study found significant associations between APOE ε4 and faster cognitive decline, as well as between engagement in leisure activities and mitigated cognitive decline. Moreover, there were significant interactions between APOE ε4 and leisure activities, particularly in relation to productive activities reducing the risk of APOE ε4-related cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Jose M. Aravena, Jakyung Lee, Anna E. Schwartz, Kate Nyhan, Shi-Yi Wang, Becca R. Levy
Summary: Societal factors can reduce the harmful impact of APOE-epsilon 4 and enhance the beneficial impact of APOE-epsilon 2 on cognitive outcomes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Aleksandra A. Szwedo, Ingvild Dalen, Kenn Freddy Pedersen, Marta Camacho, David Backstrom, Lars Forsgren, Charalampos Tzoulis, Sophie Winder-Rhodes, Gavin Hudson, Ganqiang Liu, Clemens R. Scherzer, Rachael A. Lawson, Alison J. Yarnall, Caroline H. Williams-Gray, Angus D. Macleod, Carl E. Counsell, Ole-Bjorn Tysnes, Guido Alves, Jodi Maple-Grodem
Summary: This study conducted a pooled analysis of six cohorts of newly diagnosed PD patients and found that APOE-ε4 and GBA mutations are closely associated with cognitive decline and risk of dementia in PD. The risk is even higher in patients carrying both genetic variants. However, no significant effects were observed for MAPT and SNCA rs356219 in PD cognitive decline.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Emily Rosenich, Lisa Bransby, Nawaf Yassi, Jurgen Fripp, Simon M. Laws, Ralph N. Martins, Christopher Fowler, Stephanie R. Rainey-Smith, Christopher C. Rowe, Colin L. Masters, Paul Maruff, Yen Ying Lim
Summary: This study aimed to determine the association of modifiable/nonmodifiable components in the CAIDE risk score with hippocampal volume loss and episodic memory decline. The results showed that age and APOE epsilon 4 were associated with these declines. Interventions to reduce modifiable cardiovascular risk factors may be beneficial in reducing the hippocampal volume loss and episodic memory decline in cognitively normal older adults.
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Genetics & Heredity
Xi Richard Chen, Yongzhao J. Shao, Martin Sadowski
Summary: KL-VShet+ status promotes longevity and protects against cognitive decline, particularly in individuals without the APOE epsilon 4 allele.
Article
Neurosciences
Akiko Mizuno, Helmet T. Karim, Maria J. Ly, Ann D. Cohen, Brian J. Lopresti, Chester A. Mathis, William E. Klunk, Howard J. Aizenstein, Beth E. Snitz
Summary: Subjective cognitive decline (SCD) may be an early sign of pre-clinical Alzheimer's disease, with elevated amyloid-beta (Aβ) potentially correlating with SCD symptoms. This study found that education level moderates the association between brain activation during memory encoding, SCD symptoms, and Aβ, indicating different patterns of brain activation in individuals with varying levels of cognitive reserve. Individuals with greater cognitive reserve may show increased neural compensation for SCD symptoms, while those with lower cognitive reserve may exhibit diminishing neural resources.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cell Biology
Xin Zhao, Xiaomin Liu, Aiping Zhang, Huashuai Chen, Qing Huo, Weiyang Li, Rui Ye, Zhihua Chen, Liping Liang, Qiong A. Liu, Juan Shen, Xin Jin, Wenwen Li, Marianne Nygaard, Xiao Liu, Yong Hou, Ting Ni, Lars Bolund, William Gottschalk, Wei Tao, Jun Gu, Xiao-Li Tian, Huanming Yang, Jian Wang, Xun Xu, Michael W. Lutz, Junxia Min, Yi Zeng, Chao Nie
Article
Clinical Neurology
Ornit Chiba-Falek, William K. Gottschalk, Michael W. Lutz
ALZHEIMERS & DEMENTIA
(2018)
Article
Clinical Neurology
Kan Li, Richard O'Brien, Michael Lutz, Sheng Luo
ALZHEIMERS & DEMENTIA
(2018)
Article
Geriatrics & Gerontology
Ramon Casanova, Santiago Saldana, Michael W. Lutz, Brenda L. Plassman, Maragatha Kuchibhatla, Kathleen M. Hayden
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2020)
Article
Clinical Neurology
Yi Tang, Michael W. Lutz, Yi Xing
ALZHEIMERS & DEMENTIA
(2019)
Article
Geriatrics & Gerontology
Michael W. Lutz, Ramon Casanova, Santiago Saldana, Maragatha Kuchibhatla, Brenda L. Plassman, Kathleen M. Hayden
NEUROBIOLOGY OF AGING
(2019)
Article
Geriatrics & Gerontology
Maragatha Kuchibhatla, Jaimie C. Hunter, Brenda L. Plassman, Michael W. Lutz, Ramon Casanova, Santiago Saldana, Kathleen M. Hayden
AGING & MENTAL HEALTH
(2020)
Article
Clinical Neurology
Michael W. Lutz, Daniel Sprague, Ornit Chiba-Falek
ALZHEIMERS & DEMENTIA
(2019)
Article
Psychiatry
Michael W. Lutz, Daniel Sprague, Julio Barrera, Ornit Chiba-Falek
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Clinical Neurology
Michael W. Lutz, Sheng Luo, Douglas E. Williamson, Ornit Chiba-Falek
ALZHEIMERS & DEMENTIA
(2020)
Article
Geriatrics & Gerontology
Tianqi Li, Colleen Pappas, Scott T. Le, Qian Wang, Brandon S. Klinedinst, Brittany A. Larsen, Amy Pollpeter, Ling Yi Lee, Mike W. Lutz, William K. Gottschalk, Russell H. Swerdlow, Kwangsik Nho, Auriel A. Willette
Summary: APOE ε4 carriers showed weaker connectivity in multiple networks, while '650 G carriers had higher connectivity in the language comprehension network. In APOE ε4 carriers, '650 G carriers exhibited decreased network strength with age, which was observed in women but not men among non-G carriers. TOMM40 may modulate network activity in aging APOE ε4 carriers depending on sex.
NEUROBIOLOGY OF AGING
(2022)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Gerontology
Elizabeth Vasquez, Cassandra M. Germain, Fei Tang, Matthew C. Lohman, Karen L. Fortuna, John A. Batsis
JOURNAL OF APPLIED GERONTOLOGY
(2020)
Article
Medicine, General & Internal
Yi Zeng, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, Chen Bai, Enjun Xie, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Ting Ni, Lars Bolund, Kenneth C. Land, Anatoliy Yashin, Angela M. O'Rand, Liang Sun, Ze Yang, Wei Tao, Anastasia Gurinovich, Claudio Franceschi, Jichun Xie, Jun Gu, Yong Hou, Xiao Liu, Xun Xu, Jean-Marie Robine, Ions Deelen, Paola Sebastiani, Eline Slagboom, Thomas Perls, Elizabeth Hauser, William Gottschalk, Qihua Tan, Kaare Christensen, Xiaoming Shi, Mike Lutz, Xiao-Li Tian, Huanming Yang, James Vaupel
Article
Clinical Neurology
Daniel K. Burns, Carl Chiang, Kathleen A. Welsh-Bohmer, Stephen K. Brannan, Meredith Culp, Janet O'Neil, Grant Runyan, Patrick Harrigan, Brenda L. Plassman, Michael Lutz, Eric Lai, Stephen Haneline, David Yarnall, Deborah Yarbrough, Craig Metz, Sridevi Ponduru, Scott Sundseth, Ann M. Saunders
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2019)