Article
Chemistry, Multidisciplinary
Jie Tang, Richard Schutzman, Carlos A. Rodriguez, Joerg Lahann, Nair Rodriguez-Hornedo, Mark R. Prausnitz, Steven P. Schwendeman
Summary: This study aimed to develop an injectable poly(D,L-lactide) (PLA) microparticle for sustained release of contraceptive hormone, etonogestrel (ENG). The ENG-cs-MPs prepared by the coaxial electrospray method showed high drug loading, high encapsulation efficiency, and long-term stable release, suggesting their potential as a long-acting injectable contraceptive with improved pharmacokinetic profile.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Medicinal
Manhong Xu, Ruiyan Fan, Xiaoe Fan, Yan Shao, Xiaorong Li
Summary: Currently, intravitreal injection of anti-VEGF drugs is the main treatment for ocular neovascular diseases. However, this invasive treatment modality has drawbacks such as complications and reduced patient adherence. To overcome these challenges, sustained-release materials are being explored for their potential to reduce the frequency of injections and prolong drug action.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Syed Wajahat Ali, Farhana Akbar Mangrio, Fenfen Li, Pankaj Dwivedi, Muhammad Umer Rajput, Rizwan Ali, Muhammad Imran Khan, Weiping Ding, Ronald X. Xu
Summary: The development of core-shell microparticles loaded with artemether and piperine shows potential in enhancing sustained drug release and drug encapsulation efficiency for malaria treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhepeng Liu, Haini Chen, Fengmei Lv, Jun Wang, Shoujin Zhao, Yijun Li, Xuexin Xue, Yu Liu, Gang Wei, Weiyue Lu
Summary: The core-shell microparticles prepared by coaxial electrospray can enhance the anti-tumor efficacy of combination therapy with paclitaxel and imatinib, showing excellent drug loading capacity and sequential release characteristics, significantly inhibiting the growth of cervical-cancer-related cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Seher Yaylaci, Erdem Dinc, Bahri Aydin, Ayse B. Tekinay, Mustafa O. Guler
Summary: In this study, self-assembled hydrogels composed of peptide amphiphile molecules were developed for sustained release of ranibizumab in the treatment of wet age-related macular degeneration. The hydrogel system showed extended release patterns of ranibizumab without dose dumping, and the released drug was biologically functional and effective in blocking angiogenesis. In vivo experiments demonstrated that the drug released from the hydrogel nanofiber system had longer retention time in the posterior chamber of the rabbit eye compared to a control group. The peptide-based hydrogel nanofiber delivery system holds promise for intravitreal anti-VEGF drug delivery in clinics.
Article
Pharmacology & Pharmacy
Ayaka Hanaki, Koki Ogawa, Tatsuaki Tagami, Tetsuya Ozeki
Summary: In this study, antibodies were successfully loaded into PLGA microparticles while maintaining their activity and demonstrating long-acting properties.
Article
Pharmacology & Pharmacy
Pratibha Anchi, Shrilekha Chilvery, Sayali Tekalkar, Lavanya Bolla, Siva Nageswara Rao Gajula, Rajesh Sonti, Chandraiah Godugu
Summary: Sustained-release formulations play an important role in drug development by improving the pharmacokinetic and pharmacodynamic properties of drugs. Nimbolide (NMB), an active constituent of the Neem tree, has shown anti-carcinogenic, anti-fibrotic, and anti-inflammatory properties, but suffers from poor pharmacokinetics. This study successfully prepared an injectable NMB-PLGA microparticle formulation that releases NMB in a sustained manner, offering potential for the treatment of arthritis. The formulated microparticles demonstrated extended drug release and superior therapeutic effects compared to free NMB in an arthritis rat model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biophysics
Xiao Ma, Caihong Yang, Ruirui Zhang, Jie Yang, Yan Zu, Xin Shou, Yongxiang Zhao
Summary: A novel natural biomass-based hydrogel microparticle was developed using microfluidic electrospray technology. The microparticles showed enhanced chemotherapy effect, inhibited tumor growth, and exhibited good biocompatibility and sustained drug release.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Paper & Wood
Necla Yaman Turan, Erkan Turker, Ozge Insaatci
Summary: The study demonstrates the long-lasting antibacterial effects of cotton fabrics embedded with propolis-containing microcapsules, indicating their potential application in antibacterial textiles.
Article
Materials Science, Ceramics
Cong Wu, Xinghui Wei, Kang Zhao, Junyi Jiang, Mengzhen Jiao, Junhua Cheng, Zhen Tang, Zheng Guo, Yufei Tang
Summary: This study utilized the piezoelectric effect to create a high concentration drug region resembling a dam on the surface of nanotube coatings, reducing the free diffusion rate of the drug and showing potential value in controlled drug delivery applications.
CERAMICS INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Dhruti Avlani, Avichal Kumar, H. N. Shivakumar
Summary: TDF-loaded bioadhesive chitosan microparticles (CM) were successfully developed using an emulsification internal gelation technique. These microparticles demonstrated high drug entrapment efficiency and sustained drug release. They were incorporated into dispersible tablets (DT-TCM) to create a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sang Jun Kim, Youngbo Choi, Khee Tae Min, Surin Hong
Summary: This study proposes radially mesoporous silica nanoparticles as a carrier for dexamethasone, achieving sustained anti-inflammatory effects in rheumatoid arthritis. The nanoparticles demonstrate high-capacity loading and sustained release of the drug, resulting in improved delivery efficiency compared to traditional silica nanoparticles. In vivo evaluation confirms the sustained anti-inflammatory effects and cartilage recovery in a rat model of the disease.
Review
Medicine, General & Internal
Margaux Van Wynsberghe, Joanne Flejeo, Hamza Sakhi, Mario Ollero, Dil Sahali, Hassan Izzedine, Carole Henique
Summary: This review examines the use of VEGF/VEGFR2 signaling inhibitors in cancer treatment, focusing on their impact on kidney physiology and the emergence of adverse nephrotoxic effects. The paper also discusses the pathophysiological mechanisms of common renal diseases and outlines cellular damage associated with these therapies.
Article
Chemistry, Multidisciplinary
Ke Peng, Lalitkumar K. Vora, Ismaiel A. Tekko, Andi Dian Permana, Juan Dominguez-Robles, Delly Ramadon, Philip Chambers, Helen O. McCarthy, Eneko Larraneta, Ryan F. Donnelly
Summary: Fungal infections are a global issue affecting millions of individuals, with conventional treatments often proving ineffective due to low drug bioavailability and drug resistance. Amphotericin B (AmB) loaded dissolving microneedle patches were introduced for localized and long-acting intradermal delivery to treat cutaneous fungal infections, demonstrating significant inhibition and killing of Candida albicans. Moreover, pharmacokinetic studies showed lower systemic exposure and reduced systemic side effects compared to intravenous injection, highlighting the potential of this novel drug delivery system.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Agriculture, Multidisciplinary
Youwu Liao, Haiqiao Wang, Shuang Li, Yuanyuan Xue, Yunqiu Chen, Michael Adu-Frimpong, Ying Xu, Jiangnan Yu, Ximing Xu, Hugh D. C. Smyth, Yuan Zhu
Summary: Astaxanthin-loaded composite micelles were successfully prepared via coaxial electrospray technology, showing enhanced drug solubility and release rate. The delivery system improved the absorption of AST in the gastrointestinal tract and significantly increased antioxidant capacity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Mechanics
Zhaodong Ding, Kai Mu, Ting Si, Yongjun Jian
Summary: This study comprehensively investigates the instability characteristic of a viscoelastic jet in a co-flowing gas stream. It clarifies the important role of the non-uniform basic velocity in the instability analysis of viscoelastic jets, as well as the competition between the elastic tension and the coupling term in promoting or stabilizing the jet's instability. Three instability mechanisms are identified through energy budget analysis, and the general features of viscoelastic jet instability are obtained through analyzing the variations of the disturbances' growth rate and phase speed. Theoretical investigation of the transitions of instability modes in parameter spaces is also provided.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Physics, Fluids & Plasmas
Kai Mu, Chunyu Zhang, Ting Si, Hang Ding
Summary: This study investigates the interfacial instability and flow patterns of a coaxial liquid cone in a CFF process through experiments and numerical simulations, providing important guidance for the generation of microcapsules using the CFF technique in practical applications.
PHYSICAL REVIEW FLUIDS
(2022)
Article
Engineering, Environmental
Ming Zhang, Zhiyuan Zheng, Yuanqing Zhu, Zhiqiang Zhu, Ting Si, Ronald X. Xu
Summary: Collecting water from fog using microscale fibrous materials is a promising solution to the global water scarcity crisis. The dynamic interfacial spinning (DIS) process is used to fabricate a novel type of fog harvesting microfibers that combine multiple biomimetic structures. The resultant microfibers have unique surface topography and geometric structure, resulting in significantly higher water transport velocity and hanging ability, and improved water collection efficiency compared to previous designs.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Mechanics
Xu Guo, Zhouyang Cong, Ting Si, Xisheng Luo
Summary: The Richtmyer-Meshkov instability of heavy/light single-mode, trapezoid, and sawtooth interfaces is experimentally studied by considering the reshock. The results show that the initial interface shapes have a significant influence on the interface evolution after reshock, and the reshock amplifies the effects of high-order modes, leading to interface shape dependence of mixing width growths. The growth rates of mixing widths are different for different interface shapes, with the sawtooth interface having the largest growth rates.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Mechanics
Xiao Xu, Zhiqiang Zhu, Kai Mu, Fangsheng Huang, Ting Si
Summary: A systematic experimental study was conducted on the effects of mechanical disturbance on jet and droplet generation in gas-driven flow focusing. The results showed that the jet and droplet size can be regulated by changing the flow rate and pressure drop condition.
Article
Mechanics
Xu Guo, Ting Si, Zhigang Zhai, Xisheng Luo
Summary: This study investigates the Richtmyer-Meshkov (RM) instability of heavy/light gaseous interfaces with reshock through experimental and theoretical studies. The effects of interface shape and amplitude on the instability are highlighted. The results show that linear perturbation growths can be predicted well by the impulsive model for small-amplitude interfaces, while for large-amplitude interfaces, the reshock acceleration promotes mode interaction and reduces the perturbation growth rates. The evolution of bubble and spike structures is strongly influenced by initial shapes, and the perturbation growth after reshock is more sensitive to initial amplitudes for quasi-single-mode interfaces.
Article
Mechanics
Zhouyang Cong, Xu Guo, Ting Si, Xisheng Luo
Summary: The study investigates the Richtmyer-Meshkov instability of a heavy fluid layer with reshock, highlighting the effects of initial layer thickness on interface evolution. A general one-dimensional theory is constructed to describe the interaction between unperturbed interfaces and waves under reshock conditions.
Article
Mechanics
Chengxi Zhao, Yixin Zhang, Ting Si
Summary: Boundary conditions at the liquid-solid interface play a crucial role in the dynamics of a liquid film on a fiber. This study develops a theoretical framework based on axisymmetric Stokes equations to investigate the influence of liquid-solid slip on the Rayleigh-Plateau instability of a cylindrical film. The new model reveals that the growth rate of perturbations is overestimated by the classical lubrication model and predicts a slip-dependent dominant wavelength, leading to larger drops on a more slippery fiber. The findings are validated through direct numerical simulations and agree with experimental results.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Nanoscience & Nanotechnology
Chen Li, Jijie Fu, Fangsheng Huang, Zhiqiang Zhu, Ting Si
Summary: Researchers have successfully developed highly controllable phase-change microcapsules that can precisely regulate temperature. The diameter of the microcapsules can be adjusted using a liquid-driven active flow focusing technique platform, and the shell thickness can be controlled by adjusting the monomer ratio. The fabricated microcapsules have uniform particle size, smooth surface, and compact structure, while exhibiting good phase-change performance and thermal stability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Mechanics
Duo Zhang, Juchun Ding, Ting Si, Xisheng Luo
Summary: Experiments on divergent Richtmyer-Meshkov (RM) instability at a heavy gas layer are conducted using a novel soap-film technique. The behavior of unperturbed and perturbed gas layers is examined, and a one-dimensional theory applicable to layers of arbitrary thickness is established. The results show the effects of rarefaction wave, interface coupling, and layer thickness on the instability growth.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Engineering, Mechanical
Ran Qiao, Kai Mu, Ting Si
Summary: This work presents a linear temporal instability analysis of a liquid jet entering a stationary gas environment under a radial thermal field. The basic temperature distribution is obtained by solving the heat conduction problem between the liquid jet and the surrounding gas. The normal mode method is used to solve the temporal evolution of small disturbances, and an analytical dispersion relation for disturbance growth is derived. The effects of different control parameters on the disturbance growth of an inviscid liquid jet are investigated through a parametric study. Theoretical results show that increasing the temperature ratio, enhancing the Marangoni stress, weakening thermal conduction, and decreasing surface tension can suppress the jet instability. The physical mechanisms of Rayleigh-Plateau instability and Marangoni instability are distinguished as contributors to disturbance growth. The applicable range of the inviscid asymptotic solution is identified through comparison with the disturbance growth of a viscous jet, with Reynolds number ranges of Re = O(10^2).
ACTA MECHANICA SINICA
(2023)
Review
Chemistry, Multidisciplinary
Zhiqiang Zhu, Tianao Chen, Fangsheng Huang, Shiyu Wang, Pingan Zhu, Ronald X. Xu, Ting Si
Summary: This review paper provides a comprehensive overview of recent advancements in free-boundary microfluidic manufacturing (FBMM) for advanced materials. It covers technical principles, manufacturing processes, and applications in various fields. The paper discusses in detail the processes and mechanisms of fluid manipulation, presents manufacturing methods for advanced materials in different dimensions, and showcases their applications in material science, biomedical engineering, and engineering. Additionally, the review summarizes the current progress in FBMM and highlights future challenges.
ADVANCED MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Dong He, Ting Si, Fei Li, Xisheng Luo
Summary: A mid-infrared interference-free laser absorption technique was developed to simultaneously measure rotational temperature, vibrational temperature, and CO concentration. The technique was validated and showed high sensitivity in detecting temperature and CO concentration in non-equilibrium conditions. The measurement of CO concentration at ultra-high temperatures is significant for research on scramjet engines.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Mechanics
Chengxi Zhao, Zhao Zhang, Ting Si
Summary: The instability and dewetting of bounded liquid films at the nanoscale are found to be strongly influenced by thermal fluctuations. This study investigates the fluctuation-driven instability on a chemically heterogeneous substrate using a stochastic lubrication equation and molecular dynamics. The results show that slip and intermolecular forces enhance the fluctuation-driven instability, with the latter becoming dominant towards the final rupture. Additionally, the study suggests that a heterogeneous substrate can be approximated as a homogeneous one using effective slip lengths and Hamaker constants for the intermolecular forces, while the gradients of slip and intermolecular forces due to heterogeneity have little effect on the instability.
Article
Materials Science, Multidisciplinary
Zhiqiang Zhu, Tianao Chen, Yuanqing Zhu, Fangsheng Huang, Kai Mu, Ting Si, Ronald X. Xu
Summary: Programmable pulsed aerodynamic printing (PPAP) is a method for patterning soft materials with extensive compatibility and multi-scale and multi-interface properties. PPAP utilizes programmable pulsed airflow to shear pendant droplets at the nozzle orifice, covering a broad range of parameters. Demonstrations of PPAP include cell-loaded annular particles, liquid metal circuits, laser stimuli-responsive microcapsules, calcium alginate elastomers, and 3D multi-interface clusters.
