Article
Environmental Sciences
Yuanyuan Zhang, Di Wu, Ze Fan, Jinnan Li, Lei Gao, Yu'e Wang, Liansheng Wang
Summary: Previous studies have shown that MC-LR enters intestinal tissues through organic anion-transporting polypeptides, resulting in ferroptosis-related damage including ER stress, iron accumulation, and changes in glutathione levels. The GSH/GPx 4 pathway plays a significant role in response to MC-LR exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Seyyed Morteza Hoseini, Kave Khosraviani, Fatemeh Hosseinpour Delavar, Mohammad Arghideh, Fatemeh Zavvar, Seyed Hossein Hoseinifar, Hien Van Doan, Erfan Zabihi, Miriam Reverter
Summary: This study investigated the combined effects of copper and polyvinyl chloride (PVC) microparticles on metal accumulation, histopathological biomarkers, and targeted transcriptomics in Cyprinus carpio liver. The presence of PVC microparticles in water facilitated hepatic copper accumulation. All treatments induced significant hepatic stress and inflammation, but transcriptional responses related to detoxification pathways and apoptotic mechanisms were mixed and often down-regulated in fish exposed to copper and/or PVC microparticles. Exposure to copper and/or PVC microparticles resulted in hyperemia, leukocyte infiltration, and an increase in melanomacrophage centers number and area. Generally, the severity of the lesions followed the order: PVC microparticles < copper < copper+ PVC microparticles. In conclusion, PVC microparticles act as a copper vector, facilitating copper accumulation in the fish liver and increasing tissue damage.
MARINE POLLUTION BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Xinyue Liang, Zsolt Csenki, Bence Ivanovics, Illes Bock, Balazs Csorbai, Jozsef Molnar, Erna Vasarhelyi, Jeffrey Griffitts, Arpad Ferincz, Bela Urbanyi, Andras Acs
Summary: This study reveals the subacute effects of the common pharmaceutical residue carbamazepine (CBZ) on common carp, indicating significant adverse effects of CBZ exposure at concentrations often found in surface waters, including liver tissue damage and oxidative stress.
Article
Environmental Sciences
Esraa Ammar, Mahmoud S. Mohamed, Alaa El-Din H. Sayed
Summary: This study investigated the effects of combined exposure to polyethylene microplastics (PE-MPs) and 4-nonylphenol (4-NP) on juvenile common carp using histopathological and histochemical biomarkers. The results showed that the treatment groups exhibited histopathological changes compared to the control group, and some tissue changes improved during the recovery period but did not return to normal.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Fisheries
David Waikhom, Jeena Kezhedath, Rahul Krishnan, Tincy Varghese, Pani Prasad Kurcheti, Rajendran Kooloth Valappil
Summary: This study evaluated the induction of trained immunity markers in common carp using ll-glucan and revealed the metabolic basis and epigenetic modifications of trained immunity induced by ll-glucan. The study also confirmed the increased metabolic activity and expression profiles of proinflammatory cytokines in cells stimulated with ll-glucan. These findings further support the importance of trained immunity in fish and provide genomic evidence.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Vojtech Kaspar, Martin Hubalek, Martin Psenicka, Katsutoshi Arai, John B. Taggart, Roman Franek
Summary: Methods of induction of uniparental inheritance have been developed for model organisms as well as for species of commercial interest, with cold-shock androgenesis showing promise in successfully inducing haploid progeny in common carp. Compared to other techniques, cold-shock androgenesis was found to be effective in common carp, providing a new possibility for isogenic line production.
Article
Environmental Sciences
Rui Jia, Jinliang Du, Liping Cao, Wenrong Feng, Qin He, Pao Xu, Guojun Yin
Summary: The study investigated the responses of common carp to long-term H2O2 exposure, revealing significant immune, inflammatory, autophagic, and DNA damage responses in different tissues. The immune response was evident through changes in immune parameters, while the inflammatory response was associated with TLRs and NF-kappa B activation. Autophagy process and DNA damage response were affected by H2O2 exposure in a tissue-specific manner, with cell cycle regulation genes showing differential expression patterns. Overall, the responses to H2O2 exposure were dose-dependent and tissue-specific, providing insights into the potential toxicity and risk assessment of H2O2 in aquatic environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agriculture, Dairy & Animal Science
Yuhan Jiang, Xiangbing Cheng, Junjie Lu, Guanhong Xu, Qigen Liu, Jiamin Sun
Summary: In this study, metabolomics was used to investigate the impact of thermal stress on the metabolic profile of Qingtian paddy field carp. The results showed that thermal stress altered multiple metabolic pathways, including lipid, amino acid, and carbohydrate metabolism. The findings clarify the molecular regulatory mechanism of PF carp adaptation to thermal stress and provide novel hypotheses for the biological regulation of other fish species under thermal stress.
Article
Fisheries
Yating Mou, Bing Li, Yiran Hou, Rui Jia, Jian Zhu
Summary: This study investigated the response mechanism of fish to chronic H2O2 exposure and found that it causes incomplete gill structure, decreases potassium concentration while increasing sodium concentration in the plasma, and raises calcium level but decreases potassium and chlorine levels in the gills. Moreover, H2O2 exposure activates the calcium signaling pathway and affects the expression levels of ion-regulation-related genes. Overall, chronic H2O2 exposure alters gill structure, disturbs ion transport, and negatively affects ion equilibrium and osmotic pressure.
Article
Fisheries
Chen Li, Yunli Zhang, Mengdi Yuan, Wenping Zhu, Chao Pei, Xianliang Zhao, Xianghui Kong
Summary: In this study, a fusion protein combining the glycoprotein (G) of Spring viremia of carp virus (SVCV) and the beta-defensin3 (BD3) of Yellow River carp was created and expressed in E. coli. The fusion protein was used to develop an oral vaccine for Yellow River carp, which showed a higher immune protection rate (77.28%) against SVCV. This study provides guidance for the prevention of SVCV in aquaculture.
Article
Fisheries
Artem V. Nedoluzhko, Maria V. Gladysheva-Azgari, Gulmira M. Shalgimbayeva, Alexander A. Volkov, Natalia V. Slobodova, Svetlana V. Tsygankova, Eugenia S. Boulygina, Van Q. Nguyen, The T. Pham, Duc T. Nguyen, Fedor S. Sharko, Sergey M. Rastorguev
Summary: The study used ddRAD-seq to assess the genetic impact of aquaculture carps on wild common carp populations in northern Vietnam. The research revealed that some wild carp populations have a significant contribution to farmed fish ancestry, with pure aquaculture specimens being quite rare in wild habitats.
Article
Environmental Sciences
Rui Jia, Jinliang Du, Liping Cao, Wenrong Feng, Qin He, Pao Xu, Guojun Yin
Summary: The study revealed that exposure to H2O2 caused oxidative damage and neurotoxicity in the brain of common carp, potentially related to dysregulation of neurotransmitters and calcium, cAMP, and HIF-1 signaling pathways, which may adversely affect the learning, memory, and social responses of common carp.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Ping Li, Cheng-Zhuang Chen, Xue-Li Zhao, Ling Liu, Zhi-Hua Li
Summary: This study assessed the chronic toxicity of norfloxacin (NOR) on the gut microbiota of juvenile common carp. The results showed that environmental levels of NOR can alter the composition, structure, and abundance of the gut microbiota, as well as enhance antibiotic resistance genes (ARGs), affecting the intestinal health of fish.
Article
Environmental Sciences
Hassan Ahmed, Karima A. Bakry, Ahmed Abdeen, Halla E. K. El Bahgy, Mohamed Abdo, Florin Imbrea, Liana Fericean, Mona A. Elshemy, Samah F. Ibrahim, Mustafa Shukry, Samar H. Baloza, Walaa F. A. Emeish
Summary: This study investigates the molecular mechanisms underlying the response to salinity stress in common carp. The results demonstrate that high salinity adversely affects biochemical markers and modulates the expression of immune, endocrine, and neural-related genes in different organs.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Physiology
Giovanni Castaldo, Marion Pillet, Leen Ameryckx, Lieven Bervoets, Raewyn M. Town, Ronny Blust, Gudrun De Boeck
Summary: The study investigated the effects of exposing common carp to a ternary metal mixture of Cu, Zn, and Cd at different temperatures. The results showed differences in metal accumulation in the tissues, as well as changes in gene expression related to ionoregulation and defensive responses. Additionally, analysis of electrolyte levels did not show significant losses, suggesting compensation through ion uptake from food.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lu Zhang, Zichen Wang, Ruijie Liu, Zhengzhe Li, Jennifer Lin, Megan L. Wojciechowicz, Jiyi Huang, Kyung Lee, Avi Ma'ayan, John Cijiang He
Summary: Utilizing a connectivity mapping approach and LINCS L1000 dataset, we identified a PLK1 inhibitor that can reverse DKD-related gene expression and confirmed its potential therapeutic effect on DKD in experiments. Additionally, the PLK1 inhibitor was found to impact pathways related to inflammation and fibrosis.
Article
Urology & Nephrology
Jie Feng, Li Bao, Xuan Wang, Huilin Li, Yuqiang Chen, Wenzhen Xiao, Zhengzhe Li, Liyi Xie, Wanhong Lu, Hongli Jiang, Kyung Lee, John Cijiang He
Summary: With the widespread use of combination antiretroviral therapy, the prevalence of HIV-associated nephropathy has significantly decreased. However, chronic kidney disease (CKD) remains high among patients living with HIV, particularly when also affected by diabetes. The synergistic effects of HIV infection and diabetes in driving CKD progression highlight the importance of exploring potential therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Oncology
Defa Huang, Jie Chen, Die Hu, Fangfang Xie, Tong Yang, Zhengzhe Li, Xiaoxing Wang, Yongwei Xiao, Jianing Zhong, Yu Jiang, Xiaokang Zhang, Tianyu Zhong
Summary: Small extracellular vesicles carry membrane proteins with cell-specific signatures that can be used as biomarkers and target proteins for disease diagnosis and treatment. This article classifies and summarizes the pathophysiological functions of small extracellular vesicle membrane proteins in disease management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Urology & Nephrology
Quan Hong, Hong Cai, Lu Zhang, Zhengzhe Li, Fang Zhong, Zhaohui Ni, Guangyan Cai, Xiang-Mei Chen, John Cijiang He, Kyung Lee
Summary: The abnormal expression of secreted leucine-rich alpha-2 glycoprotein-1 (LRG1) is associated with the progression of chronic kidney diseases, promoting kidney fibrosis through enhanced endothelial transforming growth factor-beta (TGF-beta) signaling. LRG1 expression increases in glomerular endothelial cells and the tubulointerstitial compartment. In mouse models, loss of LRG1 attenuated kidney fibrosis, while overexpression exacerbated fibrosis. These findings suggest that therapeutic targeting of LRG1 may effectively halt the progression of kidney fibrosis in chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Construction & Building Technology
Zhongzhe Li, Meihui Ba, Jian Kang
Summary: This study aimed to identify trends in physiological indicators and subjective restorativeness in response to audio-visual interactions in the environment. Physiological responses and subjective restoration of subjects were measured for different audio-visual modalities, finding differences between dynamic and static visual presentations. Using static images and sound to replicate the natural environment evoked more physiological comfort and subjective restorativeness.
SUSTAINABLE CITIES AND SOCIETY
(2021)
Article
Cell Biology
Lun Fang, Gang Zhang, Yadi Wu, Zhongzhe Li, Shan Gao, Lu Zhou
Summary: The study demonstrates that SIRT6 plays an important role in glucocorticoid-induced osteonecrosis of the femoral head by inhibiting ferroptosis, restoring bone formation, and promoting angiogenesis to prevent the occurrence of the disease.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Oncology
Xiaomei Yi, Defa Huang, Zhengzhe Li, Xiaoxing Wang, Tong Yang, Minghong Zhao, Jiyang Wu, Tianyu Zhong
Summary: Breast cancer is the most common malignancy and leading cause of cancer-related deaths in women worldwide. Small extracellular vesicles (sEVs) play a crucial role in breast cancer pathogenesis by supporting tumor proliferation, invasion, metastasis, immune evasion, and drug resistance. Additionally, sEVs can serve as potential liquid biopsy biomarkers for breast cancer diagnosis and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Xiaomei Yi, Jie Chen, Defa Huang, Shuo Feng, Tong Yang, Zhengzhe Li, Xiaoxing Wang, Minghong Zhao, Jiyang Wu, Tianyu Zhong
Summary: This review describes the important molecular cargoes involved in exosome biogenesis and highlights the regulation of exosome release by exogenous factors. It emphasizes the potential of exosome molecular cargoes as biomarkers for cancer diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
Lun Fang, Zhongzhe Li, Beilei Yu, Lu Zhou
Summary: This study reveals that FGF23 is highly expressed in osteosarcoma cells and overexpression of FGF23 significantly promotes the proliferation, migration, and invasion of osteosarcoma cells. Further investigation suggests that FGF23 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-340-5p gene expression.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Neurosciences
Zhengzhe Li, Dongdong Chen, Renjie Pan, Yanbiao Zhong, Tianyu Zhong, Zhigang Jiao
Summary: Small extracellular vesicles (sEVs) are generated by cells in various conditions. Tissue-derived small extracellular vesicles (tdsEVs) have gained attention because of their ability to be isolated from a specific tissue source. In this study, midbrain tissue-derived sEVs (bdsEVs) were analyzed to understand their microRNA (miRNA) profile and their role in Parkinson's disease (PD). The expression levels of 180 miRNAs were found to be significantly different between PD rats and the sham group. Further analysis identified potential targets and their involvement in signaling pathways and cellular functions. Additionally, the expression levels of specific miRNAs were explored in bdsEVs, sEVs derived from plasma, and plasma samples from both groups of rats. These findings suggest that miRNAs may play a significant role in the development of PD and can be potential therapeutic targets and diagnostic markers.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Xiaoxing Wang, Jie Chen, Zhengzhe Li, Defa Huang, Xiaomei Yi, Jiyang Wu, Tianyu Zhong
Summary: Isolation of small extracellular vesicles (sEVs) from tumor tissue is challenging. This study presents a method for the rapid enrichment of high-quality sEVs from liver cancer tissue. The method involves a four-step process: incubation with digestive enzymes, filtration through a cell strainer, differential ultracentrifugation, and filtration through a membrane filter. The purity of the sEVs obtained by this method is higher than that achieved by classic differential ultracentrifugation, providing an important methodology for the study of tissue-derived sEVs.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Orthopedics
Tong Zheng, Xingjian Huang, Yong Yang, Bin Li, Feng Li, Zhongzhe Li
Summary: Arthroscopic excision of recurrent dorsal wrist ganglion cysts resulted in satisfactory outcomes with no second recurrence, significant pain relief, and good wrist function at a minimum of 2-year follow-up. Clear identification of the location and limits of the ganglion based on preoperative MRI was helpful for complete excision and prevention of a second recurrence.
ORTHOPAEDIC SURGERY
(2023)
Review
Cell Biology
Xiaoxing Wang, Defa Huang, Jiyang Wu, Zhengzhe Li, Xiaomei Yi, Tianyu Zhong
Summary: This review systematically describes the potential mechanisms of small extracellular vesicles (sEVs) in tumor development and discusses their role in colorectal cancer (CRC) metastasis. Understanding these mechanisms can improve early diagnosis and treatment of CRC metastasis.
Article
Environmental Studies
Meihui Ba, Zhongzhe Li, Jian Kang
Summary: This study conducted multisensory environmental evaluations in three urban open spaces in China, and found that audio-olfactory interaction has an impact on the quality and evaluation of urban environments.
ENVIRONMENT AND PLANNING B-URBAN ANALYTICS AND CITY SCIENCE
(2023)
Article
Cell & Tissue Engineering
Jie Chen, Zhigang Jiao, Jianwen Mo, Defa Huang, Zhengzhe Li, Wenjuan Zhang, Tong Yang, Minghong Zhao, Fangfang Xie, Die Hu, Xiaoxing Wang, Xiaomei Yi, Yu Jiang, Tianyu Zhong
Summary: The study established a simple and effective approach for isolating high-quality sEVs, which can reflect the physiological and pathological state of the organism.
STEM CELL REVIEWS AND REPORTS
(2022)
