Article
Chemistry, Medicinal
Alejandra Daruich, Emilie Picard, Justine Guegan, Thara Jaworski, Lea Parenti, Kimberley Delaunay, Marie-Christine Naud, Marianne Berdugo, Jeffrey H. Boatright, Francine Behar-Cohen
Summary: This study evaluated the neuroprotective effects of UDCA versus TUDCA in a neuroretinal degeneration model and compared the transcriptionally regulated pathways. The results showed that TUDCA regulated more neuroprotective genes than UDCA.
Review
Biochemistry & Molecular Biology
Stefania Vernazza, Francesco Oddone, Sara Tirendi, Anna Maria Bassi
Summary: Glaucoma is a neurodegenerative disease that causes damage to retinal ganglion cells and results in permanent vision loss. While Intra Ocular Pressure (IOP) is the main therapeutic target, other pathological conditions and neuroprotective therapeutic approaches also play important roles in the disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Amany Tawfik, Riyaz Mohamed, Dina Kira, Suhib Alhusban, Mohamed Al-Shabrawey
Summary: Elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with diabetic retinopathy (DR) and age-related macular degeneration (AMD). This study suggests that HHcy alters blood-retinal barrier (BRB) by activating N-methyl-D-aspartate receptor (NMDAR). Inhibition or elimination of NMDAR can potentially improve retinal hyperpermeability and morphology under HHcy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen, Akbar Shakoor, Ivana K. Kim, Margaret M. DeAngelis, Nader Sheibani, Mohamed Al-Shabrawey, Amany Tawfik
Summary: The study suggests that the activation of NMDAR in the retina pigment epithelium may be a mechanism for AMD induced by HHcy. Inhibition of NMDAR could be a promising therapeutic target for AMD, as knocking down RPE NMDAR improved retinal structure and CNV in mice with AMD-like features induced by HHcy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shinhui Lee, Sanung Eom, Khoa V. A. Nguyen, Jiwon Lee, Youngseo Park, Hye Duck Yeom, Junho H. Lee
Summary: The study found that ergotamine effectively inhibits the NR1a/NR2A subunit of NMDAR, preventing excessive Ca2+ influx and neuronal death.
Article
Clinical Neurology
Yan Zhang, Lili Cui, Weibi Chen, Huijin Huang, Gang Liu, Yingying Su, Johannes Boltze
Summary: This study aims to explore the clinical characteristics and outcome of SD in anti-NMDAR encephalitis. The results show that SD is rare in adult patients but is associated with severity and worse short-term outcomes. Early recognition of SD and timely treatment is crucial for shortening the recovery time.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Federica Conti, Giovanni Luca Romano, Chiara Maria Eandi, Mario Damiano Toro, Robert Rejdak, Giulia Di Benedetto, Francesca Lazzara, Renato Bernardini, Filippo Drago, Giuseppina Cantarella, Claudio Bucolo
Summary: The study demonstrated that brimonidine effectively protected the function of RGCs in mouse eyes and regulated the inflammatory biomarkers induced by retinal ischemia reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao
Summary: This study aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity. The results showed that serum D-dimer and neutrophil levels were independent predictors of disease severity in patients with first-attack anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang
Summary: This study investigated the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. The findings suggest that low FT3 levels upon admission may be associated with more severe disease progression and poorer outcomes in these patients. Monitoring FT3 levels could potentially aid in clinical prediction and decision-making in the treatment of anti-NMDAR encephalitis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Oskar Stevens-Jones, Hana Mojzisova, Martin Elisak, Radu Constantinescu, Jitka Hanzalova, Markus Axelsson, David Krysl
Summary: This study aimed to discover clinically relevant biomarkers in NMDAR and LGI1 encephalitis using a proteomic approach. The results showed that SIRT2 may serve as a biomarker for NMDAR encephalitis and be associated with ovarian teratoma.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Stefan Macher, Tobias Zrzavy, Romana Hoeftberger, Patrick Altmann, Ekatarina Pataraia, Fritz Zimprich, Thomas Berger, Paulus Rommer
Summary: CSF-NfL levels in anti-NMDARE patients do not predict short-term outcomes, but are associated with ICU stay and extreme delta brushes. High CSF-NfL levels are associated with long-term outcomes, suggesting early aggressive immunotherapy to prevent neuroaxonal damage.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Meeting Abstract
Ophthalmology
Oksana Kutsyr, Agustina Noailles, Natalia Martinez-Gil, Lucia Maestre-Carballa, Manuel Martinez-Garcia, Laura Fernandez-Sanchez, Victoria Maneu, Nicolas Cuenca, Pedro Lax
ACTA OPHTHALMOLOGICA
(2022)
Meeting Abstract
Ophthalmology
Henar Albertos-Arranz, Xavier Sanchez-Saez, Natalia Martinez-Gil, Agustina Noailles Gil, Ramon Calvo Andres, Clara Monferrer Adsuara, Lidia Remoli Sargues, Javier Montero Hernandez, Nicolas Cuenca
ACTA OPHTHALMOLOGICA
(2022)
Review
Clinical Neurology
Jee-Young Lee, Antonio Martin-Bastida, Ane Murueta-Goyena, Inigo Gabilondo, Nicolas Cuenca, Paola Piccini, Beomseok Jeon
Summary: This review highlights the importance of in vivo imaging biomarkers for early diagnosis and monitoring of Parkinson disease (PD). By combining various imaging techniques such as PET, single-photon emission CT, MRI, and retinal optical coherence tomography (OCT), the early diagnosis and management of PD can be aided.
NATURE REVIEWS NEUROLOGY
(2022)
Editorial Material
Cell Biology
Victoria Maneu, Pedro Lax, Nicolas Cuenca
NEURAL REGENERATION RESEARCH
(2022)
Article
Cell Biology
Lorena Perdices, Lorena Fuentes-Broto, Francisco Segura, Ana Cavero, Elvira Orduna-Hospital, Gema Insa-Sanchez, Ana Isabel Sanchez-Cano, Laura Fernandez-Sanchez, Nicolas Cuenca, Isabel Pinilla
Summary: EGCG can protect against retinal degenerative diseases and reduce visual function loss in animal models of RP.
NEURAL REGENERATION RESEARCH
(2022)
Article
Anatomy & Morphology
Laura Fernandez-Sanchez, Henar Albertos-Arranz, Isabel Ortuno-Lizaran, Pedro Lax, Nicolas Cuenca
Summary: The study demonstrates that Tauroursodeoxycholic acid (TUDCA) not only has a neuroprotective effect on photoreceptor cells but also prevents vascular and glial degeneration. This finding provides support for the potential use of TUDCA as a therapy for neurodegenerative diseases.
FRONTIERS IN NEUROANATOMY
(2022)
Review
Biochemistry & Molecular Biology
Jorge Navarro-Calvo, Gema Esquiva, Violeta Gomez-Vicente, Luis M. Valor
Summary: The retina, as one of the most highly organized tissues in the central nervous system, requires finely regulated developmental processes to form the specialized retinal layers and allow precise phototransduction. MicroRNAs have crucial roles in retinal development, including the rearrangement of microRNA expression program and the differentiation and maintenance of retinal cell subtypes. This review provides an overview of the important findings regarding the involvement of microRNAs in retinal development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Anatomy & Morphology
Luis Perez de Sevilla, Laura Fernandez-Sanchez
FRONTIERS IN NEUROANATOMY
(2023)
Article
Cell Biology
Anna Sires, Mateo Pazo-Gonzalez, Joaquin Lopez-Soriano, Ana Mendez, Enrique J. J. de la Rosa, Pedro de la Villa, Joan X. X. Comella, Catalina Hernandez-Sanchez, Montse Sole
Summary: The short and long isoforms of FAIM play important roles in the central nervous system and are highly expressed in the retina. Knockout of Faim gene in mice leads to functional loss of rod photoreceptor and ganglion cells, as well as a delay in dark adaptation. Abnormal redistribution of Arrestin-1 and its ubiquitination may contribute to the impairments observed in Faim knockout mice.
Article
Neurosciences
Xavier Sanchez-Saez, Isabel Ortuno-Lizaran, Carla Sanchez-Castillo, Pedro Lax, Nicolas Cuenca
Summary: This study aimed to determine if starburst amacrine cells, involved in motion direction selectivity, are degenerated in Parkinson's disease (PD) and if the dopaminergic system is related to this degeneration. The results showed a reduction in starburst amacrine cell density and a decrease in dopaminergic synaptic contacts in PD retinas. In conclusion, the degeneration of starburst amacrine cells in PD is related to dopaminergic degeneration, and dopaminergic amacrine cells play a role in modulating the function of starburst amacrine cells. Assessment of motion perception circuitries using visual tests could be a valuable tool for PD diagnosis.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Ophthalmology
Henar Albertos-Arranz, Natalia Martinez-Gil, Xavier Sanchez-Saez, Agustina Noailles, Clara Monferrer Adsuara, Lidia Remoli Sargues, Juan J. Perez-Santonja, Pedro Lax, Ramon Calvo Andres, Nicolas Cuenca
Summary: This study aimed to determine whether COVID-19 affected retinal cells and establish correlations with clinical parameters. Immunostaining and confocal microscopy analysis revealed that Muller cells in COVID-19 patients showed stronger expression of ACE2 and CRALBP, and the retinas exhibited glial activation and neuronal alterations, mainly related to inflammation, hypoxic conditions, and age.
Article
Ophthalmology
Agustina Noailles, Oksana Kutsyr, Aloma Mayordomo-Febrer, Pedro Lax, Maria Lopez-Murcia, Silvia M. Sanz-Gonzalez, Maria Dolores Pinazo-Duran, Nicolas Cuenca
Summary: By studying a rat model of chronic glaucoma, it was found that intraocular injections of sodium hyaluronate result in increased intraocular pressure and changes in retinal morphology, similar to the characteristics of human open-angle glaucoma.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
