Article
Multidisciplinary Sciences
Nam Hyun Cho, Sunil Puria
Summary: This study used optical coherence tomography to measure the motion of outer hair cells in the cochlea and found that the gain of the third row near the pillar-cell heads was more than three times greater than that of the first row. This implies that the reticular lamina, composed of outer hair cells and supporting cells, is more flexible than the cells connected to its bottom surface, supporting a mosaic-like bending and stretching of the cochlear structure.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
Alessandro Altoe, James B. Dewey, Karolina K. Charaziak, John S. Oghalai, Christopher A. Shera
Summary: The mammalian ear contains a cellular amplifier that enhances sound-induced waves in the cochlea. The mechanism behind this amplifier is not fully understood. Recent studies suggest that the power transfer from the outer hair cells to the basilar membrane may be negative or highly inefficient, and the vibration of the top side of the organ of Corti plays a significant role in amplification, challenging previous assumptions.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Editorial Material
Acoustics
Sunil Puria, John J. Guinan
Summary: The Reflections series reviews historical articles from The Journal of the Acoustical Society of America that have made significant contributions to the field of acoustics.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Acoustics
Yasuki Murakami
Summary: A fast numerical time-domain solution of a nonlinear 3D cochlear model is proposed, utilizing Fast Fourier Transform (FFT) to replace the matrix product and reducing computational complexity from n(2) to n log n. This method successfully computes 3D models, exhibiting nonlinear responses for pure tones and clicks, and supports the development of cochlear mechanics 3D models.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Article
Biology
Sebastiaan W. F. Meenderink, Wei Dong
Summary: Recent observations using optical coherence tomography have revealed complex motions of the cochlea's sensory organ of Corti in response to sound, including significant longitudinal displacements. This finding emphasizes the importance of considering these longitudinal motions when interpreting inner-ear sound processing.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Raquel de Sousa Lobo Ferreira Querido, Xiang Ji, Rabina Lakha, Richard J. Goodyear, Guy P. Richardson, Christina L. Vizcarra, Elizabeth S. Olson
Summary: This study used a probe that binds to unfixed collagen fibrils to image the shapes and fibrous properties of the TM and BM in the cochlea. The CNA35 collagen probe stained the BM and TM, providing a unique view of collagenous structures. The study demonstrates the potential usefulness of the CNA35 probe in cochlear imaging.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2023)
Article
Neurosciences
Wenxiao Zhou, Talat Jabeen, Sultan Sabha, Jonathan Becker, Jong-Hoon Nam
Summary: This article focuses on the mechanical properties of outer hair cells and the surrounding structures in the mammalian cochlea, as well as their impact on mammalian hearing. The study finds that the stiffness of the tectorial membrane and the Deiters cell play a critical role in determining the relative motion among different structures in the organ of Corti. The Deiters cells act as a mechanical equalizer to ensure that the outer hair cells are neither too rigid nor too weak.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biophysics
Amir Nankali, Christopher A. Shera, Brian E. Applegate, John S. Oghalai
Summary: Sounds entering the mammalian ear produce traveling waves that are amplified by an electromechanical active process. This study measured the traveling waves along the apical turn of the mouse cochlea and found a gradual reduction in key features of the active process towards the apex. The study also showed that the spatial wavelength along the basilar membrane was level dependent and varied with sound intensity.
BIOPHYSICAL JOURNAL
(2022)
Article
Audiology & Speech-Language Pathology
Elika Fallah, C. Elliott Strimbu, Elizabeth S. Olson
Summary: Studying the in-vivo mechanical and electrophysiological cochlear responses in several species provides a comprehensive understanding of cochlear sensitivity and frequency selectivity. Different species may utilize different mechanisms for sharp frequency tuning, with outer hair cells playing a crucial role in this process. Observations in guinea pigs and gerbils showed similarities in best frequency band responses but differences in sub-best frequency responses, suggesting unique mechanisms for sub-best frequency filtering between the two species. Technical measurement differences could also contribute to these discrepancies.
Review
Biochemistry & Molecular Biology
Gloria Lazzeri, Francesca Biagioni, Michela Ferrucci, Stefano Puglisi-Allegra, Paola Lenzi, Carla Letizia Busceti, Francesco Giannessi, Francesco Fornai
Summary: Tinnitus is the perception of noise in the absence of acoustic stimulation. Alterations in outer hair cells and the involvement of autophagy may play a role in the onset of tinnitus. Defective autophagy explains the neuropathology of tinnitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Tingfang Chen, Alex M. Rohacek, Matthew Caporizzo, Amir Nankali, Jeroen J. Smits, Jaap Oostrik, Cornelis P. Lanting, Erdi Kucuk, Christian Gilissen, Jiddeke M. van de Kamp, Ronald J. E. Pennings, Staci M. Rakowiecki, Klaus H. Kaestner, Kevin K. Ohlemiller, John S. Oghalai, Hannie Kremer, Benjamin L. Prosser, Douglas J. Epstein
Summary: In mammals, sound is detected by mechanosensory hair cells, with inner ear supporting cells playing a crucial role in transmitting sound energy through the cochlear partition. Mutations in the GAS2 gene can lead to hearing loss by disrupting the organization and stability of microtubule bundles in these supporting cells, affecting cochlear micromechanics. The bundling activity of GAS2 is essential for imparting mechanical properties to supporting cells for sound energy transmission in the cochlea.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Thomas Bowling, Haiqi Wen, Sebastiaan W. F. Meenderink, Wei Dong, Julien Meaud
Summary: The detection of low-level sounds in the mammalian cochlea relies on electromechanical feedback from outer hair cells. Nonlinearity in mechano-sensitive ion channels creates distortion-products known as DPOAEs, which can potentially be used as diagnostic tools for sensory hearing loss. Understanding the cochlear extent contributing to DPOAEs is crucial for clinical applications.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Suvrajit Saha, Amit Das, Chandrima Patra, Anupama Ambika Anilkumar, Parijat Sil, Satyajit Mayor, Andmadan Rao
Summary: The spatiotemporal organization of proteins and lipids on the cell surface plays a crucial role in cellular functions. This study investigates the molecular interactions that drive the formation of nanoclusters of GPI-APs and transmembrane proteins, and proposes a theoretical model to explain the organization of membrane domains in living cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Mathematics, Applied
J. Y. Liang, Wenjuan Yao
Summary: Explaining the mechanism of cochlear active phonosensitive amplification has been a major problem in medicine. Previous models only considered the traveling wave motion of the basilar membrane (BM) and ignored its biological activity. A new model based on the immersed boundary method, which considers changes of BM's stiffness in space and time, has been established to describe its biological activity.
APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION
(2023)
Article
Computer Science, Artificial Intelligence
Deepak Baby, Arthur van den Broucke, Sarah Verhulst
Summary: The researchers proposed a hybrid approach combining convolutional neural networks with computational neuroscience for real-time end-to-end modeling of human cochlear mechanics. This model accurately simulates human cochlear frequency selectivity and its dependence on sound intensity, essential for robust speech intelligibility at negative speech-to-background-noise ratios.
NATURE MACHINE INTELLIGENCE
(2021)
Article
Biophysics
Charlsie Lemons, Jonathan B. Sellon, Elisa Boatti, Daniel Filizzola, Dennis M. Freeman, Julien Meaud
BIOPHYSICAL JOURNAL
(2019)
Article
Engineering, Mechanical
Kaikai Che, Michael Rouleau, Julien Meaud
EXTREME MECHANICS LETTERS
(2019)
Article
Acoustics
Julien Meaud
JOURNAL OF SOUND AND VIBRATION
(2020)
Article
Physics, Multidisciplinary
Aritra Sasmal, Nathan Geib, Bogdan-Ioan Popa, Karl Grosh
NEW JOURNAL OF PHYSICS
(2020)
Article
Physics, Applied
Alison E. Hake, Chuming Zhao, Lichuan Ping, Karl Grosh
APPLIED PHYSICS LETTERS
(2020)
Article
Multidisciplinary Sciences
Amir Nankali, Yi Wang, Clark Elliott Strimbu, Elizabeth S. Olson, Karl Grosh
SCIENTIFIC REPORTS
(2020)
Article
Biochemical Research Methods
Maral Budak, Karl Grosh, Aritra Sasmal, Gabriel Corfas, Michal Zochowski, Victoria Booth
Summary: Hidden hearing loss (HHL) is an auditory disorder characterized by deficits in sound-evoked auditory nerve activity, despite normal hearing thresholds, caused by mechanisms such as loss of IHC synapses or disruption of auditory-nerve myelin. Computational models have shown that disruptions in myelinization desynchronize auditory neuron spiking, whereas synapse loss decreases firing probability, ultimately leading to reduced auditory nerve activity and perceptual deficits.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Alison E. Hake, Chuming Zhao, Wang-Kyung Sung, Karl Grosh
Summary: The study introduces a piezoelectric MEMS accelerometer designed for auditory prostheses, providing analytic models for sensitivity and noise to optimize sensor designs. An experimental device with high sensitivity and low input noise was tested, showing promising results for potential applications in auditory prostheses.
IEEE SENSORS JOURNAL
(2021)
Article
Neurosciences
Adam J. Iliff, Can Wang, Elizabeth A. Ronan, Alison E. Hake, Yuling Guo, Xia Li, Xinxing Zhang, Maohua Zheng, Jianfeng Liu, Karl Grosh, R. Keith Duncan, X. Z. Shawn Xu
Summary: The ability to sense airborne sound extends beyond vertebrates and arthropods to include invertebrates as well, suggesting convergent evolution of auditory capabilities in the animal kingdom. The discovery challenges the conventional view that invertebrates are insensitive to sound and highlights the unexpected role of nAChRs in mechanosensation. Animals without ears should not be automatically presumed to be sound insensitive.
Article
Multidisciplinary Sciences
Thomas Bowling, Haiqi Wen, Sebastiaan W. F. Meenderink, Wei Dong, Julien Meaud
Summary: The detection of low-level sounds in the mammalian cochlea relies on electromechanical feedback from outer hair cells. Nonlinearity in mechano-sensitive ion channels creates distortion-products known as DPOAEs, which can potentially be used as diagnostic tools for sensory hearing loss. Understanding the cochlear extent contributing to DPOAEs is crucial for clinical applications.
SCIENTIFIC REPORTS
(2021)
Article
Acoustics
Haiqi Wen, Julien Meaud
Summary: In this article, a three-dimensional computational model of the gerbil cochlea is used to simulate stimulus frequency otoacoustic emissions (SFOAEs) and elucidate their generation mechanisms and characteristics. The simulations reveal a quasiperiodic fine structure and a fast varying phase in SFOAEs. Increasing the sound pressure level broadens the peaks and reduces the phase-gradient delay. Analysis of the model predictions suggests that SFOAEs originate from the peak of the traveling wave.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Neurosciences
Maral Budak, Michael T. Roberts, Karl Grosh, Gabriel Corfas, Victoria Booth, Michal Zochowski
Summary: Hidden hearing loss (HHL) is a deficit in auditory perception and speech intelligibility despite normal audiometric thresholds, and it can be caused by noise exposure, aging, or myelin defects. This study used animal models and a network model to investigate the effects of peripheral auditory neuropathies on sound localization, and found that myelinopathy and synaptopathy in cochlear spiral ganglion neurons (SGNs) may contribute to the perceptual deficits observed in HHL patients.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Engineering, Mechanical
Michael Rouleau, Steven Craig, Yiwei Xia, Roy Shieh, Major L. Robinson, Chengzhi Shi, Julien Meaud
Summary: This research advances the understanding of the nonlinear dynamic behavior of bistable systems under impact by considering both computational models and experimental validation. By varying the excitation amplitude and frequency, rich dynamics including intrawell and interwell motion can be observed. The results are important for the design and control of bistable systems.
NONLINEAR DYNAMICS
(2022)
Article
Biophysics
George Samaras, Haiqi Wen, Julien Meaud
Summary: In the mammalian cochlea, both the basilar membrane (BM) and the organ of Corti (OoC) structures exhibit nonlinearity in their responses, even at frequencies below the best frequency (BF). A physiological model of the gerbil cochlea suggests that this difference in nonlinearity is due to greater compliance in the structures at the top of the outer hair cells (OHCs). The model's predictions align with experimental evidence and demonstrate that optimal OHC function at BF leads to nonlinearity in the response of the OoC structures over a broad frequency range.
BIOPHYSICAL JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Nathan Geib, Aritra Sasmal, Zhuzhu Wang, Yuxin Zhai, Bogdan-Ioan Popa, Karl Grosh
Summary: This paper introduces a new nonlocal active metamaterial architecture that utilizes a purely active approach to tailor the acoustic field. The analytical closed-form equations describing the acoustic properties allow for engineering extremely nonreciprocal wave transmission. The system's remarkable flexibility is demonstrated through electronic tuning of acoustic isolation characteristics, highlighting the expansive design space uncovered by this approach.
