Article
Biochemistry & Molecular Biology
Ping Zhang, Yanjie Wang, Jingyu Zhang, Tie Hong
Summary: This study investigates the anti-pseudoallergy effect of allantoin (AT) and its underlying mechanism. The results demonstrate that AT can inhibit degranulation and improve pathological changes induced by Compound 48/80. Additionally, AT helps restore body temperature decrease caused by Compound 48/80.
Article
Pharmacology & Pharmacy
Shuqi Meng, Xiaotong Sun, Zhaodong Juan, Mingling Wang, Ruoguo Wang, Lina Sun, Yaozu Li, Anran Xin, Shuping Li, Yao Li
Summary: This study demonstrates that clemastine fumarate attenuates myocardial ischemia reperfusion injury by inhibiting mast cell degranulation. Pretreatment with CLE significantly improves cardiac function and reduces cytotoxicity, reversing the damage caused by I/R.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Physiology
B. Malique Jones, Gerald C. Mingin, Nathan R. Tykocki
Summary: Mast cells and degranulation of inflammatory mediators contribute to lower urinary tract symptoms. This study found that the mast cell stimulator compound 48/80 alters urinary bladder smooth muscle contractility via urothelium-dependent inflammatory pathways, independent of mast cells. These findings suggest that compound 48/80 could be used to manage inflammatory nonneurogenic bladder hyperactivity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yaozu Li, Xiaotong Sun, Zhaodong Juan, Xuehao Guan, Mingling Wang, Yanmei Meng, Ruijin Ma
Summary: Propofol has a protective effect on myocardial ischemia-reperfusion (I/R) injury by inhibiting mast cell degranulation and calcium influx through store-operated Ca2+ channels (SOCs).
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Chenxi Lu, Changyu Wang, Haoxiang Xiao, Mengfan Chen, Zhi Yang, Zhenxing Liang, Haiying Wang, Yonglin Liu, Yang Yang, Qiang Wang
Summary: Ischemia-reperfusion injury (IRI) is a process characterized by innate immune response and changes in the structure and function of multiple organs. Ethyl pyruvate (EP), a derivative of pyruvate, has gained attention for its stability and low toxicity, with various pharmacological activities such as anti-inflammation, anti-oxidative stress, anti-apoptosis, and anti-fibrosis. EP has shown beneficial effects in acute injury models and has the potential for therapeutic intervention in multiple organ IRI.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Wei Xiong, Rui Zhou, Yan Qu, Yuqiao Yang, Zhuoran Wang, Ning Song, Rongbi Liang, Jinqiao Qian
Summary: The study demonstrated that dexmedetomidine preconditioning can alleviate degranulation of mast cells and apoptosis of cardiomyocytes caused by I/R injury, and inhibit the activation of inflammatory related factors HMGB1, TLR4, and NF-KB p65.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Jun Li, Gang Peng, Kuikui Zhu, Xiaohua Jie, Yingzhuo Xu, Xinrui Rao, Yunhong Xu, Yunshang Chen, Biyuan Xing, Gang Wu, Liangliang Shi
Summary: This study found that mast cells are poor prognostic factors associated with resistance to anti-PD-1 immunotherapy. The PD-1 antibody can activate PD-1(+) mast cells to release histamine and cytokines, thereby playing a negative role in the tumor microenvironment. Inhibition of mast cells may provide a new solution to improve the response rate of anti-PD-1 immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Thayse R. Brueggemann, Hadas Pahima, David Mankuta, Bruce D. Levy, Francesca Levi-Schaffer
Summary: The study found that Cromolyn Sodium has immunomodulatory actions in allergic inflammation that go beyond just stabilizing mast cells, indicating broader mechanisms at play.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Multidisciplinary Sciences
Zhu Li, Matthew J. W. Hampton, Matthew B. Barajas, Matthias L. Riess
Summary: Ischemic heart disease is a major cause of death worldwide, with reperfusion causing additional injury. Endothelial cells can protect cardiomyocytes from reperfusion injury through cell-cell interactions. Optimal spatial distance between endothelial cells and cardiomyocytes is necessary for effective communication and protection against ischemia/reperfusion injury.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Oncology
Bin Wang, Ping Yu, Wei Lin, Zhaohui Zhai
Summary: The study revealed the significant role of miR-21-5p in H/R-induced cell damage, showing its regulation of the EGFR/PI3K/AKT signaling pathway by targeting CPEB3 to reduce apoptosis and damage.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Chenglong Wang, Li Peng, Yuan Wang, Ying Xue, Tianyi Chen, Yanyan Ji, Yishan Li, Yong Zhao, Shanshan Yu
Summary: P2ry12 is a microglial marker gene whose expression levels can vary in response to different CNS disorders. This study aimed to investigate the expression and function of P2ry12 in microglia during ischemia-reperfusion injury (IRI). Computational analysis was performed to obtain microglia-specific P2ry12 genes (MSPGs) and evaluate their expression levels during IRI. Bioinformatics analysis and animal experiments were conducted to explore the function of P2ry12 in microglia. The results showed that P2ry12 expression decreased gradually after the injury and inhibition of P2ry12 blocked microglial migration towards vessels during IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Weixiong Wu, Xingfeng Chen, Qingyang Hu, Xuefei Wang, Jingyu Zhu, Qianzhen Li
Summary: The study found that knockdown of miR-199a-3p accelerated myocardial cell injury, leading to increased expression of mTOR and suppressed autophagy, ultimately worsening cell damage.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Weixiong Wu, Xingfeng Chen, Qingyang Hu, Xuefei Wang, Jingyu Zhu, Qianzhen Li
Summary: This study suggests that silencing miR-199a-3p accelerates myocardial cell injury and inhibits autophagy, potentially worsening the condition. In addition, overexpression of mTOR aggravates cell injury through the inhibition of autophagy.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)