Article
Medicine, General & Internal
S. Dhanani, L. Hornby, A. van Beinum, N. B. Scales, M. Hogue, A. Baker, S. Beed, J. G. Boyd, J. A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C. J. Doig, F. Duska, J. O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. Isac, A. H. Kramer, D. J. Kutsogiannis, D. M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W. N. K. A. van Mook, P. Waldauf, M. Weiss, J. T. Wind, S. D. Shemie
Summary: This study investigated the timing of resumption of cardiac activity in patients after planned withdrawal of life-sustaining measures. It found that 14% of patients experienced transient resumption of cardiac activity after pulselessness, with only 1% of resumptions being identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Arnold, Adrian Segiser, Selianne Graf, Natalia Mendez-Carmona, Maria N. Sanz, Rahel K. Wyss, Nina Kalbermatter, Nino Keller, Thierry Carrel, Sarah Longnus
Summary: DCD-related pre-ischemic lactate levels negatively impact post-ischemic functional and mitochondrial recovery in hearts, while inhibition of mitochondrial calcium uptake during reperfusion could improve recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl
Summary: Mitochondria play a crucial role in myocardial ischemia/reperfusion injury and pharmacological cardiac conditioning, including maintaining cellular function, regulating calcium balance and cell death, participating in aging and mitochondrial regeneration, etc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Junyi Yu, Che Xu, Janet S. Lee, Jonathan K. Alder, Zongmei Wen, Guifang Wang, Agustin Alejandro Gil Silva, Pablo G. Sanchez, Joseph M. Pilewski, John F. McDyer, Xingan Wang
Summary: Maintaining alveolar ventilation can extend the tolerable warm ischemia time of murine lungs at 37 degrees Celsius up to 4 hours. Nonhypoxic lungs undergoing warm ischemia-reperfusion injury exhibit early transcriptional signatures of myeloid cell recruitment and extracellular matrix proteolysis before the dysfunction of blood-gas barrier and significant tissue damage occur.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Surgery
Wenfu Zhang, Yingting Wu, Mingwang Zeng, Chao Yang, Zhengang Qiu, Rongrong Liu, Lifeng Wang, Maolin Zhong, Qiaoling Chen, Weidong Liang
Summary: In this systematic review and meta-analysis, the effect of remote ischemic conditioning (RIC) in reducing renal ischemia-reperfusion injury in patients undergoing kidney transplantation or partial nephrectomy was investigated. The results showed that the protective effect of RIC on renal ischemic-reperfusion was weak, and more studies are needed to confirm its nephroprotective effect.
FRONTIERS IN SURGERY
(2023)
Review
Neurosciences
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Stroke is a major global health concern, and remote ischemic conditioning (RIC) has emerged as a convenient, simple, non-intrusive, and effective method for treating stroke. RIC improves brain tolerance to ischemia, increases cerebral blood perfusion, and reduces the risk of brain tissue damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Henry Aceros, Shant Der Sarkissian, Melanie Borie, Roberto Vanin Pinto Ribeiro, Simon Maltais, Louis-Mathieu Stevens, Nicolas Noiseux
Summary: This study investigates the use of a HSP90 inhibitor as a cardioprotective agent in DCD hearts, showing promising results in preserving ventricular function and reducing ischemic injury. These findings suggest that HSP90i could potentially expand the use of DCD hearts and improve organ availability for transplantation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Tim C. van Smaalen, Danielle M. H. Beurskens, Jasper J. H. F. M. Kox, Rasheendra Polonia, Rein Vos, Hans Duimel, Willine J. van de Wetering, Carmen Lopez-Iglesias, Chris P. Reutelingsperger, L. W. Ernest van Heurn, Carine J. Peutz-Kootstra, Gerry A. F. Nicolaes
Summary: Extracellular histones are released in warm ischemia and the resulting damage can be prevented by blocking histone release. The release of extracellular histones in patients receiving a renal transplant is associated with worse graft outcome. The findings suggest that targeting histones may be beneficial in preventing renal injury during transplantation.
Article
Multidisciplinary Sciences
Kyeong Deok Kim, Kyo Won Lee, Sang Jin Kim, Okjoo Lee, Manuel Lim, Eun Sung Jeong, Jieun Kwon, Jaehun Yang, Jongwook Oh, Jae Berm Park
Summary: This study evaluated the impact of kidney transplantation from donors with acute kidney injury (AKI) on long-term graft survival and found that AKI in donor did not affect long-term death-censored graft survival. Among recipients receiving kidneys with AKI, using low-dose r-ATG as an induction immunosuppression may offer better graft survival compared to basiliximab.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
M. V. Basalay, James M. Downey, S. M. Davidson, D. M. Yellon
Summary: This study aimed to investigate the impact of aspirin on remote ischemic conditioning (RIC) in the treatment of myocardial infarction. The results showed that aspirin did not affect the infarct-limiting effect of RIC.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Qian Chen, Xiangfeng Liu, Zhiheng Liu, Shujing Zhang, Lin Chen, Shiori Eguchi, Azeem Alam, Zhen Cahilog, Qizhe Sun, Lingzhi Wu, Enqiang Chang, Zhiping Wang, Jianteng Gu, Hailin Zhao, Daqing Ma
Summary: This study found that adding dexmedetomidine to the graft preservation solution in lung transplantation can inhibit cell death, reduce injury, and improve the morphology of the lung graft. This may help expand the donor lung pool and improve lung transplant outcomes.
Article
Cardiac & Cardiovascular Systems
Thomas Ravn Lassen, Jesper Just, Marie Vognstoft Hjortbak, Nichlas Riise Jespersen, Katrine Tang Stenz, Tingting Gu, Yan Yan, Junyi Su, Jakob Hansen, Rikke Baek, Malene Moller Jorgensen, Jens Randel Nyengaard, Steen Buus Kristiansen, Kim Ryun Drasbek, Jorgen Kjems, Hans Erik Botker
Summary: The study demonstrates that cardioprotection by RIC may be mediated by circulating EVs that accumulate in the injured myocardium. The EV miRNAs may promote cell survival during reperfusion, suggesting a potential mechanism for the protective effect.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liwei Xu, Zifeng Zeng, Chuanjie Niu, Deshen Liu, Shaoyan Lin, Xiu Liu, Gabor Szabo, Jun Lu, Shaoyi Zheng, Pengyu Zhou
Summary: Studies have shown that the inhibition of NLRP3 inflammasome with the novel inhibitor mcc950 can protect DCD hearts from ischemia/reperfusion injury. The application of mcc950 in a rat heart transplantation model effectively reduces oxidative stress, inflammation, and apoptosis through inhibiting NLRP3 inflammasome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ramio Cabello, Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Ana M. Lopez-Diaz, Susana Carrasco, Ignacio Mahillo, Carmen Gonzalez-Enguita, Maria D. Sanchez-Nino, Alberto Ortiz, Ana B. Sanz
Summary: CypA is a potential biomarker of kidney injury, released by kidney tubular cells during different forms of cell death, and increased during IRI-induced clinical kidney injury independently from kidney function parameters.
Article
Biochemical Research Methods
Darragh P. O'Brien, Adam M. Thorne, Honglei Huang, Elisa Pappalardo, Xuan Yao, Peter Sondergaard Thyrrestrup, Kristian Ravlo, Niels Secher, Rikke Norregaard, Rutger J. Ploeg, Bente Jespersen, Benedikt M. Kessler
Summary: In a porcine kidney transplant model, subtle molecular changes were observed in kidneys following Remote Ischemic Conditioning (RIC), including suppression of tissue inflammatory profiles and accumulation of muscle extracellular matrix assembly proteins. However, most of these protein changes did not reach statistical significance.
CLINICAL PROTEOMICS
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)