Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Mathematics, Applied
Y. Yang, F. Z. Nian, J. S. Liu
Summary: In this paper, the evolutionary characteristics and laws of group networks under information dissemination are studied from the perspective of network groups and based on the feedback mechanism. A feedback-based model of information dissemination in group networks is developed, taking into account the differences between same-group and cross-group dissemination of information. The experimental results show that the main factor affecting the final evolutionary results of each group size in the small-world network is group positivity, and the main factor affecting the average degree of each group in the scale-free network is also group positivity.
Article
Food Science & Technology
Shiyi Tian, Jue Wang, Ren Gao, Jing Wang, Weiyun Zhu
Summary: GOS has a direct protective effect on intestinal epithelial cells during inflammatory response, relieving barrier damage, inflammation, and oxidative stress induced by lipopolysaccharides (LPS), and promoting the expression of tight junction proteins.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Marlene Fabiola Escobedo-Monge, Enrique Barrado, Joaquin Parodi-Roman, Maria Antonieta Escobedo-Monge, Maria Carmen Torres-Hinojal, Jose Manuel Marugan-Miguelsanz
Summary: This study evaluated the magnesium status and nutritional indicators in 78 children and adolescents with chronic diseases. The results showed that 79% of individuals had abnormal magnesium status and were at risk of developing other chronic illnesses.
Review
Nutrition & Dietetics
Diana Fiorentini, Concettina Cappadone, Giovanna Farruggia, Cecilia Prata
Summary: Magnesium is essential for many physiological functions and its deficiency can increase the risk of illness, particularly chronic degenerative diseases. Assessing magnesium status is crucial but difficult, as serum magnesium concentration, the most commonly used method, may not correlate reliably with total body magnesium levels. This review provides insights into the importance of magnesium and strategies to address deficiency.
Review
Neurosciences
Fathimath Zaha Ikram, Alina Arulsamy, Thaarvena Retinasamy, Mohd Farooq Shaikh
Summary: HMGB1 plays a crucial role in neurodegenerative diseases, with levels elevated in most cases. It may act on distinctive pathways to elicit its pathological response leading to various neurodegenerative processes.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Review
Neurosciences
Ruihua Fan, Lvxia Wang, Benson O. A. Botchway, Yong Zhang, Xuehong Liu
Summary: Spinal cord injury is a common disease of the central nervous system that causes paralysis. Chronic inflammation and axonal regeneration difficulties hinder recovery. Ethyl pyruvate has anti-inflammatory and neuroprotective effects and may be a potential therapeutic agent for spinal cord injury.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Ji-Cheng Huang, Zhan-Peng Yue, Hai-Fan Yu, Zhan-Qing Yang, Yu-Si Wang, Bin Guo
Summary: TAZ plays an important role in anti-inflammation by preventing microglia from producing proinflammatory cytokines. It interacts with Nrf2 to enhance antioxidant capacity and inhibit mitochondrial dysfunction, leading to a reduction in oxidative stress and the inflammatory response. Nrf2 acts as a downstream target of TAZ to repress NF-kappa B activation and improve the microglia-mediated inflammatory response.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Microbiology
Matteo Bulati, Rosalia Busa, Claudia Carcione, Gioacchin Iannolo, Giuseppina Di Mento, Nicola Cuscino, Roberto Di Gesu, Antonio Palumbo Piccionello, Silvestre Buscemi, Anna Paola Carreca, Floriana Barbera, Francesco Monaco, Francesca Cardinale, Pier Giulio Conaldi, Bruno Douradinha
Summary: Multidrug resistant Klebsiella pneumoniae with LPS O2afg serotypes are able to evade the initial inflammatory immune response and systematically spread inside the host, resulting in various pathologies associated with this bacterium.
Article
Biochemistry & Molecular Biology
Weijian Chen, Zhihuai Deng, Jianxiong Zhu, Liang Yuan, Shuangxing Li, Yangyang Zhang, Jiajun Wu, Zhengqi Huang, Tianyu Qin, Wei Ye
Summary: The current study aims to investigate the regulatory effect of rosuvastatin on intervertebral disc degeneration (IDD) and the potential mechanism. In vitro experiments demonstrate that rosuvastatin promotes matrix anabolism, suppresses catabolism, and inhibits cell pyroptosis and senescence induced by TNF-alpha. The study also reveals that the gene HMGB1, regulated by rosuvastatin, plays a crucial role in IDD progression by modulating the NF-kappa B pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Immunology
Talha Umar, Xiaofei Ma, Baoyi Yin, Saqib Umer, Arshad Zahoor, Muhammad Akhtar, Zaima Umar, Aftab Shaukat, Ganzhen Deng
Summary: Research has shown that miR-424-5p inhibits the inflammatory response in endometritis by suppressing IRAK2 expression, indicating its potential as a unique medical treatment for endometritis and other inflammation-related diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Bin Zheng, Yakun Yang, Jinghan Li, Jing Li, Saijie Zuo, Xi Chu, Shan Xu, Donglai Ma, Li Chu
Summary: The study demonstrated that MgIG could significantly reduce ATO-induced cardiac toxicity through its anti-inflammation, anti-oxidation, and anti-apoptosis effects. Additionally, MgIG exerted its protective effects by modulating the Nrf2 pathway and suppressing the TLR4/NF-kappa B pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Surgery
Zhaohui Liu, Zhengping Wang, Guangwei Han, Lina Huang, Jihong Jiang, Shitong Li
JOURNAL OF SURGICAL RESEARCH
(2016)
Article
Nutrition & Dietetics
Yuanfeng Gong, Zhaohui Liu, Yadi Liao, Cong Mai, Tiejun Chen, Hui Tang, Yunqiang Tang
Article
Cell Biology
Zhaohui Liu, Junjie Zhang, Shitong Li, Jihong Jiang
Article
Cell Biology
Zhaohui Liu, Min Qu, Lili Yu, Panpan Song, Yulin Chang
Article
Surgery
Zhaohui Liu, Junjie Zhang, Xiaojing Huang, Lina Huang, Shitong Li, Zhengping Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Surgery
Yulin Chang, Xiaojing Huang, Zhaohui Liu, Guangwei Han, Lina Huang, Yuan-Chang Xiong, Zhengping Wang
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Zhaohui Liu, Qiang Yang, Qianjie Wei, Yulin Chang, Min Qu, Lili Yu
MOLECULAR IMMUNOLOGY
(2019)
Article
Genetics & Heredity
Qianjie Wei, Jinjuan Zhao, Xingguo Zhou, Lili Yu, Zhaohui Liu, Yulin Chang
Article
Engineering, Biomedical
Zhaohui Liu, Xiangge Liu, Qiang Yang, Lili Yu, Yulin Chang, Min Qu
ACTA BIOMATERIALIA
(2020)
Article
Biotechnology & Applied Microbiology
Peng Jiao, Weiming Li, Lin Shen, Yan Li, Lili Yu, Zhaohui Liu
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2020)
Article
Genetics & Heredity
Zhaohui Liu, Ji Zhang, Fang Zhang, Yulin Chang
Article
Cell Biology
Zhaohui Liu, Yan Li, Lili Yu, Yulin Chang, Jingui Yu
Article
Medicine, Research & Experimental
Qiang Yang, Zhaohui Liu, Yulin Chang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2016)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)