Article
Chemistry, Analytical
Fuentes-Velez Susana, Fagoonee Sharmila, Sanginario Alessandro, Gallo Valentina, Riganti Chiara, Pizzi Marco, Altruda Fiorella, Demarchi Danilo
Summary: Interest in impedance-based cellular assays is growing due to their multiple advantages, and our study demonstrates the potential of ECIS in cancer treatment decisions and early detection of chemoresistance. The analysis of impedance-based curves distinguishes between chemo-sensitive and chemo-resistant cells, and promises the study of time-dependent factors related to resistance acquisition in cells. The continuous monitoring and highthroughput early detection of drug resistance using the ECIS device presents new possibilities for cancer treatment and drug screening.
Article
Chemistry, Medicinal
Juhee Park, Ga-Eun Lee, Hyung-Jung An, Cheol-Jung Lee, Eun Suh Cho, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Jin-Sung Choi, Dae Joon Kim, Jong-Soon Choi, Yong-Yeon Cho
Summary: Kaempferol targeting RSKs may be a strategy to reduce oxaliplatin-resistant colon cancer cells. The study provides evidence that molecular mechanisms for drug resistance in human cancer are crucial in overcoming this challenge.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Oncology
Jimin Park, Seung Ki Kim, Steffanus Pranoto Hallis, Bo-Hyun Choi, Mi-Kyoung Kwak
Summary: This study investigated the potential relationship between the CSC marker CD133 and the master transcription factor NRF2 in colon cancer. The results indicate that the CD133/NRF2 axis plays a critical role in the development of CSC-like properties in colon cancer cells, with activation of the PI3K/AKT signaling pathway involved in CD133-mediated NRF2 activation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Angela Patricia Moreno-Londono, Maria Cristina Castaneda-Patlan, Miguel Angel Sarabia-Sanchez, Marina Macias-Silva, Martha Robles-Flores
Summary: The presence of cancer stem cells (CSCs) is associated with drug resistance and disease recurrence. This study aimed to investigate the role of the canonical Wnt/beta-catenin pathway in CSCs resistance to 5FU treatment. Using tumor spheroids as a model, the researchers found that activating the canonical Wnt pathway decreased 5FU-induced cell death, while inhibiting the pathway compromised the clonogenic capacity and stem cell markers expression. The combined treatment induced the survival of a small cell subpopulation that could recover and re-grow after treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ruijun Pan, Dingye Yu, Jiajia Hu, Xiao Yang, Chenxing Wang, Luyang Zhang, Pei Xue, Jing Sun, Xiaoping Zhang, Wei Cai
Summary: SFMBT1 is up-regulated in colorectal cancer and is associated with resistance to 5-fluorouracil and the proliferation, migration, and invasion of CRC cells. SFMBT1 is positively correlated with HMG20A and acts through down-regulation of HMG20A downstream. These findings suggest that the SFMBT1/HMG20A axis could be targeted to increase the resistance of CRC cells to 5-FU.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Minkyeong Lee, Changwon Yang, Sunwoo Park, Gwonhwa Song, Whasun Lim
Summary: Fraxetin is a natural compound with anticancer properties, capable of inhibiting colon cancer cell growth and inducing apoptosis through various mechanisms. Additionally, it shows synergistic effects with 5-fluorouracil or irinotecan in targeting colon cancer cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Anatomy & Morphology
K. Yasodha, L. Lizha Mary, Pathak Surajit, R. Satish
Summary: The exchange of biological material between cells is essential for homeostasis, but can also play a role in cancer progression. This study aims to understand the effect of cancer cell-derived exosomes on primary colon cancer cells and their expression of cancer stem cell markers. The findings suggest that treatment with metastatic exosomes increases the proliferation, migration, and invasion of primary colon cancer cells, potentially contributing to metastasis.
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anpei Huang, Ruizhi Wang, Ji Cui, Ying Gao, Zheng Yin, Lianzhou Chen, Meifang He, Wen Li
Summary: This study found that GOLPH3 is overexpressed in colorectal cancer tissues and cells, and it promotes the metastasis and progression of colorectal cancer by facilitating STAT3 activation and regulating the expression of EMT transcription factor ZEB1 and integrin alpha 3.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, Research & Experimental
Iram Fatima, Jaya Prakash Uppada, Yashpal S. Chhonker, Saiprasad Gowrikumar, Susmita Barman, Sourav Roy, Kirsten T. Tolentino, Nicholas Palermo, Amar Natarajan, Daniel R. Beauchamp, Alex Vecchio, Daryl J. Murry, Amar B. Singh, Corey R. Hopkins, Punita Dhawan
Summary: Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and there is an urgent need for developing novel and targeted therapies to inhibit CRC progression and metastasis. Through rigorous analysis and testing, we identified a specific inhibitor called PDS-0330, which can inhibit claudin-1-dependent CRC progression and has favorable pharmacokinetic properties. In conclusion, our study suggests that PDS-0330 interferes with the association of claudin-1 and Src to inhibit CRC progression and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Junxing Qu, Zhiheng Sun, Chen Peng, Daoqian Li, Wenyue Yan, Zhen Xu, Yayi Hou, Sunan Shen, Ping Chen, Tingting Wang
Summary: Candida tropicalis has been found to promote chemotherapy resistance in colon cancer by producing lactate and inhibiting the expression of MLH1, providing a new insight into improving the efficacy of colorectal cancer chemotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Linglong Peng, Yongfu Xiong, Rong Wang, Ling Xiang, He Zhou, Zhongxue Fu
Summary: PRDX2 is highly expressed in colon cancer stem cells (CCSCs) and its overexpression is closely correlated with stemness maintenance, tumor initiation, and invasion of CCSCs. Inhibition of PRDX2 leads to increased ROS production in CCSCs, sensitizing them to oxidative stress and chemotherapy. These findings suggest that PRDX2 could be a potential therapeutic target in CCSCs.
Article
Medicine, Research & Experimental
Aiora Cenigaonandia-Campillo, Roberto Serna-Blasco, Laura Gomez-Ocabo, Sonia Solanes-Casado, Natalia Banos-Herraiz, Laura Del Puerto-Nevado, Jose Antonio Canas, Maria Jesus Acenero, Jesus Garcia-Foncillas, Oscar Aguilera
Summary: The study revealed a significant role of vitamin C in regulating pyruvate dehydrogenase (PDH) activity, thus modulating the TCA cycle and mitochondrial metabolism in KRAS mutant colon cancer. Vitamin C downregulated PDK-1 expression in KRAS mutant CRC cells and murine xenografts by reducing proline hydroxylation of HIF-1α, leading to decreased GLUT-1 expression.
Article
Biochemistry & Molecular Biology
Chen Xie, Pen-Jen Lin, Jijun Hao
Summary: PDE4D is highly expressed in chemo-resistant prostate cancer cells, and inhibiting PDE4D with Eggmanone effectively reduces invasion, proliferation, and induces cell death in these cells. Eggmanone also enhances docetaxel cytotoxicity and down-regulates CSC marker gene expression, attenuating sphere formation in chemo-resistant prostate cancer cells.
Review
Surgery
Manabu Kaneko, Shigenobu Emoto, Koji Murono, Hirofumi Sonoda, Masaya Hiyoshi, Kazuhito Sasaki, Yasutaka Shuno, Takeshi Nishikawa, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa
Article
Oncology
Keiichi Arakawa, Keisuke Hata, Hiroaki Nozawa, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa, Kazuhito Sasaki, Yasutaka Shuno, Manabu Kaneko, Masaya Hiyoshi, Shigenobu Emoto, Koji Murono, Hirofumi Sonoda, Satoshi Okada, Soichiro Ishihara
ANTICANCER RESEARCH
(2019)
Review
Surgery
Shigenobu Emoto, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Yasutaka Shuno, Takeshi Nishikawa, Kazuhito Sasaki, Manabu Kaneko, Masaya Hiyoshi, Koji Murono, Soichiro Ishihara
ASIAN JOURNAL OF SURGERY
(2019)
Article
Gastroenterology & Hepatology
Hiroaki Miyake, Koji Murono, Hiroshi Nagata, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Yasutaka Shuno, Kazuhito Sasaki, Soichiro Ishihara
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Gastroenterology & Hepatology
Hiroshi Nagata, Soichiro Ishihara, Koji Oba, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa
DISEASES OF THE COLON & RECTUM
(2019)
Article
Gastroenterology & Hepatology
Takeshi Nishikawa, Kazushige Kawai, Shigenobu Emoto, Koji Murono, Masaya Hiyoshi, Manabu Kaneko, Hirofumi Sonoda, Kazuhito Sasaki, Yasutaka Shuno, Toshiaki Tanaka, Keisuke Hata, Hiroaki Nozawa
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2019)
Article
Obstetrics & Gynecology
Masashi Takamura, Kaori Koga, Shigenobu Emoto, Kazushige Kawai, Yutaka Osuga, Soichiro Ishihara
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2019)
Article
Gastroenterology & Hepatology
K. Ochiai, M. Kaneko, H. Nozawa, K. Kawai, K. Hata, T. Tanaka, T. Nishikawa, Y. Shuno, K. Sasaki, M. Hiyoshi, S. Emoto, K. Murono, H. Sonoda, S. Ishihara
COLORECTAL DISEASE
(2020)
Article
Surgery
Daisuke Hojo, Koji Murono, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Koji Oba, Soichiro Ishihara
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Editorial Material
Gastroenterology & Hepatology
D. Hojo, T. Nishikawa, T. Takayama, M. Hiyoshi, S. Emoto, H. Nozawa, K. Kawai, K. Hata, T. Tanaka, Y. Shuno, M. Kaneko, K. Sasaki, K. Murono, H. Ishii, H. Sonoda, K. Hoshina, S. Ishihara
TECHNIQUES IN COLOPROCTOLOGY
(2019)
Editorial Material
Gastroenterology & Hepatology
T. Nishikawa, K. Kawai, H. Ishii, S. Emoto, K. Murono, M. Kaneko, K. Sasaki, Y. Shuno, T. Tanaka, K. Hata, H. Nozawa, S. Ishihara
TECHNIQUES IN COLOPROCTOLOGY
(2019)
Editorial Material
Surgery
Kosuke Ozaki, Kazuhito Sasaki, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Masako Ikemura, Soichiro Ishihara
ANZ JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
K. Murono, H. Miyake, D. Hojo, H. Nozawa, K. Kawai, K. Hata, T. Tanaka, T. Nishikawa, Y. Shuno, K. Sasaki, M. Kaneko, S. Emoto, H. Ishii, H. Sonoda, S. Ishihara
COLORECTAL DISEASE
(2020)
Article
Gastroenterology & Hepatology
Hiroaki Nozawa, Hirofumi Sonoda, Hiroaki Ishii, Shigenobu Emoto, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Takeshi Nishikawa, Yasutaka Shuno, Toshiaki Tanaka, Kazushige Kawai, Keisuke Hata, Soichiro Ishihara
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Article
Gastroenterology & Hepatology
Hiroshi Shiratori, Hiroaki Nozawa, Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Manabu Kaneko, Shigenobu Emoto, Hirofumi Sonoda, Soichiro Ishihara
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2020)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)