Review
Cell Biology
Bram DeWulf, Laurens Minsart, Franck Verdonk, Veronique Kruys, Michael Piagnerelli, Mervyn Maze, Sarah Saxena
Summary: Targeting HMGB1 can be a strategy to reduce sepsis-induced encephalopathy and complement non-pharmacological interventions.
Review
Critical Care Medicine
Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao, Baihai Su
Summary: Both HMGB1 and histones play major roles in mediating inflammation, immune thrombosis, and organ dysfunction in critical illnesses. Targeting them with specific antibodies or inhibitors has shown promise in animal models, but their routine clinical use is not recommended. On the other hand, extracorporeal blood purification may remove these DAMPs and exert an immunomodulatory effect in critically ill patients. This review summarizes the immunopathological roles of HMGB1 and histones, discusses the rationale for using hemofilters to remove these DAMPs, and gathers the latest evidence for the use of extracorporeal blood purification to improve clinical outcomes in critically ill patients.
Article
Pharmacology & Pharmacy
Chao Ren, Ren-qi Yao, Li-xue Wang, Jun-cong Li, Kun-wei Chen, Yao Wu, Ning Dong, Yong-wen Feng, Yong-ming Yao
Summary: This study found that HMGB1 plays a critical role in dysregulating immune response in sepsis, with the relationship between cerebral HMGB1 and splenic DC dysfunction being dependent on cholinergic system activity. The findings shed light on the mechanisms of immune dysfunction in sepsis and the potential therapeutic targets involving HMGB1 and cholinergic pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
William A. Banks, Kim M. Hansen, Michelle A. Erickson, Fulton T. Crews
Summary: High-mobility group box 1 (HMGB1) is a protein that regulates transcription in the cell nucleus and activates the innate immune system. It can cross the blood-brain barrier (BBB) and affect neuroimmune signaling in the brain and periphery. In this study, the ability of radioactively labeled HMGB1 to cross the BBB was examined. The results showed that HMGB1 could bidirectionally cross the BBB and its transport rates were enhanced by inflammation. This finding suggests that HMGB1 levels have an impact on neuroimmune signaling in various conditions.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Xiangqin He, Kunzhe Dong, Jian Shen, Guoqing Hu, Jinhua Liu, Xiuhua Kang, Liang Wang, Reem T. Atawia, Islam Osman, Robert W. Caldwell, Meixiang Xiang, Wei Zhang, Zeqi Zheng, Liwu Li, David J. R. Fulton, Keyu Deng, Hongbo Xin, Jiliang Zhou
Summary: The study demonstrates the critical role of HMGXB4 in exacerbating endotoxemia by regulating the expression of inflammatory genes and inducing excessive NO production. Targeting HMGXB4 may serve as an effective therapeutic strategy for the treatment of sepsis as it can reduce pulmonary injury and mortality induced by LPS. Additionally, HMGXB4 also promotes inflammation by regulating the expression of ICAM1 in endothelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Ruediger Gerstberger, Marita Meurer, Maren von Koeckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Summary: This study revealed the mechanisms of HMGB1 action in the brain during rat sepsis, finding that HMGB1 enhances brain inflammatory responses and is associated with sustained sepsis symptoms.
Article
Cardiac & Cardiovascular Systems
Emilie Boissady, Yara Abi Zeid Daou, Estelle Faucher, Matthias Kohlhauer, Fanny Lidouren, Cynthia El Hedjaj, Sophie Chateau-Joubert, Hakim Hocini, Sophie Hue, Bijan Ghaleh, Renaud Tissier
Summary: The inhibition of the HMGB1-signaling pathway by glycyrrhizin improves neurological recovery and systemic immune response in rabbits after cardiac arrest. Glycyrrhizin reduces the levels of HMGB1, interleukin-6, and interleukin-10 in the blood. It also improves clinical recovery and histopathological damages associated with reduced cerebral CD4(+) and CD8(+) T-cell infiltration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Jie Zhao, Fang Xu, Wanying Xu, Rong Lv, Juan Wang, Xufeng Yang
Summary: This study found an association between elevated HMGB1 levels and the severity of white matter lesions (WMLs) in stroke patients, particularly in the periventricular region.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medical Laboratory Technology
Dong Zang, Wen Li, Fan Cheng, Xiaobin Zhang, Ting Rao, Weimin Yu, Jie Wei, Yangyiyan Song, Wanli Jiang
Summary: This study investigated the diagnostic value of HMGB1 levels in patients with acute kidney injury (AKI) caused by sepsis and its relationship with disease prognosis. The results showed that HMGB1 in serum and urine could be used as diagnostic markers for sepsis complicated with AKI, and serum HMGB1 could also be used to assess disease prognosis with good clinical promotion.
CLINICA CHIMICA ACTA
(2022)
Review
Cell Biology
Lanyi Wei, Wenrui Zhang, Yueyang Li, Jinghui Zhai
Summary: This review introduces how the signaling axis between SIRT1 and HMGB1 regulates inflammation-related responses and tumor occurrence. It explores upstream regulators and potential treatment methods for inflammatory responses. Additionally, it suggests that SIRT1 and HMGB1 may be potential targets for treating inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Critical Care Medicine
Tiantian Wu, Chao Ren, Xiaowei Dou, Yao Wu, Ning Dong, Hui Zhang, Yongming Yao
Summary: Immunosuppression plays a crucial role in sepsis development and is closely associated with poor outcomes. This study investigated the novel role of the anti-inflammatory cytokine IL-35 in sepsis. Results showed that IL-35 inhibited CD4(+) T cell proliferation and the Th1/Th2 ratio, and exerted immunosuppressive effects by suppressing HMGB1-dependent autophagy.
Article
Biochemistry & Molecular Biology
Jinwoo Hur, Hyuk Gyoon Lee, Eunsu Kim, Jun Pil Won, Youngjae Cho, Mi-Jung Choi, Hwan Lee, Han Geuk Seo
Summary: The study demonstrates that ginseng leaf extract can inhibit the release of HMGB1 in endotoxemia by regulating cellular signal networks, improving the survival rate of mice. This suggests that ginseng leaf extract could be used as a functional food to modulate immune responses in the pathology of endotoxemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Microbiology
Haoran Zhong, Xiang Gui, Ling Hou, Rongxue Lv, Yamei Jin
Summary: Schistosomiasis is a chronic parasitic disease that seriously damages the liver, and the current drugs cannot reverse the liver damage. Research has found that HMGB1 is a cytokine associated with schistosomiasis, and its inhibition can protect against liver fibrotic diseases. Therefore, HMGB1 may be a potential target for the treatment of schistosomiasis sequelae.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)