Article
Medicine, Research & Experimental
Haidong Guo, Runfang Yang, Jin He, Ke Chen, Wen Yang, Junjun Liu, Kai Xiao, Hongxia Li
Summary: Edaravone combined with dexamethasone showed significant protective effects on smoke-induced inhalational lung injury in rats by regulating oxidative stress, inflammatory response, and apoptosis. The combination therapy could be a potential therapeutic option for the treatment of smoke inhalation-induced pulmonary dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hannah R. Hall, Cressida Mahung, Julia L. M. Dunn, Laurel M. Kartchner, Roland F. Seim, Bruce A. Cairns, Shannon M. Wallet, Robert Maile
Summary: The study aimed to investigate the role of mTOR in the immune response after burn and inhalation injury. The results showed that the murine B+I model had inhalation-specific immune phenotypes and suggested the involvement of mTOR in acute immune dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Xiaoyuan Yang, Victor Chatterjee, Ethan Zheng, Amanda Reynolds, Yonggang Ma, Nuria Villalba, Thanh Tran, Michelle Jung, David J. Smith, Mack H. Wu, Sarah Y. Yuan
Summary: This study comprehensively analyzed plasma extracellular vesicles (EVs) from burn patients and healthy subjects, revealing a significant increase in circulating EVs in burn patients, which correlated with injury severity and clinical outcomes. The burn-induced EVs were largely derived from leukocytes and endothelial cells, and contained unique cargo proteins. Functionally, burn EVs caused barrier dysfunction and disrupted cell-cell junction continuity.
Article
Medicine, Research & Experimental
Zhifang Niu, Ziling Ding, Yion Chan, Li Yan, Wenyu Zhang, Hongyu Wang, Jie Shi, Qi Lv, Shike Hou, Xiaoqin Guo, Haojun Fan
Summary: Smoke inhalation injuries refer to the damage to the respiratory tract and lung tissue caused by fire smoke entering the human lungs. This study analyzed the clinical characteristics of patients with smoke inhalation injuries and identified the risk factors affecting their prognosis. The findings showed that certain indicators were elevated with increasing severity of smoke inhalation injuries, while others decreased. Some indicators (such as white blood cells and lactic acid) could serve as markers for predicting the severity and mortality risk. These findings can contribute to the development of improved treatment plans for smoke inhalation injuries.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Toxicology
Yong Ho Kim, Sarah H. Warren, Ingeborg Kooter, Wanda C. Williams, Ingrid J. George, Samuel A. Vance, Michael D. Hays, Mark A. Higuchi, Stephen H. Gavett, David M. DeMarini, Ilona Jaspers, M. Ian Gilmour
Summary: The study found that the adverse health effects of burn pit smoke exposure vary depending on the type of waste and combustion temperature, with burning plastic at high temperatures being the most significant contributor to toxicity outcomes. These findings help better understand the complex chemical and combustion temperature factors that determine the toxicity of burn pit smoke and its potential health risks at military bases.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Review
Surgery
Yong-zhi Zhou, Chao-qun Wang, Meng-hua Zhou, Zhong-yu Li, Dong Chen, Ai-ling Lian, Yong Ma
Summary: Surgical smoke is a byproduct of aerosols produced by energy equipment, and its composition varies depending on tissue type and energy device used. It may pose a significant risk to the health and safety of operating room staff and patients, but few people take corresponding protective measures.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Health Care Sciences & Services
Krisztian Csomo, Andrea Belik, Andras Hrabak, Benedek Kovacs, Orsolya Fabian, Sandor Valent, Gabor Varga, Zoltan Kukor
Summary: Statins are commonly used to treat hypercholesterolemia and have pleiotropic effects. This research suggests that statins may influence mitochondrial oxygen consumption through cytochrome c, potentially inducing apoptosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ezgi Saman, Martina Cebova, Andrej Barta, Martina Koneracka, Vlasta Zavisova, Anita Eckstein-Andicsova, Martin Danko, Jaroslav Mosnacek, Olga Pechanova
Summary: They studied the effects of simvastatin- and coenzyme-Q10-loaded polymeric nanoparticles on the lipid profile and nitric oxide (NO)/reactive oxygen species (ROS) balance in the heart and aorta of adult male obese Zucker rats, and found that the combined therapy increased NOS activity and upregulated the Akt-eNOS pathway, which may be a promising tool for the treatment of cardiometabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Mark Taylor, Hulya Francis, John Fielding
Summary: This article examines the factors associated with inhalation injuries of smoke and toxic fumes in accidental dwelling fires. The study found that single occupancy dwellings had more cases of inhalation injuries compared to multiple occupancy dwellings, with a ratio of 2 to 1. Most of the injuries occurred in areas with high levels of deprivation. Alcohol/drug consumption and attempting to fight the fire were also contributing factors.
Article
Biochemistry & Molecular Biology
Cressida Mahung, Shannon M. Wallet, Jordan E. Jacobs, Laura Y. Zhou, Haibo Zhou, Bruce A. Cairns, Robert Maile
Summary: Burn patients experience significant immune and metabolic dysfunction, which is further exacerbated by inhalation injury. This study identified specific immune and metabolic signaling pathways that are altered in burn and combined burn-inhalation injuries, and their correlation with patient outcomes. These findings could potentially serve as biomarkers and therapeutic targets for the management of burn patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Roland F. Seim, Michelle Mac, Lucas M. Sjeklocha, Alex J. Kwiatkowski, Ben G. Keselowsky, Shannon M. Wallet, Bruce A. Cairns, Robert Maile
Summary: Major burn injury is associated with systemic hyperinflammatory and oxidative stresses. Combined burn and inhalation injury exacerbate these stresses and lead to increased morbidity and mortality. The transcription factor NRF2 functions to maintain homeostasis during stress, but its activation may be insufficient after burn and combined B-I injury. By activating the NRF2 pathway with CDDO-MPs, it is possible to reduce acute hyperinflammatory responses and improve clinical outcomes in burn and B+I patients.
Article
Biochemistry & Molecular Biology
Gerber Adam, Takayuki Shiomi, Goldklang Monica, Sonett Jarrod, Anguiano Vincent, Mercer Becky, Zelonina Tina, D'Armiento Jeanine
Summary: COPD is a major cause of disability and death globally, with approximately 14 million sufferers in the United States alone. A potentially novel therapeutic agent targeting cigarette smoke-induced mechanisms was identified through high throughput screening, suggesting further investigation into SSRIs as a novel therapeutic for COPD may be warranted.
Article
Chemistry, Organic
Chander Shekhar, Gedu Satyanarayana
Summary: In this study, a triflic acid-driven dual cyclization pathway was developed to produce functionalized molecules from readily available starting materials under metal-free conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Respiratory System
Premila D. Leiphrakpam, Hannah R. Weber, Andrea McCain, Roser Romaguera Matas, Ernesto Martinez Duarte, Keely L. Buesing
Summary: This study successfully developed a novel large animal model to simulate smoke inhalation-induced ARDS, which could be beneficial for studying the pathophysiology of inhalation injury or developing new therapeutics.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Tie-ning Zhang, Te Ba, Fang Li, Qiang Chen, Zhi-peng Chen, Biao Zhou, Zeng-qiang Yan, Quan Li, Sheng-jun Cao, Ling-feng Wang
Summary: This study examined the coagulation changes in severe burn patients and found that coagulation dysfunction was most prominent around one week after injury, showing a hypercoagulable state. Factors such as large-area burn injury, fluid resuscitation, inhalation injury, and sepsis may contribute to coagulation dysfunction, which can further develop into disseminated intravascular coagulation (DIC) and even death in severe burn patients.
Article
Transplantation
Selin Akad Dincer, Feride Iffet Sahin, Yunus Kasim Terzi, Kaan Gulleroglu, Esra Baskin, Mehmet Haberal
Summary: Functional polymorphisms of MMP2, MMP9, and TIMP2 genes are associated with renal allograft rejection and interstitial fibrosis in pediatric renal transplant recipients. These genetic variations could serve as important predictive biological markers for the follow-up of kidney transplant recipients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Meraj Alam Siddiqui, Esra Baskin, Feza Yarbug Karakayali, Atilla Gemici, Kaan Gulleroglu, Aysun Caltik Yilmaz, Gokhan Moray, Mehmet Haberal
Summary: We report 2 pediatric cases of severe late antibody-mediated rejection resistant to conventional immunosuppressive therapy who were successfully treated with eculizumab. Eculizumab therapy effectively reduced the markers of late antibody-mediated rejection and improved kidney function in both patients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Leyla Elif Sade, Ayse Colak, Selin Ardali Duzgun, Tuncay Hazirolan, Atilla Sezgin, Erwan Donal, Steele C. Butcher, Handan Ozdemir, Bahar Pirat, Serpil Eroglu, Haldun Muderrisoglu
Summary: This study aimed to investigate the relative merits of echocardiography and cardiac magnetic resonance (CMR) with T1 mapping for the assessment of functional adaptation and remodelling of the right ventricle (RV) in heart transplant recipients. The study found that echocardiographic parameters can reflect changes in cardiac function and structure in patients, while CMR is better at reflecting changes in myocardial microstructure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Surgery
Berivan Bitik, Bugra Hatipoglu, Burak Sayin, Aysenur Yalcintas Kanbur, Nurbanu Bursa, Cagdas Sahap Oygur, Handan Ozdemir, Turan Colak, Mehmet Haberal, Ahmet Eftal Yucel
Summary: This study reviewed the long-term survival outcomes of patients with familial Mediterranean fever (FMF)-related amyloidosis who underwent kidney transplantation (KT). The study found that the survival rate of these patients was lower compared to the control group, but there was no statistically significant difference. However, short- and long-term complications still need to be resolved.
CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Aibolat Smagulov, Myltykbay Rysmakhanov, Yerlan Sultangereyev, Emre Karakaya, Aydincan Akdur, Ahmet Cagri Uysal, Pelin Borcek, Nadiar Mussin, Mehmet Haberal
Summary: This study was conducted to evaluate the positive effect of platelet-rich plasma on the healing process of an anastomotic wound in a rat model of ureterocystoanastomosis. The results showed that the use of platelet-rich plasma significantly increased tissue hydroxyproline levels, and there were no significant differences in epithelial damage, acute inflammation, or fibrosis between the platelet-rich plasma group and the control group.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Murat Muratoglu, Afsin Emre Kayipmaz, Cemil Kavalci, Mahir Kirnap, Gokhan Moray, Mehmet Haberal
Summary: The platelet-to-lymphocyte ratio is significantly elevated in renal transplant patients with infection. It can be used as an indicator of inflammation in these patients presenting to emergency departments. The platelet-to-lymphocyte ratio can be used in conjunction with other biomarkers to assess systemic inflammation.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Acoustics
Funda Ulu Ozturk, Sehnaz Tezcan, Ebru Hatice Ayvazoglu Soy, Nihal Uslu, Mehmet Haberal
Summary: This study investigated the hepatic arterial Doppler ultrasound findings related to cholangitis after liver transplantation. It was found that the hepatic arterial flow, resistive index, and diameter decreased in patients with cholangitis after recovery. These findings can help in the early diagnosis of cholangitis and prevent graft loss.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Pediatrics
Esra Baskin, Meraj Alam Siddiqui, Kaan Gulleroglu, Binnaz Handan Ozdemir, Aysun Caltik Yilmaz, Meric Yavuz Colak, Aydincan Akdur, Ebru Ayvazoglu Soy, Gokhan Moray, Mehmet Haberal
Summary: The long-term administration of eplerenone can attenuate chronic allograft nephropathy in pediatric renal transplant patients by maintaining stable kidney function and reducing urine protein-creatinine ratio.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Ophthalmology
Mustafa Aksoy, Leyla Asena, Mustafa Agah Tekindal, Ebru Hatice Ayvazoglu Soy, Gursel Yilmaz, Mehmet Haberal
Summary: This study aimed to evaluate the changes in subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), estimated glomerular filtration rate (GFR), mean arterial pressure (MAP), and intraocular pressure (IOP) after renal transplantation. The results showed a significant increase in SFCT with GFR, while CVI values did not change.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Transplantation
Alev Arslan, Gonul Parmaksiz, Zekiye Aytul Noyan, Kenan Caliskan, Sedat Yildirim, Mehmet Haberal
Summary: The aim of this study was to evaluate the gradual changes in left and right ventricle functions in children and young adults before and after renal transplant. The results showed that both systolic and diastolic dysfunctions of both ventricles were common in pediatric renal transplant recipients, and these dysfunctions usually decreased with time. However, improvements in right ventricle dysfunction were slower, even in optimally treated posttransplant patients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
B. Handan Ozdemir, Alev Ok Atilgan, Aydan Akyuez Ozdemir, Eda Akcay, Mehmet Haberal
Summary: This study aimed to investigate the relationship between histopathological characteristics of polyomavirus-associated nephropathy and graft outcome, and emphasized the importance of follow-up biopsies in guiding clinical decisions.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Meeting Abstract
Immunology
Nuran Sari, Hande Arslan, Emre Karakaya, Mehmet Haberal
Meeting Abstract
Immunology
Rengin Erdal, Gulnaz Arslan, Gokhan Moray, Sedat Boyacioglu, Figen Ozcay, Adnan Torgay, Mehmet Haberal
Meeting Abstract
Pediatrics
Hande Ayraler Taner, Burcu Akin Sari, Esra Baskin, Nafia Ozlem Kazanci, Jale Karakaya, Kaan Gulleroglu, Ebru H. Ayvazoglu Soy, Gokhan Moray, Mehmet Haberal
PEDIATRIC TRANSPLANTATION
(2022)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)