期刊
JOURNAL OF SURGICAL RESEARCH
卷 168, 期 2, 页码 325-U214出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2009.09.030
关键词
wound healing; NKT cells; chemokines; inflammation
类别
资金
- Ralph and Marion C. Falk Medical Research Trust
- [NIH R01 AI056108]
- [NIH R21 AI073987]
- [NIH T32 GM08750]
Here, we report the novel observation that natural killer T (NKT) cells contribute to the cutaneous wound repair process. Using an excisional wound model in wild-type versus NKT cell-deficient mice, this report shows that when NKT cells are absent, initial wound closure is markedly accelerated. We report here for the first time that NKT cells are a significant constituent of early wound inflammation and that they regulate the local production of a key subset of neutrophil and monocyte/macrophage chemokines, as well as TGF-beta 1 content and collagen deposition. Together, our findings support the concept that NKT cells regulate the early inflammatory and fibroproliferative phases of nonpathologic healing wounds, positioning the NKT cell as an attractive potential therapeutic target for modulation of impaired wound healing. (C) 2011 Elsevier Inc. All rights reserved.
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