Article
Medicine, Research & Experimental
Kunsheng Li, Pengyu Zhou, Jie Li, Yongqing Cheng, Shiliang Li, Yumeng Wang, Weipeng Jiang, Yang Bai, Hailong Cao, Dongjin Wang
Summary: The expression and function of P2Y14 receptor in neutrophils after myocardial infarction/reperfusion (MIR) injury were investigated. The results showed that P2Y14 receptor is involved in the regulation of inflammation in the infarct area after MIR, and it establishes a novel signaling pathway concerning the interplay between cardiomyocytes and neutrophils in the heart tissue.
Article
Multidisciplinary Sciences
Zi-jie Zhang, Zhi-xiang Sun, Hai-jian Liu
Summary: The treatment of myocardial ischemia-reperfusion (IR) injury is a clinical challenge. Dexmedetomidine (DEX) has been found to protect the myocardium, but its regulatory mechanism is unclear. This study discovered that a series of cytokines and chemokines, as well as Eukaryotic translation elongation factor 1 alpha 2 (EEF1A2), were induced by IR and reduced by DEX pretreatment. PRDX1 interacted with EEF1A2 and played a significant role in the regulation of cytokine and chemokine gene expression.
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Biotechnology & Applied Microbiology
Jing Chen, Yanan Song, Qiaozi Wang, Qiyu Li, Haipeng Tan, Jinfeng Gao, Ning Zhang, Xueyi Weng, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Juying Qian, Zhiqing Pang, Zheyong Huang, Junbo Ge
Summary: Researchers have developed biomimetic nanoparticles for targeted and broad-spectrum anti-inflammation therapy of acute myocardial infarction (MI). These nanoparticles can neutralize proinflammatory cytokines and regulate the immune microenvironment, thereby suppressing inflammation and promoting angiogenesis in a mouse model of MI.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Payam Hashemi, Masoud Nouri-Vaskeh, Leila Alizadeh, Amir Baghbanzadeh, Reza Badalzadeh, Elham Askari, Behzad Baradaran
Summary: NETosis is an important inflammatory mechanism of the immune system, exerting its role through various mechanisms and playing a key role in the prognosis of various diseases including coronary artery disease.
Article
Multidisciplinary Sciences
Seung Min Lee, Jin Woo Lee, Inki Kim, Dong-Cheol Woo, Chan-Gi Pack, Young Hoon Sung, In-Jeoung Baek, Chang Hee Jung, Young-Hak Kim, Chang Hoon Ha
Summary: CTRP9 induces a vasoprotective response via the AMPK/HDAC7/p38 MAPK pathway in vascular endothelial cells, promoting angiogenesis and preventing atherosclerosis and myocardial infarction (MI).
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Physiology
Stacy L. Anderson, Tanya Duke-Novakovski, Alexandra R. Robinson, Hugh G. G. Townsend, Baljit Singh
Summary: Following surgery, systemic inflammation was observed in all horses. In the IR group, ex vivo neutrophil apoptosis was significantly delayed after 12 or 24 hours in culture, with reduced caspase activity, which was not observed in the IRGC group. Additionally, serum TNF-alpha concentration was elevated in IRGC horses following jejunal ischemia for 6-18 hours.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuo Liu, Jiaqi Liu, Xue Yang, Minghong Jiang, Qingqing Wang, Lianfeng Zhang, Yuanwu Ma, Zhongyang Shen, Zhigang Tian, Xuetao Cao
Summary: Chemokine production by epithelial cells is crucial for neutrophil recruitment during viral infection, with the regulation being key to controlling inflammation. A newly discovered lncRNA named lnc-Cxcl2 selectively inhibits the expression of Cxcl2 in mouse lung epithelial cells but not in macrophages. This study highlights the importance of understanding the functional interactions of lncRNAs and RNA-binding proteins in regulating chemokine expression and inflammation during viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Takefumi Inada, Takahiko Kamibayashi
Summary: The study demonstrated that propofol has anti-inflammatory properties in a mouse air pouch model of local inflammation, by inhibiting the production of pro-inflammatory cytokines and chemokines, as well as reducing the recruitment of white blood cells into the pouch.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Christopher T. Turner, Megan Pawluk, Juliana Bolsoni, Matthew R. Zeglinski, Yue Shen, Hongyan Zhao, Tatjana Ponomarev, Katlyn C. Richardson, Christopher R. West, Anthony Papp, David J. Granville
Summary: This study investigated the therapeutic effect of sulfaphenazole (SP) in pressure injuries. The results showed that SP could alleviate the severity of pressure injuries, promote wound closure, and improve wound tensile strength. Additionally, SP rapidly restored tissue perfusion, reduced tissue hypoxia, inflammation, and fibrosis. Moreover, SP demonstrated bactericidal activity through enhanced macrophage activity. The effectiveness of SP in reducing thermal injury severity was also demonstrated. Therefore, SP has the potential to be a therapeutic option for pressure injuries and other ischemic skin injuries.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Meiling Bai, Ruize Sun, Bin Cao, Juan Feng, Jue Wang
Summary: Ischemic stroke is a leading cause of death worldwide and the most common cause of disability in Western countries. Inflammation plays a vital role in the development and progression of ischemic stroke, and peripheral blood immune cells, particularly monocytes, are involved in the immune cascade after stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Xiaoling Qiang, Jianhua Li, Shu Zhu, Mingzhu He, Weiqiang Chen, Yousef Al-Abed, Max Brenner, Kevin J. Tracey, Ping Wang, Haichao Wang
Summary: The study suggests that DCD and its analog have protective effects in hepatic ischemia-reperfusion injury, possibly by attenuating inflammation through impairing the EGFR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shaoyong Zhuang, Shengqiang Xia, Peiqi Huang, Jiajin Wu, Junwen Qu, Ruoyang Chen, Nan Sun, Dawei Li, Haoyu Wu, Ming Zhang, Jianjun Zhang, Xiaodong Yuan, Xu Wang
Summary: Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury, with mechanisms not fully elucidated. Results from RNA sequencing showed disrupted mitochondrial dynamics and upregulated expression of P2RX1 in renal IRI. P2RX1 promoted the formation of NETs, leading to impairment of mitochondrial dynamics.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Isamu Hosokawa, Hiroaki Shimizu, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Keiji Koda, Masaru Miyazaki, Masayuki Ohtsuka
Article
Surgery
Youhei Miyauchi, Katsunori Furukawa, Daisuke Suzuki, Hideyuki Yoshitomi, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
INTERNATIONAL JOURNAL OF SURGERY
(2019)
Article
Pathology
Kensuke Sugiura, Takashi Mishima, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Mamoru Takada, Masaru Miyazaki, Masayuki Ohtsuka
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Article
Oncology
Atsuhiko Ueda, Nozomu Sakai, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Masaru Miyazaki, Masayuki Ohtsuka
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2019)
Letter
Gastroenterology & Hepatology
Tsukasa Takayashiki, Hideyuki Yoshitomi, Katsunori Furukawa, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2020)
Article
Oncology
Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masaru Miyazaki, Masayuki Ohtsuka
Review
Gastroenterology & Hepatology
Nami Sato, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Rintaro Mikata, Naoya Kato, Masayuki Ohtsuka
BMC GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Takao Ohtsuka, Yuichi Nagakawa, Hirochika Toyama, Yutaka Takeda, Atsuyuki Maeda, Yusuke Kumamoto, Yoshiharu Nakamura, Kazuki Hashida, Goro Honda, Kengo Fukuzawa, Eiji Toyoda, Minoru Tanabe, Naoto Gotohda, Ippei Matsumoto, Tomoki Ryu, Ichiro Uyama, Toru Kojima, Michiaki Unno, Daisuke Ichikawa, Yosuke Inoue, Hiroyoshi Matsukawa, Takeshi Sudo, Kyoichi Takaori, Hiroki Yamaue, Susumu Eguchi, Munenori Tahara, Makoto Shinzeki, Hidetoshi Eguchi, Masanao Kurata, Mamoru Morimoto, Hiromitsu Hayashi, Shigeru Marubashi, Masafumi Inomata, Kenjiro Kimura, Koji Amaya, Masayuki Sho, Ryuichi Yoshida, Akihiro Murata, Hideyuki Yoshitomi, Kenichi Hakamada, Masafumi Yasunaga, Nobutsugu Abe, Masayoshi Hioki, Masaru Tsuchiya, Takeyuki Misawa, Yasuji Seyama, Hirokazu Noshiro, Eiji Sakamoto, Kiyoshi Hasegawa, Yasunari Kawabata, Yoichiro Uchida, Shinichiro Kameyama, Saiho Ko, Takashi Takao, Kenji Kitahara, Shin Nakahira, Ilideo Baba, Masahiko Watanabe, Masakazu Yamamoto, Masafumi Nakamura
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2020)
Article
Nutrition & Dietetics
Arata Furukawa, Katsunori Furukawa, Daisuke Suzuki, Hideyuki Yoshitomi, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
Summary: This study revealed that preoperative immunonutrition can reduce the incidence of postoperative infectious complications in low skeletal muscle mass patients undergoing pancreaticoduodenectomy (PD).
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Makoto Takahashi, Hiroyuki Nojima, Satoshi Kuboki, Takuro Horikoshi, Tetsuo Yokota, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Masayuki Ohtsuka
Article
Gastroenterology & Hepatology
Masato Nagino, Satoshi Hirano, Hideyuki Yoshitomi, Taku Aoki, Katsuhiko Uesaka, Michiaki Unno, Tomoki Ebata, Masaru Konishi, Keiji Sano, Kazuaki Shimada, Hiroaki Shimizu, Ryota Higuchi, Toshifumi Wakai, Hiroyuki Isayama, Takuji Okusaka, Toshio Tsuyuguchi, Yoshiki Hirooka, Junji Furuse, Hiroyuki Maguchi, Kojiro Suzuki, Hideya Yamazaki, Hiroshi Kijima, Akio Yanagisawa, Masahiro Yoshida, Yukihiro Yokoyama, Takashi Mizuno, Itaru Endo
Summary: The Japanese Society of Hepato-Biliary-Pancreatic Surgery has launched the 3rd version of clinical practice guidelines for biliary tract cancers, covering 31 clinical questions on six topics. Recommendations were categorized as strong or weak, with three questions having no specific recommendation.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Oncology
Takashi Mitsui, Kazuyuki Saito, Yuhei Hakozaki, Yoshiyuki Miwa, Takuji Noro, Emiko Takeshita, Taizen Urahashi, Yasuyuki Seto, Takashi Okuyama, Hideyuki Yoshitomi
Summary: This study aimed to develop a new method of anastomosis (NoCEAM) to prevent postoperative infections after gastrectomy and evaluate its feasibility. The results showed that NoCEAM was successful in both porcine and human cases, and there were no significant complications.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Gastroenterology & Hepatology
Yosuke Ashizawa, Satoshi Kuboki, Hiroyuki Nojima, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Masaru Miyazaki, Masayuki Ohtsuka
HEPATOLOGY COMMUNICATIONS
(2019)
Article
Oncology
Tetsuo Yokota, Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Hiroyuki Nojima, Takashi Mishima, Eri Nakadai, Masayuki Ohtsuka
MOLECULAR AND CLINICAL ONCOLOGY
(2019)
Article
Surgery
Makoto Takahashi, Hideyuki Yoshitomi, Atsushi Kato, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Kensuke Sugiura, Keishi Kawasaki, Masaru Miyazaki, Masayuki Ohtsuka
SURGICAL CASE REPORTS
(2019)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)