Article
Oncology
Tatsuya Fujikawa, Fumihiro Sanada, Yoshiaki Taniyama, Kana Shibata, Naruto Katsuragi, Nobutaka Koibuchi, Kaori Akazawa, Yuko Kanemoto, Hidehito Kuroyanagi, Kenzo Shimazu, Hiromi Rakugi, Ryuichi Morishita
Summary: This study focused on the urgent need for new treatments for triple-negative breast cancer (TNBC) patients by developing an antibody to inhibit TNBC progression. Periostin alternative splicing variants may serve as a therapeutic target for TNBC patients. The experiment found that Pn-positive TNBC influences the recruitment of tumor-associated macrophages and angiogenesis.
Article
Oncology
Zhengwei Gui, Yao Tian, Shiyang Liu, Tianyao Yu, Chenguang Liu, Lin Zhang
Summary: This study investigated the expression of Centromere protein L (CENPL) in breast cancer and its relationship with patient prognosis. High CENPL expression was found to be associated with the cell cycle, nuclear division, organelle fission, and chromosome segregation in breast cancer. Furthermore, high CENPL expression was correlated with immune cell infiltration and ICP gene expression. Inhibition of CENPL reduced the proliferation and migration ability of breast cancer cells. Therefore, CENPL may function as an oncogene in breast cancer and serve as a predictor of immunotherapy efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Nicole J. Chew, Terry C. C. Lim Kam Sian, Elizabeth V. Nguyen, Sung-Young Shin, Jessica Yang, Mun N. Hui, Niantao Deng, Catriona A. McLean, Alana L. Welm, Elgene Lim, Peter Gregory, Tim Nottle, Tali Lang, Melissa Vereker, Gary Richardson, Genevieve Kerr, Diana Micati, Thierry Jarde, Helen E. Abud, Rachel S. Lee, Alex Swarbrick, Roger J. Daly
Summary: This study utilized an integrated multi-omic approach to examine breast cancer PDXs and PDOs, identifying heterogeneity in FGFR activation. The findings suggest that specific FGFRs, such as FGFR4, have the potential to serve as targets for precision treatment.
BREAST CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Masoumeh Amirian, Amir Masoud Jafari-Nozad, Majid Darroudi, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Accumulating evidence has shown the significant role of miR-29 in human malignancies, particularly breast cancer (BC). MiR-29 acts as a tumor suppressor by targeting multiple signaling pathways and transcripts, but it can also promote BC progression through gene and transcription factor targeting. The conflicting roles of miR-29 in BC may be attributed to its regulatory roles dependent on the environment and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Nuria G. Martinez-Illescas, Silvia Leal, Patricia Gonzalez, Osvaldo Grana-Castro, Juan Jose Munoz-Oliveira, Alfonso Cortes-Pena, Maria Gomez-Gil, Zaira Vega, Veronica Neva, Andrea Romero, Miguel Quintela-Fandino, Eva Ciruelos, Consuelo Sanz, Sofia Aragon, Leisy Sotolongo, Sara Jimenez, Eduardo Caleiras, Francisca Mulero, Cristina Sanchez, Marcos Malumbres, Maria Salazar-Roa
Summary: A hallmark of many malignant tumors is the presence of dedifferentiated cells that have lost their resemblance to normal cells. These dedifferentiated cells have a higher survival capacity and can incite tumor relapse. Differentiation therapy that induces cancer cell differentiation could be combined with current standard care to treat aggressive tumors. MicroRNA 203 has been shown to promote the differentiation of breast cancer cells, preventing tumor growth in vivo. This research sheds light on differentiation-based antitumor therapies and highlights the potential of miR-203 as a tool to directly combat tumor maintaining and regeneration capabilities.
BREAST CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hiroyuki Yamato, Kenji Kimura, Eriko Fukui, Takashi Kanou, Naoko Ose, Soichiro Funaki, Masato Minami, Yasushi Shintani
Summary: This study found that periostin secreted by fibroblasts from IPF patients plays a critical role in promoting the proliferation of NSCLC cells, suggesting targeting periostin could be a potential therapy for NSCLC patients with IPF.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Heba Ghozlan, Adrian Showalter, Eunkyung Lee, Xiang Zhu, Annette R. Khaled
Summary: The study found that high expression of CCT2 in breast cancer cells is inversely correlated with patient survival, potentially due to copy number alterations caused by genomic amplification. The exogenous expression of CCT2 promoted the proliferation of breast cancer cells, which may involve pathways such as MYC and CCND1 in regulating cell growth.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Adhika Balgobind, Aliscia Daniels, Mario Ariatti, Moganavelli Singh
Summary: This study assessed the efficacy of cationic lipid-based systems for the delivery of HER2/neu siRNA in breast cancer. The results showed that cationic liposomes efficiently bound, compacted, and protected the therapeutic siRNA against degradation. The non-PEGylated Chol-T-siRNA lipoplexes exhibited the highest HER2/neu silencing.
Article
Biotechnology & Applied Microbiology
Hernan Gonzalez-King, Sandra Tejedor, Maria Ciria, Marta Gil-Barrachina, Mario Soriano-Navarro, Rafael Sanchez-Sanchez, Pilar Sepulveda, Nahuel A. Garcia
Summary: This study investigates the involvement of small extracellular vesicles (SEVs) in functional Notch signaling and finds that SEVs in breast cancer cells can regulate Notch signal transduction, leading to increased invasiveness and proliferation of breast cancer cells.
CANCER GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Ana Luisa Correia, Joao C. Guimaraes, Priska Auf Der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber, Mohamed Bentires-Alj
Summary: The study investigates how different tissue-specific microenvironments can either inhibit or support the progression of breast cancer in the liver. It identifies the interplay between natural killer (NK) cells and activated hepatic stellate cells (aHSCs) as a master switch of cancer dormancy, suggesting that therapies aimed at normalizing the NK cell pool may be successful in preventing metastatic outgrowth.
Review
Microbiology
Erik Kudela, Eva Kudelova, Erik Kozubik, Tomas Rokos, Terezia Pribulova, Veronika Holubekova, Kamil Biringer
Summary: Estimates suggest that 15 to 20 percent of human malignancies are caused by viruses. Human papillomavirus (HPV) is considered an interesting but controversial risk factor for breast cancer. HPV infection is thought to trigger breast cancer development, followed by cumulative changes over time through interaction with other environmental factors. However, the association between HPV and breast cancer is still inconclusive due to conflicting data and unclear transmission routes. Extensive research with larger studies and unified diagnostic methods is needed to better understand the role of HPV in breast carcinogenesis.
Article
Cell Biology
Jianing Tang, Zeyu Wu, Zelin Tian, Wei Chen, Gaosong Wu
Summary: This study identified OTUD7B as a deubiquitylase of ER alpha in breast cancer, which is positively correlated with ER alpha expression and associated with poor prognosis. Depletion of OTUD7B decreased ER alpha protein level and suppressed breast cancer cell proliferation and migration. Overexpression of ER alpha could rescue the suppressive effect induced by OTUD7B depletion, suggesting the essential role of ER alpha in the function of OTUD7B in breast carcinogenesis.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Yuanjiang Wang, Zhaodan Lv, Feihong Chen, Xing Wang, Shaohua Gou
Summary: A new compound 3a was synthesized to inhibit TNBC stem cells and reverse drug resistance in MDA-MB-231 cells induced by lapatinib. It effectively suppressed tumor invasion and migration by inhibiting relevant signaling pathways and protein expression, proving to be a potential dual inhibitor for EGFR and CSC in TNBC treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Vincent Tambay, Valerie-Ann Raymond, Marc Bilodeau
Summary: In the last decade, metabolic reprogramming has been recognized as a key characteristic of cancer cells, with the MYC oncogene playing a crucial role in regulating differential cancer cell metabolism, particularly through the involvement of glutamine. Understanding the metabolic pathways, such as glutaminolysis, controlled by MYC activation provides insights into the potential vulnerabilities of cancer cells from a metabolic perspective.
Article
Biochemistry & Molecular Biology
Christian Bassi, Jerome Fortin, Bryan E. Snow, Andrew Wakeham, Jason Ho, Jillian Haight, Annick You-Ten, Emily Cianci, Luke Buckler, Chiara Gorrini, Vuk Stambolic, Tak W. Mak
Summary: The tumor suppressor gene PTEN is frequently mutated in various cancers, and its phosphorylation by ATM plays a critical role in apoptosis, genomic stability, and tumorigenesis. The PTEN-398A mutation accelerates tumor formation in HER2-positive breast cancer by disrupting the S phase checkpoint controlled by the PI3K-p27(Kip1)-CDK2 axis, leading to DNA damage accumulation and decreased apoptosis. Defects in PTEN-398A protein relocalization to the plasma membrane in response to genotoxic stress contribute to these effects.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Gastroenterology & Hepatology
Yifan Xv, Jiajun Fan, Yuan Ding, Yang Hu, Yingjie Hu, Zhengjie Jiang, Qingsong Tao
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2020)
Article
Biochemistry & Molecular Biology
Guangyuan Zhang, Lei Zhang, Si Sun, Ming Chen
Summary: This study identified CANX, BID, NAMPT, and BIRC5 as immune-autophagy-related genes with independent prognostic value in kidney renal clear cell carcinoma. These genes were significantly correlated with immune score, immune checkpoint, iron death, methylation, and OCLR score. The risk prognostic model based on them was well constructed, and experimental results were consistent with the bioinformatics analysis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Si Sun, Weipu Mao, Lilin Wan, Kehao Pan, Liting Deng, Lei Zhang, Guangyuan Zhang, Ming Chen
Summary: This study found that FGF17, PRKCG, SSTR1, and SCTR were metastatic immune-related differentially expressed genes (mIR-DEGs) with independent prognostic values in renal clear cell carcinoma. These genes were significantly associated with clinicopathological factors and immune checkpoint-related genes. The risk prognostic model based on these genes showed good predictive potential.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Surgery
Si Sun, Weipu Mao, Shuchun Tao, Lilin Wan, Xiangyu Zou, Guangyuan Zhang, Ming Chen
Summary: The aim of this study was to assess the effect of preoperative blood glucose levels on the length of stay in patients with kidney stones undergoing percutaneous nephrolithotomy. The results demonstrated that higher preoperative blood glucose levels were significantly associated with longer length of stay in these patients.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Weipu Mao, Shuqiu Chen, Lijie Zhang, Tao Li, Si Sun, Bin Xu, Weidong Zhu, Guangyuan Zhang, Lei Zhang, Jianping Wu, Ming Chen
Summary: This study presents the functional outcomes and postoperative complications of modified Y-shaped ileal orthotopic neobladder reconstruction. The surgery is shown to be simple, safe, and clinically applicable.
FRONTIERS IN SURGERY
(2022)
Review
Medicine, General & Internal
Ahmed A. S. Al-Magedi, Rong Wu, Qingsong Tao
Summary: This study compared the incidence of postoperative pancreatic fistula (POPF) in patients undergoing open gastrectomy (OG) and laparoscopic gastrectomy (LG) for gastric cancer. The results showed no significant difference in POPF incidence between the OG group and LG group in patients undergoing gastric cancer surgery. The study emphasizes the need for improvement in surgical techniques and further research to explore the risk factors.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Orthopedics
Qingsong Tao, Ahmed A. S. AL-Magedi, Zhi Wang, Wei Xu, Rong Wu
Summary: This study compared different approaches for performing intraoperative endoscopy (IOE) to treat overt obscure gastrointestinal bleeding (OGIB). The results showed that IOE through enterotomy had the lowest morbidity rate and shortest hospital stay, making it a safer and more efficient method for managing OGIB.
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2022)
Article
Gastroenterology & Hepatology
Yifan Xv, Qingsong Tao
GASTROENTEROLOGY NURSING
(2022)
Article
Urology & Nephrology
Guangyuan Zhang, Lei Zhang, Sun Si, Tiancheng Jiang, Yi Xia, Yongkun Zhu, Xiangyu Zhang, Chi Yao, Ming Chen, Shuqiu Chen
Summary: Low fibrinogen is an independent predictor of in-hospital mortality in critically ill patients with AKI. Low ATIII activity is also likely to impact the risk of in-hospital death.
Article
Oncology
Ruishuang Ma, Xin Li, Shengping Gong, Xiaoqin Ge, Ting Zhu, Xiaoxu Ge, Lijuan Weng, Qingsong Tao, Jianxin Guo
Summary: This study reveals that lactate promotes TKI resistance in non-small-cell lung cancer (NSCLC) through GPR81 and MCT1 pathways, activating AKT signaling and providing energy supply. These findings offer new therapeutic modalities for TKI resistance in NSCLC.
JOURNAL OF ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Qingsong Tao, Ting Zhu, Xiaoqin Ge, Shengping Gong, Jianxin Guo
Summary: This study observed the efficacy and safety of low dose TMZ maintenance therapy in elderly patients with glioblastoma after receiving standard STUPP regimen. The results showed that reducing TMZ dosage for maintenance therapy may improve survival time in elderly patients with tolerable adverse reactions.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Cell Biology
Chi Yao, Guangyuan Zhang, Nieke Zhang, Renjie Li, Si Sun, Lei Zhang, Yi Xia, Shuqiu Chen, Jin Sun, Ming Chen
Summary: This study found that fibrinogen levels are associated with the prognosis of sepsis patients. The relationship between elevated and decreased levels of fibrinogen and mortality was shown to be nonlinear. Subgroup analysis confirmed the robustness of this association. However, after adjusting for confounding factors, the association between decreased fibrinogen levels and increased inhospital mortality was denied.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biology
Wei Zhu, Chengjie Wu, Zhen Zhou, Guangyuan Zhang, Lianmin Luo, Yang Liu, Zhicong Huang, Guoyao Ai, Zhijian Zhao, Wen Zhong, Yongda Liu, Guohua Zeng
Summary: Acetate treatment can improve renal injury and fibrosis in hyperoxaluria by inhibiting macrophage infiltration through the promotion of miR-493-3p expression and suppression of macrophage migration inhibitory factor expression.
COMMUNICATIONS BIOLOGY
(2023)
Article
Surgery
Ahmed A. S. AL-Magedi, Yifan Xv, Zhi Wang, Wei Xu, Rong Wu, Weiyu Zhang, Qingsong Tao
Summary: This study aimed to identify the causes of small bowel refractory bleeding and overcome the challenges of surgical treatment. The causes of SB bleeding include vascular lesions, tumors, diverticular disease, ulcers/erosion, inflammatory bowel disease, and others. Age and patient history played a role in determining the etiology.
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2023)
Article
Cell Biology
Guang-Yuan Zhang, Yan-Wei Wang, Li-Ying Guo, Liang-Ru Lin, Shao-Peng Niu, Chang-Hao Xiong, Jing-Yan Wei
Summary: In this study, a hGPx1 mutant (GPx1M) with high activity was prepared using a single protein production (SPP) system. The GPx1M was conjugated with SS-mPEG to enhance its stability, and it showed good antioxidant effects both in vitro and in vivo.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)
