Article
Biotechnology & Applied Microbiology
Wayne M. Barnes, Zhian Zhang, Milko B. Kermekchiev
Summary: Changing an amino acid of Taq DNA polymerase leads to faster PCR; surprising results from negative controls reveal additional abilities of the enzyme.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Virology
Selen Zeliha Mart Komurcu, Yakup Artik, Nevra Pelin Cesur, Arzu Tanriverdi, Derya Cakir Erdogan, Sule Celik, Elif Yilmaz Gulec
Summary: Rapid and reliable detection of SARS-CoV-2 mutations is crucial in controlling virus transmission. Study found N501Y mutation in positive patients, providing important information for public health efforts.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dandan Chen, Xinqing Jiang, Yong Hong, Zhihui Wen, Shuquan Wei, Guangming Peng, Xinhua Wei
Summary: In this study, chest CT was found to be valuable in diagnosing COVID-19 pneumonia, especially for patients with negative initial RT-PCR results. Most COVID-19 lesions were located in multiple lobes in both lungs, with ground-glass opacity and consolidation being the main CT features. Patients with negative initial RT-PCR results were less likely to show pulmonary consolidation on CT.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Biochemical Research Methods
Yiting Zhu, Ni Hong, Liu Li, Yujie Gao, Liping Wang, Wenxing Xu, Guoping Wang
Summary: This study developed a SYBR Green-based RT-qPCR assay for the reliable detection of Pear chlorotic leaf spot associated virus (PCLSaV) infecting pear trees. This technique is important for the supervision of viral disease and the certification of pear planting materials.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Chemistry, Analytical
Ian T. Hull, Enos C. Kline, Gaurav K. Gulati, Jack Henry Kotnik, Nuttada Panpradist, Kamal G. Shah, Qin Wang, Lisa Frenkel, James Lai, Joanne Stekler, Barry R. Lutz
Summary: The study presents a novel quantitative detection method for HIV DNA or RNA using a combination of recombinase polymerase amplification and lateral flow detection technologies, allowing for rapid and accurate testing in low-resource healthcare settings, with the potential to improve the quality of HIV treatment.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
A. Yuwono Soeroto, R. Antartika, N. Nauli Asriputri, H. Suryadinata, B. Andriyoko
Summary: This study aimed to determine the association between RT-PCR Ct value and COVID-19 clinical severity in the second week of illness. The results showed no significant difference in Ct values among different severity groups, suggesting that Ct value is clinically insignificant in terms of association with the severity of COVID-19 in the second week of illness.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Surgery
Jiuyan Shang, Meng Zhao, Huiyan Deng, Chang Liu, Lijing Cai, Yueping Liu
Summary: This study investigated the sensitivity and specificity of SLN detection using RT-PCR, which showed high sensitivity and specificity in detecting SLNs, with results close to those of IHC detection.
Article
Biochemistry & Molecular Biology
Javier Martinez del Rio, Nerea Lopez-Carrobles, Jesus I. Mendieta-Moreno, Oscar Herrera-Chacon, Adrian Sanchez-Ibanez, Jesus Mendieta, Luis Menendez-Arias
Summary: The combination of PCR and RTs has been widely used in RNA detection and gene expression analysis. Improving thermostability and nucleic acid binding affinity of RTs is crucial for enhancing the efficiency of these applications. This study investigated the effects of amino acid substitutions in the RT RNase H domain on its properties. It was found that specific substitutions resulted in loss of activity and mutations that improved cDNA synthesis efficiency also affected RNase H activity. This discovery provides evidence for a novel mechanism of RNase H inactivation.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Microbiology
Bryanna Lexus Freitas, Lynn Leach, Vishnu Chaturvedi, Sudha Chaturvedi
Summary: A new detection method has been developed to rapidly detect live multidrug-resistant yeast Candida auris in healthcare environments. This method is highly sensitive and specific, and it correlates with the results from traditional culture methods.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Oncology
Lucas W. Thornblade, Ernest Han, Yuman Fong
Summary: Patients with colorectal cancer ovarian metastasis have favorable long-term survival. Survival rates are higher if the tumor is isolated to the ovary or if metachronous to the primary cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Biophysics
John Daniels, Shekhar Wadekar, Ken DeCubellis, George W. Jackson, Alexander S. Chiu, Quentin Pagneux, Hiba Saada, Ilka Engelmann, Judith Ogiez, Delphine Loze-Warot, Rabah Boukherroub, Sabine Szunerits
Summary: This study introduces a novel concept of using exhaled breath condensate (EBC) collected by a mask-based sampling device and detected with an electrochemical biosensor for fast and specific detection of COVID-19. Results showed detection of SARS-CoV-2 in samples from positive patients, and the electrochemical biosensor was able to detect viral particles, providing information about the infectivity state of the patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Lianhua Dong, Junbo Zhou, Chunyan Niu, Quanyi Wang, Yang Pan, Sitong Sheng, Xia Wang, Yongzhuo Zhang, Jiayi Yang, Manqing Liu, Yang Zhao, Xiaoying Zhang, Tao Zhu, Tao Peng, Jie Xie, Yunhua Gao, Di Wang, Xinhua Dai, Xiang Fang
Summary: The COVID-19 outbreak caused by a novel Coronavirus has spread globally. Current gold standard RT-qPCR for SARS-CoV-2 diagnosis shows varying sensitivity, highlighting the need for more accurate methods. A study on RT-dPCR demonstrated significant improvement in detection sensitivity, particularly for asymptomatic patients, making it a highly accurate method for screening suspected cases.
Article
Multidisciplinary Sciences
Catherine T. Chia, Andrew T. Bender, Lorraine Lillis, Benjamin P. Sullivan, Coleman D. Martin, Wynn Burke, Charles Landis, David S. Boyle, Jonathan D. Posner
Summary: This study reports a rapid, highly accurate, and minimally instrumented assay for HCV RNA detection using RT-RPA. The assay can detect all HCV genotypes with a limit of detection of 25 copies per reaction for genotype 1. Clinical experiments showed that the RT-RPA assay has a sensitivity and specificity of 100%. The accuracy, short runtime, and low heating demands of RT-RPA make it potentially valuable for point-of-care HCV testing.
Article
Pharmacology & Pharmacy
Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M. M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Hiroshi Yamazaki
Summary: In this study, the authors identified and characterized several CYP2Js in dogs, cats, and pigs, which are homologous to the human CYP2J2 enzyme. The expression patterns of these CYP2Js in the intestines of the different species were analyzed. It was found that dog, cat, and pig CYP2Js likely play a role in drug metabolism in the small intestine, similar to human CYP2J2.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Medicine, General & Internal
Huijing Ma, Qinghao Ye, Weiping Ding, Yinghui Jiang, Minhao Wang, Zhangming Niu, Xi Zhou, Yuan Gao, Chengjia Wang, Wade Menpes-Smith, Evandro Fei Fang, Jianbo Shao, Jun Xia, Guang Yang
Summary: This study investigated whether clinical symptoms and laboratory results can predict chest CT outcomes for pediatric patients with positive RT-PCR testing results, finding age, lymphocyte, neutrophils, ferritin, and C-reactive protein as the most related indicators. The study suggests that the necessity of CT for pediatric patients should be reconsidered, based on the predictive ability of clinical indicators.
FRONTIERS IN MEDICINE
(2021)
Correction
Oncology
Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P. M. H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa Garcia-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwe, Paul De Leyn, Johan Vansteenkiste, Birgit Weynand, Xavier Sagaert, Erik Verbeken, Albert Wolthuis, Baki Topal, Wouter Everaerts, Hanibal Bohnenberger, Alexander Emmert, Dena Panovska, Frederik De Smet, Frank J. T. Staal, Rene J. Mclaughlin, Francis Impens, Vincenzo Lagani, Stefan Vinckier, Massimiliano Mazzone, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Tobias K. Karakach, Huanming Yang, Jian Wang, Lars Bolund, Lin Lin, Bernard Thienpont, Xuri Li, Diether Lambrechts, Yonglun Luo, Peter Carmeliet
Article
Surgery
Joachim Geers, Halit Topal, Joris Jaekers, Baki Topal
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2020)
Article
Oncology
Isabelle Vanden Bempt, Sara Vander Borght, Raf Sciot, Lien Spans, Sofie Claerhout, Hilde Brems, Stefan Lehnert, Luc Dehaspe, Sabine Fransis, Bart Neuville, Baki Topal, Patrick Schoffski, Eric Legius, Maria Debiec-Rychter
Summary: Mutational analysis plays a critical role in guiding therapeutic decision making for patients with advanced-stage gastrointestinal stromal tumors (GISTs). The study evaluated the effectiveness of three targeted next-generation sequencing (NGS) assays in detecting driver alterations in GISTs, leading to the identification of additional mutations beyond the commonly found KIT or PDGFRA mutations. The comprehensive NGS approach proved to be feasible in routine mutational analysis of GISTs and helped reduce the number of Wild Type GISTs.
GENES CHROMOSOMES & CANCER
(2021)
Editorial Material
Gastroenterology & Hepatology
Michiel Bronswijk, Giuseppe Vanella, Baki Topal, Schalk Van der Merwe
Article
Cardiac & Cardiovascular Systems
Willeke de Haan, Wouter Dheedene, Katerina Apelt, Sofiane Decombas-Deschamps, Stefan Vinckier, Stefaan Verhulst, Andrea Conidi, Thomas Deffieux, Michael W. Staring, Petra Vandervoort, Ellen Caluwe, Marleen Lox, Inge Mannaerts, Tsuyoshi Takagi, Joris Jaekers, Geert Berx, Jody Haigh, Baki Topal, An Zwijsen, Yujiro Higashi, Leo A. van Grunsven, Wilfred F. J. van IJcken, Eskeatnaf Mulugeta, Mickael Tanter, Franck P. G. Lebrin, Danny Huylebroeck, Aernout Luttun
Summary: This study demonstrated the specific role of Zeb2 in liver endothelial cells, showing that Zeb2 deficiency leads to significant changes in gene expression related to angiogenesis and potential promotion of endothelial dedifferentiation. Furthermore, Zeb2 regulates LSEC-HSC communication and HSC activation to maintain vascular structure and inhibit liver fibrosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Victor Lopez-Lopez, Pedro Jose Gil-Vazquez, David Ferreras, Ahmad H. M. Nassar, Virinder K. Bansal, Baki Topal, Jie-Gao Zhu, Shu-Hung Chuang, Rosa Jorba, Mohamed Bekheit, David Martinez-Cecilia, Pablo Parra-Membrives, Georgios Sgourakis, Anne Mattila, Aldo Bove, Silvia Quaresima, Javier Ernesto Barreras Gonzalez, Anil Sharma, Juan Jose Ruiz, Francisco Sanchez-Bueno, Ricardo Robles-Campos, Alberto Martinez-Isla
Summary: This study investigated the current status of laparoscopic management of common bile duct stones with gallbladder in situ (LBDE). The results showed that LBDE is a safe and effective approach when performed by experienced teams. However, the current training for LBDE was considered poor or very poor, indicating a need for the development of training programs for its wider application.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Olivier Govaere, Sine Kragh Petersen, Nuria Martinez-Lopez, Jasper Wouters, Matthias Van Haele, Rosellina M. Mancina, Oveis Jamialahmadi, Orsolya Bilkei-Gorzo, Pierre Bel Lassen, Rebecca Darlay, Julien Peltier, Jeremy M. Palmer, Ramy Younes, Dina Tiniakos, Guruprasad P. Aithal, Michael Allison, Michele Vacca, Melker Goransson, Rolando Berlinguer-Palmini, James E. Clark, Michael J. Drinnan, Hannele Yki-Jarvinen, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Jorn M. Schattenberg, Christopher P. Day, Heather J. Cordell, Baki Topal, Karine Clement, Stefano Romeo, Vlad Ratziu, Tania Roskams, Ann K. Daly, Quentin M. Anstee, Matthias Trost, Anetta Hartlova
Summary: MSR1 plays a critical role in the pathogenesis of obesity-associated NAFLD by regulating lipid uptake and accumulation, influencing hepatic inflammation and metabolic disorder, and could be a potential therapeutic target for the treatment of NAFLD.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
G. Roeyen, F. Berrevoet, I Borbath, K. Geboes, M. Peeters, B. Topal, E. Van Cutsem, J-L Van Laethem
Summary: Pancreatic exocrine insufficiency (PEI) is a common condition in patients with pancreatic cancer (PC). PERT treatment is widely used, but there is limited clinical evidence supporting its effectiveness. More research is needed to evaluate the efficacy of PERT in PC patients.
Article
Gastroenterology & Hepatology
S. De Meulder, X. Sagaert, H. Brems, C. Brekelmans, P. Nafteux, B. Topal, C. Verslype, S. Tejpar, E. Van Cutsem, J. Dekervel
Summary: This study retrospectively analyzed a single-center cohort of patients with gastroesophageal adenocarcinoma in Belgium, and found a low prevalence of MSI-H and EBV+. Among them, MSI-H tumors were more common at the gastroesophageal junction, and one patient with MSI-H metastatic GEC achieved a complete response with nivolumab.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2022)
Article
Surgery
Halit Topal, Joris Jaekers, Joachim Geers, Baki Topal
Summary: This study evaluated the clinical and oncologic outcomes of 3D laparoscopic pancreaticoduodenectomy (3dLPD) with stented pancreaticogastrostomy (sPG) and Roux-en-Y gastroenterostomy (ryGES) in patients with pancreatic or periampullary tumors. The study found that 3dLPD had a high risk of complications, including clinically relevant pancreatic fistula and mortality. However, intraoperatively placed drains were effective in managing complications in some patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Halit Topal, Raymond Aerts, Annouschka Laenen, Andre Collignon, Joris Jaekers, Joachim Geers, Baki Topal
Summary: A comparative study of 396 patients with pancreatic adenocarcinoma found that minimally invasive pancreatic surgery (MIPS) was associated with better long-term overall survival (OS) and disease-free survival (DFS) compared to open pancreatic surgery (OPS).
Article
Oncology
Federica Cappellesso, Marie-Pauline Orban, Niranjan Shirgaonkar, Emanuele Berardi, Jens Serneels, Marie-Aline Neveu, Daria Di Molfetta, Francesca Piccapane, Rosa Caroppo, Lucantonio Debellis, Tessa Ostyn, Nicolas Joudiou, Lionel Mignion, Elena Richiardone, Benedicte F. Jordan, Bernard Gallez, Cyril Corbet, Tania Roskams, Ramanuj DasGupta, Sabine Tejpar, Mario Di Matteo, Daniela Taverna, Stephan J. Reshkin, Baki Topal, Federico Virga, Massimiliano Mazzone
Summary: SLC4A4 inhibition in pancreatic ductal adenocarcinoma (PDAC) improves the acidic tumor microenvironment, enhances T cell-mediated immune response, and suppresses tumor growth and metastasis.
Article
Gastroenterology & Hepatology
Michiel Bronswijk, Giuseppe Vanella, Roy L. J. van Wanrooij, Jayanta Samanta, Jonas Lauwereys, Enrique Perez-Cuadrado-Robles, Giuseppe Dell'Anna, Jahnvi Dhar, Vikas Gupta, Hannah van Malenstein, Wim Laleman, Joris Jaekers, Halit Topal, Baki Topal, Stefano Crippa, Massimo Falconi, Marc G. Besselink, Nouredin Messaoudi, Paolo Giorgio Arcidiacono, Rastislav Kunda, Schalk Van der Merwe
Summary: Same-session double EUS-guided bypass achieves similar technical and clinical success and is associated with fewer overall and severe adverse events compared to surgical gastroenterostomy and hepaticojejunostomy. Median time to oral intake and hospital stay are significantly shortened in the EUS group. Despite a patient population with more comorbidities, EUS-guided bypass shows promise as a less invasive alternative to surgical double bypass.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wout Vermeersch, Halit Topal, Annouschka Laenen, Lawrence Bonne, Eveline Claus, Joris Jaekers, Jacques Pirenne, Baki Topal, Geert Maleux
Summary: Coronary covered stents are a safe and efficient treatment option for late-onset arterial complications after hepato-pancreato-biliary surgery, with an acceptable recurrent bleeding rate and no late, ischemic, parenchymal complications.
ABDOMINAL RADIOLOGY
(2023)
Article
Surgery
Anne-Marleen van Keulen, Stefan Buettner, Joris Erdmann, Johann Pratschke, Francesca Ratti, William R. Jarnagin, Andreas A. Schnitzbauer, Hauke Lang, Andrea Ruzzenente, Silvio Nadalin, Matteo Cescon, Baki Topal, Pim B. Olthof, Bas Groot Koerkamp
Summary: Two preoperative prognostic models were created to predict 90-day mortality and survival after major liver resection for perihilar cholangiocarcinoma. The results showed that 17.6% of patients were suitable for surgical treatment, 26.8% of patients were not suitable for surgical treatment, and 66.2% of patients were in the intermediate risk group. These prognostic models can help identify patients with resectable perihilar cholangiocarcinoma who are unlikely to benefit from surgical resection.
BRITISH JOURNAL OF SURGERY
(2023)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)