4.5 Article

Peptides of CD200 modulate LPS-Induced TNF-α induction and mortality in vivo

期刊

JOURNAL OF SURGICAL RESEARCH
卷 145, 期 1, 页码 87-96

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jss.2007.04.043

关键词

tolerance; immunosuppression; inflammation; immunoglobulin superfamily

类别

向作者/读者索取更多资源

Interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R, expressed on cells of myeloid and lymphoid origin, delivers immunoregulatory signals that modulate inflammation in a number of diseases, including transplant rejection and arthritis. A number of isoforms of CD200R have been described in mice with distinct function. We have synthesized small (9-13 mer) peptides defining distinct regions of CD200, and asked whether different peptides would function as agonists and/or antagonists of different CD200R isoforms. The assays used to characterize these functions include a model of inflammation and tumor necrosis factor-alpha production induced following lipopolysaccharide administration in vivo, and mixed leukocyte cultures in vitro. Discrete agonist and antagonist peptides were defined for different CD200Rs, which suggests this approach may have some clinical utility. (c) 2008 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据