Article
Medicine, Research & Experimental
Tengyang Ni, Haibo Wang, Dongmei Zhan, Li Tao, Mengying Lv, Weimin Wang, Zewen Chu, Zhen Zhou, Masataka Sunagawa, Yanqing Liu
Summary: This study aimed to identify and isolate gastric cancer stem cells, using magnetic-activated cell sorting to isolate CD133+/CD166+ cell populations from human gastric adenocarcinoma cell lines. It was found that these cell populations exhibited more malignant features and higher expression levels of Oct-4 and c-Myc compared to other cell populations. Therefore, CD133+/CD166+ populations in human gastric cancer cell lines BGC-823 and SGC-7901 have cancer stem cell characteristics.
Article
Gastroenterology & Hepatology
Shunsuke Horitani, Toshiro Fukui, Yuji Tanimura, Yasushi Matsumoto, Sachi Miyamoto, Toshihiro Tanaka, Takashi Tomiyama, Tsukasa Ikeura, Yugo Ando, Akiyoshi Nishio, Kazuichi Okazaki
Summary: This study identified the presence of stem-like cells and cancer stem cells in non-neoplastic and neoplastic esophageal epithelia in humans, with pSmad2/3L-Thr serving as a potential biomarker for these cells. The co-localization of pSmad2/3L-Thr-positive cells with specific proteins in different layers of esophageal tissues suggests their involvement in esophageal neoplasms progression.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, Jihye Hwang, Ji Eun Lee, Belong Cho, Yun-Mi Song
Summary: This study evaluated fear of cancer recurrence (FCR) and factors related to FCR in Korean stomach cancer survivors. The results showed that FCR was associated with social, psychological, and health-related quality of life factors, rather than demographic, socioeconomic, or cancer-related factors. This suggests the importance of addressing FCR and providing comprehensive survivorship care for stomach cancer survivors.
Article
Oncology
Cheol Min Shin, Nayoung Kim, Hyuk Yoon, Yoon Jin Choi, Ji Hyun Park, Young Soo Park, Dong Ho Lee
Summary: This study investigated the potential of MOS methylation as a predictor for metachronous recurrence after endoscopic resection of gastric neoplasms. The results showed that high levels of MOS methylation were associated with an increased risk of metachronous recurrence, while OLGA or OLGIM stages were not predictive of the risk. Further validation studies are needed to confirm the usefulness of MOS methylation.
CANCER RESEARCH AND TREATMENT
(2022)
Review
Oncology
Jianhui Yang, Omar Aljitawi, Peter Van Veldhuizen
Summary: This review summarizes the recent research progress on the role of CD133 in prostate cancer stem cells (PCSC), including its selective expression in undifferentiated cells, its correlation to treatment resistance, its gene regulation and functional analysis, and its targeted therapy in vitro, in vivo, and in clinical trials.
Article
Oncology
Ji Soo Park, Eun-Ah Choe, Sejung Park, Chung Mo Nam, Woo Jin Hyung, Sung Hoon Noh, Seoyoung Lee, Hyo Song Kim, Minkyu Jung, Hyun Cheol Chung, Sun Young Rha
Summary: This study compared the prognosis of Korean patients with recurrent gastric cancer based on the presence or absence of cancer-related symptoms at the time of recurrence detection. It found that asymptomatic detection of recurrence was associated with improved survival and suggested the potential benefit of long-term surveillance.
Article
Biochemistry & Molecular Biology
Cynthia M. Simbulan-Rosenthal, Yogameenakshi Haribabu, Sahar Vakili, Li-Wei Kuo, Havens Clark, Ryan Dougherty, Ryyan Alobaidi, Bonnie Carney, Peter Sykora, Dean S. Rosenthal
Summary: This study investigates the underlying mechanisms of CD133's anti-apoptotic activity in malignant melanoma, revealing that CD133 activates a survival pathway and contributes to drug resistance. Targeting the CD133, AKT, or BCL-2 survival pathways shows potential for more effective treatments for high-risk melanoma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Ana R. Flores, Marisa Castro, Alexandra Rema, Joao R. Mesquita, Marian Taulescu, Fatima Gartner, Fernanda Seixas, Irina Amorim
Summary: Gastric carcinoma is a common malignancy in dogs, and the reduced expression of TFF1 protein may play a role in the development and progression of canine gastric cancer. Further studies are needed to determine the potential of TFF1 as a prognostic indicator in canine gastric carcinoma.
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shambhavi Pandey, Myungchul Lee, Jaewoon Lim, Sangbae Park, Yun-Hoon Choung, Jae Eun Kim, Pankaj Garg, Jong Hoon Chung
Summary: In this study, a therapy targeting cancer stem cells and non-stem cells in glioblastoma was developed by using CRISPR/Cas9 and siRNA to suppress key signaling pathways. The combined treatment effectively inhibited tumor growth and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Neli Patricia Pereira Feitosa, Venucia Bruna Magalhaes Pereira, Bruno Gadelha Bezerra Silva, Andreia Victoria Franklin Queroz, Bruno Juca Rodrigues, Marcelo Leite Vieira Costa, Carlos Henrique Alencar, Roberto Cesar Pereira Lima-Junior, Deysi Viviana Tenazoa Wong, Cristiane Cunha Frota, Paulo Roberto Carvalho Almeida
Summary: The expression of CD44 and CD133 varies in gastric cancer, and these markers are not specific to cancer, as they are also present in intestinal metaplasia and normal mucosa.
Article
Medicine, General & Internal
Joon Hyung Jhi, Gwang Ha Kim, Su Jin Park, Dong Uk Kim, Moon Won Lee, Bong Eun Lee, Chae Hwa Kwon, Yoon-Kyoung Cho
Summary: This study found that high levels of CTCs and TWIST (+) CTCs in patients with metastatic gastric cancer are associated with worse overall survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Sergio Gaspar-Figueiredo, Pierre Allemann, Alexander B. J. Borgstein, Gaetan-Romain Joliat, Valentine Luzuy-Guarnero, Christophe Brunel, Christine Sempoux, Suzanne Sarah Gisbertz, Nicolas Demartines, Mark Ivo van Berge Henegouwen, Markus Schafer, Styliani Mantziari
Summary: This study aimed to assess the prognostic value of microscopically positive margins (R1) after gastrectomy on survival and tumor recurrence in diffuse-type gastric cancer (DTGC) patients. It showed that patients with R1 had poorer overall survival and disease-free survival, as well as higher early tumor recurrence rates. Therefore, achieving R0 resection should be pursued whenever possible.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Review
Cell Biology
Oleg Shuvalov, Alyona Kizenko, Alexey Petukhov, Olga Fedorova, Alexandra Daks, Nikolai Barlev
Summary: CTAs are proteins strictly expressed in male reproductive tissues under normal conditions, but are frequently re-expressed in neoplastic tissues upon malignisation, affecting tumor cell growth, migration, and invasion. SEMGs, major components of human seminal fluid, play a role in sperm motility and capacitation, and their re-expression in different malignancies including breast cancer is known, but their functional properties in cancer cells remain largely unknown.
CELL DEATH DISCOVERY
(2021)
Review
Biochemical Research Methods
Mohammad Rizwan Alam, Kyung Jin Seo, Jamshid Abdul-Ghafar, Kwangil Yim, Sung Hak Lee, Hyun-Jong Jang, Chan Kwon Jung, Yosep Chong
Summary: The status of predicting gene mutations on histologic images using artificial intelligence (AI) models was assessed through a systematic review. The study found that while the accuracy of predicting cancer driver gene mutations in specific organs was relatively high, the overall accuracy of gene mutation prediction needs improvement. Therefore, further validation with larger datasets is necessary before AI models can be used in clinical practice to predict gene mutations.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Hyeonhui Kim, Hyo-Suk Ahn, Nahee Hwang, Yune Huh, Seonghyeon Bu, Kyung Jin Seo, Se Hwan Kwon, Hae-Kyung Lee, Jae-woo Kim, Bo Kyung Yoon, Sungsoon Fang
Summary: After the outbreak of the SARS-CoV-2 pandemic, a novel mRNA vaccine (BNT162b2) was developed at an unprecedented speed. Although widespread immunity has been achieved through vaccination and infections, even individuals who have recovered from SARS-CoV-2 infection are recommended to receive BNT162b2 vaccination due to its effectiveness in lowering the risk of recurrent infection. However, the BNT162b2 vaccine has been reported to increase the risk of myocarditis. This study tracked changes in chromatin dynamics in peripheral blood mononuclear cells (PBMCs) of a patient who developed myocarditis after BNT162b2 vaccination, revealing alterations in interferon signaling and RUNX2/3 activity.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sung Soo Park, Young Mi Ku, Kyung Jin Seo, In Yong Whang, Yun Sup Hwang, Min Ji Kim, Na Young Jung
Summary: This study investigates the use of a deep neural network based algorithm to filter mammography phantom images that will pass or fail. Based on 543 phantom images from a mammography unit, VGG16 based phantom shape scoring models were created, and filtering algorithms were designed to filter out failed or passed phantom images. External validation using 61 phantom images from two different medical institutions showed that the scoring models achieved F1-scores of 0.69 (95% confidence interval 0.65, 0.72) for multi-class classifiers and 0.93 (95% CI 0.92, 0.95) for binary-class classifiers, with an area under the receiver operating characteristic curve of 0.97 (95% CI 0.96, 0.98). Out of the 61 phantom images, 42 (69%) were filtered by the algorithms without the need for further assessment by a human observer. This study demonstrates the potential of using deep neural network based algorithms to reduce the human workload in mammographic phantom interpretation.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Reshmee Bhattacharya, Mohammad Rizwan Alam, Mohammad Azhar Kamal, Kyung Jin Seo, Laishram Rajendrakumar Singh
Summary: Advanced glycation end-products (AGEs) are toxic compounds that modify proteins and interact with their receptor RAGE, leading to various pathological consequences in the brain. Recent research has shown the involvement of the AGE-RAGE axis in neurodegenerative diseases, such as disruption of blood brain barrier and dysregulation of antioxidant enzymes. Specific inhibitors of TIR domains of TLR or RAGE receptors are considered to be important for the therapeutic intervention of these diseases. Clinical perspectives have also been discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Jamshid Abdul-Ghafar, Kyung Jin Seo, Hye-Ra Jung, Gyeongsin Park, Seung-Sook Lee, Yosep Chong
Summary: This study evaluated the prediction accuracy of the ImmunoGenius software using nationwide data to validate its clinical utility for hematolymphoid neoplasms. The results showed high diagnostic accuracy for lymphoid neoplasms.
Review
Oncology
Chul-Hyo Jeon, So-Jung Kim, Han-Hong Lee, Kyo-Young Song, Ho-Seok Seo
Summary: ICG-guided robotic gastrectomy improves the chances of achieving proper lymphadenectomy in gastric cancer cases, suggesting its potential as a promising surgical approach.
Article
Cell Biology
Hong Sik Park, Yosep Chong, Yujin Lee, Kwangil Yim, Kyung Jin Seo, Gisu Hwang, Dahyeon Kim, Gyungyub Gong, Nam Hoon Cho, Chong Woo Yoo, Hyun Joo Choi
Summary: This study evaluates the diagnostic accuracy of an artificial intelligence-based model in detecting malignant pleural effusion cytology associated with breast cancer. The deep convolutional neural network model (DCNN) outperforms pathologists in terms of accuracy, sensitivity, and specificity. The study highlights the potential of DCNN to support pathologists in diagnosing malignant pleural effusion cytology.
Editorial Material
Medicine, General & Internal
Yeongjoo Lee, Hye Sung Won, Kyung Jin Seo, Sae Jung Na
Summary: This article presents an interesting case of distant lymph node metastasis in a patient with common bile duct cancer, which was detected using F-18-FDG PET scanning.
Editorial Material
Medicine, General & Internal
Yoo Dong Won, Su Lim Lee, Kyung Jin Seo
Summary: A rare case of metastatic urothelial carcinoma of the renal pelvis presenting as a duodenal ulcer in a 78-year-old male patient is reported. Endoscopic examination revealed an ulcerative lesion in the duodenum, while colonoscopy showed no abnormalities. Computed tomography revealed tumor infiltration in multiple tissues. Histopathology and immunohistochemistry confirmed the diagnosis of metastatic urothelial carcinoma.
Editorial Material
Medicine, General & Internal
Jiwon Lee, Seoyeon Shin, Jin-Hwi Kim, Su Lim Lee, Yosep Chong, Kyung Jin Seo, Kwangil Yim
Summary: In this case study, a 49-year-old female patient with menorrhagia was initially suspected to have cervical squamous cell carcinoma based on magnetic resonance imaging (MRI) findings. However, histological examination confirmed the lesion to be angioleiomyoma after hysterectomy. This is the first reported case of angioleiomyoma presenting with MRI findings suggestive of uterine SCC. Recognizing the imaging mimics of angioleiomyomas can be beneficial for accurate diagnosis and appropriate treatment strategies.
Article
Oncology
Ho Seok Seo, Sojung Kim, Kyo Young Song, Han Hong Lee
Summary: This study aimed to determine the feasibility of 3-port totally laparoscopic total gastrectomy (TLTG) with overlapping esophagojejunal (EJ) anastomosis for gastric cancer surgery. The results showed that performing total gastrectomy with overlapping EJ anastomosis using a 3-port approach is a feasible reduced port surgery (RPS) procedure for treating gastric cancer.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Oncology
Hyun Joo Yoo, Hayemin Lee, Han Hong Lee, Jun Hyun Lee, Kyong-Hwa Jun, Jin-jo Kim, Kyo-young Song, Dong Jin Kim
Summary: This study aimed to develop a nomogram for estimating the risk of extraperigastric lymph node metastasis (LNM) in early gastric cancer (EGC). The possible risk factors for extraperigastric LNM were determined through comparing the clinicopathological characteristics of positive and negative LNM groups and conducting univariate and multivariate analyses. A risk prediction model was developed based on these factors, and it showed good agreement in internal validation.
JOURNAL OF GASTRIC CANCER
(2023)
Meeting Abstract
Medicine, Research & Experimental
Yosep Chong, Kwangil Yim, Jamshid Abdul-Ghafar, Kyung Jin Seo, Ok Ran Shin, Gisu Hwang
LABORATORY INVESTIGATION
(2023)
Article
Medicine, General & Internal
Kwangil Yim, Won Mo Jang, Uiju Cho, Der Sheng Sun, Yosep Chong, Kyung Jin Seo
Summary: This study examined the prognostic factors and neoadjuvant therapy effect prediction in patients with advanced or unresectable CRC, finding that high-grade ITB may be associated with unfavorable prognosis, while immature DR, TSR, and KM grade cannot predict prognosis or therapy response.
MEDICINA-LITHUANIA
(2022)
Meeting Abstract
Oncology
Kwangil Yim, Won Mo Jang, Yosep Chong, O. K. Ran Shin, Kyung Jin Seo