期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 106, 期 4, 页码 386-392出版社
WILEY-BLACKWELL
DOI: 10.1002/jso.23095
关键词
CX3CL1; breast carcinoma; CD8+T cells; natural killer cells; dendritic cells; prognosis
资金
- Research Institute of Medical Sciences, Chonnam National University [2010-CURIMS-DR010]
- Chonnam National University [2010-CURIMS-DR010]
- Ministry of Education, Science and Technology [2011-0030034]
- Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea(NRF)
- National Research Foundation of Korea [2011-0030034] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background CX3CL1 is the only CX3C chemokine that can chemoattract T cells, natural killer (NK) cells, and dendritic cells (DCs). The role of CX3CL1 in breast carcinoma remains unknown. Methods Immunohistochemical staining for CX3CL1, CD8, CD57, and CD1a was performed on 204 breast carcinoma specimens using tissue microarray blocks to determine whether CX3CL1 expression correlated with a good prognosis and antitumor immunity. Results The number of stromal CD8+ T cells, intratumoral CD1a+ DCs, and stromal CD57+ NK cells were significantly increased in the high CX3CL1 expression group compared with those in the low CX3CL1expression group. Patients with high CX3CL1 expression had a significantly better disease-free and overall survival than those with low CX3CL1 expression (P?=?0.002 and P?
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