Article
Biochemistry & Molecular Biology
Anna Minaidou, Stella Tamana, Coralea Stephanou, Maria Xenophontos, Cornelis L. Harteveld, Celeste Bento, Marina Kleanthous, Petros Kountouris
Summary: This article presents an online tool called IthaCNVs, which aids in the diagnosis of haemoglobinopathies associated with copy number variants (CNVs). The tool allows filtering of entries based on breakpoint information, chromosomal and locus positions, MLPA probes, and affected genes, assisting laboratory staff and clinicians in confirming the diagnosis of CNVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Timothy E. Richardson, Jamie M. Walker, Kalil G. Abdullah, Samuel K. McBrayer, Mariano S. Viapiano, Zarmeen M. Mussa, Nadejda M. Tsankova, Matija Snuderl, Kimmo J. Hatanpaa
Summary: Chromosomal instability (CIN) is a fundamental property of cancer and a key mechanism of tumorigenesis and progression. It is found in various cancers and is associated with poor clinical outcomes. However, there have been relatively few studies on this process, mainly due to the difficulty of measuring it clinically.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Oncology
Juanli Qiao, Yuan Tian, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing, Dajun Deng
Summary: The study suggests that somatic copy number deletion of the CDKN2A gene may drive gastric cancer metastasis and could serve as a predictor for hematogenous metastasis of gastric cancers.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vincenza Ylenia Cusenza, Alessandra Bisagni, Monia Rinaldini, Chiara Cattani, Raffaele Frazzi
Summary: Cytogenetic and molecular assessments play crucial roles in the diagnosis and treatment of cancer. Laboratory approaches like multiplex ligation-dependent probe amplification and droplet digital PCR are exceptional tools for detecting genetic alterations accurately and sensitively in molecular oncology. Personalized medicine relies on the correct and reliable molecular characterization of diseases, influencing therapeutic choices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ako Matsuhashi, Shota Tanaka, Hirokazu Takami, Masashi Nomura, Masako Ikemura, Yoshitaka Matsubayashi, Yusuke Shinoda, Keisuke Yamada, Yu Sakai, Yasuaki Karasawa, Shunsaku Takayanagi, Nobuhito Saito
Summary: This article presents a case of vertebral metastasis in a patient with glioblastoma. The study found that younger age at initial presentation, multiple surgical interventions, and long overall survival seem to be risk factors for vertebral metastasis. As the prognosis of glioblastoma improves over time, vertebral metastasis appears to be more common, therefore extradural metastasis should be considered in the treatment of glioblastoma. Further genomic analysis on multiple paired specimens is necessary to elucidate the molecular mechanisms of vertebral metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Teresa Ramone, Chiara Mule, Raffaele Ciampi, Valeria Bottici, Virginia Cappagli, Alessandro Prete, Antonio Matrone, Paolo Piaggi, Liborio Torregrossa, Fulvio Basolo, Rossella Elisei, Cristina Romei
Summary: The study clarified the prevalence of RET gene CNVs in sporadic MTC cases and their potential role in MTC development. Results showed that RET gene CNVs are rare events in sporadic MTC and are associated with RET somatic mutation, suggesting that they may not be a primary driver mechanism of tumoral transformation.
Article
Oncology
B. B. M. Suelmann, A. Rademaker, C. van Dooijeweert, E. van der Wall, P. J. van Diest, C. B. Moelans
Summary: This study provides insights into the genomic background of triple-negative breast cancer during pregnancy and identifies CNAs that are associated with prognosis. FGFR1 loss and TOP2A loss may serve as biomarkers for poor prognosis and provide clues for personalized therapy.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Pathology
Pier Selenica, Barbara Alemar, Cathleen Matrai, Karen L. Talia, Emanuela Veras, Yaser Hussein, Esther Oliva, Regina G. H. Beets-Tan, Yoshiki Mikami, W. Glenn McCluggage, Takako Kiyokawa, Britta Weigelt, Kay J. Park, Rajmohan Murali
Summary: In this study, genetic alterations in a large cohort of gastric-type cervical adenocarcinomas (GCA) and other related adenocarcinomas were analyzed and compared. It was found that GCAs commonly harbor mutations in TP53, CDKN2A, KRAS, and STK11, and exhibit low levels of copy number alterations. GCAs show distinctive genetic mutation characteristics compared to other adenocarcinomas, with higher mutation frequencies in certain genes.
Article
Cell Biology
Wei Chen, Jian Zhang, Huafeng Fu, Xun Hou, Qiao Su, Yulong He, Dongjie Yang
Summary: Gastric cancer is the third leading cause of cancer death globally. This study revealed that KLF5 amplification and over-expression in gastric cancer may support cell proliferation, suggesting an oncogene-like role for KLF5 in gastric cancer. The findings also showed a correlation between higher KLF5 expression and more locally invasive gastric cancer with higher T stage.
Article
Biology
Ba Van Vu, Quyet Nguyen, Yuki Kondo-Takeoka, Toshiki Murata, Naoki Kadotani, Giang Thi Nguyen, Takayuki Arazoe, Shuichi Ohsato, Hitoshi Nakayashiki
Summary: In fungi, homologous recombination and RNA silencing mechanisms cooperatively regulate the de novo DNA methylation of transposable elements such as MAGGY, with RecA domain-containing proteins and uncharacterized Ddnm1 protein forming complexes to mediate the process. Mutants of specific RNA silencing components in Pyricularia oryzae show impaired copy number-dependence of MAGGY methylation, suggesting a physical interaction between RNA silencing machinery and homologous recombination components.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
G. Yahya, P. Menges, P. S. Amponsah, D. A. Ngandiri, D. Schulz, A. Wallek, N. Kulak, M. Mann, P. Cramer, V Savage, M. Raeschle, Z. Storchova
Summary: Ploidy changes are common in nature and have significant impacts on evolution, functional specialization, and tumorigenesis. This study reveals that gene expression scales allometrically with cellular ploidy, and the scaling is achieved through decreased rRNA and ribosomal protein abundance and reduced translation. The reduced activity of Tor1 with increasing ploidy leads to diminished rRNA gene repression, which is regulated by the Tor1-Sch9-Tup1 signaling pathway. The mTORC1-Sch9/S6K-Tup1/TLE1 pathway plays a crucial role in proteome remodeling in response to increased ploidy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Karen Gambaro, Maud Marques, Suzan McNamara, Mathilde Couetoux du Tertre, Zuanel Diaz, Cyrla Hoffert, Archana Srivastava, Steven Hebert, Benoit Samson, Bernard Lesperance, Yoo-Joung Ko, Richard Dalfen, Eve St-Hilaire, Lucas Sideris, Felix Couture, Ronald Burkes, Mohammed Harb, Errol Camlioglu, Adrian Gologan, Vincent Pelsser, Andre Constantin, Celia M. T. Greenwood, Sabine Tejpar, Petr Kavan, Claudia L. Kleinman, Gerald Batist
Summary: A study on genomic plasticity in liver metastatic samples of colorectal cancer revealed an increased frequency of specific CN in metastatic lesions after first-line treatment. Comparison of CNA profiles in lesions with different treatment responses showed focal genomic divergences in post-treatment resistant lesions but not in responder lesions. Examining metastatic lesions is crucial as 15 out of 18 independently validated CNA regions associated with progression-free survival were only identified in metastatic lesions, not in primary tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Fumi Murakami, Yumi Tsuboi, Yuka Takahashi, Yoshiya Horimoto, Kaoru Mogushi, Takeshi Ito, Mitsuru Emi, Daisuke Matsubara, Tatsuhiro Shibata, Mitsue Saito, Yoshinori Murakami
Summary: Copy number variation (CNV) is a common polymorphism in the human genome, with somatic alterations at CNV sites detected in 39.9% of the CNV probes examined in invasive breast cancers. The most frequently altered regions included gains of 1q21-22, 8q21-24, 1q44, 3q11, and losses of 16q22-24. Gene ontology analysis revealed correlations between CNAs and transcription/RNA metabolism in relation to HER2 positivity and menopausal status in breast cancer patients.
Article
Biochemistry & Molecular Biology
Nick Riddiford, Katarzyna Siudeja, Marius van den Beek, Benjamin Boumard, Allison J. Bardin
Summary: Studying neoplasia in Drosophila has provided insights into the impact of spontaneous mutations on early cancer development. Using whole-genome sequencing data from neoplasia in the fly intestine, key gene abnormalities driving tumor formation were identified. The genomic mutational burden in fly neoplasia was found to be similar to several human cancers, shedding light on mutational dynamics over a short timescale.
Article
Anatomy & Morphology
Huiyuan Guan, Xin Wang, Yongxi Song, Peng Gao, Yuan Li, Zhonghua Wu, Jinliang Zhu, Zhenning Wang
Summary: The study found that the expression pattern and prognosis of CSF1R are closely related in colorectal cancer, with expression on the cell membrane reducing its prognostic predictive value.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jaffer A. Ajani, Yan Xu, Longfei Huo, Ruiping Wang, Yuan Li, Ying Wang, Melissa Pool Pizzi, Ailing Scott, Kazuto Harada, Lang Ma, Xiaodan Yao, Jiankang Jin, Wei Zhao, Xiaochuan Dong, Brian D. Badgwell, Namita Shanbhag, Ghia Tatlonghari, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Makoto Kobayashi, Jody V. Vykoukal, Samir M. Hanash, George Adrian Calin, Guang Peng, Ju-Seog Lee, Randy L. Johnson, Zhenning Wang, Linghua Wang, Shumei Song
Summary: YAP1 is highly upregulated in peritoneal carcinomatosis tumor cells, contributing to cancer stem cell properties and metastasis. Inhibition of YAP1 can significantly slow tumor growth and eliminate peritoneal carcinomatosis in preclinical models. Pharmacological inhibition of YAP1 can reduce cancer stem cell-like properties and suppress tumor growth, especially in combination with cytotoxic drugs in vivo models.
Article
Gastroenterology & Hepatology
Jin-yu Huang, Wei-lan Zhang, Ya-nan Xing, Wen-bin Hou, Song-cheng Yin, Zhen-ning Wang, Yu-en Tan, Ying-ying Xu, Zhi Zhu, Hui-mian Xu
Summary: High expression of LIPC is associated with poor clinical outcomes and plays an important role in regulating cell migration and invasion in Borrmann type 4 gastric cancer. High LIPC expression correlates with lymph node metastasis, advanced TNM stage, and poor overall survival in Borrmann type 4 gastric cancer patients. By reducing LIPC expression, cell invasion and migration are suppressed and specific gene expression is altered in Borrmann type 4 gastric cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Pengfei Gu, Jingyu Deng, Zhe Sun, Zhenning Wang, Wei Wang, Han Liang, Huimian Xu, Zhiwei Zhou
Summary: The study compared different staging systems for predicting the prognosis of gastric cancer patients, finding that the LODDS staging system was superior to other lymph-node classifications. For predicting the prognosis of GC patients, the modified TLM staging system showed better discriminative ability and optimistic prognostic stratification compared to the 8th TNM or TRM staging systems.
Article
Oncology
Linhao Tong, Weixu Zhang, Bicheng Qu, Fei Zhang, Zhonghua Wu, Jinxin Shi, Xiaowan Chen, Yongxi Song, Zhenning Wang
Summary: This study found that higher levels of tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients, and tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing the tumor suppressor NELL2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Meng-Shen Wang, Mo-Zhi Wang, Zhenning Wang, Yongxi Song, Peng Gao, Pengliang Wang, Chong Wang, Xueting Yu, Fengheng Wei, Jingyi Guo, Yingying Xu
Summary: A study investigated axillary lymph node staging in breast cancer patients, finding that the LODDS method showed better performance in prognosis evaluation, aiding in assessing survival differences among patients with negative lymph node staging and guiding postoperative treatment.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Xuan-zhang Huang, Jun-hua Zhao, Peng Gao, Xiao-wan Chen, Yong-xi Song, Yan Xu, Qiong Xiao, Song-chen Dai, Jia-yi Li, Zhen-ning Wang
Summary: This meta-analysis of 121 high-quality articles found that CWI with local anesthetic can effectively reduce postoperative pain and increase satisfaction with analgesia in abdominal surgeries, but did not show significant analgesic benefits in laparoscopic surgeries.
Article
Gastroenterology & Hepatology
Xiaochuan Dong, Shumei Song, Yuan Li, Yibo Fan, Lulu Wang, Ruiping Wang, Longfei Huo, Ailing Scott, Yan Xu, Melissa Pool Pizzi, Lang Ma, Ying Wang, Jiangkang Jin, Wei Zhao, Xiaodan Yao, Randy L. Johnson, Linghua Wang, Zhenning Wang, Guang Peng, Jaffer A. Ajani
Summary: Genetic alterations in ARID1A were found in over 30% of gastric adenocarcinoma cases, and the loss of ARID1A leads to activation of the mTOR pathway and increased sensitivity to mTOR inhibitors, suggesting a new therapeutic strategy for targeting the mTOR pathway in patients with gastric adenocarcinoma with ARID1A deficiency.
Article
Biotechnology & Applied Microbiology
Jia-yi Li, Xuan-zhang Huang, Peng Gao, Xiao-wan Chen, Yong-xi Song, Xing-er Lv, Yv Fu, Qiong Xiao, Zhen-ning Wang
Summary: For patients with LARC who have received neoadjuvant treatment and surgery, adjuvant chemotherapy improves overall survival and disease-free survival compared to observation. However, adding oxaliplatin to fluorouracil-based adjuvant chemotherapy does not provide additional survival benefits.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Yu Fu, Xiaowan Chen, Yongxi Song, Xuanzhang Huang, Quan Chen, Xinger Lv, Peng Gao, Zhenning Wang
Summary: Our study found that platelet to lymphocyte ratio (PLR) is an effective marker to predict the effects of chemotherapy in patients with stage II colorectal cancer. In the low-PLR subgroup, chemotherapy did not significantly improve overall survival compared to non-chemotherapy patients, while in the high-PLR subgroup, chemotherapy patients had a significantly longer overall survival.
Review
Chemistry, Medicinal
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Xu
Summary: Gastric cancer is a common global cancer, and dysregulation of the Hippo signaling pathway may be related to its development and drug resistance. YAP, as a crucial co-transcription factor, is a potential drug target for treating gastric cancer, and various drugs inhibiting YAP have been developed.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Jia-Yi Li, Xuan-Zhang Huang, Peng Gao, Yong-Xi Song, Xiao-Wan Chen, Xing-Er Lv, Yv Fu, Qiong Xiao, Shi-Yv Ye, Zhen-Ning Wang
Summary: The study found that patients with rectal cancer achieving pathologic complete response (pCR) had significantly higher 10-year overall survival and 5-year disease-free survival compared to those in the non-pCR group. Improvement in tumor regression after neoadjuvant therapy was associated with increased overall survival and disease-free survival, and the pCR group had longer overall survival and disease-free survival than the non-pCR group. The results suggest a positive relationship between better tumor regressions and improved survival benefits, highlighting the importance of achieving pCR in the treatment of rectal cancer.
Article
Chemistry, Multidisciplinary
Hanwei Huang, Mingyang Liu, Mengchi Sun, Shijie Duan, Siwei Pan, Pengfei Liu, Zhenguo Cheng, Onder Ergonul, Fusun Can, Zhenning Wang, Zhiqing Pang, Funan Liu
Summary: Preventing the interaction between oncolytic adenoviruses (OVs) and key virus-protein corona components in the plasma can significantly prolong circulation time and improve tumor distribution, leading to enhanced antitumor efficacy. This finding provides a new perspective on intravenous delivery of OVs.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Medicine, General & Internal
Kai-Wen Tang, Zhe-Xu Guo, Zhong-Hua Wu, Cen Zhou, Jie Sun, Xin Wang, Yong-Xi Song, Zhen-Ning Wang
Summary: This study reveals that the novel circRNA circ_0049447 is downregulated in gastric cancer and acts as a tumor suppressor by reducing proliferation, migration, invasion, and EMT. It also serves as a promising biomarker for diagnosis with high sensitivity and specificity.
CHINESE MEDICAL JOURNAL
(2021)
