4.2 Article

Cognitive, On-road, and Simulator-based Driving Assessment after Stroke

期刊

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 23, 期 10, 页码 2654-2670

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.jstrokecerebrovasdis.2014.06.010

关键词

Stroke; driving; driving simulation; on-road; cognitive; assessment

资金

  1. Heart and Stroke Foundation of Canada
  2. Ontario Ministry of Research and Innovation

向作者/读者索取更多资源

Driving is a complex activity that requires intact cognitive, behavioral, and motor function. Stroke is one of the most prevalent neurologic impairments and can affect all of these functions. However, diagnosis of stroke is not a definitive indicator of driving impairment. Determining fitness to drive after stroke is a very complex process and is typically based on cognitive assessments, on-road performance, simulator based assessment, or a combination of the three. The aim of this review was to provide (1) a systematic review of the literature on cognitive, on-road, and simulator assessment after stroke, and (2) address the existing limitations and inconsistencies in stroke and driving research. Our results indicated that of 1413 total stroke patients, 748 definitively passed and 367 definitely failed an on-road assessment, with minimal information provided about clinical presentation. In addition, although the Stroke Driver Screening Assessment, the Useful Field of View Test, and the Rey-O Complex Figure test may have some utility in predicting driving performance, most cognitive measures have been inconsistently and minimally explored. Several limitations were observed across studies such as procedural inconsistencies, including outcome variables used (eg, driving cessation and pass/ fail classification) and the heterogeneity of patient samples (eg, time since stroke and stroke location). Due, in part, to the larger variability in results of cognitive, on-road, and simulator-based assessment, there is no consensus regarding a valid and reliable driving assessment for physicians. Future studies should assess poststroke driving fitness by differentiating different stages, severities, and locations of stroke.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Clinical Neurology

Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort

Kelly M. Sunderland, Derek Beaton, Stephen R. Arnott, Peter Kleinstiver, Donna Kwan, Jane M. Lawrence-Dewar, Joel Ramirez, Brian Tan, Robert Bartha, Sandra E. Black, Michael Borrie, Donald Brien, Leanne K. Casaubon, Brian C. Coe, Benjamin Cornish, Allison A. Dilliott, Dar Dowlatshahi, Elizabeth Finger, Corinne Fischer, Andrew Frank, Julia Fraser, Morris Freedman, Barry Greenberg, David A. Grimes, Ayman Hassan, Wendy Hatch, Robert A. Hegele, Christopher Hudson, Mandar Jog, Sanjeev Kumar, Anthony Lang, Brian Levine, Wendy Lou, Jennifer Mandzia, Connie Marras, William McIlroy, Manuel Montero-Odasso, David G. Munoz, Douglas P. Munoz, Joseph B. Orange, David S. Park, Stephen H. Pasternak, Frederico Pieruccini-Faria, Tarek K. Rajji, Angela C. Roberts, John F. Robinson, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christopher J. M. Scott, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Michael J. Strong, Stephen C. Strother, Richard H. Swartz, Sean Symons, David F. Tang-Wai, Maria Carmela Tartaglia, Angela K. Troyer, John Turnbull, Lorne Zinman, Paula M. McLaughlin, Mario Masellis, Malcolm A. Binns

Summary: This is a multi-site, longitudinal, observational cohort study that aims to understand the impact of neurodegenerative and cerebrovascular diseases on dementia presentation. The study recruited 520 participants with prevalent neurodegenerative and cerebrovascular diseases and comprehensively assessed them. Results showed that the participants were predominantly White males with higher education levels. The data will be shared with the global scientific community to identify markers of disease severity, progression, and therapy targets.

ALZHEIMERS & DEMENTIA (2023)

Article Cardiac & Cardiovascular Systems

Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke

Di Yu, Nuanyi Liang, Julia Zebarth, Qing Shen, Miracle Ozzoude, Maged Goubran, Jennifer S. Rabin, Joel Ramirez, Christopher J. M. Scott, Fuqiang Gao, Robert Bartha, Sean Symons, Seyyed Mohammad Hassan Haddad, Courtney Berezuk, Brian Tan, Donna Kwan, Robert A. Hegele, Allison A. Dilliott, Nuwan D. Nanayakkara, Malcolm A. Binns, Derek Beaton, Stephen R. Arnott, Jane M. Lawrence-Dewar, Ayman Hassan, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Leanne Casaubon, Gustavo Saposnik, Yurika Otoki, Krista L. Lanctot, Mario Masellis, Sandra E. Black, Richard H. Swartz, Ameer Y. Taha, Walter Swardfager

Summary: A study found that cerebral small vessel disease is associated with the ratio of certain fatty acid metabolites, and this association has not been examined in stroke patients before. The study analyzed clinical and imaging data of stroke patients and found that the ratio of these fatty acid metabolites is related to small vessel stroke, white matter hyperintensities, and temporal lobe atrophy.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2023)

Article Clinical Neurology

Rare neurovascular genetic and imaging markers across neurodegenerative diseases

Allison A. Dilliott, Stephanie A. Berberian, Kelly M. Sunderland, Malcolm A. Binns, Julia Zimmer, Miracle Ozzoude, Christopher J. M. Scott, Fuqiang Gao, Anthony E. Lang, David P. Breen, Maria C. Tartaglia, Brian Tan, Richard H. Swartz, Ekaterina Rogaeva, Michael Borrie, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, Sanjeev Kumar, Stephen Pasternak, Bruce G. Pollock, Tarek K. Rajji, David F. Tang-Wai, Agessandro Abrahao, John Turnbull, Lorne Zinman, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, David Grimes, Connie Marras, Thomas Steeves, Mario Masellis, Sali M. K. Farhan, Robert Bartha, Sean Symons, Robert A. Hegele, Sandra E. Black, Joel Ramirez

Summary: This study investigated the burden of cerebral small vessel disease (SVD) in patients with neurodegenerative diseases as a function of rare genetic variant carrier status. The NOTCH3/HTRA1 variants were found to significantly influence SVD neuroimaging outcomes, but the mechanisms and clinical implications are still unknown. Further studies are needed to develop genetic and imaging markers to enhance our understanding of their potential contribution to neurodegenerative diseases.

ALZHEIMERS & DEMENTIA (2023)

Article Rehabilitation

Responsiveness of the Reaching Performance Scale for Stroke

Sandeep K. Subramanian, Gita Margolese, Andrea Turolla, Gustavo Saposnik, Mindy F. Levin

Summary: The study aimed to estimate the responsiveness of the RPSS in individuals with stroke. The findings demonstrated that the RPSS had high internal responsiveness and positive correlations with FMA-UE scores. Therefore, using the RPSS along with the FMA-UE can provide a comprehensive assessment of motor improvement in poststroke upper limb.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2023)

Article Neurosciences

Men Are at Higher Risk of Screening Positive for Vascular Cognitive Impairment Compared to Women after Stroke and Transient Ischemic Attack

Julia Zinman, Arunima Kapoor, Kevin Si, Sajeevan Sujanthan, Alisia Southwell, Megan L. Cayley, Michelle N. Sicard, Karen Lien, Brian J. Murray, Krista Lanctot, Nathan Herrmann, Dar Dowlatshahi, Demetrios J. Sahlas, Gustavo Saposnik, Jennifer L. Mandzia, Leanne K. Casaubon, Ayman Hassan, Yael Perez, Richard H. Swartz

Summary: This study examined sex differences in the risk of cognitive impairment after stroke. Men showed a higher risk of cognitive impairment after adjusting for age, education, stroke severity, and vascular risk factors, suggesting that other factors may contribute to increased risk among men.

JOURNAL OF ALZHEIMERS DISEASE (2023)

Article Clinical Neurology

Understanding social media: how its popularity could be used to advance medical education in stroke care?

Gustavo Saposnik

Summary: The wide availability of social media has greatly influenced human interactions and education in various settings. Users spend a significant amount of time on social media platforms each day, which reshape their perceptions, choices, and communication. The science behind social media lies in the activation of brain reward pathways, which explains the success of platforms like TikTok. Understanding users' interests, access patterns, and screen time is crucial in advancing medical education and stroke care. New strategies utilizing engaging learning technologies and social media platforms are needed to enhance educational content delivery and provide rewarding experiences.

JOURNAL OF NEUROLOGY (2023)

Article Clinical Neurology

Specialist Perspectives on the Imaging Selection of Large Vessel Occlusion in the Late Window

Piers Klein, Xiaochuan Huo, Yimin Chen, Mohamad Abdalkader, Zhongming Qiu, Simon Nagel, Jean Raymond, Liping Liu, James E. Siegler, Daniel Strbian, Thalia S. Field, Shadi Yaghi, Muhammad M. Qureshi, Jelle Demeestere, Volker Puetz, Anne Berberich, Patrik Michel, Urs Fischer, Johannes Kaesmacher, Hiroshi Yamagami, Fana Alemseged, Georgios Tsivgoulis, Wouter J. Schonewille, Wei Hu, Xinfeng Liu, Chuanhui Li, Xunming Ji, Brian Drumm, Soma Banerjee, Simona Sacco, Else C. Sandset, Espen Saxhaug Kristoffersen, Peter Slade, Robert Mikulik, Michele Romoli, Francesco Diana, Kailash Krishnan, Permesh Dhillon, Jin Soo Lee, Ekkehard Kasper, Hormuzdiyar Dasenbrock, Mai Duy Ton, Rytis Masiliunas, Anita Ante Arsovska, Joao Pedro Marto, Adam A. Dmytriw, Robert W. Regenhardt, Gisele Sampaio Silva, Timo Siepmann, Dapeng Sun, Hongfei Sang, Jose Danilo Diestro, Pengfei Yang, Mahmoud H. Mohammaden, Fengli Li, Hesham E. Masoud, Alice Ma, Aravind Ganesh, Jianmin Liu, Lukas Meyer, Diederik W. J. Dippel, Goetz Thomalla, Mark Parsons, Adnan I. Qureshi, Mayank Goyal, Albert J. Yoo, Bertrand Lapergue, Osama O. Zaidat, Hui-Sheng Chen, Bruce C. V. Campbell, Tudor G. Jovin, Raul G. Nogueira, Zhongrong Miao, Gustavo Saposnik, Thanh N. Nguyen

Summary: The imaging modality used for selecting patients for endovascular thrombectomy (EVT) in the late window varies among clinicians with different specialty training. In an international survey, interventionists were more likely to proceed directly to EVT and prefer less advanced imaging techniques compared to non-interventionists. When faced with uncertainty, non-interventionists were more likely to follow clinical guidelines, while interventionists relied more on their assessment of evidence.

CLINICAL NEURORADIOLOGY (2023)

Article Clinical Neurology

White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

Miracle Ozzoude, Brenda Varriano, Derek Beaton, Joel Ramirez, Sabrina Adamo, Melissa Holmes, Christopher J. M. Scott, Fuqiang Gao, Kelly Sunderland, Paula McLaughlin, Maged Goubran, Donna Kwan, Angela Roberts, Robert Bartha, Sean Symons, Brian Tan, Richard Swartz, Agessandro Abrahao, Gustavo Saposnik, Mario Masellis, Anthony Lang, Connie Marras, Lorne Zinman, Christen Shoesmith, Michael Borrie, Corinne Fischer, Andrew Frank, Morris Freedman, Manuel Montero-Odasso, Sanjeev Kumar, Stephen Pasternak, Stephen Strother, Bruce Pollock, Tarek Rajji, Dallas Seitz, David Tang-Wai, John Turnbull, Dar Dowlatshahi, Ayman Hassan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, David A. Breen, David Grimes, Mandar Jog, Thomas D. L. Steeves, Stephen Arnott, Sandra Black, Elizabeth Finger, Jennifer Rabin, Maria Carmela Tartaglia

Summary: White matter hyperintensities and cortical thickness are both associated with neuropsychiatric symptoms, but they contribute differently. Neurodegenerative and cerebrovascular diseases are associated with neuropsychiatric symptoms, with frontotemporal dementia and Parkinson's disease having more severe symptoms.

ALZHEIMERS RESEARCH & THERAPY (2023)

Article Clinical Neurology

Design of a Non-Interventional Study to Assess Neurologists' Perspectives and Pharmacological Treatment Decisions in Early Alzheimer's Disease

Gustavo Saposnik, Gonzalo Sanchez-Benavidez, Elena Garcia-Arcelay, Emilio Franco-Macias, Catalina Bensi, Sebastian Carmelingo, Ricardo F. Allegri, David A. Perez-Martinez, Jorge Maurino

Summary: This study aims to explore the factors associated with therapeutic decisions on the use of new AD DMTs among neurologists, investigate their attitude towards uncertainty in making treatment choices, and identify the prevalence of therapeutic inertia in the management of early AD.

NEUROLOGY AND THERAPY (2023)

Article Clinical Neurology

Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases

Heidi C. Riek, Donald C. Brien, Brian C. Coe, Jeff Huang, Julia E. Perkins, Rachel Yep, Paula M. McLaughlin, Joseph B. Orange, Alicia J. Peltsch, Angela C. Roberts, Malcolm A. Binns, Wendy Lou, Agessandro Abrahao, Stephen R. Arnott, Derek Beaton, Sandra E. Black, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew R. Frank, David A. Grimes, Sanjeev Kumar, Anthony E. Lang, Jane M. Lawrence-Dewar, Jennifer L. Mandzia, Connie Marras, Mario Masellis, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Demetrios J. Sahlas, Gustavo Saposnik, Dallas P. Seitz, Christen Shoesmith, Thomas D. L. Steeves, Stephen C. Strother, Kelly M. Sunderland, Richard H. Swartz, Brian Tan, David F. Tang-Wai, Maria Carmela Tartaglia, John Turnbull, Lorne Zinman, Douglas P. Munoz

Summary: Oculomotor tasks can provide rich behavioral biomarkers for neurodegenerative diseases. Examining the correlation between saccade parameters and disease-impaired circuitry can reveal the location and severity of disease processes. Comprehensive cognitive assessment and direct inter-disease comparisons are crucial for accurately identifying potential saccade biomarkers.

BRAIN COMMUNICATIONS (2023)

Article Clinical Neurology

World Stroke Organization Brain and hEart globAl iniTiative Program

Luciano A. Sposato, Sheila Martins, Jan F. Scheitz, Sara Aspberg, M. Edip Gurol, Mohamed Abdalla, Antonio Arauz, Vanessa Cano-Nigenda, Paul Fiorilli, Carsten Israel, Kengo Kusano, Ossama Mansour, Steven R. Messe, Arthur Pille, Thais Secchi, Carisi Polanczyk, Andreia Biolo, Ismail Ramadan, Ashraf Sallam, Wolf Schaebitz, Kazunori Toyoda, Sharon Valencia, Shang Wang, Yunyun Xiong, Amr Zaki, Gustavo Saposnik, Marc Fisher, M. Cecilia Bahit

Summary: The World Stroke Organization (WSO) has developed a pilot program called the Brain & Heart globAl iniTiative (BEAT) to establish clinical collaborations between cardiologists and stroke physicians. The program focuses on detecting and managing atrial fibrillation (AF), patent foramen ovale (PFO), and post-stroke cardiovascular complications. The pilot program achieved the primary composite outcome in 90% of the participating sites.

CEREBROVASCULAR DISEASES (2023)

Article Neurosciences

Perivascular spaces mediate a relationship between diabetes and other cerebral small vessel disease markers in cerebrovascular and neurodegenerative diseases

Julia Zebarth, Radia Kamal, George Perlman, Michael Ouk, Lisa Y. Xiong, Di Yu, William Z. Lin, Joel Ramirez, Mario Masellis, Maged Goubran, Bradley J. MacIntosh, Sandra E. Black, Hugo Cogo-Moreira, Christopher J. M. Scott, Robert Bartha, Sean Symons, Seyyed M. H. Haddad, Miracle Ozzoude, Nuwan Nanayakkara, Derek Beaton, Stephen Arnott, Dariush Dowlatshahi, Richard H. Swartz, Gustavo Saposnik, David Grimes, Anthony Lang, Corinne E. Fischer, Andrew Frank, Sanjeev Kumar, Bruce G. Pollock, David Tang-Wai, Elizabeth Finger, Jennifer S. Rabin, Walter Swardfager

Summary: Type 2 diabetes mellitus (T2DM) and hypertension are risk factors for cerebral small vessel disease (SVD), and their relationships with MRI-visible perivascular spaces (PVS) were investigated. T2DM patients had greater volumes of PVS in the white matter, and those with T2DM and hypertension had even greater volumes. Mediation models revealed indirect effects of T2DM on other SVD markers mediated by PVS in patients with hypertension. Understanding the regulation of cortical perivascular fluid dynamics may elucidate mechanisms linking T2DM to cerebral small vessel damage.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2023)

Review Biochemistry & Molecular Biology

Current Biomarkers for Carotid Artery Stenosis: A Comprehensive Review of the Literature

Hamzah Khan, Farah Shaikh, Muzammil H. Syed, Muhammad Mamdani, Gustavo Saposnik, Mohammad Qadura

Summary: Carotid artery stenosis (CAS), an atherosclerotic disease, is a leading cause of TIAs and CVAs. Currently, there is no clinically validated blood biomarker for diagnosing CAS or predicting adverse outcomes. This comprehensive literature review evaluates plasma and serum proteins as potential biomarkers for CAS and provides an up-to-date overview of the research in this field.

METABOLITES (2023)

Article Clinical Neurology

Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI

Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M. H. Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A. Dilliott, Christopher Scott, Yanina Sarquis-Adamson, Alanna Black, Karen Van Ooteghem, Leanne Casaubon, Dar Dowlatshahi, Ayman Hassan, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Brian Tan, Robert Hegele, Dennis Bulman, Mahdi Ghani, John Robinson, Ekaterina Rogaeva, Sali Farhan, Sean Symons, Nuwan Nanayakkara, Stephen R. Arnott, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Miracle Ozzoude, Mojdeh Zamyadi, Wendy Lou, Sujeevini Sujanthan, Robert Bartha, Sandra E. Black, Richard H. Swartz, William McIlroy, Manuel Montero-Odasso, ONDRI Investigators

Summary: In older individuals with history of stroke, dual-task gait cost (DTC) is associated with increased hyperintensity volume in specific brain regions, particularly in the basal ganglia and thalamus. This change may affect cognitive processing and gait automaticity.

NEUROREHABILITATION AND NEURAL REPAIR (2023)

Correction Clinical Neurology

The CASSISS Randomized Clinical Trial (vol 54, pg 286, 2023)

Keith Muir, Gustavo Saposnik

STROKE (2023)

Article Neurosciences

Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke AI delineation of ICH on CT

Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw

Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Long-term prognostic value of [15O]H2O PET imaging in patients suspected for cerebral hemodynamic insufficiency

Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner

Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Joblessness, decreased income, and disability in intensive care unit survivors of nontraumatic intracranial hemorrhage in South Korea

Tak Kyu Oh, Saeyeon Kim, In-Ae Song

Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Chagas disease stroke and associated risk factors: A case-control study

Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca

Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Pulmonary abscess combined with pulmonary vein thrombosis and stroke: A case report

Pingping Zheng, Ning Zhang, Zixi Chen

Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Predictors of recurrent cerebral ischemia after patent foramen ovale closure: A single center observational study

Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli

Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Safety and efficacy of endovascular thrombectomy for primary and secondary MeVO

Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni

Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Ischemic Stroke with Positive Antiphospholipid Antibodies in Bloom Syndrome: A Case Report

Jing Zhang, Chenming Wei, Jian Wu

Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

One year clinical outcome of dual anti-platelet therapy with the Novel Ticagrelor plus Aspirin versus Clopidogrel plus Aspirin for Endovascular Intervention of patients with Intracranial Aneurysm: A meta-analysis

Yunxia Zhou, Shenglan He, Yanhong Hu

Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Predicting self-perceived manual ability at three and six months after stroke: A prospective longitudinal study

Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini

Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

A qualitative study of barriers and facilitators to using tenecteplase to treat acute ischemic stroke

Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika

Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Somatosensory evoked potentials amplitude is enhanced after non-invasive brain stimulation in chronic ischemic stroke: Preliminary results from a randomised control trial

Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar

Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

An examination of geographic access to outpatient stroke rehabilitation services in Tennessee, a stroke belt state

Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran

Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Association of Chinese visceral adiposity index with clinical outcome in patients after endovascular thrombectomy

Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du

Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)

Article Neurosciences

Role of serum alkaline phosphatase as a potential biomarker of severity and prognosis in intracerebral hemorrhage

Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang

Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2024)