Article
Pharmacology & Pharmacy
Yansong Xu, Yuansong Sun, Ran Yin, Tao Dong, Kai Song, Yang Fang, Guodong Liu, Bing Shen, He Li
Summary: The incidence rate of acute pancreatitis is increasing, and understanding its pathogenesis is crucial for reducing the high mortality rate associated with severe acute pancreatitis (SAP). This study aimed to identify potential biomarkers for early detection and monitoring of acute pancreatitis and shed light on the underlying mechanisms of SAP. The expression levels of plasma exosomal microRNA (miRNA) were compared between patients with SAP and healthy participants, revealing three differentially expressed novel miRNAs. Further analysis predicted a target gene, complement component 3 (C3), which was found to be consistently expressed in both patients and a mouse model of acute pancreatitis. These findings suggest that C3 may serve as an early biomarker and therapeutic target for SAP.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Shoujiang You, Yucong Bi, Mengyuan Miao, Anran Bao, Jigang Du, Tan Xu, Chun-Feng Liu, Yonghong Zhang, Jiang He, Yongjun Cao, Chongke Zhong
Summary: This study investigated the association between plasma soluble DPP4 (sDPP4) levels and poststroke cognitive impairment (PSCI). The results showed that higher plasma sDPP4 levels were associated with decreased risk of cognitive impairment after noncardioembolic ischemic stroke. Adding sDPP4 to the basic model significantly improved risk reclassification for PSCI. Therefore, plasma sDPP4 levels play an important predictive role in the development of cognitive impairment after noncardioembolic ischemic stroke.
Article
Medical Laboratory Technology
Olli S. Mattila, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Heini Harve-Rytsala, Saana Pihlasviita, Juhani Ritvonen, Gerli Sibolt, Tiina Nukarinen, Sami Curtze, Daniel Strbian, Mikko Pystynen, Turgut Tatlisumak, Markku Kuisma, Perttu J. Lindsberg
Summary: This study demonstrates the potential of plasma GFAP and total tau measurements in aiding the differentiation of acute cerebral ischemia and hemorrhagic stroke in the prehospital setting. Monitoring the GFAP release rate can improve early subtype differentiation in stroke patients, particularly in ruling out hemorrhagic stroke.
CLINICAL CHEMISTRY
(2021)
Review
Microbiology
Gokulakannan Venkatesan, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Salfarina Iberahim, Alwi bin Muhd Besari Hashim
Summary: Early disease diagnosis is crucial for effective management and treatment. Diagnostic methods should be accurate, consistent, low-cost, and non-invasive. Exosomal microRNA (miRNA) has shown potential as biomarkers for various diseases, but its application in vector-borne diseases is limited. This review focuses on discussing miRNAs derived from exosomal plasma that may serve as disease biomarkers for early detection of vector-borne diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Ying Bai, Hui Ren, Yi Zhu, Xufeng Chen, Li Yang, Jiangyan Xia, Guofang Shu, Bing Han
Summary: This study found that circular RNA circDLGAP4 is significantly decreased in the plasma of patients with acute ischemic stroke (AIS), and its level is associated with smoking history and previous transient ischemic attack/stroke/myocardial infarction. CircDLGAP4 has high sensitivity and specificity in diagnosing AIS. Furthermore, the change rate of circDLGAP4 can predict stroke outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jacek Kabzinski, Monika Maczynska, Ireneusz Majsterek
Summary: This article discusses the potential use of microRNAs in the diagnosis of head and neck squamous cell carcinoma, highlighting their application in radiotherapy and immunotherapy, as well as addressing the challenges and future research directions in developing this promising technology.
Article
Clinical Neurology
Zicheng Hu, Haihua Li, Yongping Zhu, Jun Zhang, Xiao Yang, Rongzhong Huang, Yongyong Li, Haitao Ran, Tingting Shang
Summary: This study found that plasma calprotectin is associated with short-term functional outcomes of acute ischemic stroke (AIS). High levels of calprotectin are related to poor prognosis and disease progression.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Doudou Lou, Keqing Shi, Hui-Ping Li, Qingfu Zhu, Liang Hu, Jiaxin Luo, Rui Yang, Fei Liu
Summary: Metabolic profiling analysis of plasma EVs revealed four biomarkers for SAP detection and specific differences in metabolite composition between EVs derived from patients with SAP and MAP. This has significant potential for improving the early diagnosis and severity differentiation of acute pancreatitis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
He-Guo Jiang, Chun-Hua Dai, Ya-Ping Xu, Qian Jiang, Xian-Bin Xia, Yang Shu, Jian Li
Summary: This study investigated the diagnostic and prognostic value of four plasma miRNAs in non-small cell lung cancer (NSCLC), confirming that miR-210, miR-1290, miR-150, and miR-21-5p were highly expressed in NSCLC patients. The four-miRNA panel showed high accuracy in distinguishing NSCLC patients from healthy controls and those with benign lung disease, suggesting their potential as useful biomarkers for early diagnosis and prognosis of NSCLC.
Article
Endocrinology & Metabolism
Yi Yu, Xue Wen, Jin-Guang Lin, Jun Liu, Hong-Feng Liang, Shan-Wen Lin, Qiu-Gui Xu, Ji-Cheng Li
Summary: This study aimed to identify potential reliable blood-based biomarkers for early diagnosis of acute ischemic stroke (AIS) using quantitative plasma lipid profiling and machine learning approaches. Three key differential lipid metabolites, CarnitineC10:1, CarnitineC10:1-OH, and Cer(d18:0/16:0), were identified as potential biomarkers. Logistic regression analyses showed that these metabolites and the resulting diagnostic model exhibited a strong ability in discriminating between AIS patients and healthy controls.
Article
Clinical Neurology
Gerrit M. Grosse, Anselm A. Derda, Ricarda D. Stauss, Lavinia Neubert, Danny D. Jonigk, Mark P. Kuehnel, Maria M. Gabriel, Ramona Schuppner, Mathias Wilhelmi, Christian Baer, Johann Bauersachs, Claudia Schrimpf, Thomas Thum, Karin Weissenborn
Summary: This study did not find strong associations between specific circulating miRs and symptomatic state in a group of patients with carotid stenosis. Further research is needed to understand the role of circulating miRs as targets in advanced carotid atherosclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Teodora Barbalata, Alina Scarlatescu, Gabriela M. Sanda, Laura Toma, Camelia S. Stancu, Maria Dorobantu, Miruna M. Micheu, Anca Sima, Loredan S. Niculescu
Summary: This study aimed to assess the potential of circulating microRNAs, cell-free DNA, and mitochondrial DNA as prognostic tools for unfavorable outcomes in ST-segment elevation myocardial infarction (STEMI). The results showed that the levels of miRNAs, cfDNA, and mtDNA were highest at hospital discharge, and these levels were increased in STEMI patients with major adverse cardiovascular events. Combination of mtDNA and miR-142-3p levels had the highest predictive value for MACE. These findings suggest that increased plasma levels of mtDNA, along with miR-142-3p, could be used as predictive markers for unfavorable outcomes in STEMI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ziyu Kuang, Jingyuan Wu, Ying Tan, Guanghui Zhu, Jie Li, Min Wu
Summary: Doxorubicin (DOX) is a widely used chemotherapy drug for cancer treatment; however, its clinical utility is limited due to DOX-induced cardiotoxicity (DIC). Conventional detection methods are ineffective in early monitoring and detecting DIC. Therefore, there is a need for sensitive, accurate, and specific diagnostic and treatment methods. MicroRNAs (miRNAs) have been identified as stable and detectable molecules and are being studied as potential biomarkers and therapeutic targets for DIC. This review summarizes the current research on the diagnosis and treatment of miRNAs in DIC, discusses the feasibility and challenges of using miRNAs as diagnostic biomarkers and therapeutic targets, and provides recommendations for future studies.
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Iason Psilopatis, Kleio Vrettou, Stefania Kokkali, Stamatios Theocharis
Summary: This review investigates the role of miRNAs in the diagnosis and treatment of uterine sarcoma. The study found that miRNAs exhibit differential expression in uterine sarcoma cell lines and interact with certain genes correlating with tumorigenesis and cancer progression. Furthermore, miRNA levels correlate with various clinical prognostic parameters in uterine sarcoma patients, and each uterine sarcoma subtype is characterized by a unique miRNA profile. Overall, miRNAs appear to be novel trustworthy biomarkers for the diagnosis and treatment of uterine sarcoma.
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)