4.2 Article

Circulating MicroRNAs as Novel Potential Biomarkers for Early Diagnosis of Acute Stroke in Humans

期刊

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 23, 期 10, 页码 2607-2613

出版社

ELSEVIER
DOI: 10.1016/j.jstrokecerebrovasdis.2014.06.002

关键词

MicroRNA; acute stroke; biomarker; diagnosis; plasma

资金

  1. China Natural Science Foundation [81000963, 81370062, 81302196]
  2. Jiangsu Province's 333 Talent Program [BRA2011046]
  3. Jiangsu Province six personnel peak [2013-WSN-028]
  4. Jiangsu Province's Natural Science Foundation [BK2012670]
  5. Medical Research Foundation by Jiangsu Province Health Department [YG201301, Z201318]
  6. Clinical Technology Development of Jiangsu University [JLY20120053]
  7. Kunshan Social Development Foundation [KS1006, KS1009, KS1233]
  8. Suzhou Social Development Foundation [SYS201063]

向作者/读者索取更多资源

Background: Many diseases include microRNAs (miRNAs) as reported biomarkers. The significance of circulating miRNAs for early diagnosis of acute stroke in humans is unknown. We aim to determine whether circulating miRNAs potentially serve as novel biomarkers for acute stroke. Methods: We prospectively recruited patients with acute stroke and those with nonstroke disease. Patients with acute stroke were identified using magnetic resonance imaging (MRI) for early diagnosis. If the patient suffered from acute stroke that was detected with diffusion-weighted imaging, the patient was defined as an MRI(+) patient. Otherwise, it was defined as an MRI(-) patient. Circulating miRNAs were measured by miRNA microarray and real-time polymerase chain reaction (PCR) analysis. Results: A total of 136 patients were included in the study. Testing by miRNA microarray and real-time PCR analyses showed that hsa-miR-106b-5P and hsa-miR-4306 were present with markedly high abundance in patients of acute stroke, whereas hsa-miR-320e and hsa-miR320d were present with quite low abundance in patients compared with healthy individuals. Compared with healthy individuals, the miRNAs were increased as in patients with acute stroke as follows: hsa-miR-106b-5P, 3.63-fold in MRI(-) patients and 23.90-fold in MRI(+) patients; hsa-miR-4306, 3.19-fold in MRI(-) patients and 5.30-fold in MRI(+) patients; hsa-miR-320e, .33-fold in MRI(-) patients and .13-fold in MRI(+) patients; and hsa-miR-320d, .23-fold in MRI(-) patients and .07-fold in MRI(+) patients. Conclusions: Elevated hsa-miR-106b-5P and hsa-miR4306 and decreased hsa-miR-320e and hsa-miR-320d in plasma may be novel biomarkers for the early detection of acute stroke in humans.

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