Review
Oncology
Daniel C. McFarland, Meredith Doherty, Thomas M. Atkinson, Robin O'Hanlon, William Breitbart, Christian J. Nelson, Andrew H. Miller
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between inflammation and depression in cancer patients. The findings suggest that peripheral inflammatory markers, such as IL-6, TNF, and CRP, are associated with depressive symptoms in various cancer settings. These results have implications for the identification and management of depression in cancer patients.
Article
Biochemistry & Molecular Biology
Wolfgang Marx, Amelia J. McGuinness, Tetyana Rocks, Anu Ruusunen, Jasmine Cleminson, Adam J. Walker, Susana Gomes-da-Costa, Melissa Lane, Marsal Sanches, Alexandre P. Diaz, Ping-Tao Tseng, Pao-Yen Lin, Michael Berk, Gerard Clarke, Adrienne O'Neil, Felice Jacka, Brendon Stubbs, Andre F. Carvalho, Joao Quevedo, Jair C. Soares, Brisa S. Fernandes
Summary: The study conducted a meta-analysis and found that tryptophan and kynurenine concentrations are reduced in patients with MDD, BD, and SZ, while kynurenic acid and the kynurenic acid to quinolinic acid ratio are decreased in mood disorders (i.e., MDD and BD).
MOLECULAR PSYCHIATRY
(2021)
Article
Immunology
Yun Wang, Ce Gao, Tianyu Gao, Lu Zhao, Shiguang Zhu, Lin Guo
Summary: Exosomes from patients with depression showed antidepressant-like effects by ameliorating depressive-like behaviors, BDNF deficiency, and neuro-inflammation in LPS-challenged mice, which was found to be Sig-1R dependent. Additionally, these exosomes prevented LPS-induced inflammation responses in microglial BV2 cells.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Britta Stapel, Daniela Fraccarollo, Mechthild Westhoff-Bleck, Johann Bauersachs, Ralf Lichtinghagen, Kirsten Jahn, Alexandra Burkert, Vanessa Buchholz, Stefan Bleich, Helge Frieling, Xiao-Qi Ding, Kai G. Kahl
Summary: Patients with Major Depressive Disorder (MDD) often have poor response to treatment. Disruptions in central energy metabolism and calorie restriction can improve neuroplasticity and affect mood and cognition. Fasting can improve cognitive-affective symptoms in MDD patients with moderate/severe symptoms that did not respond to prior therapy.
SCIENTIFIC REPORTS
(2022)
Review
Psychiatry
Xue Xiao, Hu Deng, Peng Li, Jifei Sun, Jing Tian
Summary: This study found that compared to treatment with selective serotonin reuptake inhibitors (SSRIs) alone, treatment with statins plus SSRIs can significantly reduce depressive symptoms and inflammation status, decrease C-reactive protein levels, and improve lipid profiles. Additionally, it is associated with comparable treatment response and remission rates.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Francieli Cristina Krey, Bruna Alvim Stocchero, Kerstin Camile Creutzberg, Bernardo Aguzzoli Heberle, Saulo Gantes Tractenberg, Li Xiang, Wei Wei, Bruno Kluwe-Schiavon, Thiago Wendt Viola
Summary: The study conducted a meta-analysis of 16 studies and found significantly lower BDNF and NT-3 levels in preterm infants compared to term infants, with no significant difference in NGF and NT-4 levels. Sample type was identified as a significant moderator of heterogeneity in BDNF meta-analysis.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Qinyuan Pan, Yang Liu, Wenrui Ma, Rongsheng Kan, Hong Zhu, Dongye Li
Summary: Luteolin has cardioprotective effects against myocardial ischemia-reperfusion injury (MIRI) by reducing myocardial infarct size and improving intracardiac hemodynamics. It exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects through different signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ray Norbury
Summary: The association between eveningness and depression is small in magnitude and heterogeneous, with mean age having a significant impact on this relationship. More research is needed to better understand the mechanisms linking diurnal preference to depression and to conduct suitably powered prospective studies for causal inference.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Review
Nutrition & Dietetics
Yuanyuan Li, Xu Han, Jinlin Tong, Yuhe Wang, Xin Liu, Zeqi Liao, Miao Jiang, Hongyan Zhao
Summary: This study used metabolomics to summarize the changes of metabolites in the literature and explore their potential value in predicting the occurrence and development of gout. The results highlighted specific metabolites such as uric acid, hypoxanthine, xanthine, KYNA, guanosine, adenosine, creatinine, LB4, and DL-2-Aminoadipic acid in the development of gout.
Review
Clinical Neurology
Kwonmok Ko, Emma I. Kopra, Anthony J. Cleare, James J. Rucker
Summary: Psychedelic therapy shows promising therapeutic effects on depressive symptoms according to recent clinical research. Psilocybin, ayahuasca, and LSD demonstrated significant reduction of symptoms in both short-term and long-term treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Ming-Chia Lee, Tzu-Rong Peng, Bi-Li Chen, Chih-Hsin Lee, Jann-Yuan Wang, Cheng-Pin Lai, Jen-Ai Lee, Shih-Ming Chen, Jeng-Chuan Shiang
Summary: This study concluded that atorvastatin is the optimal choice of statin for treating depression, as it significantly reduces the severity of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Cell Biology
Abbas F. Almulla, Yanin Thipakorn, Asara Vasupanrajit, Chavit Tunvirachaisakul, Gregory Oxenkrug, Hussein K. Al-Hakeim, Michael Maes
Summary: Patients with severe affective disorders, including major depressive disorder and bipolar disorder, show lower levels of tryptophan and tryptophan/competing amino acids. The ratio of kynurenine/tryptophan is significantly increased in patients with psychotic features. Quinolinic acid level is increased while kynurenic acid level is decreased in severe affective disorders. IDO enzyme activity is normal, but the availability of plasma/serum tryptophan to the brain is reduced in patients with melancholic and psychotic features and suicidal behaviors.
Article
Rehabilitation
Tamara Tse, Thomas Linden, Leonid Churilov, Stephen Davis, Geoffrey Donnan, Leeanne M. Carey
DISABILITY AND REHABILITATION
(2019)
Article
Pediatrics
Susan Taylor, Sonya Girdler, Sara McCutcheon, Belinda McLean, Richard Parsons, Torbjorn Falkmer, Peter Jacoby, Leeanne Carey, Catherine Elliott
PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
(2019)
Article
Neuroimaging
Peter Goodin, Gemma Lamp, Rishma Vidyasagar, David McArdle, Ruediger J. Seitz, Leeanne M. Carey
NEUROIMAGE-CLINICAL
(2018)
Article
Rehabilitation
Susan Taylor, Belinda McLean, Torbjorn Falkmer, Leeanne M. Carey, Sonya Girdler, Catherine Elliott, Eve Blair
BRITISH JOURNAL OF OCCUPATIONAL THERAPY
(2019)
Article
Environmental Sciences
Brendon S. Haslam, David S. Butler, Anthony S. Kim, Leeanne M. Carey
Summary: This study investigated the presence of chronic pain and altered somatosensory ability in stroke survivors. The results showed that stroke survivors with somatosensory impairment were more likely to experience chronic pain than those without. This suggests that somatosensory impairment may be a potential target for rehabilitation to improve pain-related outcomes for stroke survivors.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Chemistry, Analytical
Urvashy Gopaul, Derek Laver, Leeanne Carey, Thomas Matyas, Paulette van Vliet, Robin Callister
Summary: Sensor-based devices can provide a comprehensive approach to quantifying grip strength during sustained contractions. This study investigated the reliability and concurrent validity of measures of maximal tactile pressures and forces using a TactArray device in people with stroke. The study found that the device demonstrated satisfactory reliability and concurrent validity for measures of maximal tactile pressures.
Article
Neurosciences
Yvonne Y. K. Mak-Yuen, Thomas A. Matyas, Leeanne M. Carey
Summary: Somatosensory loss post-stroke is common, with touch sensation characteristically impaired. Yet, quantitative, standardized measures of touch discrimination available for clinical use are currently limited. The study aimed to characterize touch impairment and determine the sensitivity and specificity of shorter versions of the Tactile Discrimination Test (TDT). The findings showed that touch impairment was common in stroke survivors, and briefer versions of the TDT demonstrated high sensitivity and specificity.
Article
Neurosciences
Thomas A. Matyas, Yvonne Y. K. Mak-Yuen, Tristan P. Boelsen-Robinson, Leeanne M. Carey
Summary: Comparison of impairment severity across somatosensory domains is important, but the distributions of test score vary greatly, making it difficult to calibrate impairment. An alternative approach is to determine comparable locations in the psychophysical score ranges. Simulation studies and theoretical analysis were conducted to establish the expected score distributions for completely insensate responders in each domain. Comparable ranges of impairment were found, enabling the normalization of the three test scales for comparison in clinical and research settings.
Article
Neurosciences
Isuru Senadheera, Beverley C. Larssen, Yvonne Y. K. Mak-Yuen, Sarah Steinfort, Leeanne M. Carey, Damminda Alahakoon
Summary: This study aimed to characterize post-stroke somatosensation profiles of the upper limb using unsupervised machine learning cluster analysis and identified distinct impairment subgroups. The findings demonstrate the potential utility of this approach in improving the diagnosis and characterization of somatosensory impairment patterns.
Article
Rehabilitation
Susan Taylor, Belinda McLean, Eve Blair, Leeanne Mary Carey, Jane Valentine, Sonya Girdler, Catherine Elliott
AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
(2018)
Article
Rehabilitation
Corrin Walmsley, Susan Taylor, Timothy Parkins, Leeanne Carey, Sonya Girdler, Catherine Elliott
AUSTRALIAN OCCUPATIONAL THERAPY JOURNAL
(2018)
Article
Clinical Neurology
Leeanne M. Carey, David F. Abbott, Gemma Lamp, Aina Puce, Rudiger J. Seitz, Geoffrey A. Donnan
NEUROREHABILITATION AND NEURAL REPAIR
(2016)
Review
Rehabilitation
Leeanne M. Carey, Gemma Lamp, Megan Turville
OTJR-OCCUPATION PARTICIPATION AND HEALTH
(2016)
Article
Rehabilitation
Megan Turville, Leeanne M. Carey, Thomas A. Matyas, Jannette Blennerhassett
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
(2017)
Article
Rehabilitation
Belinda McLean, Susan Taylor, Eve Blair, Jane Valentine, Leeanne Carey, Catherine Elliott
AMERICAN JOURNAL OF OCCUPATIONAL THERAPY
(2017)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)