Review
Endocrinology & Metabolism
Edward S. Bliss, Rachel H. X. Wong, Peter R. C. Howe, Dean E. Mills
Summary: This review examines the effects of aging on cerebrovascular, cognitive, and neuroanatomical adaptations, as well as the potential benefits of exercise training in adults aged 50 and older. The evidence suggests that exercise can improve cerebrovascular function, cognition, and neuroplasticity in this age group, particularly in areas of the brain associated with executive function and memory, regardless of their health status. However, further research is needed to determine the mechanisms involved.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Engineering, Biomedical
Heidi Nedergard, Ashokan Arumugam, Marlene Sandlund, Anna Brandal, Charlotte K. Hager
Summary: Robotic-Assisted Gait Training (RAGT) may have potentially superior effects on biomechanical gait measures post-stroke, with slight improvements in stride length, step length, and temporal asymmetry. However, there is a very low certainty in current evidence, highlighting the need for further high-quality clinical trials to investigate the impact of RAGT on gait biomechanics post-stroke.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Medicine, General & Internal
Xin Zheng, Hong-da She, Qiao-xin Zhang, Tong Si, Ku-sheng Wu, Ying-xiu Xiao
Summary: The meta-analysis found a significant association between increased serum Cys C and future stroke risk in the elderly, especially in patients with carotid atherosclerosis. Serum levels of Cys C could serve as a predictive biomarker for stroke events.
Article
Geriatrics & Gerontology
Edward S. Bliss, Rachel H. X. Wong, Peter R. C. Howe, Dean E. Mills
Summary: Cerebrovascular function and cognition decline with age and are exacerbated by obesity and physical inactivity. Aerobic exercise training can improve cerebrovascular function and cognition, and there is a dose-response relationship between the number of exercise sessions and cerebrovascular responsiveness to cognitive stimuli.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Emergency Medicine
Jia Liu, Kathryn A. Volz
Summary: This article reports a case of visual hallucinations in a 74-year-old woman, which worsened progressively and were later found to be caused by an acute stroke. The study highlights the importance of considering stroke as a potential cause of hallucinations in the differential diagnosis.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Rehabilitation
Pornprom Chayasit, Kristen Hollands, Mark Hollands, Rumpa Boonsinsukh
Summary: This study compared the immediate effects of voluntary-induced stepping response training (VSR) and DynSTABLE perturbation training (DST) on protective stepping in stroke patients. The results showed that both types of training improved step width, but DST led to increased step length and more positive center of mass (CoM) position. Single-step incidence increased, while multiple-step incidence decreased in both groups. Only participants in the VSR group showed a higher percentage of protective stepping with the affected leg after the training.
DISABILITY AND REHABILITATION
(2022)
Article
Clinical Neurology
Esmee Verburgt, Esther Janssen, Mina Jacob, Mengfei Cai, Annemieke Ter Telgte, Kim Wiegertjes, Roy P. C. Kessels, David G. Norris, Jose Marques, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: Small hyperintense lesions on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD) are found to be associated with the radiological progression of SVD and cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Chemistry, Multidisciplinary
Junseo Lee, Byungchol Ma
Summary: Research in the training simulation sector focuses on improving the realism and immersive experience of operator training simulators by using cutting-edge technologies like VR and AR. In this study, an immersive OTS was developed to facilitate mutual cooperation in response to chemical accidents. A communication system using a DCS and AR technology was implemented to relay information between the worksite and control room. The OTS allowed trainees to learn prompt and accurate responses to chemical accidents and was found to be 4.5 times more effective than traditional training methods.
APPLIED SCIENCES-BASEL
(2023)
Review
Nutrition & Dietetics
Tammy Thornton, Dean Mills, Edward Bliss
Summary: Impaired cognition is a common symptom of dementia, especially in the elderly population. Ageing is associated with oxidative stress, inflammation, and endothelial dysfunction, which can lead to cognitive decline. Capsaicin, found in chilli, has shown potential in improving cognition by reducing inflammation, oxidative stress, and improving endothelial function. However, there is a lack of studies on the effects of capsaicin on cerebrovascular function and cognition in humans. Capsimax, a capsaicin supplement, may be a safe option for future clinical trials to test the effects of capsaicin on cerebrovascular function and cognition.
Review
Public, Environmental & Occupational Health
Husna Ahmad Ainuddin, Muhammad Hibatullah Romli, Tengku Aizan Hamid, Mazatulfazura S. F. Salim, Lynette Mackenzie
Summary: Research on rehabilitation for falls after stroke in Southeast Asia is limited, with a focus on physical rehabilitation and traditional therapies. Individual-centric interventions are prominent, while community-based and environmental-focused studies are lacking. More innovative research is needed to advance falls prevention and intervention practice with stroke survivors.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Physiology
Edward S. S. Bliss, Samia M. M. Biki, Rachel H. X. Wong, Peter R. C. Howe, Dean E. E. Mills
Summary: We compared the differences in cerebrovascular and cognitive function between older adults who received aerobic exercise training and sedentary, untrained controls. The trained group showed better cerebrovascular and cognitive function compared to the controls, but these differences disappeared after adjusting for other factors. There were positive correlations between the total cognitive score and cerebrovascular responsiveness to hypercapnia and cognitive stimuli. The study highlights the relationship between cerebrovascular and cognitive function in older adults and the impact of aerobic exercise training and cardiometabolic factors.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shivani Mehta, Roxana Mehran, Shahzad Hassan, Jasmeet Kaur, Anupam Sule, Camelia Arsene, Geetha Krishnamoorthy, Moyses Szklo
Summary: The occurrence of acute non-ST-elevation myocardial infarction (NSTEMI) in acute ischemic stroke has not been well studied. This study examined data from 2016 to 2019 and found that approximately 1.6% of patients with acute ischemic stroke also had NSTEMI, which was associated with increased mortality and other adverse events. However, performing percutaneous coronary intervention (PCI) in NSTEMI patients was not associated with increased mortality or intracranial bleeding.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Clinical Neurology
Nathan A. Shlobin, Steven C. Hoffman, Jeffrey R. Clark, Rebecca Y. Du, Sandi Lam
Summary: This study found that genetic factors are associated with the presentation and outcomes of MMD, including age of onset, severity, symptoms, and angiographic and clinical results after surgery. Incorporating genetic testing panels into practice may help with risk stratification, management, and follow-up of children and adults with MMD. Further studies are needed to confirm the utility of genetic testing for MMD.
WORLD NEUROSURGERY
(2021)
Article
Veterinary Sciences
Philippa Weston, Sebastien Behr, Laurent Garosi, Christian Maeso, Ines Carrera
Summary: This multicenter retrospective descriptive study investigates the presence of T1w hyperintensity in canine stroke without associated signal void on GE sequences. The study found that all 12 cases had intralesional T1w hyperintense signal, suggesting that it may be caused by partial tissue infarction or selective neuronal necrosis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Clinical Neurology
Laurent Puy, Marco Pasi, Mark Rodrigues, Susanne J. van Veluw, Georgios Tsivgoulis, Ashkan Shoamanesh, Charlotte Cordonnier
Summary: Cerebral microbleeds (CMBs) are hypointense foci visible on MRI sequences, helpful in identifying the nature and severity of chronic small vessel disease. Harmonising MRI parameters is crucial for improving cross-study comparisons.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Sanghee Moon, Maud Ranchet, Mark Tant, Abiodun E. Akinwuntan, Hannes Devos
MAYO CLINIC PROCEEDINGS
(2017)
Review
Behavioral Sciences
Maud Ranchet, John C. Morgan, Abiodun E. Akinwuntan, Hannes Devos
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2017)
Article
Geriatrics & Gerontology
Viswa Gangeddula, Maud Ranchet, Abiodun E. Akinwuntan, Kathryn Bollinger, Hannes Devos
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Rehabilitation
Suzanne Perea Burns, Jaclyn K. Schwartz, Shannon L. Scott, Hannes Devos, Mark Kovic, Ickpyo Hong, Abiodun Akinwuntan
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2018)
News Item
Rehabilitation
Hannes Devos, Ickpyo Hong, Amanda Frias, Suzanne Burns, Jaclyn Schwartz, Abiodun Akinwuntan
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2018)
Article
Clinical Neurology
A. E. Akinwuntan, D. Backus, J. Grayson, H. Devos
EUROPEAN JOURNAL OF NEUROLOGY
(2018)
Article
Geriatrics & Gerontology
Sanghee Moon, Maud Ranchet, Abiodun Emmanuel Akinwuntan, Mark Tant, David Brian Carr, Mukaila Ajiboye Raji, Hannes Devos
Article
Geriatrics & Gerontology
Melike Kahya, Sanghee Moon, Kelly E. Lyons, Rajesh Pahwa, Abiodun E. Akinwuntan, Hannes Devos
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Oncology
Jamie S. Myers, Melike Kahya, Melissa Mitchell, Junqiang Dai, Jianghua He, Sanghee Moon, Kevin Hamilton, Mary Valla, Anne O'Dea, Jennifer Klemp, Monica Kurylo, Abiodun Akinwuntan, Hannes Devos
SUPPORTIVE CARE IN CANCER
(2019)
Article
Public, Environmental & Occupational Health
Hannes Devos, Maud Ranchet, Kathryn Bollinger, Amber Conn, Abiodun E. Akinwuntan
TRAFFIC INJURY PREVENTION
(2018)
Review
Rehabilitation
Sarah Krasniuk, Sherrilene Classen, Sarah A. Morrow, Marisa Tippett, Melissa Knott, Abiodun Akinwuntan
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Review
Rehabilitation
Jaclyn K. Schwartz, Carmen E. Capo-Lugo, Abiodun Emmanuel Akinwuntan, Pamela Roberts, Shilpa Krishnan, Samir R. Belagaje, Mark Kovic, Suzanne Perea Burns, Xiaolei Hu, Megan Danzl, Hannes Devos, Stephen J. Page
Meeting Abstract
Clinical Neurology
Melike Kahya, Sanghee Moon, Kelly Lyons, Rajesh Pahwa, Abiodun Akinwuntan, Hannes Devos
MOVEMENT DISORDERS
(2018)
Article
Gerontology
Maud Ranchet, Mark Tant, Abiodun E. Akinwuntan, John C. Morgan, Hannes Devos
Article
Pharmacology & Pharmacy
Askiel Bruno, Desiree D. Brooks, Taryn A. Abrams, Mitra D. Poorak, Drew Gunio, Prianka K. Kandhal, Aleena Lakhanpal, Arun K. Nagabandi, Abiodun E. Akinwuntan, Stephen Looney, Pascha E. Schafer
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2017)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)