Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Broocks, Lukas Meyer, Tobias D. Faizy, Sarah Elsayed, Helge Kniep, Andre Kemmling, Wolfgang Haupt, Rosalie McDonough, Matthias Bechstein, Peter Sporns, Thilo Rusche, Gerhard Schoen, Jawed Nawabi, Jens Fiehler, Uta Hanning
Summary: This study aimed to test a novel imaging score (pcASCO) that combines the collateral status with the rating of pcASPECTS in ischemic posterior circulation stroke. The results showed that pcASCO can predict functional outcome and malignant cerebellar edema. This score can serve as a simple and feasible imaging tool to assess and select patients for thrombectomy.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Xinke Peng, Xiaomei Wu, Lingling Lv, Qile Xiao, Yajing Zhan, Chunyu Wang, Hainan Zhang
Summary: Tuberculous meningitis can lead to ischemic stroke as a common complication, and intravenous thrombolysis may be an effective treatment option for infectious stroke caused by TBM.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jean-Marc Olivot, Jean-Francois Albucher, Adrien Guenego, Claire Thalamas, Michael Mlynash, Vanessa Rousseau, Amel Drif, Soren Christensen, Agnes Sommet, Alain Viguier, Jean Darcourt, Lionel Calviere, Patrice Menegon, Nicolas Raposo, Anne-Christine Januel, Fabrice Bonneville, Thomas Tourdias, Mikael Mazighi, Igor Sibon, Gregory W. Albers, Christophe Cognard
Summary: This study found that baseline perfusion imaging profiles can predict the clinical response to mechanical thrombectomy, with TMM and MM profiles being associated with higher rates of functional recovery.
Article
Clinical Neurology
Yuxuan Jiang, Xiangqin Xu, Zhuoxin Guo, Yuxin Liu, Jiahao Lin, Lijun Suo, Ying Jiang, Bo Liu, Tingting Lu
Summary: This study aimed to identify the risk factors and prognostic impact of myelitis for patients with tuberculous meningitis (TBM). The study found that myelitis was a common complication of TBM and independently predicted a poor outcome. Disease severity and cerebrospinal fluid protein level were identified as independent risk factors for myelitis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mehrnam Amouei, Sara Momtazmanesh, Hoda Kavosi, Amir H. Davarpanah, Ali Shirkhoda, Amir Reza Radmard
Summary: Diagnosis of intestinal vasculitis is challenging due to non-specific clinical and imaging findings. MRE and CTE can provide radiologic clues, such as signs of intestinal ischemia and involvement of the abdominal aorta and visceral arteries. Extra-intestinal findings in the liver, kidneys, or spleen can also be a clue in diagnosing vasculitis.
INSIGHTS INTO IMAGING
(2022)
Article
Neurosciences
Zhiming Zhou, Hongli Zhou, Zuhua Song, Yuanyuan Chen, Dajing Guo, Jinhua Cai
Summary: This study aimed to derive and validate a location-specific radiomics score (Rad-score) based on noncontrast computed tomography as a predictive tool for poor outcomes in deep and lobar spontaneous intracerebral hemorrhage (SICH). The results showed that the Rad-score, along with other factors such as Glasgow Coma Scale score and haematoma volume, can independently predict poor outcomes in SICH patients. Combining the Rad-score with other predictors in the model can improve the identification of high-risk patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Robin Lemmens
Summary: With the introduction of imaging-based treatment selection beyond the traditional time window, the efficacy of acute ischemic stroke treatment has been expanded. Different mismatch concepts have been adopted in clinical practice to select patients for treatment in extended and unknown time windows.
JOURNAL OF NEUROLOGY
(2022)
Review
Oncology
Patricia Pinto, Andrea Burgetova, David Cibula, Ingfrid S. Haldorsen, Tereza Indrielle-Kelly, Daniela Fischerova
Summary: For advanced-stage ovarian cancer, maximal-effort debulking surgery is recommended. The role of imaging is to provide a systematic and structured preoperative report on tumor dissemination, with special emphasis on key sites affecting resectability in ovarian cancer surgery. While imaging methods cannot reliably detect small volume carcinomatosis, they are highly effective in detecting bulky disease at critical sites for cytoreduction, making them useful in avoiding unnecessary explorations.
Article
Clinical Neurology
Jang-Hyun Baek, Byung Moon Kim, Ji Hoe Heo, Dong Joon Kim, Hyo Suk Nam, Young Dae Kim, Hyun Seok Choi, Jun-Hwee Kim, Jin Woo Kim
Summary: Evaluation of hyperattenuation on FPCT using FPCT-ASPECTS is a reliable method to predict clinical outcomes after successful recanalization, showing significant differences between favorable and unfavorable outcomes, as well as between patients with and without malignant infarction. The predictive power of FPCT-ASPECTS for clinical outcomes is higher than that of CT-ASPECTS and comparable to MR-ASPECTS, making it a practical tool for acute management after EVT.
JOURNAL OF NEUROSURGERY
(2021)
Review
Cell Biology
Pragati Kakkar, Tarun Kakkar, Tufail Patankar, Sikha Saha
Summary: Neuroimaging techniques, such as computed tomography and magnetic resonance imaging, have greatly improved the visualization of brain structures, enhancing clinical management of stroke patients.
DISEASE MODELS & MECHANISMS
(2021)
Article
Oncology
Hokun Kim, Dong Hwan Kim, In Hye Song, Bohyun Kim, Soon Nam Oh, Joon-Il Choi, Sung Eun Rha
Summary: In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoral necrosis detected on CT or MRI scans significantly correlates with histopathological necrosis of the tumor. Additionally, MRI-detected necrosis is associated with poor overall survival after curative resection of PDAC, suggesting its potential as an imaging predictor for survival outcomes.
Article
Oncology
Qian Li, Yi Wei, Feng Che, Tong Zhang, Shan Yao, Jian Zhao, YuHui Zhang, Hehan Tang, Bin Song
Summary: This study found that additional multiparametric magnetic resonance imaging (mpMRI) can help clinicians in selecting better treatment options, lowering the risk of tumor recurrence, and improving the overall survival in patients with intrahepatic cholangiocarcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong-Rong Wu, Yue-Zhou Cao, Xiao-Quan Xu, Zheng-Yu Jia, Lin-Bo Zhao, Hai-Bin Shi, Sheng Liu, Fei-Yun Wu, Shan-Shan Lu
Summary: This study compared the prognostic value of net water uptake (NWU) and target mismatch (TM) on CT perfusion (CTP) in acute ischemic stroke (AIS) patients. The results showed that ASPECTS-NWU performed better than TM for outcome prediction and was the only independent neuroimaging marker associated with favorable outcomes compared with CTP parameters.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Pengjun Chen, Yiying Pan, Jingke Wang, Junguo Hui, Ruijie Gao, Guihan Lin, Bingrong Li, Jie Rao, Shuiwei Xia, Jiansong Ji
Summary: The study aimed to determine the value of computed tomography perfusion (CTP) imaging parameters in predicting functional outcomes for patients with acute isolated brainstem infarction. The results showed that perfusion deficit volumes of CTP imaging could reflect the final infarction volume and contain prognostic information on functional outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Nikhil Dongre, Varun Kumar Singh, Jayantee Kalita, Usha Kant Misra
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Jayantee Kalita, Vijay Kumar, Usha K. Misra, Sunil Kumar
Summary: Movement disorders are common neurological symptoms in Wilson disease. They include dystonia, chorea, tremor, and are associated with MRI lesions, oxidative stress, glutamate, and cytokine levels.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jayantee Kalita, Usha K. Misra, Mritunjai Kumar, Robin Bansal, Ravi Uniyal
Summary: In this study, it was found that palinopsia is more frequent in migraineurs and is associated with neuronal dysexcitability. The impaired habituation of N75 and P100 waveforms is a biomarker for palinopsia in migraine, with N75 showing more pronounced impairment than P100.
CLINICAL EEG AND NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jayantee Kalita, Abhilasha Tripathi, Nikhil Dongre, Usha K. Misra
Summary: The COVID-19 pandemic and lockdown measures have worsened symptoms, mental health, and sleep quality in myasthenia gravis patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Abhilasha Tripathi, Ravindra Singh Thakur, Jayantee Kalita, Devendra Kumar Patel, Usha K. Misra
Summary: This study found that in TBM patients, those with CSW had significantly higher levels of catecholamines, especially norepinephrine. Sequential studies revealed that dopamine and epinephrine increased at the time of hyponatremia and declined on its correction. The severity of TBM was related to dopamine levels, while the severity of CSW was related to epinephrine levels.
NEUROSCIENCE LETTERS
(2021)
Article
Public, Environmental & Occupational Health
Jayantee Kalita, Mahesh S. Jadhav, Varun K. Singh, Usha K. Misra
Summary: This report describes a patient with scrub typhus who presented with non-convulsive status epilepticus (NCSE) and recovered after treatment with antiepileptic medications. The study indicates that scrub typhus patients have the potential for recovery even after experiencing prolonged NCSE.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Ashish K. Dubey, Jayantee Kalita, Sarvesh K. Chaudhary, Usha K. Misra
Summary: This study investigated the impact of anticoagulation status on recanalization and outcome in patients with cerebral venous thrombosis. The results showed that at 3 months, recanalization and outcome were not dependent on the patients' coagulation status. Further prospective studies are needed to determine the effects of anticoagulant duration on recanalization and outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Jayantee Kalita, Prakash C. Pandey, Ruchi Shukla, Usha K. Misra
Summary: Telephonic follow-up is feasible and beneficial for patients with tuberculous meningitis, with most patients able to manage medical issues through phone calls and reducing the need for physical visits. It is cost effective, helps in treatment modifications, and overcomes the barrier of distance.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Balachandran Mani, Pradeep Pankajakshan Nair, Anamika Sekhar, Sadishkumar Kamalanathan, Sunil K. Narayan, Ramasamy Kesavan
Summary: The study found that people with epilepsy carrying CYP2C19 polymorphisms (*1/*2) and (*2/*2) had 3 times higher risk of VPA-induced weight gain compared to the wild type (*1/*1), with CYP2C19*2 being an independent predictor of weight gain.
Review
Obstetrics & Gynecology
Vignesh Durai, Haritha Sagili, Jayalakshmi Durairaj, Ramesh Ananthakrishnan, Pradeep P. Nair, Arun Keepanasseril, Anish Keepanasseril
Summary: Sturge-Weber syndrome is a rare neuro-cutaneous anomaly that can cause seizures and intracranial hemorrhage during pregnancy. There is limited research on the management and outcomes of women with this condition during pregnancy.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Clinical Neurology
Sindhu Bhuvanachandran Athira, Pravati Pal, Pradeep P. Nair, Nivedita Nanda, Rajeswari Aghoram
Summary: The quality of life is poorer for people with pharmacoresistant epilepsy (PRE) than for those with newly diagnosed epilepsy (NDE). Depression is a major determinant of quality of life in people with epilepsy.
EPILEPTIC DISORDERS
(2023)
Review
Neurosciences
Madhuri Khilari, Pradeep P. Nair, Brajesh Kumar Jha
Summary: The study evaluated the efficacy of Brivaracetam as an early adjuvant in FOS and found moderate evidence supporting its effectiveness. The study also highlighted the importance of further clinical trials and evaluation for Brivaracetam's efficacy in other indications.
Article
Primary Health Care
Ramanathan Velayutham, Pradeep Pankajakshan Nair, Prashant S. Adole, Vadivelan Mehalingam
Summary: This study found that serum calprotectin levels were significantly elevated in diabetic patients with peripheral neuropathy compared to those without neuropathy, suggesting a potential association with inflammation.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2021)
Article
Clinical Neurology
Usha K. Misra, Jayantee Kalita, Varun K. Singh, Aditya Kapoor, Abhilasha Tripathi, Prabhakar Mishra
Summary: The study found that regular exercise for 30 minutes in patients with mild to moderate MG improves their quality of life and walking distance compared to rest, without any adverse events.
EUROPEAN NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Devika Ramesh, Dilip K. Maurya, Madhavan S. Gopalakrishnan, Bhabani Pegu, Ramesh Ananthakrishnan, Pradeep P. Nair, Anish Keepanasseril
Summary: Diagnosis and management of neurocysticercosis during pregnancy pose challenges, with the need for early treatment for severe symptoms and particular attention to cases leading to intracranial hypertension.
OBSTETRIC MEDICINE
(2021)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)