Article
Nutrition & Dietetics
Dae Young Yoo, Soonwoong Jung, Jae Soon Kang, Ji Hyeong Baek, Ki Hun Park, Dong Hoon Lee, Sang Soo Kang, Hyun Joon Kim
Summary: This study investigated the effects of isoflavone-enriched soybean leaves on cognitive impairment induced by ovariectomy in female mice.
Article
Environmental Sciences
Patricia A. Janulewicz, Jeffrey M. Carlson, Amelia K. Wesselink, Lauren A. Wise, Elizabeth E. Hatch, Lariah M. Edwards, Junenette L. Peters
Summary: This study found that Daidzein and O-DMA were more strongly associated with free T4 in women, and selected urinary isoflavone concentrations were associated with serum thyroid hormone concentration in a sex-dependent fashion.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2021)
Article
Nutrition & Dietetics
Juyeon Lee, Ju-Young Kang, Kwang-Pil Ko, Sue-Kyung Park
Summary: The study found a negative association between plasma phytoestrogen concentrations of equol and enterolactone with hypertension, suggesting that higher concentrations may lower the risk of hypertension, especially in obese individuals with hypertension.
Article
Biochemistry & Molecular Biology
Aya Kitagawa, Mana Yamaguchi, Aki Fujiwara, Muneshige Shimizu, Azusa Takahashi, Hideyuki Sone, Shin Kamiyama
Summary: The study found that genistein and daidzein inhibit chondrogenesis in ATDC5 cells and have an impact on genes related to chondrocyte differentiation. Genistein decreased calcium deposition during chondrogenic differentiation, but increased calcification under non-chondrogenic mineralizing conditions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Swati Chaturvedi, Virendra Tiwari, Narwade Mahaveer Gangadhar, Mamunur Rashid, Nazneen Sultana, Sandeep Kumar Singh, Shubha Shukla, Muhammad Wahajuddin
Summary: The study found that IFN has neuroprotective effects against STZ-induced inflammation in rats by balancing oxidant/antioxidant status, modulating apoptotic gene expression, and reducing the expression of inflammation-related proteins in the cortex and hippocampus.
Article
Food Science & Technology
Maria Angeles Avila-Galvez, Antonio Gonzalez-Sarrias, Francisco Martinez-Diaz, Beatriz Abellan, Alejandro Jose Martinez-Torrano, Antonio Jose Fernandez-Lopez, Juan Antonio Gimenez-Bastida, Juan Carlos Espin
Summary: This study evaluated the metabolic profiles of isoflavones, curcuminoids, and lignans in normal and malignant breast tissues of newly-diagnosed BC patients, and their anticancer activity. The results showed that curcuminoids exerted antiproliferative effects on BC cells by inducing cell cycle arrest, senescence, and apoptosis through p53/p21 induction. These findings suggest that curcuminoids could potentially be coadjuvants in fighting against breast cancer with regular consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Plant Sciences
Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen
Summary: A novel estrogen receptor-alpha splice variant ER-α30 was found to be primarily localized in the nucleus of triple-negative breast cancer (TNBC) cells. ER-α30 was significantly overexpressed in breast cancer tissues of ER- and progesterone receptor (PR)-negative subtype as well as in TNBC cell lines compared to normal breast cell line MCF10A. ER-α30 overexpression promoted TNBC cell viability, migration, invasion, and epithelial-mesenchymal transition, while knockdown of ER-α30 had the opposite effects. Calycosin could suppress ER-α30 expression and inhibit TNBC growth and metastasis.
Article
Biochemistry & Molecular Biology
Hiroyuki Inaba, Yuzo Iwata, Takashi Suzuki, Moemi Horiuchi, Ryohei Surugaya, Shigeho Ijiri, Ai Uchiyama, Ryoko Takano, Seiji Hara, Takashi Yazawa, Takeshi Kitano
Summary: In this study, the effects of the phytoestrogens genistein and daidzein on sex differentiation and sex-specific genes in Japanese eels were examined. Genistein was found to induce feminization more efficiently than daidzein, by altering the molecular pathways responsible for eel sex differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Matus Coma, Veronika Lachova, Petra Mitrengova, Peter Gal
Summary: Estrogen plays a complex role in wound healing and cancer, with current research focusing on naturally occurring SERMs. By utilizing natural products isolated from plants, such as genistein in soy, as potential alternatives, tissue-specific effects can be achieved in a promising manner.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Mengjie Li, Qiuyin Cai, Yu-Tang Gao, Adrian A. Franke, Xianglan Zhang, Yingya Zhao, Wanqing Wen, Qing Lan, Nathaniel Rothman, Yu Shyr, Xiao-Ou Shu, Wei Zheng, Gong Yang
Summary: Moderate intake of dietary isoflavones is inversely associated with lower risk of lung cancer in never-smoking women, while further increasing intake does not provide additional benefits. Excretion of gut microbiota-derived metabolites of lignans does not seem to be related to lung cancer risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Rachel L. Shrode, Nicole Cady, Samantha N. Jensen, Nicholas Borcherding, Ashutosh K. Mangalam
Summary: The consumption of isoflavones can alter the systemic metabolic landscape by increasing anti-inflammatory monounsaturated fatty acids and beneficial polyunsaturated fatty acids while decreasing pro-inflammatory metabolites and pathways. This highlights a potential mechanism by which an isoflavone diet may modulate immune-mediated disease.
Article
Andrology
Jingyuan Xiong, Ye Tian, Aru Ling, Zhenmi Liu, Li Zhao, Guo Cheng
Summary: Genistein directly affects GnRH secretion by modulating the expression of kisspeptin receptors, SIRT1, PKC gamma, and MKRN3 in GT1-7 cells.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Chemistry, Medicinal
Ana C. Mengarda, Marcos P. Silva, Maria E. Cirino, Thiago R. Morais, Geanne A. A. Conserva, Joao Henrique G. Lago, Josue de Moraes
Summary: Schistosomiasis is a widespread human parasitic disease affecting over 200 million people, with praziquantel as the main chemotherapy. Studies show that licarin A (LIC-A) has potential antiparasitic activity against Schistosoma mansoni. LIC-A demonstrated partial cure in infected mice and moderate inhibition of parasite eggs, supporting its potential as a novel antischistosomal agent.
PHYTOTHERAPY RESEARCH
(2021)
Article
Food Science & Technology
Siddharth Bhatia, Avni Blotra, Karthikeyan Vasudevan
Summary: The efficacy of a batch of polyvalent antivenom against Echis carinatus venom from different locations was tested using in vitro assays. The antivenom's binding efficiency and ability to neutralize venom effects were evaluated. Variations in binding efficiency and neutralization were observed, indicating different efficacy of the antivenom against venom from different locations.
Review
Pharmacology & Pharmacy
Mei-An Middelkoop, Pierre M. Bet, Joost P. H. Drenth, Judith A. F. Huirne, Wouter J. K. Hehenkamp
Summary: Ulipristal is a conservative long-term treatment option for uterine fibroids with a lower risk of drug-induced liver injury compared to other medications. Although there is a potential risk of severe liver injury associated with ulipristal, it is outweighed by the higher mortality risk and incidence of severe complications after surgery. Prospective evaluation of drugs should take into consideration the risks of alternative nonpharmacological treatments.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)