Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Nicholas C. Turner, Mafalda Oliveira, Sacha J. Howell, Florence Dalenc, Javier Cortes, Henry L. Gomez Moreno, Xichun Hu, Komal Jhaveri, Petr Krivorotko, Sibylle Loibl, Serafin Morales Murillo, Meena Okera, Yeon Hee Park, Joohyuk Sohn, Masakazu Toi, Eriko Tokunaga, Samih Yousef, Lyudmila Zhukova, Elza C. de Bruin, Lynda Grinsted, Gaia Schiavon, Andrew Foxley, Hope S. Rugo
Summary: Capivasertib-fulvestrant therapy significantly improves progression-free survival in patients with hormone receptor-positive advanced breast cancer, particularly those with AKT pathway alterations.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ann E. Kearns
Summary: Osteoporosis is a common condition caused by estrogen deficiency. The use of adjuvant endocrine treatments for hormone receptor-positive breast cancer and anti-resorptive agents can optimize bone health. The effects vary depending on the specific agent used and the menopausal state of the woman. Antiresorptive medications like bisphosphonates and denosumab lower the risk of bone loss from aromatase inhibitors. The use of bisphosphonates as adjuvant treatment for breast cancer is increasing due to the benefits seen in cancer relapse and survival.
ENDOCRINE PRACTICE
(2023)
Article
Oncology
S. A. Gooijer, C. Folkersma, J. E. C. van Steenhoven, J. de Kort, S. Siesling, J. Volders, T. van Dalen
Summary: This study investigated the efficacy of endocrine monotherapy (ET) in elderly breast cancer patients in terms of avoiding invasive local treatment. The results showed that for a select group of elderly patients, the risk of death was twice as high compared to the risk of undergoing invasive local treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Nusrat Jahan, Catherine Jones, Rakhshanda Layeequr Rahman
Summary: Breast cancer is a common malignancy among women worldwide, and chemoprevention using antiestrogen therapy is an effective method of prevention. However, there is a lack of formal risk assessment and discussion of prevention options, potentially due to various contributing factors.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Oncology
S. A. Gooijer, C. Folkersma, J. E. C. van Steenhoven, J. de Kort, S. Siesling, J. Volders, T. van Dalen
Summary: For a select group of elderly breast cancer patients, endocrine therapy can be discussed as a safe and effective alternative to invasive local treatment, with a higher risk of dying than undergoing such treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Inga Bekes, Jens Huober
Summary: Seventy percent of breast cancer subtypes are hormone receptor-positive, and adjuvant endocrine therapy is crucial for these patients. Extending adjuvant endocrine therapy beyond 5 years has been shown to reduce the risk of late recurrence, but the optimal duration is still debated. Newer data suggest only marginal benefits beyond 7 to 10 years, and longer duration may result in more side effects. Therefore, it is important to select patients who qualify for extended therapy based on genomic tests and risk assessment.
Editorial Material
Oncology
Johanna E. Poterala, Kari B. Wisinski
Summary: A shorter course of endocrine therapy may be reasonable for breast cancer patients with low estrogen receptor expression, but further validation is needed.
Article
Oncology
Yiwei Tong, Siyi Zhu, Weiguo Chen, Xiaosong Chen, Kunwei Shen
Summary: The purpose of this study was to evaluate the influence of obesity on clinicopathological characteristics of breast cancer and to explore its effects on prognosis and endocrine therapy in Chinese patients. The results showed that obesity was associated with a higher risk of comorbidities and PR-positive tumors, but not with overall disease recurrence or survival in the whole population. However, obesity was found to be associated with worse relapse-free survival and overall survival in the luminal A subtype, but not in the luminal B subtype. Obesity did not impact the effectiveness of endocrine therapy in both Tamoxifen and aromatase inhibitor groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xuan Ge, Susan E. Yost, Jin Sun Lee, Paul H. Frankel, Christopher Ruel, Yujie Cui, Mireya Murga, Aileen Tang, Norma Martinez, Samuel Chung, Christina Yeon, Daphne Stewart, Daneng Li, Swapnil Rajurkar, George Somlo, Joanne Mortimer, James Waisman, Yuan Yuan
Summary: This study investigated the safety and antitumor activity of aromatase inhibitors (AIs) in combination with immune checkpoint inhibitor pembrolizumab in patients with HR+ HER2(-) metastatic breast cancer. The combination was well tolerated, but clinical activity was not significantly different from the use of AI alone.
Article
Oncology
Jooyoung Oh, Hye Sun Lee, Soyoung Jeon, Dooreh Kim, Jeong-Ho Seok, Woo-Chan Park, Jae-Jin Kim, Chang Ik Yoon
Summary: This study, using a nationwide population-based cohort, found no evidence that endocrine treatment increases the risk of depression in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Melika Shirdarreh, Rossanna C. Pezo
Summary: Studies have shown that obesity may have a negative impact on the efficacy of aromatase inhibitors in early breast cancer patients, highlighting the need for further research on optimal endocrine therapies for obese women. However, there is insufficient evidence at present to recommend tailoring adjuvant endocrine therapy with specific AIs or dosing modifications in this patient population.
Article
Oncology
Annemiek van Ommen-Nijhof, Judy N. Jacobse, Lars C. Steggink, Joop D. Lefrandt, Jourik A. Gietema, Flora E. van Leeuwen, Michael Schaapveld, Gabe S. Sonke
Summary: This study investigated the association between aromatase inhibitor (AI) exposure and early markers for cardiovascular disease in breast cancer survivors. The results showed no association between AI exposure and carotid intima media thickness (cIMT), advanced glycation end products (AGEs), or the presence of dyslipidemia.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Biochemistry & Molecular Biology
Tushar Singh Barwal, Uttam Sharma, Sonali Bazala, Ipsa Singh, Manju Jain, Hridayesh Prakash, Shashank Shekhar, Elise N. Sandberg, Anupam Bishayee, Aklank Jain
Summary: The article discusses the use of aromatase inhibitors in breast and ovarian cancers, as well as the potential role of noncoding RNAs (including miRNAs and lncRNAs) in modulating cancer hallmarks and overcoming drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Tara Hyder, Christopher C. Marino, Sasha Ahmad, Azadeh Nasrazadani, Adam M. Brufsky
Summary: Aromatase inhibitors (AIs) are essential in the management of hormone receptor-positive (HR+) breast cancer, but their use is limited by the musculoskeletal adverse effects known as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), which includes bone loss and arthralgias. The pathophysiology of AIMSS is not fully understood, but is proposed to be related to estrogen deprivation in the musculoskeletal and nervous systems.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhonglin Liu, Christy Barber, Akash Gupta, Li Wan, Young-Wook Won, Lars R. Furenlid, Qin Chen, Ankit A. Desai, Ming Zhao, David A. Bull, Evan C. Unger, Diego R. Martin
NUCLEAR MEDICINE AND BIOLOGY
(2019)
Article
Chemistry, Analytical
Marcos Duque, Edgardo Leon-Salguero, Jordi Sacristan, Jaume Esteve, Gonzalo Murillo
Article
Nanoscience & Nanotechnology
Helena Lozano, Gustau Catalan, Jaume Esteve, Neus Domingo, Gonzalo Murillo
Summary: The study explores the piezoelectric properties of ZnO nanowires using a metal-semiconductor-metal model, revealing the asymmetry caused by biased Schottky barriers at semiconductor-metal junctions. Effective piezoelectric coefficients range from 8.6 pm V-1 to 12.3 pm V(-1) for ZnO nanowires, with thin and long nanowires exhibiting higher coefficients due to geometric factors. Additionally, non-linear piezoresponse leads to multiharmonic electromechanical response, which can be generalized to various asymmetric voltage drops on piezoelectric structures and wide band-gap semiconductor ferroelectrics.
Article
Chemistry, Physical
Dong Woo Lee, Dong Geun Jeong, Jong Hun Kim, Hyun Soo Kim, Gonzalo Murillo, Gwan-Hyoung Lee, Hyun-Cheol Song, Jong Hoon Jung
Article
Materials Science, Multidisciplinary
Marc Alique, Claudia Delgado Simao, Gonzalo Murillo, Ana Moya
Summary: Recent advancements in materials and manufacturing processes have enabled the development of printed piezoelectric materials for use as flexible sensors, actuators, and generators. Key focus is on the lightweight, flexible, and high throughput manufacturing capabilities, providing disruptive advantages in integration technologies and cost-effective applications. However, challenges remain in the production of reliable flexible printed piezoelectric devices, with limitations mainly stemming from the production and processing of piezoelectric inks.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Hematology
Akash Gupta, Yu-Dong Fei, Tae Yun Kim, An Xie, Ken Batai, Ian Greener, Haiyang Tang, Sultan Ciftci-Yilmaz, Elizabeth Juneman, Julia H. Indik, Guanbin Shi, Jared Christensen, Geetanjali Gupta, Cheryl Hillery, Mayank M. Kansal, Devang S. Parikh, Tong Zhou, Jason X-J Yuan, Yogendra Kanthi, Peter Bronk, Gideon Koren, Rick Kittles, Julio D. Duarte, Joe G. N. Garcia, Roberto F. Machado, Samuel C. Dudley, Bum-Rak Choi, Ankit A. Desai
Summary: IL-18 plays a crucial role in the development of sickle cell disease-related cardiomyopathy, and the main treatment approach is to reduce cardiac fibrosis and VT occurrence by inhibiting IL-18. The level of IL-18 in the blood is related to cardiac function, suggesting IL-18 as a potential therapeutic target for patients with SCD.
Article
Biochemistry & Molecular Biology
Oriol Careta, Jordina Fornell, Eva Pellicer, Elena Ibanez, Andreu Blanquer, Jaume Esteve, Jordi Sort, Gonzalo Murillo, Carme Nogues
Summary: Coating a Ti-based alloy with an array of ZnO nanosheets enhances its biocompatibility and enables electric self-stimulation of cells, leading to increased cell proliferation and early differentiation.
Article
Biochemistry & Molecular Biology
Andreu Blanquer, Oriol Careta, Laura Anido-Varela, Aida Aranda, Elena Ibanez, Jaume Esteve, Carme Nogues, Gonzalo Murillo
Summary: This study demonstrates the potential of ZnO nanosheets-based nanogenerator arrays for electrical stimulation of cells, especially smooth muscle cells, in biomedical applications. The study also highlights the importance of optimizing the morphology, orientation, and distribution of nanogenerators for cell response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Marcos Duque, Gonzalo Murillo
Summary: In this article, a triboelectric nanogenerator (TENG) has been developed to harvest mechanical energy from human motion and convert it into electrical energy. The energy generation has been optimized through material selection, design improvement, and charge injection. The TENG is capable of collecting mechanical energy from hand tapping and using it to power miniaturized electronic sensors in a self-sufficient and sustainable way.
Article
Materials Science, Multidisciplinary
Rafael Mestre, Judith Fuentes, Laura Lefaix, Jiaojiao Wang, Maria Guix, Gonzalo Murillo, Rashid Bashir, Samuel Sanchez
Summary: Biohybrid robots, or bio-bots, integrate living and synthetic materials to acquire unique properties of biological organisms that are difficult to obtain using artificial materials alone. This study demonstrates that incorporating boron nitride nanotubes (BNNTs) with piezoelectric properties into muscle-based bio-bots can improve their force output and motion speed. The improved performance is hypothesized to be a result of the electric field generated by the nanocomposites due to stresses produced by the cells during differentiation.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Marcos Duque, Gonzalo Murillo
Summary: The rapid growth of the Internet of Things (IoT) has resulted in the development of low-power sensors. However, the energy dependency of these sensors poses a challenge to the expansion of the IoT. Energy harvesting from ambient sources and its conversion into electricity offers a promising solution to provide power autonomy to IoT sensor nodes. Through 3D printing, monolithic harvesters can be created, reducing costs and eliminating the need for additional assembly tools. This study focuses on the design, fabrication, and characterization of a piezoelectric resonant energy harvester, including physical characterization and optimization through finite element modeling. The device achieved a maximum output power of 1.46 mW when operated with an optimal load impedance of 4 MΩ and subjected to an acceleration of 1 G. A proof-of-concept device was also designed and fabricated for measuring current passing through a wire.
Article
Materials Science, Multidisciplinary
Marc Alique, Ana Moya, Martin Kreuzer, Paul Lacharmoise, Gonzalo Murillo, Claudia Delgado Simao
Summary: This study reports the fabrication of fully printed piezoelectric devices with inkjet-printed silver electrodes on a flexible film. The device exhibits high reproducibility and reversibility in multiple cycles, and can function as a sensor, an actuator, and an energy harvester.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Gonzalo Murillo
Summary: This paper introduces the application of nanogenerators and energy harvesting systems for electrical stimulation of electroactive cells. Stimulation using smart materials has shown promising results in improving cell proliferation and differentiation, making it a potential tool for future bioelectronic nanomedicines. Research is now focusing on developing biocompatible microdevices for wireless stimulation of excitable cells using ultrasound or electromagnetic signals.
2021 21ST INTERNATIONAL CONFERENCE ON SOLID-STATE SENSORS, ACTUATORS AND MICROSYSTEMS (TRANSDUCERS)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Laura Lefaix, Andreu Blanquer, Lucie Bacakova, Jaume Esteve, Gonzalo Murillo
Summary: Bioelectronic medicine is gaining importance in regenerative medicine by using electrical stimulation to promote cell migration, differentiation, and proliferation for tissue regeneration. Piezoelectric nanogenerators have the potential to wirelessly stimulate cells, expanding the range of materials for biomedical applications. Microdevices integrating piezoelectric zinc oxide nanosheets on silicon microparticles have shown cytocompatibility and the ability to generate electric fields in response to mechanical stress or ultrasonic waves, paving the way for cost-effective and reproducible bioelectronic therapies.
2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)
(2021)
Article
Chemistry, Multidisciplinary
Maria Kitsara, Andreu Blanquer, Gonzalo Murillo, Vincent Humblot, Sara De Braganca Vieira, Carme Nogues, Elena Ibanez, Jaume Esteve, Leonardo Barrios
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)