Article
Endocrinology & Metabolism
Julie Brossaud, Clementine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoit Corcuff, Marie-Pierre Moisan
Summary: Diabetes can affect the cognitive abilities of children although vascular disorders have not yet appeared. Dysregulation of the hypothalamus-pituitary-adrenal axis due to variations in glucose levels and relative insulin deficiency in treated type 1 diabetes can indirectly impact brain function. Inhibiting the activity of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) can prevent memory deficits in diabetic juvenile rats.
Article
Biotechnology & Applied Microbiology
Rui Tang, Xiaoxian Ren, Menglei Xia, Yanbing Shen, Linna Tu, Jianmei Luo, Qi Zhang, Yuying Wang, Peilin Ji, Min Wang
Summary: This study established a one-step biocatalytic carbonyl reduction strategy for the efficient biosynthesis of boldenone from phytosterol by bridging 17 beta-hydroxysteroid dehydrogenase with a cofactor regeneration strategy in Mycobacterium neoaurum. The yield of boldenone was significantly increased with the establishment of an intracellular cofactor regeneration strategy, reaching the highest reported yield for transformation from phytosterol in one step. This strategy has practical value for the production of many valuable steroidal products from natural inexpensive raw materials.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv
Summary: This study demonstrated that 11 beta-HSD1 plays a significant role in facilitating osteoclasts formation and maturation through the Hippo signaling pathway. Knock-in mice with high expression of 11 beta-HSD1 showed a significant decrease in bone volume, while specific knock-out in osteoclasts provided protection to the skeleton. In vitro experiments confirmed that high expression of 11 beta-HSD1 promoted osteoclast formation and maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Rahul Singh, Vijay Kumar Bhardwaj, Pralay Das, Rituraj Purohit
Summary: Aminoarylbenzosuberene (AAB) molecules were analyzed in silico to develop potent inhibitors for 11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD1) protein. AAB4 molecule showed stronger interactions and binding affinity compared to the standard inhibitors.
CHEMICAL COMMUNICATIONS
(2022)
Article
Cell Biology
Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez
Summary: This review provides a brief overview of the discovery and elucidation of three cloned 11 beta-hydroxysteroid dehydrogenase enzymes in humans, as well as their role in regulating metabolism and immune cell differentiation. Additionally, it discusses pathological examples associated with disruptions in the functions of these enzymes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Nantia Othonos, Riccardo Pofi, Anastasia Arvaniti, Sarah White, Ilaria Bonaventura, Nikolaos Nikolaou, Ahmad Moolla, Thomas Marjot, Roland H. Stimson, Andre P. van Beek, Martijn van Faassen, Andrea M. Isidori, Elizabeth Bateman, Ross Sadler, Fredrik Karpe, Paul M. Stewart, Craig Webster, Joanne Duffy, Richard Eastell, Fatma Gossiel, Thomas Cornfield, Leanne Hodson, K. Jane Escott, Andrew Whittaker, Ufuk Kirik, Ruth L. Coleman, Charles A. B. Scott, Joanne E. Milton, Olorunsola Agbaje, Rury R. Holman, Jeremy W. Tomlinson
Summary: The study suggests that inhibiting 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) with AZD4017 could mitigate the adverse effects of glucocorticoids while preserving their anti-inflammatory actions. Co-treatment of AZD4017 with prednisolone shows potential in limiting the adverse effects of glucocorticoids.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Israel Hernandez-Bustamante, Yanina Santander-Plantamura, Dulce Mata-Espinosa, Andres Reyes-Chaparro, Estela I. Bini, Ivan Torre-Villalvazo, Armando R. Tovar, Jorge Barrios-Payan, Brenda Marquina-Castillo, Rogelio Hernandez-Pando, Andrea Carranza
Summary: Metabolic syndrome is the precursor of type 2 diabetes mellitus, and tuberculosis is a global threat and a major cause of morbi-mortality in developing countries. People with type 2 diabetes mellitus are more susceptible to Mycobacterium tuberculosis infection. Our study found that DHEA can directly inhibit the growth of Mycobacterium tuberculosis, and in silico docking analysis and molecular dynamic simulation studies supported this conclusion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva Kathrin Lamade, Ferdinand Hendlmeier, Stefan A. Wudy, Stephanie H. Witt, Marcella Rietschel, Michaela Coenen, Maria Gilles, Michael Deuschle
Summary: The study revealed time-specific alteration of fetoplacental 11 beta-HSD2 activity, peaking in the morning to protect fetus from maternal glucocorticoids. Acute affective or anxiety disorders were found to impact fetoplacental 11 beta-HSD2 activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Hemangini A. Dhaibar, Hemant Patadia, Tabassum Mansuri, Ritu Shah, Laxmichand Khatri, Hiral Makwana, Samip Master, Pushpa Robin
Summary: Exposure to hexachlorobenzene leads to hypothyroidism, affecting reproductive ability and growth in rats. Supplementing thyroxine can rescue reproductive abnormalities, highlighting the protective role of the thyroid in reproductive biology.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Medicine, General & Internal
Jonathan Seckl
Summary: 11 beta-HSDs are enzymes that convert active 11-hydroxy glucocorticoids to their inert 11-keto forms. 11 beta-HSD2 inactivates glucocorticoids and has important roles in the kidney and developing foetal brain. In contrast, 11 beta-HSD1 amplifies active glucocorticoid levels in the brain and is associated with age-related cognitive decline.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Chloe Fenton, Claire Martin, Rachel Jones, Adam Croft, Joana Campos, Amy J. Naylor, Angela E. Taylor, Myriam Chimen, Mark Cooper, Gareth G. Lavery, Karim Raza, Rowan S. Hardy
Summary: The study identifies a novel component of therapeutic GC action, where peripheral reactivation and amplification by 11 beta-HSD1 at sites of inflammation are required for their anti-inflammatory effects.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Endocrinology & Metabolism
Yun Hu, Ying Wang, Ting-ting Cai, Lu Liu, Dong-mei Li, Jian-hua Ma, Bo Ding
Summary: Short-term intensive insulin therapy can increase serum testosterone levels in men with newly diagnosed type 2 diabetes, possibly due to enhanced conversion of DHEA to testosterone.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Yuki Nouchi, Eiji Munetsuna, Hiroya Yamada, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Miyuki Ikeya, Itsuki Kageyama, Takuya Wakasugi, Atsushi Teshigawara, Yuji Hattori, Yoshiki Tsuboi, Hiroaki Ishikawa, Koji Suzuki, Koji Ohashi
Summary: This study aimed to elucidate the molecular mechanism by which maternal high-fructose corn syrup (HFCS) intake increases circulating GC levels in rat offspring. By giving female Sprague Dawley rats HFCS solution, it was found that HFCS led to a decrease in activity of GC-metabolizing enzyme 11 beta-Hsd2 and an increase in renal miR-27a expression. These findings suggest that the elevation of circulating GC levels in offspring induced by maternal HFCS consumption may be explained by a decrease in 11 beta-Hsd2 activity via renal miR-27a expression.
Article
Endocrinology & Metabolism
Anna J. Anderson, Ruth Andrew, Natalie Z. M. Homer, Katherine A. Hughes, Luke D. Boyle, Mark Nixon, Fredrik Karpe, Roland H. Stimson, Brian R. Walker
Summary: Insulin upregulates cortisol regeneration in adipose tissue but not in skeletal muscle. In obesity, the balance between 11 beta-reductase and 11 beta-dehydrogenase activities likely leads to cortisol accumulation in adipose tissue, which may have adverse metabolic consequences.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Developmental Biology
Johanna R. Jahnke, Enrique Teran, Francisca Murgueitio, Holger Cabrera, Amanda L. Thompson
Summary: Maternal distress may influence the functioning of HSD11B2 gene, which in turn affects infant HPA axis development. Maternal HPA axis dysregulation is linked to lower placental HSD11B2 expression, leading to exaggerated cortisol reactivity in infants.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)