Article
Environmental Sciences
Anna Lovinskaya, Saule Kolumbayeva, Mariya Suvorova
Summary: This study investigates the genotoxic potential in rivers and lakes of the Almaty agglomeration, Kazakhstan, and finds that the surface water contamination poses a threat to both organisms and human populations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Sakthi Thesai Annadurai, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Rajakumar Sundaram, Mohankumar Periyasamy, Manikandan Rajendran, Ayyasamy Pudukadu Munusamy, Leticia Paiva Matos, Guilherme Malafaia
Summary: The present study focuses on the use of dead fungal mycelium as novel adsorbents for defluorination, and the results showed that the isolated fungus Aspergillus niger exhibited high fluoride adsorption capacity. The biosorption behavior followed pseudo-second-order kinetics and the Langmuir isotherm. Additionally, the study also found genotoxic effects of fluoride water contamination on biota through chromosome analysis. Therefore, the research has both theoretical and practical significance in the management of environmental pollution.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Environmental Sciences
Marwa F. F. Ali, Wafaa H. H. Mohamed
Summary: The present study investigated the genotoxic effects of pyridaben (PDB) in male Sprague Dawley rats. Four groups of rats were exposed to different doses of PDB for 4 weeks. Blood samples, femoral bone marrow, and liver samples were collected for various analyses. The results showed changes in hematological and biochemical parameters, increased gene expression of IL-6 and Casp-3, and histopathological findings in the liver with PDB exposure. However, there was no significant change in chromosomal aberrations.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sagar S. Arya, James E. Rookes, David M. Cahill, Sangram K. Lenka
Summary: This study observed significant genotoxicity in off-target bioindicator cells treated with high concentrations of green-synthesized vanillin capped gold nanoparticles, while protein-coated gold nanoparticles of similar concentrations had negligible genotoxic effects. These findings suggest that the toxicological signatures of AuNPs are influenced by their interaction with biological systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Oksal Macar
Summary: The study demonstrated that various toxic, cytotoxic, and genotoxic effects of tetraconazole fungicide occurred at different doses on the meristematic cells of onion root tips.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Tugce Kalefetoglu Macar, Oksal Macar, Emine Yalcin, Kultigin Cavusoglu
Summary: The study revealed that grape seed extract (GSE) can effectively reduce the adverse effects of cobalt(II) nitrate (Co(NO3)2) on onion root tip growth and genotoxicity, while enhancing the antioxidant defense system. Addition of GSE under Co(NO3)2 exposure significantly improved growth parameters.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Farhana Masood, Ranjan Pandey, Harminder Pal Singh, Aditya Sen Gupta, Shalinder Kaur, Daizy Rani Batish, Ravinder Kumar Kohli
Summary: This study found that agricultural sites near industrial areas were contaminated with high concentrations of heavy metals and organic compounds, which poses genotoxic and mutagenic risks. Adequate measures should be taken to reduce the toxicity of industrial effluents discharged onto agricultural fields.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Article
Biotechnology & Applied Microbiology
Recep Liman, Bermal Basbug, Muhammad Muddassir Ali, Yaser Acikbas, Ibrahim Hakki Cigerci
Summary: Tungsten oxide nanoparticles exhibit cytotoxic and genotoxic effects on Allium cepa cells, leading to a decrease in mitotic index, an increase in chromosomal aberrations, and significant DNA damage at different concentrations. Further investigation at the molecular level is warranted to evaluate the cytogenetic effects of WO(3)NPs.
JOURNAL OF APPLIED GENETICS
(2021)
Article
Food Science & Technology
Ting Lyu, Hongyuan Zhou, Yihui Wang, Minyan Jiang, Qian Tao, Juanlin Chen, Yitong Guo, Qiuping Zhang, Xu Wang, Xihan Guo
Summary: This study demonstrates that metformin can suppress cancer cell proliferation and colony formation by increasing genotoxic stress. The effect is dependent on the glucose environment and is weakened in high glucose conditions. Additionally, metformin can increase genotoxicity in non-cancer cells, suggesting that its effects may vary in different cell types.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Anithadevi Kenday Sivaram, Panneerselvan Logeshwaran, Aravind Surapaneni, Kalpit Shah, Nicholas Crosbie, Zoe Rogers, Elliot Lee, Kartik Venkatraman, Kurunthachalam Kannan, Ravi Naidu, Mallavarapu Megharaj
Summary: The study found that PFOS has significant cytotoxic and genotoxic effects on Allium cepa root meristem cells. As the concentration increases, cell division decreases and chromosomal aberrations increase. This is the first study to investigate the cyto-genotoxic potential of PFOS in higher plants.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Toxicology
Priyanka Mathur, Kusum Rani, Pradeep Bhatnagar
Summary: The cytogenetic study of hospital effluent indicated improvements in treatment efficiency after January 2020, with previous flaws leading to cell aberrations and changes in cell ratios. Thus, hospital management should enhance supervision of the wastewater treatment process to ensure its quality.
TOXICOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maha A. Fahmy, Entesar E. Hassan, Ayman A. Farghaly, Zeinab M. Hassan
Summary: This study found that the genotoxicity of vinblastine (VB) not only affects somatic cells but also germ cells, leading to sperm defects and DNA damage. These findings have serious implications for future generations and the fertility of cancer survivors.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Kavya Prasad, Mathew Bloomfield, Hagai Levi, Kristina Keuper, Sara Bernhard, Nicolaas C. Baudoin, Gil Leor, Yonatan Eliezer, Maybelline Giam, Cheng Kit Wong, Giulia Rancati, Zuzana Storchova, Daniela Cimini, Uri Ben-David
Summary: The interactions between whole-genome duplication and aneuploidy are crucial for tumor evolution, emphasizing the importance of considering genome status in the analysis and modeling of cancer aneuploidy.
Article
Obstetrics & Gynecology
Seo-Jin Park, Ji-You Min, Jeom-Soon Kang, Byung-Guk Yang, Seung-Yong Hwang, Sung-Hee Han
Summary: This study investigated the demographic data and karyotypes of 19,000 couples who experienced recurrent spontaneous abortion (RSA). The results showed that 4.44% of the couples had chromosomal aberrations, with females being more likely to have them. The mean age of individuals with chromosomal aberrations was younger, and there were significant correlations between sex and age distribution and the subtypes of chromosomal aberrations.
FERTILITY AND STERILITY
(2022)
Article
Biology
Torsha Das, Soham Hazra, Sudip Sengupta, Pranab Hazra, Dipayan Chattopadhyay
Summary: The study found that aqueous saccharin solution can induce genotoxic effects on root growth inhibition, mitotic index, and chromosomal aberrations in Allium cepa, indicating the need for moderate and regulated dietary intake of saccharin.
Article
Chemistry, Multidisciplinary
Aida El Makawy, Dalia M. Mabrouk, Faten M. Ibrahim, Kawkab A. Ahmed
Summary: The aim of this study was to evaluate the potential toxic effects of topiramate (TMP) on the liver and kidney in male mice. The results showed that TMP caused dose-dependent toxicity, including DNA damage, increased levels of liver enzymes, creatinine, and uric acid, as well as decreased antioxidant enzyme activities. In addition, topiramate induced histopathological alterations in the liver and kidney tissues.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sherif A. Mohamed, Dina S. El-Kady, Ahmed A. Abd-Rabou, Mohamed A. Tantawy, Mervat M. AbdElhalim, Samia R. Elazabawy, Amira E. M. Abdallah, Gamal A. Elmegeed
Article
Biochemistry & Molecular Biology
Shahad W. Kattan, Mohamed S. Nafie, Gamal A. Elmgeed, Walla Alelwani, Muhammad Badar, Mohamed A. Tantawy
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Karima F. Mahrous, Dalia M. Mabrouk, Mohamad M. Aboelenin, Heba A. M. Abd El-Kader, Alkhateib Y. Gaafar, Abdelgayed M. Younes, Mahmoud A. Mahmoud, Wagdy K. B. Khalil, Mohamed S. Hassanane
JOURNAL OF PEPTIDE SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Mohamed A. Tantawy, Sameerah Shaheen, Shahad W. Kattan, Walla Alelwani, Ibrahim O. Barnawi, Gamal A. Elmgeed, Mohamed S. Nafie
Summary: This study provides new molecular insights into the antiproliferative activity of six 3 beta-acetoxy-5 alpha-androstane heterocycle compounds against non-small-cell lung carcinoma (NSCLC). Compound 4 shows potential cytotoxicity on NSCLC cells and acts as a dual inhibitor of IL6/JAK2/STAT3 and tubulin formation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Doaa S. Nada, Dina S. Elkady, Ghada H. Elsayed, Adel A. -H. Abdel-Rahman, Gamal A. Elmegeed
Summary: A novel class of hybrid estrane heterocyclic compounds were synthesized and evaluated, showing more inhibitory influence on three human cancer cell lines than the reference drug doxorubicin. The results were confirmed by morphology study.
Article
Biochemistry & Molecular Biology
Amel A. Refaie, Aziza B. Shalby, Salwa M. Kassem, Wagdy K. B. Khalil
Summary: This study evaluated the nephroprotective effects of Arabic gum against butralin-induced nephrotoxicity. The results showed that butralin led to kidney damage through oxidative stress, DNA damage, and alterations in gene expression. However, pretreatment with Arabic gum was able to prevent these degenerative changes in kidney tissues, possibly through enhancing antioxidant activity.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shaimaa T. Mansour, Ahmed Hashem, Mansoura A. Abd-El-Maksoud, Marwa El-Hussieny, Aida El-Makawy, Sekena H. Abdel-Aziem, Fouad M. Soliman
Summary: Phosphonium compounds are an attractive area of research for producing novel drugs. Different sulfidomethyl phosphonium derivatives can be synthesized through reactions. The synthesized compounds have shown potential anticancer activity by promoting programmed cell death (apoptosis).
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Dalia M. Mabrouk, Aida El Makawy, Kawkab A. Ahmed, Mohamed Fawzy Ramadan, Faten M. Ibrahim
Summary: The study findings suggest that topiramate may have neurotoxic effects, but the interaction with ginger oil could attenuate these effects. This has potential significance for the treatment of epilepsy and migraine.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aida El Makawy, Dalia M. Mabrouk, Shaimaa E. Mohammed, Sekena H. Abdel-Aziem, Heba A. Abd El-Kader, Hafiza A. Sharaf, Dalia A. Youssef, Faten M. Ibrahim
Summary: Chia oil nanocapsules have the ability to inhibit rat breast cancer cells by reducing the increased levels of ROS and PC caused by DMBA, controlling the expression levels of tumor suppressor genes, and improving the tissue architecture of breast tumors.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mohamed A. Tantawy, Aziza B. Shalby, Ibrhim El-bernawy, Shahad W. Kattan, Ahmed A. Abd-Rabou, Gamal A. Elmegeed
Summary: In order to discover new steroidal agents with potential biological activities, hybrid steroids with thiazole, pyrazole, isoxazole, thiophene, or phthalazine moiety were synthesized. The structures of the newly synthesized compounds were confirmed through experiments and spectroscopic analyses. Several of these compounds showed promising anti-cancer activities, with compound 7 being the most effective against various cancer cell lines, particularly HepG2. Compound 7 induced cell cycle arrest, DNA fragmentation, and apoptosis in HepG2 cells, suggesting its potential as an anti-hepatocellular carcinoma agent. Further investigations are needed to elucidate its chemotherapeutic value.
Article
Chemistry, Multidisciplinary
Dina S. El-kady, Mostafa Mabrouk, Soheir E. Kotob, Mervat M. Abdelhalim, Gamal A. Elmegeed, Hanan H. Behierei, Hanaa H. Ahmed
Summary: The newly synthesized hybrid steroid compounds demonstrated effectiveness in treating metabolic syndrome in mice by preventing weight gain, reducing blood lipids, decreasing blood glucose, improving insulin resistance, and exhibiting powerful free radical scavenging activity.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mahmoud Alsayed, Dina S. El-Kady, Mohamed A. Tantawy, Mervat M. AbdElhalim, Samia R. Elazabawy, Amira E. M. Abdallah, Gamal A. Elmegeed
Summary: In this study, several novel Melatonin derivatives with different heterocyclic ring systems were synthesized and evaluated for their anti-cancer effects on two human cancer cell lines. Compound 16 showed the lowest IC50 and the highest cytotoxic effects, and was identified as the best-docked ligand against the targeted proteins CDK2 and P53-MDM2, indicating its potential as a promising anti-cancer agent.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Mohamed M. Abd Elrahman, Aida I. El Makawy, Mohamed S. Hassanane, Sally S. Alam, Nagwa H. A. Hassan, Medhat K. Amer
Summary: This study focused on investigating the relationship between mitochondrial DNA mutations in human spermatozoa of patients with asthenozoospermia and fertility. Results indicated a significant negative correlation between seminal plasma malondialdehyde levels and sperm motility, as well as lower TAC activity in asthenozoospermic samples. At the molecular level, 31 diverse nucleotide substitutions were identified in mitochondrial DNA.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Fisheries
Karima F. Mahrous, Mohamad M. Aboelenin, Heba A. M. Abd El-Kader, Dalia M. Mabrouk, Alkhateib Y. Gaafar, Abdelgayed M. Younes, Mahmoud A. Mahmoud, Wagdy K. B. Khalil, Mohamed S. Hassanane
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
