Article
Medicine, Research & Experimental
Qingqing Hou, Shiming Zhang, Yuan Li, Huanjun Wang, Dan Zhang, Dongmei Qi, Yunlun Li, Haiqiang Jiang
Summary: This study aimed to investigate the association of lipid metabolites, circadian genes, and lipid metabolism associated genes in spontaneously hypertensive rats. Through lipidomics and gene expression analysis, it was found that SHR exhibited significant differences in lipid metabolites levels compared to WKY, as well as disturbances in circadian and lipid metabolism associated gene expressions. Moreover, a strong association between the levels of lipid metabolites and circadian genes and lipid metabolism associated genes was identified.
Editorial Material
Cell Biology
Zhangyuan Yin, Daniel J. Klionsky
Summary: Macroautophagy/autophagy plays a crucial role in aging and age-related diseases. A recent study showed that a newly designed dietary regimen, called intermittent time-restricted feeding (iTRF), can extend the healthspan and lifespan of flies through the circadian rhythm-dependent activation of autophagy. Specifically, the induction of autophagy during the night is both necessary and sufficient for the health benefits of iTRF. This study suggests that novel interventions promoting night-specific autophagy could be used to promote healthy aging.
Review
Biochemistry & Molecular Biology
Sandra Haupt, Max L. Eckstein, Alina Wolf, Rebecca T. Zimmer, Nadine B. Wachsmuth, Othmar Moser
Summary: The circadian rhythmicity of endogenous metabolic and hormonal processes is crucial for overall health. Adjusting the timing of diet and exercise can help reset disrupted circadian pacemakers and potentially prevent metabolic diseases. However, these lifestyle interventions cannot address the underlying issue of the misalignment between our biological and social time.
Article
Chemistry, Medicinal
Xialin Zhu, Qingqing Hou, Ling Zhang, Danyang Wang, Zhenhua Tian, Yuecheng Liu, Yu Wang, Yunlun Li, Haiqiang Jiang
Summary: Hypertension is a progressive metabolic disease characterized by circadian regulation of lipid metabolism disorder. This study found that isorhynchophylline (IRP) can improve lipid metabolism rhythm disorder by regulating specific genes, providing a potential treatment strategy for hypertension.
PHYTOTHERAPY RESEARCH
(2023)
Article
Ophthalmology
Suna Ye, Zhijie Wang, Jacey Hongjie Ma, Shangli Ji, Yanfang Peng, Yinhua Huang, Jiansu Chen, Shibo Tang
Summary: This study found that diabetes impairs the circadian rhythm of the transcriptomic profile in retinas, including composition, phase, and amplitude. These findings offer new perspectives on the negative effects of diabetes on the retina and may provide important information for the development of new treatments for diabetic retinopathy (DR).
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Sport Sciences
Raphael Knaier, Jingyi Qian, Ralf Roth, Denis Infanger, Timo Notter, Wei Wang, Christian Cajochen, Frank A. J. L. Scheer
Summary: This systematic review investigates the diurnal variation in maximum endurance and strength performance. The findings suggest that anaerobic power and jump height reach their maximum between 1300 and 2000 hours, while handgrip strength peaks between 1400 and 2100 hours. However, there is only limited evidence regarding the time of peak performance in maximum endurance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Genetics & Heredity
Jia Luo, Zheng Yan, Manyun Dai, Liping Xu, Haoyue Zhang, Yang Xi, Julin Yang, Aiming Liu
Summary: This study aimed to investigate the role of PPAR alpha in modifying the circadian clock and its relevance to NAFLD. The authors used a mouse model and hepatocyte experiments to verify the effects of PPAR alpha on CLOCK regulation and lipid accumulation. They found that high-fat diet led to the down-regulation of CLOCK in the liver, and this down-regulation was dependent on PPAR alpha activity. Furthermore, they observed that down-regulation of hepatic CLOCK by basal PPAR alpha contributed to the inhibition of NAFLD development, while inhibition of CLOCK by activated PPAR alpha was involved in the inhibition of NAFLD by PPAR alpha agonists.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Jinjoo Shim, Elgar Fleisch, Filipe Barata
Summary: Repeated disruptions in circadian rhythms are associated with implications for health outcomes and longevity. The use of wearable devices to quantify circadian rhythms and their connection to longevity through continuous data collection is lacking research. By analyzing data from 7,297 U.S. adults from the 2011-2014 National Health and Nutrition Examination Survey, we identified five categories based on 24-hour accelerometer activity profiles: High activity, Low activity, Mild circadian rhythm disruption, Severe circadian rhythm disruption, and Very low activity. Our findings suggest that circadian alignment is important for longevity across all ages, and data from wearable accelerometers can help identify at-risk populations and personalize treatments for healthier aging.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Celeste Allaband, Amulya Lingaraju, Cameron Martino, Baylee Russell, Anupriya Tripathi, Orit Poulsen, Ana Carolina Dantas Machado, Dan Zhou, Jin Xue, Emmanuel Elijah, Atul Malhotra, Pieter C. Dorrestein, Rob Knight, Gabriel G. Haddad, Amir Zarrinpar
Summary: The study demonstrates that obstructive sleep apnea induces global changes in the cyclical dynamics of the gut microbiome and metabolome, increasing proinflammatory and proatherogenic substances while decreasing protective ones.
Article
Medicine, General & Internal
Magdalena Gebska, Bartosz Dalewski, Lukasz Palka, Lukasz Kolodziej, Ewa Sobolewska
Summary: This study analyzed the importance of chronotype profile for stress level, depression and TMD occurrence in young adults with type D personalities. The results showed that evening chronotypes and type D personalities were associated with higher stress levels, more frequent depression, and TMD symptoms. Female gender and mild to moderate depression were also found to have an impact on the occurrence of type D personalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Bohan Rong, Qiong Wu, Russel J. Reiter, Chao Sun
Summary: The study shows that oral melatonin improves lipid dysmetabolism by modulating gut microbiota and ANGPTL4, resulting in reduced lipid intake in the ileum and fat accumulation in eWAT. LPS derived from E coli triggers changes similar to jet-lag, activating multiple signaling pathways that regulate lipid uptake. The findings suggest that melatonin-mediated improvement of circadian rhythm disruption and metabolic syndrome may be achieved through microbe-generated metabolites.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Clinical Neurology
Robert Gonzalez, Alok Dwivedi, Jamie Zeitzer, Trisha Suppes, Mauricio Tohen, Angelica Forero, Andres Alvarado
Summary: This study used latent profile analysis (LPA) and assessments of activity, sleep, and circadian characteristics to classify bipolar disorder type I (BDI) subjects into high and low chronobiological disturbance sub-groups. Circadian variables were found to be the distinguishing factors between the sub-groups. Future research should further explore the role of circadian characteristics in defining sub-phenotypes of bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Critical Care Medicine
Imre W. K. Kouw, Leonie K. Heilbronn, Arthur R. H. van Zanten
Summary: This article reviews the disruptors of circadian rhythms during ICU admission and evaluates the potential benefits of intermittent feeding on metabolism and circadian rhythms.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Nutrition & Dietetics
Guoliang Deng, Zhiqing Jiang, Hui Lu, Naiyan Lu, Rongxiang Zhu, Chengkai Zhu, Peng Zhou, Xue Tang
Summary: This study examines the impact of high-protein diets, specifically milk protein, on the circadian rhythm of hepatic lipid metabolism. The researchers aimed to investigate how high-protein interventions affect biological clock genes, lipid metabolism balance, and antioxidant levels in vivo. The study involved dividing 120 mice into different groups and analyzing the expression of lipid metabolism enzymes and the levels of lipid-related substances. The results showed that high-protein interventions restored lipid metabolism and improved the disrupted circadian rhythm caused by a high-fat diet.
Article
Sport Sciences
Mohamed A. Souissi, Yousri Elghoul, Hichem Souissi, Liwa Masmoudi, Achraf Ammar, Hamdi Chtourou, Nizar Souissi
Summary: This study aimed to determine which correction strategy, self-observation with direct instruction, self-observation alone, or direct instruction, would be effective in correcting errors in the snatch technique of children aged 10-12. The results showed that the group using the self-observation method combined with direct instruction demonstrated greater improvement in all kinematic parameters compared to other groups, and this effect was still present in the retention test after 2 weeks.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2023)
Article
Sport Sciences
Omar Boukhris, Khaled Trabelsi, Achraf Ammar, Hsen Hsouna, Raouf Abdessalem, Stefan Altmann, Cain C. T. Clark, Mouna Turki, Fatma Ayadi, Florian Engel, Hamdi Chtourou
Summary: This study demonstrates that a 40-minute nap can improve performance, reduce muscle damage and inflammation, alleviate fatigue, and enhance recovery.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Sport Sciences
Maher Souabni, Omar Hammouda, Mehdi J. Souabni, Mohamed Romdhani, Tarak Driss
Summary: The study suggests that a 40-minute nap opportunity can reduce sleepiness and stress and fatigue, while enhancing physical outcomes of specific skills in elite basketball players.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Sport Sciences
Omar Boukhris, Khaled Trabelsi, David W. Hill, Hsen Hsouna, Raouf Abdessalem, Achraf Ammar, Omar Hammouda, Cain C. T. Clark, Piotr Zmijewski, Peter Duking, Tarak Driss, Hamdi Chtourou
Summary: This study aimed to investigate the effects of different nap durations on exercise performance and physiological/perceptual measures. The results showed that napping improved running performance and longer naps were more effective.
RESEARCH IN SPORTS MEDICINE
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Mohamed Amine Farjallah, Ahmed Graja, Kais Ghattassi, Lobna Ben Mahmoud, Henda Elleuch, Fatma Ayadi, Tarak Driss, Kamel Jammoussi, Zouheir Sahnoun, Nizar Souissi, Omar Hammouda
Summary: This study suggests that ingestion of melatonin (MEL) before maximal running exercise may be beneficial in protecting athletes from liver damage and perturbation in renal function biomarkers. However, further research is needed to assess the chronic effects and circadian rhythm.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Review
Nutrition & Dietetics
Slaheddine Delleli, Ibrahim Ouergui, Hamdi Messaoudi, Khaled Trabelsi, Jordan M. Glenn, Achraf Ammar, Hamdi Chtourou
Summary: This systematic review examined the acute and chronic ergogenic effects of dietary nitrate intake from beetroot on combat sports performance. The findings suggest that beetroot intake may improve oxidative metabolism and muscle force production in combat sports athletes, but these effects depend on various factors.
Editorial Material
Hospitality, Leisure, Sport & Tourism
Khaled Trabelsi, Ahmed S. BaHammam, Hamdi Chtourou, Haitham Jahrami, Michael V. Vitiello
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Physiology
Nidhal Nasser, Houssem Zorgati, Hamdi Chtourou, Alexandre Guimard
Summary: Although cold water immersion is commonly used for post-exercise recovery, its benefits may be influenced by placebo effects. This study compared the effects of cold water immersion and placebo interventions on recovery after exercise. The results showed that both cold water immersion and placebo intervention were more effective in muscle damage recovery and physical performance compared to rest conditions. Moreover, the effectiveness of cold water immersion may be partially explained by placebo effects.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Houda Bougrine, Nidhal Nasser, Raouf Abdessalem, Achraf Ammar, Hamdi Chtourou, Nizar Souissi
Summary: The aim of this study was to investigate whether pre-exercise caffeine intake can mitigate the negative effects of Ramadan fasting on short-term maximal performances in young female handball players. Thirteen participants were randomly assigned to receive either placebo or 6 mg/kg(-1) of caffeine before exercise tests at two distinct times of day. The results showed that caffeine intake produced moderate improvements in performance during the post-Ramadan period, especially in the morning session, reducing the negative effects of fasting on maximal performances.
Article
Multidisciplinary Sciences
Ibrahim Ouergui, Slaheddine Delleli, Craig Alan Bridge, Hamdi Messaoudi, Hamdi Chtourou, Christopher Garrett Ballmann, Luca Paolo Ardigo, Emerson Franchini
Summary: The study aimed to assess the effects of acute caffeine supplementation on physical performance and perceived exertion in male and female athletes with varying expertise in taekwondo-specific tasks. The findings showed that caffeine supplementation improved performance in elite athletes compared to sub-elite athletes, and males performed better than females regardless of the supplement condition.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Ibrahim Ouergui, Slaheddine Delleli, Hamdi Messaoudi, Craig Alan Bridge, Hamdi Chtourou, Emerson Franchini, Luca Paolo Ardigo
Summary: This study assessed the effects of different effort-to-pause ratios and rest intervals on taekwondo physical performance. The results showed that all of the preloads provided higher performance outputs compared to the control trial. However, the specific effects varied for different fitness tests and required different lengths of rest intervals.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Sport Sciences
Morteza Taheri, Helmi Ben Saad, Jad Adrian Washif, Luis Felipe Reynoso-Sanchez, Masoud Mirmoezzi, Leila Youzbashi, Khaled Trabelsi, Mozhgan Moshtagh, Hussein Munoz-Helu, Leonardo Jose Mataruna-Dos-Santos, Ali Seghatoleslami, Farnaz Torabi, Yusuf Soylu, Cem Kurt, Rodrigo Luiz Vancini, Shabnam Delkash, Marjan Sadat Rezaei, Mahdi Ashouri, Shazia Tahira, Mansour Sayyah, Hamdi Chtourou, Ismail Dergaa, Jana Strahler, Andressa Fontes Guimaraes-Mataruna, Tyler W. Lebaron, Ebrahim Shaabani Ezdini, Ardeshir Alizade, Hassane Zouhal, Alexander T. Tarnava, Cain Clark, Nooshin Bigdeli, Achraf Ammar, Ozgur Eken, Karim Ben Ayed, Nicola Luigi Bragazzi, Hadi Nobari, Mabliny Thuany, Katja Weiss, Beat Knechtle, Khadijeh Irandoust
Summary: This study aimed to investigate the long-term impact of COVID-19 lockdown on mental health and eating behaviors in elite versus sub-elite athletes. The results showed that, compared to sub-elite athletes, elite athletes had better mental health profiles but lower diet quality.
SPORTS MEDICINE-OPEN
(2023)
Article
Education & Educational Research
Mohamed Tayoush, Ahmad Hamad, Hamdi Chtourou
Summary: This study investigates the impact of multimedia usage in teaching the theoretical aspects of volleyball rules within faculties of physical education and sports sciences. The results indicate that the use of multimedia has a positive impact on teaching the theoretical aspects of volleyball rules, improving students' learning outcomes.
PHYSICAL EDUCATION OF STUDENTS
(2023)
Article
Multidisciplinary Sciences
Slaheddine Delleli, Ibrahim Ouergui, Hamdi Messaoudi, Christopher Garrett Ballmann, Luca Paolo Ardigo, Hamdi Chtourou
Summary: This study investigated the acute effects of combining a low dose of caffeine with listening to music on taekwondo physical performance, perceived exertion, and psychological responses. The results showed that combining caffeine with music improved performance, reduced perceived exertion, and enhanced psychological responses and physical enjoyment during taekwondo-specific tasks.
Article
Psychology, Clinical
Houda Bougrine, Atef Salem, Nidhal Nasser, Achraf Ammar, Hamdi Chtourou, Nizar Souissi
Summary: This study compares the effects of early vs. late Sahur on short-term high-intensity physical exercise during Ramadan fasting. The results show that early Sahur significantly decreases physical performance in the morning, while both early and late Sahur lead to a decline in performance in the afternoon. Therefore, consuming a late Sahur closer to pre-dawn time is suggested to minimize the decline in physical performance during short-term high-intensity exercise.
EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
(2023)
